DE602006016468D1 - Verfahren zur abgabe von fusionspolypeptid in eine zelle - Google Patents

Verfahren zur abgabe von fusionspolypeptid in eine zelle

Info

Publication number
DE602006016468D1
DE602006016468D1 DE602006016468T DE602006016468T DE602006016468D1 DE 602006016468 D1 DE602006016468 D1 DE 602006016468D1 DE 602006016468 T DE602006016468 T DE 602006016468T DE 602006016468 T DE602006016468 T DE 602006016468T DE 602006016468 D1 DE602006016468 D1 DE 602006016468D1
Authority
DE
Germany
Prior art keywords
cell
fusion polypeptide
methods
fusion polypeptides
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006016468T
Other languages
English (en)
Inventor
Sang-Kyou Lee
Seung-Kyou Lee
Je-Min Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ForHumanTech Co Ltd
Original Assignee
ForHumanTech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ForHumanTech Co Ltd filed Critical ForHumanTech Co Ltd
Publication of DE602006016468D1 publication Critical patent/DE602006016468D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE602006016468T 2005-11-04 2006-11-03 Verfahren zur abgabe von fusionspolypeptid in eine zelle Active DE602006016468D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73318305P 2005-11-04 2005-11-04
PCT/IB2006/003971 WO2007052172A2 (en) 2005-11-04 2006-11-03 Methods for fusion polypeptide delivery into a cell

Publications (1)

Publication Number Publication Date
DE602006016468D1 true DE602006016468D1 (de) 2010-10-07

Family

ID=38006264

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006016468T Active DE602006016468D1 (de) 2005-11-04 2006-11-03 Verfahren zur abgabe von fusionspolypeptid in eine zelle

Country Status (8)

Country Link
US (1) US7723299B2 (de)
EP (1) EP1942925B1 (de)
JP (1) JP2010509181A (de)
KR (1) KR20080084937A (de)
CN (1) CN101355957A (de)
AT (1) ATE478676T1 (de)
DE (1) DE602006016468D1 (de)
WO (1) WO2007052172A2 (de)

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JP2009544688A (ja) * 2006-07-24 2009-12-17 フォーヒューマンテック カンパニー リミテッド 虚血性疾患の緩和及び治療のための医薬組成物並びにそれを伝達するための方法
JP2010503616A (ja) * 2006-08-29 2010-02-04 フォルマンテク．・カンパニー， リミテッド アポトーシスを抑制するための薬学的組成物および前記薬学的組成物をデリバーするための方法
US20090047703A1 (en) * 2007-08-17 2009-02-19 University Of Maryland, Baltimore ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease
JP2010537632A (ja) * 2007-08-29 2010-12-09 タフツ ユニバーシティー 組織及び細胞への核酸、タンパク質、薬物、及びアデノウイルスの送達を向上させるための細胞透過性ペプチドの製造及び使用方法、組成物並びにキット
US7981446B2 (en) 2007-11-26 2011-07-19 Forhumantech. Co., Ltd. Pharmaceutical compositions and methods for delivering nucleic acids into cells
AU2009218060B2 (en) * 2008-02-28 2014-08-28 Toray Industries, Inc. Pharmaceutical composition for transnasal administration
JP2010189302A (ja) * 2009-02-17 2010-09-02 Hiroshima Univ 病変間葉系幹細胞が関連する疾患の治療剤および間葉系幹細胞の検出マーカーの利用
EP4089169A1 (de) 2009-10-12 2022-11-16 Larry J. Smith Verfahren und zusammensetzungen zum modulieren der genexpression mit in-vivo oder in-vitro verabreichten arzneistoffen auf oligonukleotidbasis
KR101557343B1 (ko) * 2010-12-10 2015-10-06 연세대학교 산학협력단 전사인자 ｇａｔａ-3의 ｄｎａ 결합 도메인과 단백질 운반 도메인을 융합한 단백질을 이용한 알러지성 천식 치료용 약학 조성물 및 이를 이용한 치료방법
CN102349995B (zh) * 2011-10-24 2013-06-05 武汉大学 一种广谱抗病毒的药物及其制备方法和应用
CN105327350A (zh) * 2014-07-23 2016-02-17 中国科学院上海巴斯德研究所 泛素化途径相关因子在调控辅助性t细胞功能中的应用
AU2015304194B2 (en) * 2014-08-17 2018-03-01 Cellivery Therapeutics, Inc. Advanced macromolecule transduction domain (aMTD) sequences for improvement of cell-permeability, polynucleotides encoding the same, method to identify the unique features of aMTDs comprising the same, method to develop the aMTD sequences comprising the same
CN108137659B (zh) * 2015-08-21 2021-11-26 汉阳大学校产学协力团 具有预防或治疗中枢神经系统疾病作用的肽和包含其作为活性成分的药物组合物
WO2017034244A1 (ko) * 2015-08-21 2017-03-02 한양대학교 산학협력단 중추신경계 질환에 대한 예방 또는 치료효과를 갖는 펩타이드 및 이를 유효성분으로 하는 중추신경계 질환 예방 및 치료용 약학적 조성물
US11351224B2 (en) 2015-08-21 2022-06-07 Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University) Pharmaceutical composition for preventing and treating transplant rejection
CA3010811A1 (en) * 2016-01-06 2017-07-13 Sang Kyou Lee Novel fusion protein comprising transcription modulation domain of p65 and protein transport domain and use thereof
KR20180109272A (ko) * 2017-03-27 2018-10-08 한양대학교 산학협력단 세포투과성 펩타이드와 ctCTLA4 펩타이드가 융합된 융합단백질을 유효성분으로 하는 염증성 호흡기 질환 예방 또는 치료용 약학 조성물
CN107365784A (zh) * 2017-08-02 2017-11-21 滨州医学院 一种用于递送至中枢神经系统的融合蛋白及合成方法
KR101939323B1 (ko) * 2017-09-29 2019-01-16 주식회사 바이오셀트란 탈모 방지 및 발모 촉진 효과를 가지는 피부투과성 단백질 및 그의 용도
JP2023509666A (ja) * 2019-12-31 2023-03-09 シァメン・ユニヴァーシティ 分子の細胞内送達用の多量体化送達システム

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EP0927250A1 (de) 1996-08-23 1999-07-07 Chiron Corporation MENSCHLICHES POLYHOMEOTISCH 1 (hphl) WIRKT WIE EIN TUMORUNTERDRÜCKER
CA2298067A1 (en) 1997-07-24 1999-02-04 Ulo Langel Conjugates of transporter peptides and nucleic acid analogs, and their use
US6251599B1 (en) 1998-11-06 2001-06-26 Selective Genetics, Inc. Stabilized nucleic acid compositions and methods of preparation and use thereof
US6903077B1 (en) 1999-01-04 2005-06-07 University Of Vermont And State Agricultural College Methods and products for delivering nucleic acids
US20030104622A1 (en) * 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
GB0103110D0 (en) 2000-08-25 2001-03-28 Aventis Pharma Inc A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1
KR20030062789A (ko) 2002-01-19 2003-07-28 포휴먼텍(주) 생체분자 전달 펩타이드 ｓｉｍ2-ｂｔｍ 및 이것을포함하는 생명공학제품
KR20030062788A (ko) * 2002-01-19 2003-07-28 포휴먼텍(주) 생체분자 전달 펩타이드 ｍｐｈ1-ｂｔｍ 및 이것을포함하는 생명공학제품
KR100591936B1 (ko) 2002-11-12 2006-06-22 포휴먼텍(주) 세포내 ｄｎａ／ｒｎａ 전달 방법, 및 이것의 기초 및임상학적 응용
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CN100506841C (zh) 2003-05-01 2009-07-01 科内尔研究基金会 将分子递送到细胞的方法和载体复合物
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US7339042B2 (en) 2003-06-09 2008-03-04 University Of Florida Research Foundation, Inc. Gene delivery to tumors
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JP2010503616A (ja) 2006-08-29 2010-02-04 フォルマンテク．・カンパニー， リミテッド アポトーシスを抑制するための薬学的組成物および前記薬学的組成物をデリバーするための方法
US7981446B2 (en) 2007-11-26 2011-07-19 Forhumantech. Co., Ltd. Pharmaceutical compositions and methods for delivering nucleic acids into cells

Also Published As

Publication number Publication date
US7723299B2 (en) 2010-05-25
WO2007052172A8 (en) 2008-05-02
EP1942925B1 (de) 2010-08-25
US20070105775A1 (en) 2007-05-10
WO2007052172A2 (en) 2007-05-10
KR20080084937A (ko) 2008-09-22
CN101355957A (zh) 2009-01-28
JP2010509181A (ja) 2010-03-25
EP1942925A4 (de) 2009-07-22
ATE478676T1 (de) 2010-09-15
WO2007052172A3 (en) 2007-11-29
EP1942925A2 (de) 2008-07-16

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