JP2009542225A5 - - Google Patents

Download PDF

Info

Publication number
JP2009542225A5
JP2009542225A5 JP2009518576A JP2009518576A JP2009542225A5 JP 2009542225 A5 JP2009542225 A5 JP 2009542225A5 JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009542225 A5 JP2009542225 A5 JP 2009542225A5
Authority
JP
Japan
Prior art keywords
factor viii
protein
phenylalanine
serine
substitution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009518576A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009542225A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/072506 external-priority patent/WO2008005847A2/en
Publication of JP2009542225A publication Critical patent/JP2009542225A/ja
Publication of JP2009542225A5 publication Critical patent/JP2009542225A5/ja
Pending legal-status Critical Current

Links

JP2009518576A 2006-06-30 2007-06-29 組換え法によりｆｖｉｉｉタンパク質を生産する方法 Pending JP2009542225A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81817706P 2006-06-30 2006-06-30
PCT/US2007/072506 WO2008005847A2 (en) 2006-06-30 2007-06-29 Method of producing factor viii proteins by recombinant methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013161261A Division JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Publications (2)

Publication Number Publication Date
JP2009542225A JP2009542225A (ja) 2009-12-03
JP2009542225A5 true JP2009542225A5 (enExample) 2013-09-19

Family

ID=38895363

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009518576A Pending JP2009542225A (ja) 2006-06-30 2007-06-29 組換え法によりｆｖｉｉｉタンパク質を生産する方法
JP2013161261A Pending JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013161261A Pending JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Country Status (6)

Country Link
US (2) US20080070251A1 (enExample)
EP (2) EP2035572A4 (enExample)
JP (2) JP2009542225A (enExample)
AU (1) AU2007269233B2 (enExample)
CA (1) CA2656558A1 (enExample)
WO (1) WO2008005847A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
US20120028900A1 (en) * 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
CA2837995A1 (en) * 2011-06-03 2012-12-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
CN103917554B (zh) 2011-10-18 2017-03-08 杰特有限公司 用于改善重构后纯化的因子viii的稳定性的方法
US20150045303A1 (en) * 2012-04-24 2015-02-12 Novo Nordisk A/S Pharmaceutical Composition Suitable for Treatment of Haemophilia
EP3770263A1 (en) * 2013-03-12 2021-01-27 AGC Biologics, Inc. Improved recombinant protein expression using a hybrid chef1 promoter
WO2014152530A1 (en) * 2013-03-15 2014-09-25 Bayer Healthcare Llc Variant factor viii polypeptides and methods of their production and use
WO2015091130A1 (en) * 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Method for improving the recombinant production of soluble fusion polypeptides
EP3083977B1 (en) 2013-12-20 2018-02-28 F. Hoffmann-La Roche AG Improved recombinant polypeptide production methods
EP3114138B1 (en) 2014-03-05 2021-11-17 Pfizer Inc. Improved muteins of clotting factor viii
CA2942770A1 (en) * 2014-03-23 2015-10-01 Advantech Bioscience Farmaceutica Ltda. Enhancement of recombinant protein expression with copper
US9907835B2 (en) 2014-04-01 2018-03-06 Advanced Bioscience Farmacêutica LTDA Stable Factor VIII formulations with low sugar-glycine
CN106456720A (zh) 2014-04-01 2017-02-22 爱德技术生物科学有限公司 在无钙作为赋形剂下因子viii的稳定性
KR102554850B1 (ko) * 2015-02-06 2023-07-13 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 최적화된 인간 응고 인자 viii 유전자 발현 카세트 및 그의 용도
AU2016282334B2 (en) 2015-06-24 2022-07-21 F. Hoffmann-La Roche Ag Anti-transferrin receptor antibodies with tailored affinity
MX2018003822A (es) 2015-10-02 2018-06-22 Hoffmann La Roche Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso.
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
KR102219859B1 (ko) * 2016-06-24 2021-02-25 재단법인 목암생명과학연구소 재조합 단쇄 fviii 및 그 화학 접합물
CA3191743A1 (en) * 2020-09-16 2022-03-24 Generation Bio Co. Non-viral dna vectors and uses thereof for expressing fviii therapeutics
JP2025538565A (ja) 2022-11-23 2025-11-28 エフ． ホフマン－ラ ロシュ アーゲー 組換えタンパク質発現を増加させるための方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4599308A (en) 1981-10-06 1986-07-08 Hamer Dean H Protein from SV40 recombinants
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US5214033A (en) * 1983-03-31 1993-05-25 Scripps Clinic & Research Foundation Factor VIII coagulant polypeptides
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US5045455A (en) * 1984-01-12 1991-09-03 Chiron Corporation Factor VIII:C cDNA cloning and expression
US4879236A (en) 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4745057A (en) 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
US4577729A (en) * 1984-12-05 1986-03-25 Westinghouse Electric Corp. Guide rail clamping assembly
US4912038A (en) 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US4879224A (en) 1985-01-10 1989-11-07 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides
US4761371A (en) 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
MX9203440A (es) * 1985-04-12 1992-07-01 Genetics Inst Proteinas procoagulantes novedosas.
ATE87663T1 (de) 1986-01-03 1993-04-15 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ- proteinen.
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
AT388079B (de) 1986-04-18 1989-04-25 Helmut Ing Koenig Backofen
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US5422260A (en) * 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US4877729A (en) 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
CA1331157C (en) 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
US5004803A (en) 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
US5661008A (en) * 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US5563045A (en) * 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
PT1754718E (pt) * 1996-04-24 2011-07-13 Univ Michigan Factor viii resistente à inactivação
US20040092442A1 (en) * 1996-04-24 2004-05-13 University Of Michigan Inactivation resistant factor VIII
US5838437A (en) * 1997-04-09 1998-11-17 Micron Optics, Inc. Reference system for optical devices including optical scanners and spectrum analyzers
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
ATE222925T1 (de) * 1998-03-12 2002-09-15 Inst Genetics Llc Verbessertes verfahren zur herstellung von faktor viii
US7041635B2 (en) * 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
CA2703948A1 (en) * 2007-11-01 2009-05-07 University Of Rochester Recombinant factor viii having increased stability

Similar Documents

Publication Publication Date Title
JP2011508438A5 (enExample)
JP2006524283A5 (enExample)
DK2051962T3 (da) (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-eddikesyrederivater
JP2010505386A5 (enExample)
JP2007506705A5 (enExample)
JP2007510403A5 (enExample)
JP2008278122A5 (enExample)
JP2008517002A5 (enExample)
NO20053147L (no) Forsterkningsring.
NL1031705A1 (nl) Aminozuurderivaten.
JP2009506986A5 (enExample)
JP2008545704A5 (enExample)
NL1030303A1 (nl) Tweewieler.
JP2009507121A5 (enExample)
FR2891064B1 (fr) Lunettes du type galbees a encombrement reduit.
CN300747134S (zh) 容器
CN300767793S (zh) 直饮机(mr0107-d)
CN300827650S (zh) 车体
КУЗЬМИЦКИЙ www. consultant. ru
CN300830223S (zh) 全地形车(1)
CN300806757S (zh) 全地形车(2)
CN300773762S (zh) 剃刀架
CN300894417S (zh) 浴霸(ydd10c1)
CN300894416S (zh) 浴霸(ydd10c2)
CN300939415S (zh) 净水机(mro103-4)