ATE222925T1 - Verbessertes verfahren zur herstellung von faktor viii - Google Patents

Verbessertes verfahren zur herstellung von faktor viii

Info

Publication number
ATE222925T1
ATE222925T1 AT99912427T AT99912427T ATE222925T1 AT E222925 T1 ATE222925 T1 AT E222925T1 AT 99912427 T AT99912427 T AT 99912427T AT 99912427 T AT99912427 T AT 99912427T AT E222925 T1 ATE222925 T1 AT E222925T1
Authority
AT
Austria
Prior art keywords
factor viii
improved method
solution
producing factor
ion exchange
Prior art date
Application number
AT99912427T
Other languages
English (en)
Inventor
Brian D Kelley
Johanna Dalborg
Anna Petersson
Venkata Suresh Vunnum
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Application granted granted Critical
Publication of ATE222925T1 publication Critical patent/ATE222925T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99912427T 1998-03-12 1999-03-11 Verbessertes verfahren zur herstellung von faktor viii ATE222925T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7780298P 1998-03-12 1998-03-12
PCT/US1999/005329 WO1999046299A1 (en) 1998-03-12 1999-03-11 Improved methods for producing factor viii proteins

Publications (1)

Publication Number Publication Date
ATE222925T1 true ATE222925T1 (de) 2002-09-15

Family

ID=22140139

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99912427T ATE222925T1 (de) 1998-03-12 1999-03-11 Verbessertes verfahren zur herstellung von faktor viii

Country Status (11)

Country Link
US (2) US6683159B2 (de)
EP (1) EP1062244B1 (de)
JP (1) JP4405668B2 (de)
AT (1) ATE222925T1 (de)
AU (1) AU747274C (de)
CA (1) CA2306820C (de)
DE (1) DE69902639T2 (de)
DK (1) DK1062244T3 (de)
ES (1) ES2182501T3 (de)
PT (1) PT1062244E (de)
WO (1) WO1999046299A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
US7820796B2 (en) * 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
CA2306820C (en) * 1998-03-12 2008-09-09 Genetics Institute, Inc. Improved methods for producing factor viii proteins
US20050060775A1 (en) * 1998-05-14 2005-03-17 Hooker Brian S. Production of human coagulation factor VIII from plant cells and whole plants
EP1636360A4 (de) 2003-06-03 2006-11-08 Cell Genesys Inc Zusammensetzungen und verfahren zur verstärkten expression rekombinanter polypeptide von einem vektor unter verwendung einer peptidspaltstelle
US7485291B2 (en) 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
US20080070251A1 (en) * 2006-06-30 2008-03-20 Kaufman Randal J Method of Producing Factor VIII Proteins by Recombinant Methods
EP2126106B1 (de) 2007-02-23 2017-09-06 Sk Chemicals Co., Ltd. Verfahren zur herstellung und reinigung von faktor viii und dessen derivaten
EP2652491B1 (de) 2010-12-15 2017-11-29 Baxalta GmbH Eluatsammlung mit leitfähigkeitsgradient
RU2500818C1 (ru) * 2012-07-19 2013-12-10 Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК рАР227, КОДИРУЮЩАЯ ПОЛИПЕПТИД РЕКОМБИНАНТНОГО ФАКТОРА VIII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА, ЛИНИЯ КЛЕТОК Cricetulus griseus CHO 2H5 - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ФАКТОРА VIII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА И СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА, ОБЛАДАЮЩЕГО АКТИВНОСТЬЮ ФАКТОРА VIII
JP2014138614A (ja) * 2014-04-09 2014-07-31 Sk Chemicals Co Ltd 第ｖｉｉｉ因子とその誘導体の製造及び精製方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312935A (en) * 1979-08-09 1982-01-26 International Business Machines Corporation Class of E-beam resists based on conducting organic charge transfer salts
JPS5764648A (en) * 1980-10-06 1982-04-19 Takeda Chem Ind Ltd N-substituted derivative of valienamine, its preparation, and alpha-glucosidase inhibitor
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
US4868112A (en) 1985-04-12 1989-09-19 Genetics Institute, Inc. Novel procoagulant proteins
WO1987004187A1 (en) 1986-01-03 1987-07-16 Genetics Institute, Inc. METHOD FOR PRODUCING FACTOR VIII:c-TYPE PROTEINS
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
CA1331157C (en) 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
CA2306820C (en) * 1998-03-12 2008-09-09 Genetics Institute, Inc. Improved methods for producing factor viii proteins

Also Published As

Publication number Publication date
DK1062244T3 (da) 2002-12-30
US6683159B2 (en) 2004-01-27
JP4405668B2 (ja) 2010-01-27
AU3080399A (en) 1999-09-27
CA2306820A1 (en) 1999-09-16
PT1062244E (pt) 2002-12-31
EP1062244A1 (de) 2000-12-27
DE69902639T2 (de) 2003-04-24
US20040087776A1 (en) 2004-05-06
WO1999046299A1 (en) 1999-09-16
AU747274B2 (en) 2002-05-09
ES2182501T3 (es) 2003-03-01
JP2002506081A (ja) 2002-02-26
CA2306820C (en) 2008-09-09
EP1062244B1 (de) 2002-08-28
US20020115832A1 (en) 2002-08-22
AU747274C (en) 2004-03-18
DE69902639D1 (de) 2002-10-02

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UEP Publication of translation of european patent specification