JP2012517818A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012517818A5 JP2012517818A5 JP2011550552A JP2011550552A JP2012517818A5 JP 2012517818 A5 JP2012517818 A5 JP 2012517818A5 JP 2011550552 A JP2011550552 A JP 2011550552A JP 2011550552 A JP2011550552 A JP 2011550552A JP 2012517818 A5 JP2012517818 A5 JP 2012517818A5
- Authority
- JP
- Japan
- Prior art keywords
- variable domain
- single variable
- tnfr1
- seq
- dom7h
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15374609P | 2009-02-19 | 2009-02-19 | |
| US61/153,746 | 2009-02-19 | ||
| US24119809P | 2009-09-10 | 2009-09-10 | |
| US61/241,198 | 2009-09-10 | ||
| PCT/EP2010/052005 WO2010094720A2 (en) | 2009-02-19 | 2010-02-17 | Improved anti-tnfr1 polypeptides, antibody variable domains & antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151376A Division JP2016007218A (ja) | 2009-02-19 | 2015-07-31 | 改善された抗ｔｎｆｒ１ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012517818A JP2012517818A (ja) | 2012-08-09 |
| JP2012517818A5 true JP2012517818A5 (enExample) | 2013-03-07 |
Family
ID=42136168
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550552A Pending JP2012517818A (ja) | 2009-02-19 | 2010-02-17 | 改善された抗ｔｎｆｒ１ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| JP2015151376A Pending JP2016007218A (ja) | 2009-02-19 | 2015-07-31 | 改善された抗ｔｎｆｒ１ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151376A Pending JP2016007218A (ja) | 2009-02-19 | 2015-07-31 | 改善された抗ｔｎｆｒ１ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110301335A1 (enExample) |
| EP (1) | EP2398827A2 (enExample) |
| JP (2) | JP2012517818A (enExample) |
| KR (1) | KR20110119806A (enExample) |
| CN (1) | CN102405236A (enExample) |
| AU (1) | AU2010215479B2 (enExample) |
| BR (1) | BRPI1008014A2 (enExample) |
| CA (1) | CA2750477A1 (enExample) |
| EA (1) | EA022925B1 (enExample) |
| IL (1) | IL214648A0 (enExample) |
| MX (1) | MX2011008799A (enExample) |
| SG (1) | SG173173A1 (enExample) |
| WO (1) | WO2010094720A2 (enExample) |
| ZA (1) | ZA201105627B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9028822B2 (en) * | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
| EP3656788A3 (en) * | 2009-02-19 | 2020-07-29 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| WO2011008814A2 (en) * | 2009-07-14 | 2011-01-20 | Immune Tolerance Institute, Inc., A California Not-For-Profit Corporation | Multiplexed measurement of exogenous and endogenous dna |
| JP2012532619A (ja) * | 2009-07-16 | 2012-12-20 | グラクソ グループ リミテッド | Ｔｎｆｒ１を部分的に阻害するためのアンタゴニスト、用途および方法 |
| JP2013507978A (ja) * | 2009-10-27 | 2013-03-07 | グラクソ グループ リミテッド | 安定な抗ｔｎｆｒ１ポリペプチド、抗体可変ドメイン及びアンタゴニスト |
| EP2571900A1 (en) * | 2010-05-20 | 2013-03-27 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| KR101871008B1 (ko) * | 2010-09-16 | 2018-06-25 | 발리오팜 아게 | 항-huTNFR1 항체 |
| WO2012172070A1 (en) * | 2011-06-17 | 2012-12-20 | Glaxo Group Limited | Tumour necrosis factor receptor 1 antagonists |
| WO2015104322A1 (en) | 2014-01-09 | 2015-07-16 | Glaxosmithkline Intellectual Property Development Limited | Treatment of inflammatory diseases with non-competitive tnfr1 antagonists |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| WO2016094309A1 (en) * | 2014-12-10 | 2016-06-16 | Myosotis | Inhibition of tnf signaling in cancer immunotherapy |
| NO2768984T3 (enExample) * | 2015-11-12 | 2018-06-09 | ||
| CN107043413A (zh) * | 2016-02-05 | 2017-08-15 | 华中农业大学 | 一种肺结核相关的尿液生物标志蛋白及其应用 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| WO2020158858A1 (ja) * | 2019-01-31 | 2020-08-06 | 積水メディカル株式会社 | 生物学的試料中の遊離ａｉｍの免疫学的分析方法及び対象におけるｎａｓｈの検出方法 |
| EP3927828A4 (en) | 2019-02-21 | 2023-02-01 | Enosi Life Sciences Corp. | ANTIBODIES AND ENONOMERS |
| CA3193273A1 (en) * | 2020-08-27 | 2022-03-03 | Enosi Therapeutics Corporation | Methods and compositions to treat autoimmune diseases and cancer |
| WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
| WO2025021184A1 (zh) * | 2023-07-27 | 2025-01-30 | 上海复宏汉霖生物医药有限公司 | 编码尿酸氧化酶的多核苷酸及其相关组合物和方法 |
| WO2025049818A1 (en) | 2023-08-29 | 2025-03-06 | Enosi Therapeutics Corporation | Tnfr1 antagonists lacking agonist activity and uses thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| WO1989007142A1 (en) | 1988-02-05 | 1989-08-10 | Morrison Sherie L | Domain-modified constant region antibodies |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
| US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| WO1994026087A2 (en) | 1993-05-14 | 1994-11-24 | Connor Kim C O | Recombinant protein production and insect cell culture and process |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| ES2230701T3 (es) | 1997-07-07 | 2005-05-01 | Medical Research Council | Procedimiento de seleccion in vitro. |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| US7148061B2 (en) | 2000-02-11 | 2006-12-12 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of a novel domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function |
| DK1399484T3 (da) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
| AU2003210806A1 (en) | 2002-03-05 | 2003-09-22 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
| AU2003244817B2 (en) | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US20060002935A1 (en) * | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| WO2004041863A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against interferon- gamma and uses therefor |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| EP1578801A2 (en) | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| US20090005257A1 (en) | 2003-05-14 | 2009-01-01 | Jespers Laurent S | Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire |
| DE602004017726D1 (de) | 2003-06-30 | 2008-12-24 | Domantis Ltd | Pegylierte Single-domain-antikörper (dAb) |
| HUE027902T2 (en) | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
| ATE479760T1 (de) | 2004-03-24 | 2010-09-15 | Domantis Ltd | Universelles signalpeptid gas1 |
| GB0418651D0 (en) | 2004-08-20 | 2004-09-22 | Medical Res Council | Method |
| CN101084014A (zh) * | 2004-10-08 | 2007-12-05 | 杜门蒂斯有限公司 | 抗肿瘤坏死因子受体1的单域抗体及其使用方法 |
| JP5030782B2 (ja) * | 2004-10-08 | 2012-09-19 | ドマンティス リミテッド | Ｔｎｆｒ１に対する単一ドメイン抗体およびその使用方法 |
| GB0521621D0 (en) | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| JP2009519011A (ja) * | 2005-12-01 | 2009-05-14 | ドマンティス リミテッド | インターロイキン１受容体１型に結合する非競合ドメイン抗体フォーマット |
| AU2006323412A1 (en) * | 2005-12-06 | 2007-06-14 | Domantis Limited | Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor |
| GB0724331D0 (en) * | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| CA2688433A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
| US7868885B2 (en) | 2007-06-22 | 2011-01-11 | Microsoft Corporation | Direct manipulation of subdivision surfaces using a graphics processing unit |
| JP2012532619A (ja) * | 2009-07-16 | 2012-12-20 | グラクソ グループ リミテッド | Ｔｎｆｒ１を部分的に阻害するためのアンタゴニスト、用途および方法 |
| WO2011006915A2 (en) * | 2009-07-16 | 2011-01-20 | Glaxo Group Limited | Improved anti-serum albumin binding single variable domains |
| JP2013507978A (ja) * | 2009-10-27 | 2013-03-07 | グラクソ グループ リミテッド | 安定な抗ｔｎｆｒ１ポリペプチド、抗体可変ドメイン及びアンタゴニスト |
-
2010
- 2010-02-17 AU AU2010215479A patent/AU2010215479B2/en not_active Ceased
- 2010-02-17 EA EA201190116A patent/EA022925B1/ru not_active IP Right Cessation
- 2010-02-17 JP JP2011550552A patent/JP2012517818A/ja active Pending
- 2010-02-17 BR BRPI1008014A patent/BRPI1008014A2/pt not_active IP Right Cessation
- 2010-02-17 KR KR1020117021824A patent/KR20110119806A/ko not_active Ceased
- 2010-02-17 SG SG2011054459A patent/SG173173A1/en unknown
- 2010-02-17 EP EP10704151A patent/EP2398827A2/en not_active Withdrawn
- 2010-02-17 CA CA2750477A patent/CA2750477A1/en not_active Abandoned
- 2010-02-17 US US13/202,349 patent/US20110301335A1/en not_active Abandoned
- 2010-02-17 WO PCT/EP2010/052005 patent/WO2010094720A2/en not_active Ceased
- 2010-02-17 MX MX2011008799A patent/MX2011008799A/es not_active Application Discontinuation
- 2010-02-17 CN CN2010800173301A patent/CN102405236A/zh active Pending
-
2011
- 2011-07-29 ZA ZA2011/05627A patent/ZA201105627B/en unknown
- 2011-08-15 IL IL214648A patent/IL214648A0/en unknown
-
2015
- 2015-07-31 JP JP2015151376A patent/JP2016007218A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012517818A5 (enExample) | ||
| US9708402B2 (en) | Anti-BAFF-anti-IL-17 bispecific antibodies | |
| JP2010530220A5 (enExample) | ||
| JP6475712B2 (ja) | サイトカインアンタゴニストの標的化 | |
| JP2018108081A5 (enExample) | ||
| JP2010507594A5 (enExample) | ||
| JP2009539349A5 (enExample) | ||
| JP2009511579A5 (enExample) | ||
| JP2017500018A5 (enExample) | ||
| CN109311974A (zh) | 抗人白细胞介素-17a单克隆抗体、其制备方法和应用 | |
| JP2012532619A5 (enExample) | ||
| JP2012021001A5 (enExample) | ||
| JP2019521647A5 (enExample) | ||
| JP2019522961A5 (enExample) | ||
| JP2017523786A5 (enExample) | ||
| JP2017029157A5 (enExample) | ||
| JP2011520989A5 (enExample) | ||
| JP2011526792A5 (enExample) | ||
| JP2008525033A5 (enExample) | ||
| JP2009518005A5 (enExample) | ||
| HRP20150799T1 (hr) | Sastavi i postupci za protutijela protiv komplementnog proteina c5 | |
| HRP20160638T1 (hr) | Antigen vezujući proteini sposobni vezati timusni stromalni limfopoetin | |
| JP2008501716A5 (enExample) | ||
| JP2014503209A5 (enExample) | ||
| ES2822431T3 (es) | Polipéptidos de unión a IL-17A |