UY37651A - Polipéptido de unión al il-1r-i - Google Patents

Polipéptido de unión al il-1r-i

Info

Publication number
UY37651A
UY37651A UY0001037651A UY37651A UY37651A UY 37651 A UY37651 A UY 37651A UY 0001037651 A UY0001037651 A UY 0001037651A UY 37651 A UY37651 A UY 37651A UY 37651 A UY37651 A UY 37651A
Authority
UY
Uruguay
Prior art keywords
polypeptide
union
present disclosure
binding
relates
Prior art date
Application number
UY0001037651A
Other languages
English (en)
Inventor
Joachim Feldwisch
Malin Lindborg
Joakim Nilsson
Erik Nordling
Robert Svensson
Original Assignee
Swedish Orphan Biovitrum Ab Publ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Swedish Orphan Biovitrum Ab Publ filed Critical Swedish Orphan Biovitrum Ab Publ
Publication of UY37651A publication Critical patent/UY37651A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Abstract

La presente divulgación se refiere a una clase de polipéptidos genéticamente modificados que tienen una afinidad de unión por receptor de interleucina-1 de tipo I (IL-1R-I) que comprende el motivo de unión (BM) EX2X3X4X5X6X7EIX10X11LPNLX16RX18QYX21A FIX25X26LX28D. La presente divulgación también se refiere al uso de dicho polipéptido de unión al IL-1R-I como agente terapéutico, de pronóstico y/o de diagnóstico.
UY0001037651A 2017-03-31 2018-04-02 Polipéptido de unión al il-1r-i UY37651A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17164226 2017-03-31

Publications (1)

Publication Number Publication Date
UY37651A true UY37651A (es) 2018-10-31

Family

ID=58536721

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037651A UY37651A (es) 2017-03-31 2018-04-02 Polipéptido de unión al il-1r-i

Country Status (14)

Country Link
US (1) US20210403533A1 (es)
EP (1) EP3601317A1 (es)
JP (2) JP2020515252A (es)
KR (1) KR20190134617A (es)
CN (1) CN110650971A (es)
AR (1) AR111348A1 (es)
AU (1) AU2018242224B2 (es)
BR (1) BR112019019819A2 (es)
CA (1) CA3056985A1 (es)
IL (1) IL269477B1 (es)
MX (1) MX2019011191A (es)
SG (1) SG11201908274YA (es)
UY (1) UY37651A (es)
WO (1) WO2018178392A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021089695A1 (en) * 2019-11-05 2021-05-14 Affibody Ab Polypeptides

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148009B1 (ko) 1988-05-27 1998-08-01 그래고리 비. 아보트 인터루킨-1 억제제
US5075222A (en) 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
ES2727425T3 (es) 2000-12-12 2019-10-16 Medimmune Llc Moléculas con semividas prolongadas, composiciones y usos de las mismas
EP1572946B1 (en) 2002-09-06 2012-03-14 Amgen, Inc. Therapeutic human anti-il-1r1 monoclonal antibody
ATE416190T1 (de) * 2003-07-04 2008-12-15 Affibody Ab Polypeptide mit bindungsaffinität für her2
AR045614A1 (es) 2003-09-10 2005-11-02 Hoffmann La Roche Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos
US20090155283A1 (en) * 2005-12-01 2009-06-18 Drew Philip D Noncompetitive Domain Antibody Formats That Bind Interleukin 1 Receptor Type 1
KR20100018040A (ko) * 2007-06-06 2010-02-16 도만티스 리미티드 프로테아제 내성 폴리펩티드를 선택하는 방법
WO2009077175A1 (en) 2007-12-19 2009-06-25 Affibody Ab Polypeptide derived from protein a and able to bind pdgf
SI2808343T1 (sl) 2007-12-26 2019-10-30 Xencor Inc Fc-variante s spremenjeno vezavo na FcRn
US8298533B2 (en) * 2008-11-07 2012-10-30 Medimmune Limited Antibodies to IL-1R1
WO2010115998A2 (en) * 2009-04-10 2010-10-14 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
EP2977088B1 (en) * 2010-03-08 2017-08-02 GE Healthcare BioProcess R&D AB Immunoglobulin g fc region binding polypeptide
US9808502B2 (en) * 2012-02-20 2017-11-07 Swedish Orphan Biovitrum Ab (Publ) Polypeptides binding to human complement C5
EP2912054B1 (en) * 2012-10-25 2017-06-21 Affibody AB Albumin binding polypeptide
JP6608288B2 (ja) * 2013-03-15 2019-11-20 アフィボディ・アーベー 新しいポリペプチド
BR112016003142A2 (pt) * 2013-08-28 2017-10-17 Swedish Orphan Biovitrum Ab Publ ligação de polipeptídeos estáveis ao c5 do complemento humano
US10167322B2 (en) * 2013-12-20 2019-01-01 Affibody Ab Engineered albumin binding polypeptide
US10669314B2 (en) 2014-06-13 2020-06-02 Affibody Ab Polypeptide
WO2016059057A1 (en) * 2014-10-13 2016-04-21 Affibody Ab Vegfr-2 binding polypeptides
CA2972683A1 (en) 2015-01-12 2016-07-21 Affibody Ab Il-17a-binding polypeptides

Also Published As

Publication number Publication date
BR112019019819A2 (pt) 2020-04-22
SG11201908274YA (en) 2019-10-30
MX2019011191A (es) 2019-12-11
AR111348A1 (es) 2019-07-03
AU2018242224B2 (en) 2021-09-02
JP2023071776A (ja) 2023-05-23
US20210403533A1 (en) 2021-12-30
KR20190134617A (ko) 2019-12-04
CN110650971A (zh) 2020-01-03
IL269477A (en) 2019-11-28
JP2020515252A (ja) 2020-05-28
IL269477B1 (en) 2024-02-01
WO2018178392A1 (en) 2018-10-04
EP3601317A1 (en) 2020-02-05
CA3056985A1 (en) 2018-10-04
AU2018242224A1 (en) 2019-10-17

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Legal Events

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Effective date: 20231026