JP2010065037A5 - - Google Patents
Info
- Publication number
- JP2010065037A5 JP2010065037A5 JP2009233816A JP2009233816A JP2010065037A5 JP 2010065037 A5 JP2010065037 A5 JP 2010065037A5 JP 2009233816 A JP2009233816 A JP 2009233816A JP 2009233816 A JP2009233816 A JP 2009233816A JP 2010065037 A5 JP2010065037 A5 JP 2010065037A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- sequence
- apo
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000007193 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 2
- 108010008478 TNF-Related Apoptosis-Inducing Ligand Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102200002107 RIOK2 S96C Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Claims (1)
- 図１（配列番号１）の天然配列Ａｐｏ−２リガンドポリペプチド配列とは異なり、次の図１（配列番号１）の残基位置のアミノ酸置換：Ｓ９６Ｃ；Ｓ１０１Ｃ；Ｓ１１１Ｃ；Ｒ１７０Ｃ；Ｋ１７９Ｃのうち１又は複数を有するアミノ酸配列を含んでなる、単離されたＡｐｏ−２リガンド変異体ポリペプチド。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39105002P | 2002-06-24 | 2002-06-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Division JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010065037A JP2010065037A (ja) | 2010-03-25 |
| JP2010065037A5 true JP2010065037A5 (ja) | 2010-12-09 |
Family
ID=30000661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Expired - Lifetime JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
| JP2009233816A Pending JP2010065037A (ja) | 2002-06-24 | 2009-10-07 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Expired - Lifetime JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20060141561A1 (ja) |
| EP (2) | EP2500032A1 (ja) |
| JP (2) | JP4574350B2 (ja) |
| AU (2) | AU2003247609A1 (ja) |
| CA (1) | CA2489348A1 (ja) |
| IL (1) | IL165777A0 (ja) |
| WO (1) | WO2004001009A2 (ja) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2348043A1 (en) * | 2001-10-02 | 2011-07-27 | Genentech, Inc. | APO-2 ligand variants and uses thereof |
| GB0328261D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
| AU2005227322A1 (en) | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
| NZ553174A (en) * | 2004-09-08 | 2010-03-26 | Genentech Inc | Methods of using death receptor ligands Apo2L/Trail and CD20 antibodies |
| GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
| KR100886783B1 (ko) | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도 |
| US8008261B2 (en) * | 2006-08-04 | 2011-08-30 | Mayo Foundation For Medical Education And Research | Methods of reducing trail-induced apoptosis by trail isoforms |
| RU2472530C2 (ru) | 2007-09-24 | 2013-01-20 | Бар-Илан Юниверсити | Полимерные наночастицы, покрытые оксидом магнитного металла, и их применение |
| KR101686247B1 (ko) * | 2007-10-31 | 2016-12-14 | 메디뮨 엘엘씨 | 단백질 스캐폴드 |
| WO2011079293A1 (en) * | 2009-12-23 | 2011-06-30 | Ambrx, Inc | Tumor necrosis factor-related apoptosis inducing ligand polypeptides and their uses |
| EP2560684A4 (en) | 2010-04-13 | 2013-11-20 | Medimmune Llc | FIBRONECTIN TYPE III DOMAIN MULTIMERIC SCAFFOLDS |
| SI2771022T1 (sl) | 2011-10-11 | 2020-12-31 | Viela Bio, Inc. | CD40L-specifična ogrodja pridobljena iz TN3 in postopki njihove uporabe |
| EP2831116A1 (en) | 2012-03-28 | 2015-02-04 | Amgen Inc. | Dr5 receptor agonist combinations |
| SG11201601044XA (en) | 2013-08-12 | 2016-03-30 | Genentech Inc | Compositions and method for treating complement-associated conditions |
| US11299528B2 (en) | 2014-03-11 | 2022-04-12 | D&D Pharmatech Inc. | Long acting TRAIL receptor agonists for treatment of autoimmune diseases |
| MA39934A (fr) | 2014-05-01 | 2017-03-08 | Hoffmann La Roche | Variants d'anticorps anti-facteur d et leurs utilisations |
| KR20150133576A (ko) * | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
| US10407510B2 (en) | 2015-10-30 | 2019-09-10 | Genentech, Inc. | Anti-factor D antibodies and conjugates |
| CN108472382A (zh) | 2015-10-30 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 抗-因子d抗体变体缀合物及其用途 |
| CA3008392C (en) | 2015-12-17 | 2021-11-09 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
| JP7281795B2 (ja) | 2016-04-07 | 2023-05-26 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 膵炎および疼痛をデス受容体アゴニストで処置するための組成物および方法 |
| IT201900024622A1 (it) * | 2019-12-18 | 2021-06-18 | Univ Degli Studi G Dannunzio Chieti Pescara | Pegilazione innovativa del killer tnf-apoptosis induced ligand (killer-trail) |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| GB8430252D0 (en) | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| EP0257956B2 (en) | 1986-08-19 | 2000-11-22 | Genentech, Inc. | Use of polypeptide growth factors and cytokines for the manufacture of a device and of a dispersion |
| WO1989005859A1 (en) | 1987-12-21 | 1989-06-29 | The Upjohn Company | Agrobacterium mediated transformation of germinating plant seeds |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| DK168302B1 (da) | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
| EP1132471A3 (de) | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| WO1992003478A1 (en) | 1990-08-17 | 1992-03-05 | Genentech, Inc. | Metal ion mediated receptor binding of polypeptide hormones |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| AU1757092A (en) | 1991-03-28 | 1992-11-02 | Genentech Inc. | Stable growth hormone metal ion formulations |
| AU2147192A (en) | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
| JPH08506095A (ja) | 1992-11-25 | 1996-07-02 | アムジェン ボールダー インコーポレイテッド | 改変インシュリン様成長因子 |
| CA2160154A1 (en) | 1993-04-07 | 1994-10-13 | George N. Cox | Methods of using insulin-like growth factor binding proteins |
| WO1995011987A1 (en) * | 1993-10-29 | 1995-05-04 | Incyte Pharmaceuticals, Inc. | Chimeric proteins including protease nexin-1 variants |
| JP4435304B2 (ja) | 1995-06-29 | 2010-03-17 | イミュネックス・コーポレーション | アポトーシスを誘導するサイトカイン |
| US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| DE122006000003I1 (de) | 1995-09-21 | 2006-05-04 | Genentech Inc | Varianten des Menschlichen Wachstumshormons |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| BR9612752A (pt) | 1996-10-25 | 2000-01-18 | Human Genome Sciences Inc | Neutrocina |
| EP0951551B9 (en) | 1996-12-23 | 2012-12-26 | Immunex Corporation | Ligand for receptor activator of nf-kappa b, ligand is member of tnf superfamily |
| ES2284199T5 (es) | 1997-01-28 | 2011-11-14 | Human Genome Sciences, Inc. | Receptor 4 que contiene dominio de muerte (dr4: receptor 4 de muerte), miembro de la superfamilia de receptores de tnf y unión a trail (apo-2l). |
| CA2279986A1 (en) | 1997-02-06 | 1998-08-13 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
| JP4330180B2 (ja) | 1997-03-17 | 2009-09-16 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 死ドメイン含有レセプター５ |
| JP2002512515A (ja) | 1997-04-16 | 2002-04-23 | ミレニアム ファーマシューティカルズ インク． | 腫瘍壊死因子受容体関連蛋白質ＴＡＮＧＯ−６３ｄおよびＴＡＮＧＯ−６３ｅ |
| EA003636B1 (ru) | 1997-04-16 | 2003-08-28 | Амген Инк. | Остеопротегеринсвязующие белки и рецепторы |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| DE69838249T3 (de) | 1997-05-15 | 2012-01-19 | Genentech, Inc. | Anti-apo-2 antikörper |
| AU8400398A (en) | 1997-07-11 | 1999-02-08 | Trustees Of The University Of Pennsylvania, The | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
| DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
| WO1999009165A1 (en) | 1997-08-15 | 1999-02-25 | Idun Pharmaceuticals, Inc. | Trail receptors, nucleic acids encoding the same, and methods of use thereof |
| IL134577A0 (en) | 1997-08-26 | 2001-04-30 | Genentech Inc | Rtd receptor |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| JP2002508962A (ja) | 1998-01-15 | 2002-03-26 | ジェネンテク・インコーポレイテッド | Ａｐｏ−２リガンド |
| ES2368823T3 (es) | 1998-01-26 | 2011-11-22 | Genentech, Inc. | Anticuerpos del receptor 4 de muerte (dr4) y usos de los mismos. |
| ES2267547T3 (es) | 1999-06-09 | 2007-03-16 | Genentech, Inc. | Sinergia de antagonista de receptores del ligando apo-2l y de cpt-11. |
| US6318934B1 (en) * | 1999-06-24 | 2001-11-20 | Anchor Wall Systems, Inc. | Segmental retaining wall system |
| MXPA01013236A (es) * | 1999-06-28 | 2002-06-21 | Genentech Inc | Metodos para hacer ligando apo-2 mediante el uso de iones metalicos divalentes. |
| ES2317924T3 (es) | 2000-07-27 | 2009-05-01 | Genentech, Inc. | Administracion secuencial de cpt-11 y polipeptido apo-2l. |
| EP2348043A1 (en) * | 2001-10-02 | 2011-07-27 | Genentech, Inc. | APO-2 ligand variants and uses thereof |
-
2003
- 2003-06-23 US US10/519,647 patent/US20060141561A1/en not_active Abandoned
- 2003-06-23 JP JP2004516142A patent/JP4574350B2/ja not_active Expired - Lifetime
- 2003-06-23 CA CA002489348A patent/CA2489348A1/en not_active Abandoned
- 2003-06-23 AU AU2003247609A patent/AU2003247609A1/en not_active Abandoned
- 2003-06-23 WO PCT/US2003/019750 patent/WO2004001009A2/en active Application Filing
- 2003-06-23 EP EP11183690A patent/EP2500032A1/en not_active Withdrawn
- 2003-06-23 EP EP03761262A patent/EP1556076A4/en not_active Withdrawn
-
2004
- 2004-12-15 IL IL16577704A patent/IL165777A0/xx unknown
-
2006
- 2006-10-02 US US11/541,821 patent/US20070098681A1/en not_active Abandoned
-
2009
- 2009-08-26 AU AU2009212834A patent/AU2009212834A1/en not_active Abandoned
- 2009-10-07 JP JP2009233816A patent/JP2010065037A/ja active Pending
-
2011
- 2011-06-06 US US13/153,710 patent/US20120165267A1/en not_active Abandoned
-
2012
- 2012-04-06 US US13/441,682 patent/US20130165383A1/en not_active Abandoned