JP4574350B2 - Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 - Google Patents
Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 Download PDFInfo
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- JP4574350B2 JP4574350B2 JP2004516142A JP2004516142A JP4574350B2 JP 4574350 B2 JP4574350 B2 JP 4574350B2 JP 2004516142 A JP2004516142 A JP 2004516142A JP 2004516142 A JP2004516142 A JP 2004516142A JP 4574350 B2 JP4574350 B2 JP 4574350B2
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- apo2l
- variant polypeptide
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| US39105002P | 2002-06-24 | 2002-06-24 | |
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| GB0328261D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
| BRPI0509201A (pt) | 2004-03-23 | 2007-08-28 | Biogen Idec Inc | agentes de acoplamento de receptor e usos terapêuticos destes |
| JP2008513367A (ja) * | 2004-09-08 | 2008-05-01 | ジェネンテック・インコーポレーテッド | デスレセプターリガンド及びｃｄ２０抗体の使用方法 |
| GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
| KR100886783B1 (ko) * | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도 |
| WO2008088582A2 (en) * | 2006-08-04 | 2008-07-24 | Mayo Foundation For Medical Education And Research | Methods and materials related to trail isoforms |
| JP5624471B2 (ja) | 2007-09-24 | 2014-11-12 | バーイラン ユニバーシティー | 磁性金属酸化物で被覆されたポリマー性ナノ粒子及びその使用 |
| EP2215246B1 (en) * | 2007-10-31 | 2015-01-07 | MedImmune, LLC | Protein scaffolds |
| WO2011079293A1 (en) * | 2009-12-23 | 2011-06-30 | Ambrx, Inc | Tumor necrosis factor-related apoptosis inducing ligand polypeptides and their uses |
| KR20130056870A (ko) | 2010-04-13 | 2013-05-30 | 메디뮨 엘엘씨 | 피브로넥틴 ⅲ형 도메인에 기초한 다량체 스캐폴드 |
| KR102434073B1 (ko) | 2011-10-11 | 2022-08-18 | 비엘라 바이오, 인크. | Cd40l 특이적 tn3 유래 스카폴드 및 이의 사용 방법 |
| WO2013148877A1 (en) | 2012-03-28 | 2013-10-03 | Amgen Inc. | Dr5 receptor agonist combinations |
| MX2016001854A (es) | 2013-08-12 | 2016-09-06 | Genentech Inc | Composiciones y metodo para tratar condiciones asociadas con el complemento. |
| WO2015138638A1 (en) | 2014-03-11 | 2015-09-17 | Theraly Pharmaceuticals, Inc. | Long acting trail receptor agonists for treatment of autoimmune diseases |
| SG11201608868PA (en) | 2014-05-01 | 2016-11-29 | Genentech Inc | Anti-factor d antibody variants and uses thereof |
| KR20150133576A (ko) * | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
| JP2018536650A (ja) | 2015-10-30 | 2018-12-13 | ジェネンテック， インコーポレイテッド | 抗ｄ因子抗体変異体コンジュゲート及びその使用 |
| TW201730211A (zh) | 2015-10-30 | 2017-09-01 | 建南德克公司 | 抗因子d抗體及結合物 |
| US11007251B2 (en) | 2015-12-17 | 2021-05-18 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
| CN109195620B (zh) | 2016-04-07 | 2022-06-28 | 约翰霍普金斯大学 | 用死亡受体激动剂治疗胰腺炎和疼痛的组合物和方法 |
| US12344645B2 (en) | 2017-03-29 | 2025-07-01 | Polaris Group | Protein conjugates |
| IT201900024622A1 (it) * | 2019-12-18 | 2021-06-18 | Univ Degli Studi G Dannunzio Chieti Pescara | Pegilazione innovativa del killer tnf-apoptosis induced ligand (killer-trail) |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| GB8430252D0 (en) | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| ES2032831T5 (es) | 1986-08-19 | 2001-02-16 | Genentech Inc | Dispositivo y dispersion para suministro intrapulmonar de factores de crecimiento polipeptidos y citoquinas. |
| JPH04501201A (ja) | 1987-12-21 | 1992-03-05 | ジ・アップジョン・カンパニー | 発芽植物種子類のアグロバクテリウム媒介形質転換 |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| DK168302B1 (da) | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| WO1992003478A1 (en) | 1990-08-17 | 1992-03-05 | Genentech, Inc. | Metal ion mediated receptor binding of polypeptide hormones |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| WO1992017200A2 (en) | 1991-03-28 | 1992-10-15 | Genentech, Inc. | Stable growth hormone metal ion formulations |
| WO1993000109A1 (en) | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
| CA2149048A1 (en) | 1992-11-25 | 1994-06-09 | George N. Cox | Modified insulin-like growth factors |
| CN1134111A (zh) | 1993-04-07 | 1996-10-23 | 赛纳根公司 | 使用胰岛素样生长因子结合蛋白质的方法 |
| JPH09504174A (ja) * | 1993-10-29 | 1997-04-28 | インサイト ファーマシューティカルズ，インク． | プロテアーゼネキシン１変異体を含むキメラ蛋白 |
| US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| CA2225378C (en) | 1995-06-29 | 2012-04-17 | Immunex Corporation | Cytokine that induces apoptosis |
| ATE455171T1 (de) | 1995-09-21 | 2010-01-15 | Genentech Inc | Varianten des menschlichen wachstumshormons |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| NZ334309A (en) | 1996-10-25 | 2000-08-25 | Human Genome Sciences Inc | Neutrokine alpha protein, a member of the TNF family, and its use in treating and/or detecting immune disorders |
| ATE497001T1 (de) | 1996-12-23 | 2011-02-15 | Immunex Corp | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
| ATE362982T1 (de) | 1997-01-28 | 2007-06-15 | Human Genome Sciences Inc | ßDEATH-DOMAINß-ENTHALTENDER REZEPTOR 4 (DR4), EIN MITGLIED DER TNF-REZEPTOR SUPERFAMILIE, WELCHER AN TRAIL (APO-2L) BINDET |
| AU740207B2 (en) | 1997-02-06 | 2001-11-01 | Novozymes A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
| NZ508381A (en) | 1997-03-17 | 2002-09-27 | Human Genome Sciences Inc | Antibodies, antagonists and agonists of the death domain containing receptor 5 (DR5) |
| EA003636B1 (ru) | 1997-04-16 | 2003-08-28 | Амген Инк. | Остеопротегеринсвязующие белки и рецепторы |
| WO1998046643A1 (en) | 1997-04-16 | 1998-10-22 | Millennium Biotherapeutics, Inc. | TUMOR NECROSIS FACTOR RECEPTOR RELATED PROTEINS TANGO-63d AND TANGO-63e |
| PT981618E (pt) | 1997-05-15 | 2007-11-23 | Genentech Inc | ''anticorpo anti-apo-2'' |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| AU8400398A (en) | 1997-07-11 | 1999-02-08 | Trustees Of The University Of Pennsylvania, The | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
| ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| JP2001514888A (ja) | 1997-08-15 | 2001-09-18 | アイドゥン ファーマシューティカルズ， インコーポレイテッド | Ｔｒａｉｌレセプター、これをコードする核酸、およびその使用方法 |
| AU8485098A (en) | 1997-08-26 | 1999-03-16 | Genentech Inc. | Rtd receptor |
| AU9376498A (en) | 1997-09-05 | 1999-03-22 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| CA2318029C (en) * | 1998-01-15 | 2009-05-19 | Genentech, Inc. | Apo-2 ligand |
| PT1053256E (pt) | 1998-01-26 | 2011-09-28 | Genentech Inc | Anticorpos para o receptor de morte 4 (dr4) e utilizações destes |
| ATE330972T1 (de) | 1999-06-09 | 2006-07-15 | Genentech Inc | Apo-2l rezeptor-agonist und cpt-11 synergie- effekt |
| US6318934B1 (en) * | 1999-06-24 | 2001-11-20 | Anchor Wall Systems, Inc. | Segmental retaining wall system |
| EP1194555B1 (en) * | 1999-06-28 | 2012-09-26 | Genentech, Inc. | Methods for making apo-2 ligand using divalent metal ions |
| WO2002009755A2 (en) | 2000-07-27 | 2002-02-07 | Genentech, Inc. | Apo-2l receptor agonist and cpt-11 synergism |
| EP2348043A1 (en) * | 2001-10-02 | 2011-07-27 | Genentech, Inc. | APO-2 ligand variants and uses thereof |
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- 2003-06-23 JP JP2004516142A patent/JP4574350B2/ja not_active Expired - Lifetime
- 2003-06-23 US US10/519,647 patent/US20060141561A1/en not_active Abandoned
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| WO2004001009A2 (en) | 2003-12-31 |
| JP2006508640A (ja) | 2006-03-16 |
| EP1556076A4 (en) | 2009-07-08 |
| JP2010065037A (ja) | 2010-03-25 |
| US20130165383A1 (en) | 2013-06-27 |
| EP1556076A2 (en) | 2005-07-27 |
| IL165777A0 (en) | 2006-01-15 |
| US20060141561A1 (en) | 2006-06-29 |
| AU2003247609A1 (en) | 2004-01-06 |
| EP2500032A1 (en) | 2012-09-19 |
| AU2009212834A1 (en) | 2009-09-24 |
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