JP2012517818A5 - - Google Patents

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Publication number
JP2012517818A5
JP2012517818A5 JP2011550552A JP2011550552A JP2012517818A5 JP 2012517818 A5 JP2012517818 A5 JP 2012517818A5 JP 2011550552 A JP2011550552 A JP 2011550552A JP 2011550552 A JP2011550552 A JP 2011550552A JP 2012517818 A5 JP2012517818 A5 JP 2012517818A5
Authority
JP
Japan
Prior art keywords
variable domain
single variable
tnfr1
seq
dom7h
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011550552A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012517818A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2010/052005 external-priority patent/WO2010094720A2/en
Publication of JP2012517818A publication Critical patent/JP2012517818A/ja
Publication of JP2012517818A5 publication Critical patent/JP2012517818A5/ja
Pending legal-status Critical Current

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JP2011550552A 2009-02-19 2010-02-17 改善された抗tnfr1ポリペプチド、抗体可変ドメインおよびアンタゴニスト Pending JP2012517818A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15374609P 2009-02-19 2009-02-19
US61/153,746 2009-02-19
US24119809P 2009-09-10 2009-09-10
US61/241,198 2009-09-10
PCT/EP2010/052005 WO2010094720A2 (en) 2009-02-19 2010-02-17 Improved anti-tnfr1 polypeptides, antibody variable domains & antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015151376A Division JP2016007218A (ja) 2009-02-19 2015-07-31 改善された抗tnfr1ポリペプチド、抗体可変ドメインおよびアンタゴニスト

Publications (2)

Publication Number Publication Date
JP2012517818A JP2012517818A (ja) 2012-08-09
JP2012517818A5 true JP2012517818A5 (enExample) 2013-03-07

Family

ID=42136168

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011550552A Pending JP2012517818A (ja) 2009-02-19 2010-02-17 改善された抗tnfr1ポリペプチド、抗体可変ドメインおよびアンタゴニスト
JP2015151376A Pending JP2016007218A (ja) 2009-02-19 2015-07-31 改善された抗tnfr1ポリペプチド、抗体可変ドメインおよびアンタゴニスト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015151376A Pending JP2016007218A (ja) 2009-02-19 2015-07-31 改善された抗tnfr1ポリペプチド、抗体可変ドメインおよびアンタゴニスト

Country Status (14)

Country Link
US (1) US20110301335A1 (enExample)
EP (1) EP2398827A2 (enExample)
JP (2) JP2012517818A (enExample)
KR (1) KR20110119806A (enExample)
CN (1) CN102405236A (enExample)
AU (1) AU2010215479B2 (enExample)
BR (1) BRPI1008014A2 (enExample)
CA (1) CA2750477A1 (enExample)
EA (1) EA022925B1 (enExample)
IL (1) IL214648A0 (enExample)
MX (1) MX2011008799A (enExample)
SG (1) SG173173A1 (enExample)
WO (1) WO2010094720A2 (enExample)
ZA (1) ZA201105627B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028822B2 (en) * 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
ES2655071T3 (es) * 2009-02-19 2018-02-16 Glaxo Group Limited Variantes de unión de anti-albúmina de suero mejoradas
WO2011008814A2 (en) 2009-07-14 2011-01-20 Immune Tolerance Institute, Inc., A California Not-For-Profit Corporation Multiplexed measurement of exogenous and endogenous dna
WO2011006914A2 (en) * 2009-07-16 2011-01-20 Glaxo Group Limited Antagonists, uses & methods for partially inhibiting tnfr1
TW201125877A (en) * 2009-10-27 2011-08-01 Glaxo Group Ltd Stable anti-TNFR1 polypeptides, antibody variable domains & and antagonists
EA201291009A1 (ru) * 2010-05-20 2013-05-30 Глаксо Груп Лимитед Улучшенные связывающие варианты против сывороточного альбумина
CN103249742B (zh) * 2010-09-16 2017-04-12 巴利奥医药股份公司 抗人肿瘤坏死因子1型受体抗体
WO2012172070A1 (en) * 2011-06-17 2012-12-20 Glaxo Group Limited Tumour necrosis factor receptor 1 antagonists
WO2015104322A1 (en) 2014-01-09 2015-07-16 Glaxosmithkline Intellectual Property Development Limited Treatment of inflammatory diseases with non-competitive tnfr1 antagonists
US9815886B2 (en) 2014-10-28 2017-11-14 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
WO2016094309A1 (en) * 2014-12-10 2016-06-16 Myosotis Inhibition of tnf signaling in cancer immunotherapy
NO2768984T3 (enExample) * 2015-11-12 2018-06-09
CN107043413A (zh) * 2016-02-05 2017-08-15 华中农业大学 一种肺结核相关的尿液生物标志蛋白及其应用
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
JP7315968B2 (ja) * 2019-01-31 2023-07-27 積水メディカル株式会社 生物学的試料中の遊離aimの免疫学的分析方法及び対象におけるnashの検出方法
US12472266B2 (en) 2019-02-21 2025-11-18 Enosi Therapeutics Corporation Antibodies and enonomers
JP2023541816A (ja) 2020-08-27 2023-10-04 イノージ・セラピューティクス・コーポレイション 自己免疫性疾患および癌を治療するための方法および組成物
WO2022117569A1 (en) 2020-12-02 2022-06-09 Oncurious Nv A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
WO2025021184A1 (zh) * 2023-07-27 2025-01-30 上海复宏汉霖生物医药有限公司 编码尿酸氧化酶的多核苷酸及其相关组合物和方法
WO2025049818A1 (en) 2023-08-29 2025-03-06 Enosi Therapeutics Corporation Tnfr1 antagonists lacking agonist activity and uses thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
GB8725529D0 (en) 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
JP3095168B2 (ja) 1988-02-05 2000-10-03 エル. モリソン,シェリー ドメイン‐変性不変部を有する抗体
EP0768377A1 (en) 1988-09-02 1997-04-16 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
ATE92107T1 (de) 1989-04-29 1993-08-15 Delta Biotechnology Ltd N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
US5977307A (en) 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
WO1994026087A2 (en) 1993-05-14 1994-11-24 Connor Kim C O Recombinant protein production and insect cell culture and process
JPH08511420A (ja) 1993-06-16 1996-12-03 セルテック・セラピューテイクス・リミテッド 抗 体
ES2283936T3 (es) 1997-07-07 2007-11-01 Medical Research Council Procedimiento de clasificacion in vitro.
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
EP1263788A2 (en) 2000-02-11 2002-12-11 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Identification of a domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function
AU2002319402B2 (en) 2001-06-28 2008-09-11 Domantis Limited Dual-specific ligand and its use
WO2003076567A2 (en) 2002-03-05 2003-09-18 Eli Lilly And Company Heterologous g-csf fusion proteins
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
EP1600459A3 (en) 2002-06-28 2005-12-07 Domantis Limited Ligand
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
EP2284192A3 (en) 2002-11-08 2011-07-20 Ablynx N.V. Camelidae antibodies for sublingual administration
JP2006523090A (ja) 2002-12-27 2006-10-12 ドマンティス リミテッド リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体
GB0230203D0 (en) 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
US20090005257A1 (en) 2003-05-14 2009-01-01 Jespers Laurent S Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire
SI1639011T1 (sl) 2003-06-30 2009-04-30 Domantis Ltd Pegilirana protitelesa z enojno domeno (dAb)
JP5010923B2 (ja) 2004-02-09 2012-08-29 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド アルブミン融合蛋白質
PL1737962T3 (pl) 2004-03-24 2011-02-28 Domantis Ltd Uniwersalny lider GAS1
GB0418651D0 (en) 2004-08-20 2004-09-22 Medical Res Council Method
EP1841452B8 (en) * 2004-10-08 2014-06-11 Domantis Limited Single domain antibodies against tnfr1 and methods of use therefor
CN101084014A (zh) * 2004-10-08 2007-12-05 杜门蒂斯有限公司 抗肿瘤坏死因子受体1的单域抗体及其使用方法
GB0521621D0 (en) 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
CN101454344A (zh) * 2005-12-01 2009-06-10 杜门蒂斯有限公司 与白细胞介素-1受体1型结合的非竞争性域抗体形式
TW200804425A (en) * 2005-12-06 2008-01-16 Domantis Ltd Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor
AU2008259590A1 (en) 2007-06-06 2008-12-11 Domantis Limited Methods for selecting protease resistant polypeptides
GB0724331D0 (en) 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
US7868885B2 (en) 2007-06-22 2011-01-11 Microsoft Corporation Direct manipulation of subdivision surfaces using a graphics processing unit
EP2454285A2 (en) * 2009-07-16 2012-05-23 Glaxo Group Limited Improved anti-serum albumin binding single variable domains
WO2011006914A2 (en) * 2009-07-16 2011-01-20 Glaxo Group Limited Antagonists, uses & methods for partially inhibiting tnfr1
TW201125877A (en) * 2009-10-27 2011-08-01 Glaxo Group Ltd Stable anti-TNFR1 polypeptides, antibody variable domains & and antagonists

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