CO2018009995A2 - Proteínas de unión y métodos de uso de las mismas - Google Patents
Proteínas de unión y métodos de uso de las mismasInfo
- Publication number
- CO2018009995A2 CO2018009995A2 CONC2018/0009995A CO2018009995A CO2018009995A2 CO 2018009995 A2 CO2018009995 A2 CO 2018009995A2 CO 2018009995 A CO2018009995 A CO 2018009995A CO 2018009995 A2 CO2018009995 A2 CO 2018009995A2
- Authority
- CO
- Colombia
- Prior art keywords
- methods
- binding proteins
- protein
- gfral
- antibodies
- Prior art date
Links
- 108091008324 binding proteins Proteins 0.000 title abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 102100040304 GDNF family receptor alpha-like Human genes 0.000 abstract 2
- 101001038371 Homo sapiens GDNF family receptor alpha-like Proteins 0.000 abstract 2
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 abstract 1
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente descripción provee proteínas de unión, tales como anticuerpos, que se unen a una proteína del Tipo de Receptor Alfa de la Familia GDNF (GFRAL), que incluye la proteína GFRAL humana, y métodos de su uso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662316516P | 2016-03-31 | 2016-03-31 | |
PCT/US2017/020654 WO2017172260A1 (en) | 2016-03-31 | 2017-03-03 | Binding proteins and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2018009995A2 true CO2018009995A2 (es) | 2018-12-14 |
Family
ID=59966343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2018/0009995A CO2018009995A2 (es) | 2016-03-31 | 2018-09-21 | Proteínas de unión y métodos de uso de las mismas |
Country Status (19)
Country | Link |
---|---|
US (3) | US10174119B2 (es) |
EP (1) | EP3436068A4 (es) |
JP (2) | JP7021099B2 (es) |
KR (2) | KR102370762B1 (es) |
CN (2) | CN117986363A (es) |
AU (2) | AU2017241161B2 (es) |
BR (1) | BR112018068898A2 (es) |
CA (1) | CA3016035A1 (es) |
CL (1) | CL2018002687A1 (es) |
CO (1) | CO2018009995A2 (es) |
IL (1) | IL261666B1 (es) |
MX (1) | MX2018011503A (es) |
MY (1) | MY194669A (es) |
NZ (1) | NZ745635A (es) |
PE (1) | PE20190126A1 (es) |
PH (1) | PH12018501882A1 (es) |
SG (1) | SG11201807279QA (es) |
TW (1) | TWI815793B (es) |
WO (1) | WO2017172260A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017241161B2 (en) | 2016-03-31 | 2022-05-26 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
CA3038846A1 (en) * | 2016-10-12 | 2018-04-19 | Janssen Biotech, Inc. | Methods for screening for modulators of gdf15-like biological activity |
JP2021533743A (ja) * | 2018-08-10 | 2021-12-09 | ノバルティス アーゲー | Gfral細胞外ドメイン及び使用方法 |
EP3920955A4 (en) * | 2019-02-05 | 2023-02-22 | The Trustees of the University of Pennsylvania | PEPTIDE LIGANDS OF THE GDNF FAMILY ALPHA-LIKE RECEPTOR (GFRAL) RECEPTOR |
WO2020227640A1 (en) * | 2019-05-08 | 2020-11-12 | Agilvax, Inc. | Compositions and methods related to xct antibodies |
US20220296707A1 (en) * | 2019-06-04 | 2022-09-22 | Regents Of The University Of Minnesota | Anti-opioid compounds and methods of making and using same |
WO2021050978A1 (en) * | 2019-09-11 | 2021-03-18 | University Of Cincinnati | Treatment of skin blistering diseases using antibodies |
KR20210150981A (ko) | 2020-06-04 | 2021-12-13 | 재단법인대구경북과학기술원 | Gfral 길항 항체 및 이의 용도 |
CN115698073A (zh) * | 2020-06-04 | 2023-02-03 | 大邱庆北科学技术院 | Gfral拮抗抗体及其用途 |
WO2022178416A1 (en) * | 2021-02-22 | 2022-08-25 | Northwestern University | Anti-cd73 monoclonal antibodies |
WO2022207785A1 (en) * | 2021-03-31 | 2022-10-06 | Kymab Limited | Antibodies to gfral |
BR112023020152A2 (pt) | 2021-03-31 | 2023-11-14 | Cambridge Entpr Ltd | Inibidores terapêuticos de sinalização gdf15 |
TW202317630A (zh) * | 2021-06-30 | 2023-05-01 | 大陸商上海津曼特生物科技有限公司 | 抗gfral抗體及其應用 |
CA3228576A1 (en) | 2021-08-10 | 2023-02-16 | Byomass Inc. | Anti-gdf15 antibodies, compositions and uses thereof |
WO2023039359A1 (en) | 2021-09-10 | 2023-03-16 | Ngm Biopharmaceuticals, Inc. | Methods of treating cancer and tumor-related weight loss and cachexia |
KR20230044121A (ko) | 2021-09-24 | 2023-04-03 | 재단법인대구경북과학기술원 | 친화도가 개선된 gfral 길항 항체 및 이의 용도 |
WO2023048425A1 (ko) * | 2021-09-24 | 2023-03-30 | 재단법인대구경북과학기술원 | 친화도가 개선된 gfral 길항 항체 및 이의 용도 |
WO2023122213A1 (en) | 2021-12-22 | 2023-06-29 | Byomass Inc. | Targeting gdf15-gfral pathway cross-reference to related applications |
CA3240270A1 (en) * | 2022-02-03 | 2023-08-10 | Keyu LI | Anti-cd38 binding molecules and uses thereof |
WO2023154953A1 (en) | 2022-02-14 | 2023-08-17 | Ngm Biopharmaceuticals, Inc. | Gdf15 polypeptides for treating and preventing autoimmune diseases |
WO2023192798A2 (en) * | 2022-03-28 | 2023-10-05 | Coherus Biosciences, Inc. | Anti-ilt4 compositions and methods |
Family Cites Families (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194596A (en) | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
US5350836A (en) | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
WO1994003599A1 (en) | 1992-08-04 | 1994-02-17 | Sagami Chemical Research Center | HUMAN cDNA AND PROTEIN WHICH SAID cDNA CODES FOR |
US6180602B1 (en) | 1992-08-04 | 2001-01-30 | Sagami Chemical Research Center | Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent |
JPH07258293A (ja) | 1994-03-23 | 1995-10-09 | Asahi Chem Ind Co Ltd | 新規な蛋白質ならびにその製造方法 |
US5994102A (en) | 1994-12-15 | 1999-11-30 | Human Genome Sciences, Inc. | Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides |
AU1830195A (en) | 1994-12-15 | 1996-07-03 | Human Genome Sciences, Inc. | Prostatic growth factor |
US6521227B1 (en) | 1999-11-18 | 2003-02-18 | Peter L. Hudson | Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides |
WO1997000958A1 (en) | 1995-06-22 | 1997-01-09 | St. Vincent's Hospital Sydney Limited | NOVEL TGF-β LIKE CYTOKINE |
US6696259B1 (en) | 1995-11-13 | 2004-02-24 | Licentia Ltd. | Assays using glial cell line-derived neurotrophic factor receptors |
WO1997018240A1 (en) | 1995-11-13 | 1997-05-22 | Carlos Ibanez | Glial cell line-derived neurotrophic factor receptors |
US6524802B1 (en) | 1996-03-29 | 2003-02-25 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-14 |
IL128872A0 (en) | 1996-09-11 | 2000-01-31 | Ortho Mcneil Pharm Inc | TNF-beta-like protein for treating prostate cancer and related nucleic acid molecules pharmaceutical compositions and methods |
EP0981625A2 (en) * | 1997-05-06 | 2000-03-01 | Human Genome Sciences, Inc. | $i(ENTEROCOCCUS FAECALIS) POLYNUCLEOTIDES AND POLYPEPTIDES |
NZ501199A (en) | 1997-05-22 | 2001-12-21 | Carlos F | Glial cell line-derived neurotrophic factor receptors (BDNFR-beta) |
WO1999006445A1 (en) | 1997-07-31 | 1999-02-11 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-15 |
WO2000005259A1 (en) | 1998-07-23 | 2000-02-03 | Smithkline Beecham Corporation | Secreted cysteine rich protein-6 (scrp-6) |
JP2002526775A (ja) | 1998-10-01 | 2002-08-20 | テイテイエブスキ,アレクセイ・ウラデイミロビチ | GDNFについての新規Ret非依存性シグナリング経路 |
US6905817B1 (en) | 1998-10-01 | 2005-06-14 | Licestia Ltd. | Ret-independent signaling pathway for GDNF |
US6465181B2 (en) | 1999-03-25 | 2002-10-15 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
US6974684B2 (en) | 2001-08-08 | 2005-12-13 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
AU5067100A (en) | 1999-05-17 | 2000-12-05 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Neuroprotective properties of gdf-15, a novel member of the tgf-beta superfamily |
US6866851B1 (en) | 1999-12-28 | 2005-03-15 | Washington University | GFRα1-RET specific agonists and methods therefor |
EP1276756A4 (en) | 2000-04-12 | 2004-06-09 | Human Genome Sciences Inc | ALBUMIN FUSION PROTEINS |
ATE470863T1 (de) | 2000-04-20 | 2010-06-15 | St Vincents Hosp Sydney | Diagnostischer assay mit makrophagenhemmendem zytokin-1 (mic-1) |
US7141661B2 (en) | 2000-09-08 | 2006-11-28 | The United States Of America As Represented By The Department Of Health And Human Services | Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties |
JP2005500815A (ja) | 2000-12-29 | 2005-01-13 | キュラジェン コーポレイション | タンパク質およびそれをコードする核酸 |
TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
CA2437958C (en) | 2001-03-09 | 2018-10-30 | University Of Chicago | Polymeric immunoglobulin fusion proteins that target low-affinity fc.gamma.receptors |
ES2387546T3 (es) | 2001-05-11 | 2012-09-25 | Amgen Inc. | Péptidos y moléculas relacionadas que se unen a TALL-1 |
GB0115195D0 (en) | 2001-06-21 | 2001-08-15 | Bae Systems Plc | Split-pin drill jig |
US20030053431A1 (en) | 2001-09-10 | 2003-03-20 | Lila Madour | Method for performing handoff in a radio telecommunications network |
ES2545090T3 (es) | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina y GCSF |
US20060253913A1 (en) | 2001-12-21 | 2006-11-09 | Yue-Jin Huang | Production of hSA-linked butyrylcholinesterases in transgenic mammals |
US7642242B2 (en) | 2002-03-05 | 2010-01-05 | Genentech, Inc. | PRO34128 polypeptides |
AU2003213166B2 (en) | 2002-03-05 | 2008-07-03 | Genentech, Inc. | Novel polypeptides having sequence similarity to GDNFR and nucleic acids encoding the same |
US20100285016A1 (en) | 2002-03-05 | 2010-11-11 | Genentech, Inc. | PRO34128 nucleic acids |
US7157235B2 (en) | 2002-06-17 | 2007-01-02 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
US7919084B2 (en) | 2002-06-17 | 2011-04-05 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
CN1241946C (zh) | 2002-07-01 | 2006-02-15 | 美国福源集团 | 对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白 |
AU2003295424A1 (en) | 2002-11-08 | 2004-06-03 | Barnes-Jewish Hospital | Methods and compositions for prostate epithelial cell differentiation |
US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
ME01775B (me) | 2003-11-05 | 2011-02-28 | Glycart Biotechnology Ag | Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom |
CN1241941C (zh) * | 2003-11-21 | 2006-02-15 | 中国科学院上海生命科学研究院 | 一种促进神经分化和抗细胞凋亡的蛋白质及其编码基因 |
EP2774620A1 (en) | 2004-04-13 | 2014-09-10 | St Vincent's Hospital Sydney Limited | Method for modulating weight loss |
WO2005113585A2 (en) | 2004-05-20 | 2005-12-01 | Acceleron Pharma Inc. | Modified tgf-beta superfamily polypeptides |
PL1844337T3 (pl) | 2005-01-24 | 2013-12-31 | Pepscan Systems Bv | Związki wiążące, związki immunogenne i peptydomimetyki |
WO2007030930A1 (en) * | 2005-09-13 | 2007-03-22 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
LT2004683T (lt) | 2006-03-24 | 2016-10-10 | Biogen Hemophilia Inc. | Pc5, kaip faktoriaus ix pro-peptidą apdorojantis fermentas |
US8974748B2 (en) | 2007-04-05 | 2015-03-10 | Corning Incorporated | Dual inlet microchannel device and method for using same |
EP2082645A1 (en) | 2006-04-19 | 2009-07-29 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
US7754689B2 (en) | 2006-06-02 | 2010-07-13 | Wyeth Llc | Finger-1 peptide analogs of the TGF-β superfamily |
AU2007277556B2 (en) | 2006-07-26 | 2012-11-29 | Pepscan Systems B.V. | Immunogenic compounds and protein mimics |
MX2009000914A (es) | 2006-08-04 | 2009-06-18 | Hannover Med Hochschule | Medios y metodos para evaluar el riesgo de intervenciones cardiacas basadas en el factor 15 de diferenciacion del crecimiento. |
WO2008051797A2 (en) | 2006-10-19 | 2008-05-02 | Genentech, Inc. | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases |
SI2144639T1 (sl) | 2007-04-25 | 2013-03-29 | Stem Cells Spin S.A. | Nova linija izvorne celice in uporaba le-te |
US8067548B2 (en) | 2007-07-26 | 2011-11-29 | Novagen Holding Corporation | Fusion proteins having mutated immunoglobulin hinge region |
EP2783698A1 (en) | 2007-08-16 | 2014-10-01 | St Vincent's Hospital Sydney Limited | Agents and methods for modulating macrophage inhibitory cytokine (MIC-1) activity |
EP2209486A1 (en) | 2007-10-09 | 2010-07-28 | St Vincent's Hospital Sydney Limited | A method of treating cachexia with the removal or inactivation of macrophage inhibitory cytokine-1 |
WO2009052557A1 (en) | 2007-10-22 | 2009-04-30 | St Vincent's Hospital Sydney Limited | Methods of prognosis |
JP6157046B2 (ja) | 2008-01-07 | 2017-07-05 | アムジェン インコーポレイテッド | 静電的ステアリング(electrostaticsteering)効果を用いた抗体Fcヘテロ二量体分子を作製するための方法 |
WO2009087190A1 (en) | 2008-01-08 | 2009-07-16 | Roche Diagnostics Gmbh | Means and methods for assessing the risk of patients presenting to emergency units based on gdf-15 |
CN102037004A (zh) | 2008-01-08 | 2011-04-27 | 生物种属学股份公司 | 使用寡糖基转移酶的多肽的糖缀合 |
US8718994B2 (en) | 2008-04-09 | 2014-05-06 | Transtech Pharma, Llc | Ligands for the GLP-1 receptor and methods for discovery thereof |
EP2279419A1 (en) | 2008-05-20 | 2011-02-02 | Roche Diagnostics GmbH | Gdf-15 as biomarker in type 1 diabetes |
WO2010007041A1 (en) | 2008-07-14 | 2010-01-21 | Roche Diagnostics Gmbh | Multimarker panel for diagnosing, monitoring and selecting the therapy for patients with heart failure |
WO2010019263A2 (en) | 2008-08-15 | 2010-02-18 | Genzyme Corporation | Soluble flt constructs for treating cancers |
JP5444363B2 (ja) | 2008-10-31 | 2014-03-19 | セントビンセンツ ホスピタル シドニー リミテッド | 慢性腎疾患における予後判定の方法 |
MX2011004563A (es) | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
EP2211182A1 (en) | 2009-01-16 | 2010-07-28 | Roche Diagnostics GmbH | Method for the assessment of severity of liver cirrhosis |
EP2209003A1 (en) | 2009-01-16 | 2010-07-21 | F. Hoffmann-Roche AG | Means and methods for differentiating between fibrosis and cirrhosis |
AU2010213575B2 (en) | 2009-02-12 | 2013-11-14 | Stryker Corporation | Peripheral administration of proteins including TGF-beta superfamily members for systemic treatment of disorders and disease |
GB0902737D0 (en) | 2009-02-19 | 2009-04-01 | Univ Gent | GDF15 as a differential marker for spondyloarthropathy |
CA2752647A1 (en) | 2009-02-24 | 2010-09-02 | The Salk Institute For Biological Studies | Designer ligands of tgf-beta superfamily |
TWI560197B (en) | 2009-05-05 | 2016-12-01 | Amgen Inc | Fgf21 mutants and uses thereof |
CA2766166A1 (en) | 2009-07-08 | 2011-01-13 | Amgen Inc. | Design of stable and aggregation free antibody fc molecules through ch3 domain interface engineering |
WO2011008956A2 (en) | 2009-07-15 | 2011-01-20 | Zirus, Inc. | Mammalian genes involved in infection |
WO2011050407A1 (en) | 2009-10-28 | 2011-05-05 | St Vincent's Hospital Sydney Limited | Methods of diagnosing and prognosing colonic polyps |
US8361744B2 (en) | 2009-11-05 | 2013-01-29 | Genentech, Inc. | Methods and composition for secretion of heterologous polypeptides |
WO2011064758A2 (en) | 2009-11-30 | 2011-06-03 | Pfizer Limited | Fusion protein |
JPWO2011105573A1 (ja) * | 2010-02-26 | 2013-06-20 | 株式会社 未来創薬研究所 | 抗icam3抗体およびその用途 |
US9212221B2 (en) | 2010-03-03 | 2015-12-15 | Detroit R & D, Inc. | Form-specific antibodies for NAG-1 (MIC-1, GDF-15), H6D and other TGF-β subfamily and heart disease and cancer diagnoses |
JP5791335B2 (ja) | 2010-04-07 | 2015-10-07 | 花王株式会社 | オルガノポリシロキサン化合物の製造方法 |
WO2011127458A2 (en) | 2010-04-09 | 2011-10-13 | University Of Southern California | Systems and methods of cell activated, controlled release delivery of growth factors for tissue repair and regeneration |
EP2383571A1 (en) | 2010-05-02 | 2011-11-02 | Prof. Hess Medical Consulting GmbH | Growth differntioation factor 15 (GDF 15) for risk prediction of diabetic foot ulcer |
CA2807213C (en) | 2010-08-26 | 2022-06-28 | F. Hoffman-La Roche Ag | Use of biomarkers in the assessment of the early transition from arterial hypertension to heart failure |
US9243057B2 (en) | 2010-08-31 | 2016-01-26 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
EP2439535A1 (en) | 2010-10-07 | 2012-04-11 | F. Hoffmann-La Roche AG | Diagnosis of diabetes related heart disease and GDF-15 and Troponin as predictors for the development of type 2 diabetes mellitus |
JP5977814B2 (ja) | 2011-04-08 | 2016-08-24 | アムジエン・インコーポレーテツド | 増殖分化因子15(gdf−15)を使用して代謝障害を治療または改善する方法 |
HUE033008T2 (hu) | 2011-04-13 | 2017-11-28 | Bristol Myers Squibb Co | FC fúziós proteinek, amelyek tartalmaznak új linkereket |
JP5997151B2 (ja) | 2011-06-30 | 2016-09-28 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
AR086823A1 (es) | 2011-06-30 | 2014-01-22 | Genentech Inc | Formulaciones de anticuerpo anti-c-met, metodos |
WO2013012648A1 (en) | 2011-07-15 | 2013-01-24 | Emory University | Gdf15 in diagnostic and therapeutic applications |
BR112014018575A2 (pt) | 2012-01-26 | 2017-07-04 | Amgen Inc | polipetídeos de fator de diferenciação de crescimento 15 (gdf-15) |
WO2013148117A1 (en) | 2012-03-27 | 2013-10-03 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
EP2863910B1 (en) | 2012-06-20 | 2020-03-11 | University Of Virginia Patent Foundation | Compositions and methods for regulating glucose homeostasis and insulin action |
WO2014000042A1 (en) | 2012-06-27 | 2014-01-03 | Prince Henry's Institute Of Medical Research | COMPOSITIONS AND METHODS FOR MODIFYING TGF-β FAMILY LIGANDS |
TW201402608A (zh) * | 2012-07-12 | 2014-01-16 | Abbvie Inc | Il-1結合蛋白質 |
CA2928851A1 (en) * | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
BR112015002085A2 (pt) | 2012-08-08 | 2017-12-19 | Roche Glycart Ag | proteína, polinucleotídeo, vetor, célula hospedeira, método para produzir a proteína, composição farmacêutica, uso da proteína, método de tratamento e invenção |
JO3462B1 (ar) * | 2012-08-22 | 2020-07-05 | Regeneron Pharma | أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها |
EP2900263B1 (en) | 2012-09-26 | 2019-06-05 | Julius-Maximilians-Universität Würzburg | Monoclonal antibodies to growth and differentiation factor 15 (gdf-15) |
WO2014066590A1 (en) * | 2012-10-24 | 2014-05-01 | Research Development Foundation | Jam-c antibodies and methods for treatment of cancer |
US20150376294A1 (en) * | 2012-12-03 | 2015-12-31 | Rigshospitalet | Anti-pad2 antibodies and treatment of autoimmune diseases |
US9175076B2 (en) * | 2012-12-21 | 2015-11-03 | Aveo Pharmaceuticals, Inc. | Anti-GDF15 antibodies |
DE102013100322A1 (de) | 2013-01-14 | 2014-07-17 | Claas Selbstfahrende Erntemaschinen Gmbh | Schneidwerk |
BR112015018104A2 (pt) | 2013-01-30 | 2017-11-21 | Ngm Biopharmaceuticals Inc | polipeptídeos de gdf15 modificados, seu uso, composições compreendendo os mesmos e recipiente estéril compreendendo as referidas composições |
US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
WO2014140374A2 (en) | 2013-03-15 | 2014-09-18 | Novo Nordisk A/S | Monovalent cd27 antibodies |
SG11201507429TA (en) | 2013-03-15 | 2015-10-29 | Genentech Inc | Il-22 polypeptides and il-22 fc fusion proteins and methods of use |
AU2014278481A1 (en) * | 2013-06-10 | 2015-12-03 | Merck Sharp & Dohme Corp. | CMV neutralizing antigen binding proteins |
EP3027642B1 (en) | 2013-07-31 | 2020-08-19 | Amgen Inc. | Growth differentiation factor 15 (gdf-15) constructs |
SG11201700476VA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
WO2016018931A1 (en) | 2014-07-30 | 2016-02-04 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
PE20171058A1 (es) | 2014-10-31 | 2017-07-21 | Ngm Biopharmaceuticals Inc | Composiciones y metodos de uso para tratar trastornos metabolicos |
GB201512733D0 (en) | 2015-07-20 | 2015-08-26 | Genagon Therapeutics Ab | Therapeutic agents for treating conditions associated with elevated GDF15 |
US11105818B2 (en) | 2016-01-15 | 2021-08-31 | Novo Nordisk A/S | MIC-1 receptor and uses thereof |
WO2017147742A1 (en) | 2016-02-29 | 2017-09-08 | Eli Lilly And Company | Gfral receptor therapies |
EP3423097A4 (en) | 2016-03-04 | 2019-08-21 | NGM Biopharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR MODULATING BODY WEIGHT |
AU2017241161B2 (en) | 2016-03-31 | 2022-05-26 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
CA3038846A1 (en) | 2016-10-12 | 2018-04-19 | Janssen Biotech, Inc. | Methods for screening for modulators of gdf15-like biological activity |
-
2017
- 2017-03-03 AU AU2017241161A patent/AU2017241161B2/en active Active
- 2017-03-03 CA CA3016035A patent/CA3016035A1/en active Pending
- 2017-03-03 WO PCT/US2017/020654 patent/WO2017172260A1/en active Application Filing
- 2017-03-03 MY MYPI2018703041A patent/MY194669A/en unknown
- 2017-03-03 KR KR1020187030069A patent/KR102370762B1/ko active IP Right Grant
- 2017-03-03 TW TW106107129A patent/TWI815793B/zh active
- 2017-03-03 SG SG11201807279QA patent/SG11201807279QA/en unknown
- 2017-03-03 BR BR112018068898A patent/BR112018068898A2/pt unknown
- 2017-03-03 JP JP2018548669A patent/JP7021099B2/ja active Active
- 2017-03-03 NZ NZ745635A patent/NZ745635A/en unknown
- 2017-03-03 CN CN202311479185.4A patent/CN117986363A/zh active Pending
- 2017-03-03 IL IL261666A patent/IL261666B1/en unknown
- 2017-03-03 MX MX2018011503A patent/MX2018011503A/es unknown
- 2017-03-03 CN CN201780030436.7A patent/CN109715206B/zh active Active
- 2017-03-03 KR KR1020227006994A patent/KR102630655B1/ko active IP Right Grant
- 2017-03-03 PE PE2018001850A patent/PE20190126A1/es unknown
- 2017-03-03 EP EP17776245.7A patent/EP3436068A4/en active Pending
- 2017-03-03 US US15/449,839 patent/US10174119B2/en active Active
-
2018
- 2018-09-04 PH PH12018501882A patent/PH12018501882A1/en unknown
- 2018-09-12 US US16/129,438 patent/US10975154B2/en active Active
- 2018-09-21 CL CL2018002687A patent/CL2018002687A1/es unknown
- 2018-09-21 CO CONC2018/0009995A patent/CO2018009995A2/es unknown
-
2021
- 2021-03-05 US US17/194,144 patent/US20220073627A1/en active Pending
-
2022
- 2022-02-03 JP JP2022015851A patent/JP2022088355A/ja active Pending
- 2022-08-31 AU AU2022224794A patent/AU2022224794A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2018009995A2 (es) | Proteínas de unión y métodos de uso de las mismas | |
CY1123163T1 (el) | Αντισωματα που δεσμευουν beta klotho επικρατεια 2 και μεθοδοι χρησης αυτων | |
CY1124106T1 (el) | Συνθεσεις μεταφορεα-αντισωματος και μεθοδοι παρασκευης και χρησης αυτων | |
BR112018074453A2 (pt) | proteínas de ligação biespecíficas ligando uma protéina imunomoduladora e um antígeno tumoral | |
AR109625A1 (es) | Proteínas de unión a antígenos (abp) que se unen selectivamente a tigit y métodos para el uso de las mismas | |
BR112016022841A2 (pt) | cadeia j modificada | |
CO2018002446A2 (es) | Moléculas de unión a linfopoyetina estromal timica (tslp) y métodos de uso de las moléculas | |
BR112017011932A2 (pt) | ?anticorpos direcionados a receptor acoplado a proteína g e métodos de uso? | |
GEP20217326B (en) | Constructs having a sirp-alpha domain or variant thereof | |
CR20170079A (es) | Agentes de unión a cd123 y usos de estos | |
UY36021A (es) | Proteìnas fc multimèricas | |
GT201700188A (es) | Anticuerpos contra tau y sus usos | |
BR112019012796A2 (pt) | proteínas de ligação ao antígeno antineuropilina e métodos de uso das mesmas | |
EA201691610A8 (ru) | Анти-jagged1 антитела и способы применения | |
BR112018068678A2 (pt) | anticorpos anti-mica | |
EA201600473A1 (ru) | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА К Tau(PS422) И СПОСОБЫ ПРИМЕНЕНИЯ | |
CR20170262A (es) | Composiciones y métodos para anticuerpos dirigidos a bmp6 | |
MX2020004801A (es) | Polipeptidos de fusion biespecificos y sus metodos de uso. | |
CL2017000212A1 (es) | Anticuerpos anti proteína similar a angiopoyetina 4 y métodos de uso | |
AR101671A1 (es) | Anticuerpos anti proteína similar a angiopoyetina-4 (angptl4) y métodos de uso | |
CL2019000999A1 (es) | Anticuerpos que se unen a la proteína de envoltura del virus zika y usos de los mismos. | |
CO2019009035A2 (es) | Proteínas de unión al receptor de glucagón y métodos para usarlas | |
BR112019010128A2 (pt) | proteínas de ligação a antígeno anti-gitr e métodos de uso das mesmas | |
MA49769A (fr) | Protéines se liant à nkg2d, cd16 et flt3 | |
AR112904A1 (es) | Proteínas de unión a antígenos anti-gitr y métodos para el uso de las mismas |