MA56119A - Procédés et réactifs pour réduire les interférences de médicaments se liant au cd47 dans des dosages sérologiques - Google Patents
Procédés et réactifs pour réduire les interférences de médicaments se liant au cd47 dans des dosages sérologiquesInfo
- Publication number
- MA56119A MA56119A MA056119A MA56119A MA56119A MA 56119 A MA56119 A MA 56119A MA 056119 A MA056119 A MA 056119A MA 56119 A MA56119 A MA 56119A MA 56119 A MA56119 A MA 56119A
- Authority
- MA
- Morocco
- Prior art keywords
- reagents
- reducing
- methods
- binding drug
- serological assays
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/34—Post-translational modifications [PTMs] in chemical analysis of biological material addition of amino acid(s), e.g. arginylation, (poly-)glutamylation, (poly-)glycylation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962858871P | 2019-06-07 | 2019-06-07 | |
US201962934395P | 2019-11-12 | 2019-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA56119A true MA56119A (fr) | 2022-04-13 |
Family
ID=71899853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA056119A MA56119A (fr) | 2019-06-07 | 2020-06-05 | Procédés et réactifs pour réduire les interférences de médicaments se liant au cd47 dans des dosages sérologiques |
Country Status (6)
Country | Link |
---|---|
US (1) | US20200400662A1 (fr) |
EP (1) | EP3980747A1 (fr) |
JP (1) | JP2022535286A (fr) |
CN (1) | CN114206912A (fr) |
MA (1) | MA56119A (fr) |
WO (1) | WO2020247820A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2020143675A (ru) | 2015-08-07 | 2021-05-26 | ЭйЭлЭкс Онколоджи Инк. | Конструкции, имеющие sirp-альфа домен или его вариант |
SG11202112733XA (en) | 2019-05-31 | 2021-12-30 | Alx Oncology Inc | Methods of treating cancer with sirp alpha fc fusion in combination with an immune checkpoint inhibitor |
US20230393144A1 (en) * | 2020-10-14 | 2023-12-07 | I-Mab Biopharma Us Limited | Methods for mitigating interference by therapeutic anti-cd47 antibodies in pre-transfusion assays |
WO2024105180A1 (fr) | 2022-11-16 | 2024-05-23 | Boehringer Ingelheim International Gmbh | Biomarqueurs d'efficacité prédictive pour anticorps anti-sirpa |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2111869A1 (fr) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions et procédés pour renforcer le système immunitaire |
AU2010334974A1 (en) | 2009-12-22 | 2012-07-12 | Novartis Ag | Tetravalent CD47-antibody constant region fusion protein for use in therapy |
EA201490020A1 (ru) | 2011-06-16 | 2014-04-30 | Новартис Аг | Растворимые белки для применения в качестве терапевтических средств |
CN104136037B (zh) | 2012-01-17 | 2018-02-23 | 小利兰·斯坦福大学托管委员会 | 高亲和力SIRP‑α试剂 |
BR112014019331A2 (pt) | 2012-02-06 | 2022-07-12 | Inhibrx Inc | anticorpos para cd47 e métodos de uso desses |
US20140140989A1 (en) | 2012-02-06 | 2014-05-22 | Inhibrx Llc | Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof |
CA3155275A1 (en) | 2012-12-03 | 2014-06-12 | Novimmune S.A. | Anti-cd47 antibodies and methods of use thereof |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
MX2015007446A (es) | 2012-12-12 | 2015-12-07 | Vasculox Inc | Anticuerpos terapeuticos para cd47. |
DK3575326T3 (da) | 2012-12-17 | 2022-05-30 | Pf Argentum Ip Holdings Llc | Behandling af CD47+ sygdomsceller med SIRP ALFA-FC-fusioner |
SG10201706383XA (en) | 2013-02-06 | 2017-09-28 | Inhibrx Lp | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
CN113621075A (zh) | 2014-08-08 | 2021-11-09 | Alx肿瘤生物技术公司 | SIRP-α变体构建体及其用途 |
EP3012271A1 (fr) | 2014-10-24 | 2016-04-27 | Effimune | Procédé et compositions pour induire la différenciation de cellule suppressives dérivées de myéloïde pour traiter le cancer et les maladies infectieuses |
EA201791093A1 (ru) | 2014-11-18 | 2018-04-30 | Янссен Фармацевтика Нв | Антитела к cd47, способы и применение |
CA2972604C (fr) | 2014-12-30 | 2023-07-04 | Celgene Corporation | Anticorps anti-cd47 et leurs utilisations |
CN108040485A (zh) | 2015-03-31 | 2018-05-15 | 诺夫免疫股份有限公司 | 用于优化异源多聚体蛋白质复合物的装配和生产的方法 |
CN106146670B (zh) | 2015-04-24 | 2019-01-15 | 宜明昂科生物医药技术(上海)有限公司 | 一种新的重组双功能融合蛋白及其制备和应用 |
WO2016179399A1 (fr) | 2015-05-06 | 2016-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Analogues du cd47 à haute affinité |
EP3298043B8 (fr) | 2015-05-18 | 2021-04-21 | AB Initio Biotherapeutics, Inc. | Compositions de polypeptide sirp et procédés d'utilisation |
RU2020143675A (ru) | 2015-08-07 | 2021-05-26 | ЭйЭлЭкс Онколоджи Инк. | Конструкции, имеющие sirp-альфа домен или его вариант |
JP6885606B2 (ja) | 2015-09-18 | 2021-06-16 | アーチ オンコロジー, インコーポレイテッドArch Oncology, Inc. | 治療用cd47抗体 |
AU2016326423A1 (en) | 2015-09-21 | 2018-04-26 | Erasmus University Medical Center | Anti-CD47 antibodies and methods of use |
EP4186927A1 (fr) | 2015-10-21 | 2023-05-31 | Ose Immunotherapeutics | Procédés et compositions de modification de la polarisation des macrophages en cellules pro-inflammatoires pour traiter le cancer |
WO2017121771A1 (fr) | 2016-01-11 | 2017-07-20 | Blink Biomedical Sas | Anticorps monoclonaux anti-cd47 humanisés, de souris ou chimériques |
CA3020373A1 (fr) | 2016-04-14 | 2017-10-19 | Ose Immunotherapeutics | Nouveaux anticorps anti-sirpa et leurs applications therapeutiques |
AU2017250029C1 (en) | 2016-04-15 | 2022-03-24 | Pfizer Inc. | Macrophage stimulation in CD47 blockade therapy |
EP3454900A4 (fr) | 2016-05-09 | 2020-01-29 | Celgene Corporation | Anticorps cd47 et leurs méthodes d'utilisation |
EP3481862A4 (fr) | 2016-07-06 | 2020-08-12 | Celgene Corporation | Anticorps à faible immunogénicité et leurs utilisations |
WO2018026600A1 (fr) | 2016-08-03 | 2018-02-08 | The Board Of Trustees Of The Leland Stanford Junior University | L'interruption de l'engagement du récepteur fc sur les macrophages améliore l'efficacité de la thérapie par anticorps anti-sirpalpha |
JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
CN108738313B (zh) | 2016-10-20 | 2022-12-30 | 天境生物科技(上海)有限公司 | 新的cd47单克隆抗体及其应用 |
WO2018075960A1 (fr) | 2016-10-21 | 2018-04-26 | Tioma Therapeutics, Inc. | Anticorps cd47 thérapeutiques |
EP3534964A4 (fr) | 2016-11-03 | 2020-07-15 | Trillium Therapeutics Inc. | Amélioration de la thérapie de blocage des cd47 par des inhibiteurs du protéasome |
WO2018081898A1 (fr) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Améliorations de la thérapie de blocage de cd47 par des inhibiteurs de hdac |
WO2018095428A1 (fr) | 2016-11-28 | 2018-05-31 | 江苏恒瑞医药股份有限公司 | Anticorps cd47, fragment de liaison à l'antigène de l'anticorps cd47 et leur utilisation médicale |
EP3551661A1 (fr) | 2016-12-09 | 2019-10-16 | Alector LLC | Anticorps anti-sirp-alpha et leurs procédés d'utilisation |
CN110300764A (zh) | 2017-02-17 | 2019-10-01 | Ose免疫疗法 | 抗SIRPg抗体的新用途 |
SG11201908602UA (en) | 2017-03-22 | 2019-10-30 | Arch Oncology Inc | Combination therapy for the treatment of solid and hematological cancers |
SG11201908678XA (en) | 2017-03-27 | 2019-10-30 | Celgene Corp | Methods and compositions for reduction of immunogenicity |
CA3057718A1 (fr) | 2017-03-28 | 2018-10-04 | Trillium Therapeutics Inc. | Therapie par blocage de cd47 |
JP7160833B2 (ja) | 2017-04-13 | 2022-10-25 | サイロパ ビー.ブイ. | 抗sirpアルファ抗体 |
CN110799536B (zh) | 2017-05-16 | 2024-04-26 | 拜奥迪斯私人有限公司 | 抗SIRPα抗体 |
WO2018236904A1 (fr) | 2017-06-19 | 2018-12-27 | Surface Oncology, Inc. | Combinaison d'anticorps anti-cd47 et d'agents induisant la mort cellulaire, et leurs utilisations |
CN110831974B (zh) | 2017-06-21 | 2024-05-14 | 小利兰·斯坦福大学托管委员会 | 针对血液恶性肿瘤的cd47靶向疗法的给药参数 |
SG11202000658PA (en) | 2017-07-26 | 2020-02-27 | Forty Seven Inc | Anti-sirp-alpha antibodies and related methods |
CN109422811A (zh) | 2017-08-29 | 2019-03-05 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
-
2020
- 2020-06-05 JP JP2021572418A patent/JP2022535286A/ja active Pending
- 2020-06-05 US US16/894,468 patent/US20200400662A1/en active Pending
- 2020-06-05 WO PCT/US2020/036425 patent/WO2020247820A1/fr unknown
- 2020-06-05 EP EP20750429.1A patent/EP3980747A1/fr active Pending
- 2020-06-05 CN CN202080041810.5A patent/CN114206912A/zh active Pending
- 2020-06-05 MA MA056119A patent/MA56119A/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP3980747A1 (fr) | 2022-04-13 |
WO2020247820A1 (fr) | 2020-12-10 |
US20200400662A1 (en) | 2020-12-24 |
CN114206912A (zh) | 2022-03-18 |
JP2022535286A (ja) | 2022-08-05 |
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