|
ES2052027T5
(es)
|
1988-11-11 |
2005-04-16 |
Medical Research Council |
Clonacion de secuencias de dominio variable de inmunoglobulina.
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
CA2090126C
(en)
|
1990-08-02 |
2002-10-22 |
John W. Schrader |
Methods for the production of proteins with a desired function
|
|
AU675223B2
(en)
|
1992-05-08 |
1997-01-30 |
Creative Biomolecules, Inc. |
Chimeric multivalent protein analogues and methods of use thereof
|
|
AU687010B2
(en)
|
1992-07-17 |
1998-02-19 |
Dana-Farber Cancer Institute |
Method of intracellular binding of target molecules
|
|
PT1621554E
(pt)
|
1992-08-21 |
2009-07-13 |
Univ Bruxelles |
Imunoglobtainas desprovidas de cadeias leves
|
|
ES2155854T3
(es)
|
1993-06-09 |
2001-06-01 |
Unilever Nv |
Procedimiento de produccion de proteinas de fusion que comprende fragmentos de scfv con la ayuda de un molde transformado.
|
|
US6562333B1
(en)
|
1993-06-14 |
2003-05-13 |
Schering Corporation |
Purified mammalian CTLA-8 antigens and related reagents
|
|
US6274711B1
(en)
|
1993-06-14 |
2001-08-14 |
Inserm, Institut National De La Sante Et De La Recherche Medicale |
Purified mammalian CTLA-8 antigens and related reagents
|
|
US6091639A
(en)
|
1993-08-27 |
2000-07-18 |
Kabushiki Kaisha Toshiba |
Non-volatile semiconductor memory device and data programming method
|
|
EP0745134A1
(en)
|
1994-02-22 |
1996-12-04 |
Danafarber Cancer Institute |
Nucleic acid delivery system, method of synthesis and uses thereof
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
US6074849A
(en)
|
1995-07-19 |
2000-06-13 |
Genetics Institute, Inc. |
Polynucleotides encoding human CTLA-8 related proteins
|
|
US6902735B1
(en)
|
1995-07-19 |
2005-06-07 |
Genetics Institute, Llc |
Antibodies to human IL-17F and other CTLA-8-related proteins
|
|
AU727480B2
(en)
|
1995-07-19 |
2000-12-14 |
Genetics Institute, Llc |
Human CTLA-8 and uses of CTLA-8-related proteins
|
|
WO1998022141A2
(en)
|
1996-11-19 |
1998-05-28 |
Sangstat Medical Corporation |
Enhanced effects for hapten conjugated therapeutics
|
|
US20020177188A1
(en)
|
1998-05-15 |
2002-11-28 |
Genentech, Inc. |
IL-17 homologous polypeptides and therapeutic uses thereof
|
|
WO1999023221A2
(en)
|
1997-10-27 |
1999-05-14 |
Unilever Plc |
Multivalent antigen-binding proteins
|
|
WO1999037681A2
(en)
|
1998-01-26 |
1999-07-29 |
Unilever Plc |
Method for producing antibody fragments
|
|
CN1316910A
(zh)
*
|
1998-02-19 |
2001-10-10 |
埃克斯西特治疗公司 |
用于调节淋巴细胞活化的组合物及方法
|
|
US6486303B1
(en)
|
1998-04-14 |
2002-11-26 |
University Of Medicine & Dentistry Of New Jersey |
Method for making hormone heterodimers
|
|
AU6277799A
(en)
|
1998-10-02 |
2000-04-26 |
Eli Lilly And Company |
Il-17 homolog nucleic acids, polypeptides, vectors, host cells, methods and usesthereof
|
|
GB9824632D0
(en)
|
1998-11-10 |
1999-01-06 |
Celltech Therapeutics Ltd |
Biological compounds
|
|
AU2291700A
(en)
|
1999-01-19 |
2000-08-07 |
Unilever Plc |
Method for producing antibody fragments
|
|
EP1053751A1
(en)
|
1999-05-17 |
2000-11-22 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Compositions and methods for treating cell proliferation disorders
|
|
CA2391374A1
(en)
|
1999-12-23 |
2001-06-28 |
Genentech, Inc. |
Il-17 homologous polypeptides and therapeutic uses thereof
|
|
US7608681B2
(en)
|
1999-12-24 |
2009-10-27 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
EP1274720A4
(en)
|
2000-04-12 |
2004-08-18 |
Human Genome Sciences Inc |
FUSION PROTEINS CONTAINING ALBUMIN
|
|
US20030190598A1
(en)
|
2000-05-26 |
2003-10-09 |
Jasmid Tanha |
Single-domain antigen-binding antibody fragments derived from llama antibodies
|
|
US7943129B2
(en)
|
2000-05-26 |
2011-05-17 |
National Research Council Of Canada |
Single-domain brain-targeting antibody fragments derived from llama antibodies
|
|
US6741957B1
(en)
|
2000-07-21 |
2004-05-25 |
Daimlerchrysler Corporation |
Analytical tire model for vehicle durability and ride comfort analysis
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
CN101684158A
(zh)
|
2001-01-17 |
2010-03-31 |
特鲁比昂药品公司 |
结合域-免疫球蛋白融合蛋白
|
|
WO2002064739A2
(en)
|
2001-02-09 |
2002-08-22 |
Johns Hopkins University |
A cytokine related structurally to il-17
|
|
EP1377306A1
(en)
|
2001-03-09 |
2004-01-07 |
Dyax Corp. |
Serum albumin binding moieties
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
US20070160576A1
(en)
|
2001-06-05 |
2007-07-12 |
Genentech, Inc. |
IL-17A/F heterologous polypeptides and therapeutic uses thereof
|
|
WO2005010044A2
(en)
|
2003-07-08 |
2005-02-03 |
Genentech, Inc. |
Il-17 a/f heterologous polypeptides and therapeutic uses thereof
|
|
US20060073141A1
(en)
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
|
AU2002319402B2
(en)
|
2001-06-28 |
2008-09-11 |
Domantis Limited |
Dual-specific ligand and its use
|
|
WO2003014960A2
(en)
|
2001-08-03 |
2003-02-20 |
Medical Research Council |
Method of identifying a consensus sequence for intracellular antibodies
|
|
US7371849B2
(en)
|
2001-09-13 |
2008-05-13 |
Institute For Antibodies Co., Ltd. |
Methods of constructing camel antibody libraries
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
KR100599789B1
(ko)
|
2001-12-03 |
2006-07-12 |
삼성에스디아이 주식회사 |
방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법
|
|
US20050214857A1
(en)
|
2001-12-11 |
2005-09-29 |
Algonomics N.V. |
Method for displaying loops from immunoglobulin domains in different contexts
|
|
JP4323317B2
(ja)
|
2001-12-21 |
2009-09-02 |
フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） |
可変領域配列のクローニング方法
|
|
WO2003055527A2
(en)
|
2002-01-03 |
2003-07-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Immunoconjugates useful for treatment of tumours
|
|
US20080241166A1
(en)
|
2002-06-28 |
2008-10-02 |
Domantis Limited |
Ligands that bind a receptor
|
|
EP1600459A3
(en)
|
2002-06-28 |
2005-12-07 |
Domantis Limited |
Ligand
|
|
US7004940B2
(en)
|
2002-10-10 |
2006-02-28 |
Ethicon, Inc. |
Devices for performing thermal ablation having movable ultrasound transducers
|
|
EP1558647B1
(en)
|
2002-11-08 |
2015-06-10 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
EP2284192A3
(en)
|
2002-11-08 |
2011-07-20 |
Ablynx N.V. |
Camelidae antibodies for sublingual administration
|
|
US7993864B2
(en)
|
2002-12-03 |
2011-08-09 |
Ucb Pharma S.A. |
Assay for identifying antibody producing cells
|
|
GB0228210D0
(en)
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
JP4490290B2
(ja)
|
2002-12-31 |
2010-06-23 |
ネクター セラピューティクス アラバマ，コーポレイション |
加水分解安定性マレイミド末端ポリマー
|
|
GB0312481D0
(en)
|
2003-05-30 |
2003-07-09 |
Celltech R&D Ltd |
Antibodies
|
|
SI1639011T1
(sl)
|
2003-06-30 |
2009-04-30 |
Domantis Ltd |
Pegilirana protitelesa z enojno domeno (dAb)
|
|
EP1656128A4
(en)
|
2003-08-12 |
2007-02-28 |
William M Yarbrough |
SINGLE ACNE TREATMENT AND METHOD OF USE
|
|
US20060263353A1
(en)
|
2003-08-20 |
2006-11-23 |
Lawson Alastair D G |
Methods for obtaining antibodies
|
|
US7235641B2
(en)
*
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
US20050279676A1
(en)
|
2004-06-21 |
2005-12-22 |
Izzy Zuhair A |
Fluid filter assembly for a dispensing faucet
|
|
US20060008601A1
(en)
|
2004-06-25 |
2006-01-12 |
Zeik Douglas B |
Flexible laminate having an integrated pressure release valve
|
|
US7882839B2
(en)
|
2004-06-25 |
2011-02-08 |
Ambis Jr Edward J |
Custom mouthguard
|
|
EP1978032A3
(en)
|
2004-07-22 |
2009-02-18 |
Erasmus University Medical Center Rotterdam |
Binding molecules
|
|
CN100396019C
(zh)
|
2004-07-31 |
2008-06-18 |
华为技术有限公司 |
移动终端数据源模拟方法
|
|
GB0417487D0
(en)
|
2004-08-05 |
2004-09-08 |
Novartis Ag |
Organic compound
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
WO2006040153A2
(en)
|
2004-10-13 |
2006-04-20 |
Ablynx N.V. |
Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
|
|
WO2006040154A2
(en)
|
2004-10-14 |
2006-04-20 |
Dublin City University |
Prokaryotic two hybrid system
|
|
GB0425569D0
(en)
*
|
2004-11-19 |
2004-12-22 |
Celltech R&D Ltd |
Biological products
|
|
FR2879605B1
(fr)
*
|
2004-12-16 |
2008-10-17 |
Centre Nat Rech Scient Cnrse |
Production de formats d'anticorps et applications immunologiques de ces formats
|
|
MY142617A
(en)
|
2004-12-23 |
2010-12-15 |
Domantis Ltd |
Dual specific ligands with increased serum half-life
|
|
CA2595682A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
EP2322553A3
(en)
|
2005-02-14 |
2011-11-16 |
Wyeth LLC |
Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor
|
|
AU2006249144B2
(en)
|
2005-05-18 |
2011-11-17 |
Ablynx Nv |
Improved NanobodiesTM against Tumor Necrosis Factor-alpha
|
|
MX2007014564A
(es)
|
2005-05-20 |
2008-02-07 |
Ablynx Nv |
Anticuerpos de vhh de dominio unico contra el factor de von willebrand.
|
|
WO2007042289A2
(en)
|
2005-10-11 |
2007-04-19 |
Ablynx N.V. |
Nanobodies™ and polypeptides against egfr and igf-ir
|
|
US20090252681A1
(en)
|
2005-10-11 |
2009-10-08 |
Ablynx N.V. |
Nanobodies and Polypeptides Against EGFR and IGF-IR
|
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
|
WO2007112940A2
(en)
|
2006-03-31 |
2007-10-11 |
Ablynx N.V. |
Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same
|
|
EP2010568A1
(en)
|
2006-04-14 |
2009-01-07 |
Ablynx N.V. |
Dp-78-like nanobodies
|
|
WO2007147019A2
(en)
|
2006-06-13 |
2007-12-21 |
Zymogenetics, Inc. |
Il-17 and il-23 antagonists and methods of using the same
|
|
TW200815469A
(en)
|
2006-06-23 |
2008-04-01 |
Astrazeneca Ab |
Compounds
|
|
WO2008000279A1
(en)
|
2006-06-26 |
2008-01-03 |
Aida Centre, S.L. |
Blister package integrating rfid based tags
|
|
GB0612928D0
(en)
|
2006-06-29 |
2006-08-09 |
Ucb Sa |
Biological products
|
|
CA2666599A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
CN101646689A
(zh)
|
2006-09-08 |
2010-02-10 |
埃博灵克斯股份有限公司 |
具有长半衰期的血清清蛋白结合蛋白
|
|
US7833527B2
(en)
|
2006-10-02 |
2010-11-16 |
Amgen Inc. |
Methods of treating psoriasis using IL-17 Receptor A antibodies
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
JP2010505435A
(ja)
|
2006-10-11 |
2010-02-25 |
アブリンクス エン．ヴェー． |
本質的にｐＨに非依存的に血清タンパク質に結合するアミノ酸配列、それを含む化合物、およびその使用
|
|
GB0620729D0
(en)
|
2006-10-18 |
2006-11-29 |
Ucb Sa |
Biological products
|
|
WO2008068280A1
(en)
|
2006-12-05 |
2008-06-12 |
Ablynx N.V. |
Peptides capable of binding to serum proteins
|
|
SG178789A1
(en)
|
2007-02-16 |
2012-03-29 |
Merrimack Pharmaceuticals Inc |
Antibodies against erbb3 and uses thereof
|
|
JP2010522564A
(ja)
|
2007-03-26 |
2010-07-08 |
ザイモジェネティクス， インコーポレイテッド |
可溶性ｉｌ−１７ｒａ／ｒｃ融合タンパク質および関連する方法
|
|
CN101990439A
(zh)
|
2007-07-06 |
2011-03-23 |
特鲁比昂药品公司 |
具有置于c末端的特异性结合结构域的结合肽
|
|
WO2009068631A1
(en)
|
2007-11-27 |
2009-06-04 |
Ablynx N.V. |
Method for obtaining polypeptide constructs comprising two or more single domain antibodies
|
|
WO2009082624A2
(en)
|
2007-12-10 |
2009-07-02 |
Zymogenetics, Inc. |
Antagonists of il-17a, il-17f, and il-23 and methods of using the same
|
|
CA2712432C
(en)
|
2008-01-29 |
2018-09-25 |
Ablynx N.V. |
Methods to stabilize single variable domains
|
|
CN102089325A
(zh)
|
2008-04-17 |
2011-06-08 |
埃博灵克斯股份有限公司 |
能够结合血清白蛋白的肽，以及包含其的化合物、构建体和多肽
|
|
CA2721713C
(en)
|
2008-05-05 |
2019-07-09 |
Novimmune Sa |
Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof
|
|
NZ589036A
(en)
|
2008-05-16 |
2012-07-27 |
Ablynx Nv |
AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME
|
|
US8790642B2
(en)
|
2008-08-29 |
2014-07-29 |
Genentech, Inc. |
Cross-reactive and bispecific anti-IL-17A/F antibodies
|
|
KR101318549B1
(ko)
|
2008-09-29 |
2013-10-16 |
로슈 글리카트 아게 |
인간 ｉｌ17 에 대한 항체 및 이의 용도
|
|
TW201613969A
(en)
|
2009-03-05 |
2016-04-16 |
Abbvie Inc |
IL-17 binding proteins
|
|
HUE053480T2
(hu)
|
2009-04-30 |
2021-06-28 |
Ablynx Nv |
Eljárás domén ellenanyagok elõállítására
|
|
EP2427203B1
(en)
|
2009-05-05 |
2018-10-17 |
Novimmune S.A. |
Anti-il-17f antibodies and use thereof
|
|
WO2010142551A2
(en)
*
|
2009-06-12 |
2010-12-16 |
Ablynx N.V. |
Single variable domain (vhh) antibodies to cytokines of the il-17 receptor family
|
|
JP5922025B2
(ja)
|
2009-10-30 |
2016-05-25 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｉｌ−１７ａ拮抗物質
|
|
SI3295957T1
(sl)
|
2010-01-15 |
2020-02-28 |
Kirin-Amgen, Inc. |
Formulacija protitelesa proti IL-17RA in terapevtski režim za zdravljenje luskavice
|
|
US8965476B2
(en)
*
|
2010-04-16 |
2015-02-24 |
Sanofi-Aventis Deutschland Gmbh |
Tissue penetration device
|
|
RU2665954C1
(ru)
|
2010-10-08 |
2018-09-05 |
Новартис Аг |
Способы лечения псориаза с использованием антагонистов il-17
|
|
TWI616204B
(zh)
|
2010-11-05 |
2018-03-01 |
諾華公司 |
Ｉｌ-１７抗體用於製備治療牛皮癬性關節炎之藥物之用途
|
|
ME02734B
(me)
|
2011-01-14 |
2017-10-20 |
Ucb Biopharma Sprl |
Antitelo koje vezuje il-17a i il-17f
|
|
TWI439451B
(zh)
|
2011-03-24 |
2014-06-01 |
Hoffmann La Roche |
雜環胺衍生物
|
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
|
BR112014009810A2
(pt)
|
2011-10-24 |
2017-04-25 |
Abbvie Inc |
imunoligantes biespecíficos dirigidos contra tnf e il-17
|
|
CA2868404A1
(en)
|
2012-04-05 |
2013-10-10 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies against human tweak and human il17 and uses thereof
|
|
AR090626A1
(es)
|
2012-04-20 |
2014-11-26 |
Lilly Co Eli |
Anticuerpos anti-baff-anti-il-17 biespecificos
|
|
MX371052B
(es)
|
2013-02-08 |
2020-01-14 |
Novartis Ag |
Anticuerpos anti-il-17a y su uso en el tratamiento de trastornos autoinmunes e inflamatorios.
|
|
CL2015001213A1
(es)
|
2015-05-07 |
2015-07-10 |
Pontificia Universidad Católica De Chile |
Método ex vivo para predecir respuesta a un tratamiento inmunomodulador en pacientes con enfermedad inflamatoria, el cual comprende la cuantificación de las razones entre las concentraciones de citoquinas seleccionadas de ifn-gamma/il-17f, il17f/il-10, il-17f/ifn-gamma e il-10/il17f; y kit para llevar a cabo el método.
|