JP2010530220A5 - - Google Patents
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- Publication number
- JP2010530220A5 JP2010530220A5 JP2010510887A JP2010510887A JP2010530220A5 JP 2010530220 A5 JP2010530220 A5 JP 2010530220A5 JP 2010510887 A JP2010510887 A JP 2010510887A JP 2010510887 A JP2010510887 A JP 2010510887A JP 2010530220 A5 JP2010530220 A5 JP 2010530220A5
- Authority
- JP
- Japan
- Prior art keywords
- variable domain
- antagonist
- sequence
- dom4
- interleukin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000010932 Interleukin-1 receptor type 1 Human genes 0.000 claims 21
- 108050001109 Interleukin-1 receptor type 1 Proteins 0.000 claims 21
- 239000005557 antagonist Substances 0.000 claims 16
- 108060003951 Immunoglobulin Proteins 0.000 claims 14
- 102000018358 immunoglobulin Human genes 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 3
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 3
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 3
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 3
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 3
- 102000000589 Interleukin-1 Human genes 0.000 claims 3
- 108010002352 Interleukin-1 Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000016387 Pancreatic elastase Human genes 0.000 claims 1
- 108010067372 Pancreatic elastase Proteins 0.000 claims 1
- 108010019160 Pancreatin Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 229940100601 interleukin-6 Drugs 0.000 claims 1
- 229940096397 interleukin-8 Drugs 0.000 claims 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229940055695 pancreatin Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 238000013389 whole blood assay Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93363207P | 2007-06-06 | 2007-06-06 | |
| US60/933,632 | 2007-06-06 | ||
| GBGB0724331.4A GB0724331D0 (en) | 2007-12-13 | 2007-12-13 | Compositions for pulmonary delivery |
| GB0724331.4 | 2007-12-13 | ||
| PCT/GB2008/050406 WO2008149149A2 (en) | 2007-06-06 | 2008-06-04 | Polypeptides, antibody variable domains and antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530220A JP2010530220A (ja) | 2010-09-09 |
| JP2010530220A5 true JP2010530220A5 (enExample) | 2011-07-14 |
| JP5444215B2 JP5444215B2 (ja) | 2014-03-19 |
Family
ID=39791116
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510887A Active JP5444215B2 (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| JP2010510888A Pending JP2010530364A (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| JP2010510886A Expired - Fee Related JP5325211B2 (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510888A Pending JP2010530364A (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| JP2010510886A Expired - Fee Related JP5325211B2 (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
Country Status (31)
| Country | Link |
|---|---|
| US (5) | US8398979B2 (enExample) |
| EP (5) | EP2162468A2 (enExample) |
| JP (3) | JP5444215B2 (enExample) |
| KR (4) | KR20100018040A (enExample) |
| CN (4) | CN101802004A (enExample) |
| AR (3) | AR066850A1 (enExample) |
| AU (4) | AU2008259590A1 (enExample) |
| BR (3) | BRPI0812268A2 (enExample) |
| CA (6) | CA2688434A1 (enExample) |
| CL (3) | CL2008001674A1 (enExample) |
| CO (2) | CO6251322A2 (enExample) |
| CR (2) | CR11195A (enExample) |
| CY (1) | CY1116762T1 (enExample) |
| DK (1) | DK2162467T3 (enExample) |
| DO (1) | DOP2009000268A (enExample) |
| EA (5) | EA200901494A1 (enExample) |
| ES (1) | ES2546943T3 (enExample) |
| HR (1) | HRP20151024T1 (enExample) |
| HU (1) | HUE025899T2 (enExample) |
| IL (2) | IL201398A0 (enExample) |
| MA (2) | MA31403B1 (enExample) |
| MX (4) | MX2009013137A (enExample) |
| NZ (1) | NZ581372A (enExample) |
| PE (3) | PE20090763A1 (enExample) |
| PL (1) | PL2162467T3 (enExample) |
| PT (1) | PT2162467E (enExample) |
| SG (2) | SG182141A1 (enExample) |
| SI (1) | SI2162467T1 (enExample) |
| TW (6) | TW200907128A (enExample) |
| WO (3) | WO2008149150A2 (enExample) |
| ZA (1) | ZA200908470B (enExample) |
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|---|---|---|---|---|
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| BR122013001996B1 (pt) | 2005-05-18 | 2022-02-01 | Ablynx N.V. | Nanocorpos melhorados contra fator alfa de necrose tumoral |
| DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
| GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| EA200901494A1 (ru) | 2007-06-06 | 2010-06-30 | Домантис Лимитед | Способы селекции протеазоустойчивых полипептидов |
| UA102993C2 (ru) * | 2007-06-06 | 2013-09-10 | Домантис Лимитед | Анти-vegf единичный вариабельный домен иммуноглобулина |
| CA2707986A1 (en) * | 2007-12-13 | 2009-06-18 | Glaxo Group Limited | Compositions for pulmonary delivery |
| US8217140B2 (en) | 2008-04-17 | 2012-07-10 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| DK2307454T3 (en) | 2008-06-25 | 2017-04-24 | Esbatech Alcon Biomed Res Unit | Stable and soluble antibodies that inhibit VEGF |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| EP2356147A1 (en) * | 2008-11-26 | 2011-08-17 | Glaxo Group Limited | Polypeptides, antibody variable domains&antagonists |
| WO2010081787A1 (en) | 2009-01-14 | 2010-07-22 | Domantis Limited | IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS |
| KR20110119806A (ko) | 2009-02-19 | 2011-11-02 | 글락소 그룹 리미티드 | 개선된 항ｔｎｆｒ1 폴리펩티드，항체 가변 도메인 및 길항제 |
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| SG173489A1 (en) | 2009-02-19 | 2011-09-29 | Glaxo Group Ltd | Improved anti-serum albumin binding variants |
| CA2753287A1 (en) | 2009-02-24 | 2010-09-02 | Glaxo Group Limited | Antigen-binding constructs |
| CN102574914A (zh) | 2009-07-16 | 2012-07-11 | 葛兰素集团有限公司 | 改进的抗血清清蛋白结合性单可变区 |
| CA2768460A1 (en) | 2009-07-16 | 2011-01-20 | Glaxo Group Limited | Antagonists, uses & methods for partially inhibiting tnfr1 |
| CA2777700A1 (en) * | 2009-10-14 | 2011-04-21 | Aileron Therapeutics, Inc. | Improved peptidomimetic macrocycles |
| ES2552177T3 (es) | 2009-10-27 | 2015-11-26 | Glaxo Group Limited | Polipéptidos anti-TNFR1 estables, dominios variables de anticuerpos y antagonistas |
| AU2011212442A1 (en) | 2010-02-05 | 2012-08-09 | Ablynx Nv | Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same |
| JP2013529080A (ja) | 2010-05-20 | 2013-07-18 | グラクソ グループ リミテッド | 改良された抗血清アルブミン結合変異体 |
| JP2013538566A (ja) * | 2010-08-13 | 2013-10-17 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 改良された抗血清アルブミン結合変異体 |
| BR112013003899A2 (pt) * | 2010-08-20 | 2016-06-07 | Glaxosmithkline Ip Dev Ltd | domínio variável único da imunoglobina anti-albumina sérica (sa), ligando multiespecífico, proteína de fusão, composição, ácido nucleico, vetor, célula hospedeira isolada, e, método de tratar ou previnir uma doença ou distúrbio em um paciente |
| WO2012035141A1 (en) * | 2010-09-16 | 2012-03-22 | Baliopharm Ag | Anti-hutnfr1 antibody |
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| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| PT2726092T (pt) * | 2011-06-28 | 2019-10-08 | Lp Inhibrx | Polipéptidos de fusão serpina e métodos para a sua utilização |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| CN103842380A (zh) * | 2011-07-27 | 2014-06-04 | 葛兰素集团有限公司 | 融合至Fc结构域的抗VEGF单可变结构域 |
| EA027160B1 (ru) * | 2011-08-17 | 2017-06-30 | Глаксо Груп Лимитед | Модифицированные белки и пептиды |
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| AU2017364818C1 (en) | 2016-11-28 | 2025-05-15 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding molecule having adjustable ligand binding activity |
| CA3041279A1 (en) | 2016-11-28 | 2018-05-31 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding domain, and polypeptide including conveying section |
| UY37651A (es) * | 2017-03-31 | 2018-10-31 | Swedish Orphan Biovitrum Ab Publ | Polipéptido de unión al il-1r-i |
| CN111295189B (zh) * | 2017-11-01 | 2023-09-15 | 艾洛基治疗公司 | 修饰的胱天蛋白酶-9多肽及其使用方法 |
| EP3719036A4 (en) | 2017-11-28 | 2021-09-08 | Chugai Seiyaku Kabushiki Kaisha | LIGAND BINDING MOLECULE HAVING ADJUSTABLE LIGAND BINDING ACTIVITY |
| TW201936208A (zh) | 2017-11-28 | 2019-09-16 | 日商中外製藥股份有限公司 | 含有抗原結合域及運輸部分之多胜肽 |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
| US12077577B2 (en) | 2018-05-30 | 2024-09-03 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide comprising aggrecan binding domain and carrying moiety |
| EP3802831A4 (en) * | 2018-05-30 | 2022-07-27 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide comprising il-1r1 binding domain and carrying moiety |
| PL3623798T3 (pl) * | 2018-09-13 | 2022-03-28 | Euroimmun Medizinische Labordiagnostika Ag | Sposób i urządzenie do wykrywania i przedstawiania obrazu immunofluorescencyjnego próbki biologicznej |
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