JP2009542225A5 - - Google Patents

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Publication number
JP2009542225A5
JP2009542225A5 JP2009518576A JP2009518576A JP2009542225A5 JP 2009542225 A5 JP2009542225 A5 JP 2009542225A5 JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009542225 A5 JP2009542225 A5 JP 2009542225A5
Authority
JP
Japan
Prior art keywords
factor viii
protein
phenylalanine
serine
substitution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009518576A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009542225A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/072506 external-priority patent/WO2008005847A2/en
Publication of JP2009542225A publication Critical patent/JP2009542225A/ja
Publication of JP2009542225A5 publication Critical patent/JP2009542225A5/ja
Pending legal-status Critical Current

Links

JP2009518576A 2006-06-30 2007-06-29 組換え法によりｆｖｉｉｉタンパク質を生産する方法 Pending JP2009542225A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81817706P 2006-06-30 2006-06-30
PCT/US2007/072506 WO2008005847A2 (en) 2006-06-30 2007-06-29 Method of producing factor viii proteins by recombinant methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013161261A Division JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Publications (2)

Publication Number Publication Date
JP2009542225A JP2009542225A (ja) 2009-12-03
JP2009542225A5 true JP2009542225A5 (enExample) 2013-09-19

Family

ID=38895363

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009518576A Pending JP2009542225A (ja) 2006-06-30 2007-06-29 組換え法によりｆｖｉｉｉタンパク質を生産する方法
JP2013161261A Pending JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013161261A Pending JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Country Status (6)

Country Link
US (2) US20080070251A1 (enExample)
EP (2) EP2035572A4 (enExample)
JP (2) JP2009542225A (enExample)
AU (1) AU2007269233B2 (enExample)
CA (1) CA2656558A1 (enExample)
WO (1) WO2008005847A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120028900A1 (en) * 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
EP2714909A4 (en) * 2011-06-03 2014-12-17 Univ Michigan PROCESS FOR THE PREPARATION OF FACTOR VIII PROTEINS BY RECOMBINATION PROCEDURES
CN103917554B (zh) 2011-10-18 2017-03-08 杰特有限公司 用于改善重构后纯化的因子viii的稳定性的方法
WO2013160005A1 (en) * 2012-04-24 2013-10-31 Novo Nordisk A/S Pharmaceutical composition suitable for treatment of haemophilia
SI2971005T1 (sl) * 2013-03-12 2020-10-30 Agc Biologics, Inc. Izboljšana rekombinantna proteinska ekspresija z uporabo hibridnega CHEF1-promotorja
US9914764B2 (en) * 2013-03-15 2018-03-13 Bayer Healthcare, Llc Variant factor VIII polypeptides and methods of their production and use
WO2015091130A1 (en) * 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Method for improving the recombinant production of soluble fusion polypeptides
US10370692B2 (en) 2013-12-20 2019-08-06 Hoffmann-La Roche Inc. Recombinant polypeptide production methods
WO2015132724A1 (en) 2014-03-05 2015-09-11 Pfizer Inc. Improved muteins of clotting factor viii
MX2016012428A (es) * 2014-03-23 2017-04-27 Advantech Bioscience Farmacêutica Ltda Aumento de la expresion de proteina recombinante con cobre.
MX2016012870A (es) 2014-04-01 2017-05-12 Advantech Bioscience Farmacêutica Ltda Formulaciones de factor viii estables con bajo tenor de azucar - glicina.
US9855319B2 (en) 2014-04-01 2018-01-02 Advantech Bioscience Farmacêutica Ltda Stabilization of factor VIII without calcium as an excipient
CA2975734C (en) 2015-02-06 2025-02-18 Univ North Carolina Chapel Hill OPTIMIZED GENE EXPRESSION CASSETTES FOR HUMAN COAGULATION FACTOR VIII AND THEIR USE
UA127809C2 (uk) 2015-06-24 2024-01-10 Ф. Хоффманн-Ля Рош Аг Антитіло до рецептора трансферину зі спеціально підібраною афінністю
KR20250052494A (ko) 2015-10-02 2025-04-18 에프. 호프만-라 로슈 아게 이중특이성 항-인간 cd20/인간 트랜스페린 수용체 항체 및 사용 방법
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
US20230151078A1 (en) * 2016-06-24 2023-05-18 Mogam Instiitute For Biomedical Research Recombinant single-chain fviii and chemical conjugate thereof
AU2021342503A1 (en) * 2020-09-16 2023-04-06 Generation Bio Co. Non-viral DNA vectors and uses thereof for expressing FVIII therapeutics
JP2025538565A (ja) 2022-11-23 2025-11-28 エフ． ホフマン－ラ ロシュ アーゲー 組換えタンパク質発現を増加させるための方法

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US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4599308A (en) 1981-10-06 1986-07-08 Hamer Dean H Protein from SV40 recombinants
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US5214033A (en) * 1983-03-31 1993-05-25 Scripps Clinic & Research Foundation Factor VIII coagulant polypeptides
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US5045455A (en) * 1984-01-12 1991-09-03 Chiron Corporation Factor VIII:C cDNA cloning and expression
US4879236A (en) 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4745057A (en) 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
US4577729A (en) * 1984-12-05 1986-03-25 Westinghouse Electric Corp. Guide rail clamping assembly
US4912038A (en) 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US4879224A (en) * 1985-01-10 1989-11-07 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides
US4761371A (en) 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
CA1341174C (en) 1985-04-12 2001-01-30 John J. Toole Jr. Procoagulant proteins derived from factor viii: c
US5250421A (en) * 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
DE3785102T2 (de) 1986-01-03 1993-07-22 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
AT388079B (de) 1986-04-18 1989-04-25 Helmut Ing Koenig Backofen
US5422260A (en) * 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US4877729A (en) 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
CA1331157C (en) 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
US5004803A (en) * 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
US5661008A (en) * 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US5563045A (en) * 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
US20040092442A1 (en) * 1996-04-24 2004-05-13 University Of Michigan Inactivation resistant factor VIII
ATE319817T1 (de) * 1996-04-24 2006-03-15 Univ Michigan Gegen inaktivierung resistenter faktor viii
US5838437A (en) * 1997-04-09 1998-11-17 Micron Optics, Inc. Reference system for optical devices including optical scanners and spectrum analyzers
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
CA2306820C (en) * 1998-03-12 2008-09-09 Genetics Institute, Inc. Improved methods for producing factor viii proteins
US7041635B2 (en) * 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
RU2531493C2 (ru) * 2007-11-01 2014-10-20 Юниверсити Оф Рочестер Рекомбинантный фактор viii, обладающий повышенной стабильностью

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