PE20190575A1 - Anticuerpos contra proteina alfa reguladora de senal y metodos de uso - Google Patents

Anticuerpos contra proteina alfa reguladora de senal y metodos de uso

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Publication number
PE20190575A1
PE20190575A1 PE2019000692A PE2019000692A PE20190575A1 PE 20190575 A1 PE20190575 A1 PE 20190575A1 PE 2019000692 A PE2019000692 A PE 2019000692A PE 2019000692 A PE2019000692 A PE 2019000692A PE 20190575 A1 PE20190575 A1 PE 20190575A1
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PE
Peru
Prior art keywords
polypeptide
sirp
human
extracellular domain
alpha
Prior art date
Application number
PE2019000692A
Other languages
English (en)
Inventor
Jaume Pons
Bang Janet Sim
Hong Wan
Tracy Chia-Chien Kuo
Steven Elliot Kauder
William Don Harriman
Shelley Izquierdo
Original Assignee
Alx Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alx Oncology Inc filed Critical Alx Oncology Inc
Publication of PE20190575A1 publication Critical patent/PE20190575A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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Abstract

En la presente se proveen anticuerpos aislados que se unen a un dominio extracelular de un polipeptido SIRP-alfa v1 humano (por ejemplo, el dominio D1), un dominio extracelular de un polipeptido SIRP-alfa v2 humano o ambos. En algunas modalidades, los anticuerpos tambien se unen a un dominio extracelular de un polipeptido SIRP-alfa de mono, un dominio extracelular de un polipeptido SIRP-alfa de raton, un dominio extracelular SIRP-beta humano y/o un dominio extracelular de un polipeptido SIRP-gamma humano. En algunas modalidades, los anticuerpos bloquean o no la union entre un dominio extracelular de un polipeptido SIRP-alfa humano y un dominio IgSF de un polipeptido CD47 humano, mientras que, en algunas modalidades, los anticuerpos reducen la afinidad de un polipeptido SIRP-alfa humano para la union a un dominio IgSF de un polipeptido CD47 humano. Tambien se proveen en la presente metodos, polinucleotidos, vectores y celulas hospedadoras relacionadas a estos
PE2019000692A 2016-09-21 2017-09-20 Anticuerpos contra proteina alfa reguladora de senal y metodos de uso PE20190575A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662397752P 2016-09-21 2016-09-21
US201762515480P 2017-06-05 2017-06-05

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PE20190575A1 true PE20190575A1 (es) 2019-04-22

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US (4) US11401338B2 (es)
EP (2) EP4119580A1 (es)
JP (2) JP7181874B2 (es)
KR (1) KR102601298B1 (es)
CN (3) CN117946268A (es)
AU (1) AU2017332285B2 (es)
BR (1) BR112019003027A2 (es)
CA (1) CA3034480A1 (es)
CL (2) CL2019000668A1 (es)
CO (1) CO2019003809A2 (es)
DK (1) DK3515490T3 (es)
ES (1) ES2932602T3 (es)
GE (2) GEP20237480B (es)
HR (1) HRP20221323T1 (es)
HU (1) HUE060170T2 (es)
IL (2) IL265439B2 (es)
JO (1) JOP20190009A1 (es)
LT (1) LT3515490T (es)
MA (1) MA46290A (es)
MX (1) MX2019003168A (es)
MY (1) MY197854A (es)
PE (1) PE20190575A1 (es)
PH (1) PH12019500600A1 (es)
PL (1) PL3515490T3 (es)
PT (1) PT3515490T (es)
RS (1) RS63658B1 (es)
SA (1) SA519401371B1 (es)
SG (1) SG10201912878UA (es)
SI (1) SI3515490T1 (es)
UA (1) UA126281C2 (es)
WO (1) WO2018057669A1 (es)
ZA (1) ZA201900937B (es)

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GEP20217326B (en) 2015-08-07 2021-11-25 Alx Oncology Inc Constructs having a sirp-alpha domain or variant thereof
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
SG10201912879YA (en) 2016-12-09 2020-02-27 Alector Llc Anti-sirp-alpha antibodies and methods of use thereof
US20190382483A1 (en) * 2017-02-17 2019-12-19 Ose Immunotherapeutics NEW USES OF ANTI-SIRPg ANTIBODIES
CN110650976B (zh) 2017-04-13 2024-04-19 赛罗帕私人有限公司 抗SIRPα抗体
BR112020001679A2 (pt) 2017-08-02 2020-07-21 Phanes Therapeutics, Inc. anticorpos anti-cd47 e usos dos mesmos
KR20200133376A (ko) * 2018-03-21 2020-11-27 알렉소 온콜로지 인크. 신호-조절 단백질 알파에 대한 항체 및 사용 방법
JP7360720B2 (ja) * 2018-04-09 2023-10-13 オリセル セラピューティクス カンパニー リミテッド 抗ｐｄ―ｌ１抗体およびその用途
BR112020021280A2 (pt) * 2018-05-08 2021-01-26 Phanes Therapeutics, Inc. anticorpos anti-dll3 e usos dos mesmos
CR20200566A (es) * 2018-05-25 2021-02-19 Alector Llc Anticuerpos anti-sirpa y metodos de utilización de los mismos
CN110577597B (zh) * 2018-06-11 2021-10-22 康诺亚生物医药科技（成都）有限公司 一种阻断CD47和SIRPα相互作用的抗体
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EP3880707A1 (en) 2018-11-15 2021-09-22 Byondis B.V. HUMANIZED ANTI-SIRPa ANTIBODIES

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