CO2019003809A2 - Anticuerpos contra proteína alfa reguladora de señal y métodos de uso - Google Patents

Anticuerpos contra proteína alfa reguladora de señal y métodos de uso

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Publication number
CO2019003809A2
CO2019003809A2 CONC2019/0003809A CO2019003809A CO2019003809A2 CO 2019003809 A2 CO2019003809 A2 CO 2019003809A2 CO 2019003809 A CO2019003809 A CO 2019003809A CO 2019003809 A2 CO2019003809 A2 CO 2019003809A2
Authority
CO
Colombia
Prior art keywords
polypeptide
human
sirp
extracellular domain
methods
Prior art date
Application number
CONC2019/0003809A
Other languages
English (en)
Inventor
William Don Harriman
Jaume Pons
Bang Janet Sim
Steven Elliot Kauder
Hong Wan
Tracy Chia-Chien Kuo
Shelley Izquierdo
Original Assignee
Alx Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alx Oncology Inc filed Critical Alx Oncology Inc
Publication of CO2019003809A2 publication Critical patent/CO2019003809A2/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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Abstract

Entre otras cosas, en la presente se proveen anticuerpos aislados que se unen a un dominio extracelular de un polipéptido SIRP-α v1 humano (por ejemplo, el dominio D1), un dominio extracelular de un polipéptido SIRP-α v2 humano o ambos. En algunas modalidades, los anticuerpos también se unen a un dominio extracelular de un polipéptido SIRP-α de mono, un dominio extracelular de un polipéptido SIRP-α de ratón, un dominio extracelular SIRP-β humano y/o un dominio extracelular de un polipéptido SIRP-γ humano. En algunas modalidades, los anticuerpos bloquean o no la unión entre un dominio extracelular de un polipéptido SIRP-α humano y un dominio IgSF de un polipéptido CD47 humano, mientras que, en algunas modalidades, los anticuerpos reducen la afinidad de un polipéptido SIRP-α humano para la unión a un dominio IgSF de un polipéptido CD47 humano. También se proveen en la presente métodos, polinucleótidos, vectores y células hospedadoras relacionadas a estos.
CONC2019/0003809A 2016-09-21 2019-04-15 Anticuerpos contra proteína alfa reguladora de señal y métodos de uso CO2019003809A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662397752P 2016-09-21 2016-09-21
US201762515480P 2017-06-05 2017-06-05
PCT/US2017/052592 WO2018057669A1 (en) 2016-09-21 2017-09-20 Antibodies against signal-regulatory protein alpha and methods of use

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CO2019003809A2 true CO2019003809A2 (es) 2019-04-30

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EP (2) EP4119580A1 (es)
JP (1) JP7181874B2 (es)
KR (1) KR102601298B1 (es)
CN (3) CN117756937A (es)
AU (1) AU2017332285A1 (es)
BR (1) BR112019003027A2 (es)
CA (1) CA3034480A1 (es)
CL (2) CL2019000668A1 (es)
CO (1) CO2019003809A2 (es)
DK (1) DK3515490T3 (es)
ES (1) ES2932602T3 (es)
GE (2) GEP20237480B (es)
HR (1) HRP20221323T1 (es)
HU (1) HUE060170T2 (es)
IL (2) IL265439B1 (es)
JO (1) JOP20190009A1 (es)
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MA (1) MA46290A (es)
MX (1) MX2019003168A (es)
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PE (1) PE20190575A1 (es)
PH (1) PH12019500600A1 (es)
PL (1) PL3515490T3 (es)
PT (1) PT3515490T (es)
RS (1) RS63658B1 (es)
SA (1) SA519401371B1 (es)
SG (1) SG10201912878UA (es)
SI (1) SI3515490T1 (es)
UA (1) UA126281C2 (es)
WO (1) WO2018057669A1 (es)
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US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
DK3331902T3 (da) 2015-08-07 2021-07-26 Alx Oncology Inc Konstruktioner med et sirp-alpha-domæne eller en variant deraf
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
JP7173971B2 (ja) 2016-12-09 2022-11-16 アレクトル エルエルシー 抗ＳＩＲＰ－α抗体及びその使用方法
JP7179743B2 (ja) * 2017-02-17 2022-11-29 オーエスイー・イミュノセラピューティクス 抗ＳＩＲＰｇ抗体の新規の使用
CN110650976B (zh) 2017-04-13 2024-04-19 赛罗帕私人有限公司 抗SIRPα抗体
JP7262440B2 (ja) 2017-08-02 2023-04-21 フェインズ セラピューティクス，インコーポレーテッド 抗ｃｄ４７抗体及びその使用
WO2019183266A1 (en) 2018-03-21 2019-09-26 ALX Oncology Inc. Antibodies against signal-regulatory protein alpha and methods of use
CN110869390B (zh) * 2018-04-09 2021-05-11 上海原能细胞医学技术有限公司 抗pd-l1抗体及其用途
MX2020011914A (es) * 2018-05-08 2021-01-29 Phanes Therapeutics Inc Anticuerpos anti-dll3 y usos de los mismos.
CR20200566A (es) * 2018-05-25 2021-02-19 Alector Llc Anticuerpos anti-sirpa y metodos de utilización de los mismos
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