AR095995A1 - MÉTODO PARA DETECTAR ANTICUERPOS ESPECÍFICOS ANTI Ab EN UNA MUESTRA BIOLÓGICA - Google Patents
MÉTODO PARA DETECTAR ANTICUERPOS ESPECÍFICOS ANTI Ab EN UNA MUESTRA BIOLÓGICAInfo
- Publication number
- AR095995A1 AR095995A1 ARP140101474A ARP140101474A AR095995A1 AR 095995 A1 AR095995 A1 AR 095995A1 AR P140101474 A ARP140101474 A AR P140101474A AR P140101474 A ARP140101474 A AR P140101474A AR 095995 A1 AR095995 A1 AR 095995A1
- Authority
- AR
- Argentina
- Prior art keywords
- specific antibodies
- biological sample
- aggregates
- variants
- detecting anti
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Rehabilitation Therapy (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Se revela un método para la detección de anticuerpos específicos de Ab en una muestra biológica, que comprende las siguientes etapas: el contacto de la muestra con agregados de variantes de Ab o con partículas que comprenden superficies de tipo agregado de variante de Ab, y la unión de los anticuerpos específicos de Ab a los agregados de variantes de Ab; y la detección de los anticuerpos específicos de Ab ligados a los agregados de variantes de Ab por medio de una técnica de detección de partícula única, preferentemente, por medio de la clasificación celular activada por fluorescencia FACS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13162106.2A EP2787347A1 (en) | 2013-04-03 | 2013-04-03 | Method for detecting Aß-specific antibodies in a biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095995A1 true AR095995A1 (es) | 2015-11-25 |
Family
ID=47998335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101474A AR095995A1 (es) | 2013-04-03 | 2014-04-03 | MÉTODO PARA DETECTAR ANTICUERPOS ESPECÍFICOS ANTI Ab EN UNA MUESTRA BIOLÓGICA |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2787347A1 (es) |
| AR (1) | AR095995A1 (es) |
| TW (1) | TW201518730A (es) |
| WO (1) | WO2014161875A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017079835A1 (en) | 2015-11-09 | 2017-05-18 | The University Of British Columbia | Amyloid beta epitopes and antibodies thereto |
| CN108350051A (zh) | 2015-11-09 | 2018-07-31 | 英属哥伦比亚大学 | 淀粉样蛋白β中的N-末端表位及其构象选择性抗体 |
| KR20180085736A (ko) | 2015-11-09 | 2018-07-27 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타 중간-영역 내 에피토프 및 이에 대해 구조적으로 선택성인 항체 |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0852004B1 (en) * | 1995-10-11 | 2011-01-19 | Luminex Corporation | Multiplexed analysis of clinical specimens |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| AT413945B (de) | 2003-01-14 | 2006-07-15 | Mattner Frank Dr | Impfstoff für die alzheimer-krankheit |
| AT413946B (de) | 2004-07-13 | 2006-07-15 | Mattner Frank Dr | Impfstoff gegen die alzheimer-krankheit |
| AT506819B1 (de) | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
| AT506820B1 (de) | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
| EP2143447A1 (en) * | 2008-07-11 | 2010-01-13 | Universität Konstanz | Bioconjugates comprising Aß-autoantibody-specific epitopes for active immunotherapy and diagnosis of Alzheimer's disease |
| US20110092445A1 (en) * | 2008-07-25 | 2011-04-21 | Abbott Laboratories | Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses |
| WO2010128139A1 (en) | 2009-05-08 | 2010-11-11 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Biomarkers and methods for diagnosing alzheimer's disease and/ or mild cognitive impairment |
| PL2579042T3 (pl) * | 2011-10-04 | 2014-12-31 | Affiris Ag | Sposób wykrywania przeciwciał swoistych wobec Aß w próbce biologicznej |
-
2013
- 2013-04-03 EP EP13162106.2A patent/EP2787347A1/en not_active Withdrawn
-
2014
- 2014-04-02 WO PCT/EP2014/056578 patent/WO2014161875A1/en active Application Filing
- 2014-04-03 TW TW103112520A patent/TW201518730A/zh unknown
- 2014-04-03 AR ARP140101474A patent/AR095995A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014161875A1 (en) | 2014-10-09 |
| EP2787347A1 (en) | 2014-10-08 |
| TW201518730A (zh) | 2015-05-16 |
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