DK1062244T3 - Forbedrede fremgangsmåder til fremstilling af faktor VIII proteiner - Google Patents

Forbedrede fremgangsmåder til fremstilling af faktor VIII proteiner

Info

Publication number
DK1062244T3
DK1062244T3 DK99912427T DK99912427T DK1062244T3 DK 1062244 T3 DK1062244 T3 DK 1062244T3 DK 99912427 T DK99912427 T DK 99912427T DK 99912427 T DK99912427 T DK 99912427T DK 1062244 T3 DK1062244 T3 DK 1062244T3
Authority
DK
Denmark
Prior art keywords
factor viii
preparation
improved methods
solution
viii proteins
Prior art date
Application number
DK99912427T
Other languages
English (en)
Inventor
Brian D Kelley
Anna Petersson
Johanna Dalborg
Venkata Suresh Vunnum
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Application granted granted Critical
Publication of DK1062244T3 publication Critical patent/DK1062244T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK99912427T 1998-03-12 1999-03-11 Forbedrede fremgangsmåder til fremstilling af faktor VIII proteiner DK1062244T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7780298P 1998-03-12 1998-03-12
PCT/US1999/005329 WO1999046299A1 (en) 1998-03-12 1999-03-11 Improved methods for producing factor viii proteins

Publications (1)

Publication Number Publication Date
DK1062244T3 true DK1062244T3 (da) 2002-12-30

Family

ID=22140139

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99912427T DK1062244T3 (da) 1998-03-12 1999-03-11 Forbedrede fremgangsmåder til fremstilling af faktor VIII proteiner

Country Status (11)

Country Link
US (2) US6683159B2 (da)
EP (1) EP1062244B1 (da)
JP (1) JP4405668B2 (da)
AT (1) ATE222925T1 (da)
AU (1) AU747274C (da)
CA (1) CA2306820C (da)
DE (1) DE69902639T2 (da)
DK (1) DK1062244T3 (da)
ES (1) ES2182501T3 (da)
PT (1) PT1062244E (da)
WO (1) WO1999046299A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
US7820796B2 (en) * 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
CA2306820C (en) * 1998-03-12 2008-09-09 Genetics Institute, Inc. Improved methods for producing factor viii proteins
US20050060775A1 (en) * 1998-05-14 2005-03-17 Hooker Brian S. Production of human coagulation factor VIII from plant cells and whole plants
EP1636360A4 (en) 2003-06-03 2006-11-08 Cell Genesys Inc COMPOSITIONS AND METHODS FOR ENHANCED EXPRESSION OF RECOMBINANT POLYPEPTIDES FROM A SINGLE VECTOR USING A PEPTIDE CLEAVAGE SITE
US7485291B2 (en) 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
US20080070251A1 (en) * 2006-06-30 2008-03-20 Kaufman Randal J Method of Producing Factor VIII Proteins by Recombinant Methods
EP2126106B1 (en) 2007-02-23 2017-09-06 Sk Chemicals Co., Ltd. Process for producing and purifying factor viii and its derivatives
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
RU2500818C1 (ru) * 2012-07-19 2013-12-10 Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК рАР227, КОДИРУЮЩАЯ ПОЛИПЕПТИД РЕКОМБИНАНТНОГО ФАКТОРА VIII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА, ЛИНИЯ КЛЕТОК Cricetulus griseus CHO 2H5 - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ФАКТОРА VIII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА И СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА, ОБЛАДАЮЩЕГО АКТИВНОСТЬЮ ФАКТОРА VIII
JP2014138614A (ja) * 2014-04-09 2014-07-31 Sk Chemicals Co Ltd 第ｖｉｉｉ因子とその誘導体の製造及び精製方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312935A (en) * 1979-08-09 1982-01-26 International Business Machines Corporation Class of E-beam resists based on conducting organic charge transfer salts
JPS5764648A (en) * 1980-10-06 1982-04-19 Takeda Chem Ind Ltd N-substituted derivative of valienamine, its preparation, and alpha-glucosidase inhibitor
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
US4868112A (en) 1985-04-12 1989-09-19 Genetics Institute, Inc. Novel procoagulant proteins
WO1987004187A1 (en) 1986-01-03 1987-07-16 Genetics Institute, Inc. METHOD FOR PRODUCING FACTOR VIII:c-TYPE PROTEINS
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
CA1331157C (en) 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
CA2306820C (en) * 1998-03-12 2008-09-09 Genetics Institute, Inc. Improved methods for producing factor viii proteins

Also Published As

Publication number Publication date
US6683159B2 (en) 2004-01-27
JP4405668B2 (ja) 2010-01-27
AU3080399A (en) 1999-09-27
CA2306820A1 (en) 1999-09-16
PT1062244E (pt) 2002-12-31
EP1062244A1 (en) 2000-12-27
ATE222925T1 (de) 2002-09-15
DE69902639T2 (de) 2003-04-24
US20040087776A1 (en) 2004-05-06
WO1999046299A1 (en) 1999-09-16
AU747274B2 (en) 2002-05-09
ES2182501T3 (es) 2003-03-01
JP2002506081A (ja) 2002-02-26
CA2306820C (en) 2008-09-09
EP1062244B1 (en) 2002-08-28
US20020115832A1 (en) 2002-08-22
AU747274C (en) 2004-03-18
DE69902639D1 (de) 2002-10-02

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