MX2014015088A - Anticuerpos anti-tofacitinib y usos de los mismos para monitorear farmacos. - Google Patents
Anticuerpos anti-tofacitinib y usos de los mismos para monitorear farmacos.Info
- Publication number
- MX2014015088A MX2014015088A MX2014015088A MX2014015088A MX2014015088A MX 2014015088 A MX2014015088 A MX 2014015088A MX 2014015088 A MX2014015088 A MX 2014015088A MX 2014015088 A MX2014015088 A MX 2014015088A MX 2014015088 A MX2014015088 A MX 2014015088A
- Authority
- MX
- Mexico
- Prior art keywords
- tofacitinib
- antibodies
- drug monitoring
- tofacitinib antibodies
- immunogenic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La invención proporciona anticuerpos de tofacitinib selectivos, conjugados de tofacitinib inmunogénicos que son útiles como moléculas inmunogénicas para la generación de anticuerpos específicos para tofacitinib, junto con los métodos para medir la concentración de tofacitinib en una muestra, procesos para elaborar los anticuerpos, y ensayos y kits para utilizar los anticuerpos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261665361P | 2012-06-28 | 2012-06-28 | |
PCT/IB2013/055008 WO2014001967A1 (en) | 2012-06-28 | 2013-06-18 | Anti-tofacitinib antibodies and uses thereof for drug monitoring |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014015088A true MX2014015088A (es) | 2015-03-05 |
Family
ID=49029140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014015088A MX2014015088A (es) | 2012-06-28 | 2013-06-18 | Anticuerpos anti-tofacitinib y usos de los mismos para monitorear farmacos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US9408922B2 (es) |
EP (1) | EP2866840A1 (es) |
JP (1) | JP2015527987A (es) |
KR (1) | KR20150014996A (es) |
CN (1) | CN104411336A (es) |
AU (1) | AU2013282863A1 (es) |
BR (1) | BR112014032916A2 (es) |
CA (1) | CA2873192A1 (es) |
HK (1) | HK1207309A1 (es) |
IL (1) | IL236291A0 (es) |
MX (1) | MX2014015088A (es) |
RU (1) | RU2014146707A (es) |
WO (1) | WO2014001967A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3347099B1 (en) * | 2015-09-10 | 2023-10-25 | Becton, Dickinson and Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
WO2018052503A1 (en) * | 2016-09-14 | 2018-03-22 | Teneobio, Inc. | Cd3 binding antibodies |
CN111108214B (zh) | 2017-09-21 | 2023-10-13 | 贝克顿·迪金森公司 | 危险污染物收集试剂盒和快速测试 |
CN107602569A (zh) * | 2017-10-23 | 2018-01-19 | 上海博悦生物科技有限公司 | 一种新型吡咯并[2,3‑d]嘧啶化合物及其合成方法和用途 |
JP7479385B2 (ja) | 2019-01-28 | 2024-05-08 | ベクトン・ディキンソン・アンド・カンパニー | 一体化されたスワブ及び検査デバイスを有する有害汚染物質採取デバイス |
AR119746A1 (es) | 2019-06-14 | 2022-01-05 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
CN116396392B (zh) * | 2023-01-17 | 2023-10-27 | 珠海重链生物科技有限公司 | 一种特异性针对异羟基洋地黄毒甙元的抗体及其相关应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
ES2330052T3 (es) | 1991-03-01 | 2009-12-03 | Dyax Corporation | Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas. |
GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
EP1724282B1 (en) | 1997-05-21 | 2013-05-15 | Merck Patent GmbH | Method for the production of non-immunogenic proteins |
JP5084103B2 (ja) * | 2002-07-18 | 2012-11-28 | サイトス バイオテクノロジー アーゲー | ハプテン担体抱合体およびその用法 |
UY33492A (es) * | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
-
2013
- 2013-05-18 BR BR112014032916A patent/BR112014032916A2/pt not_active IP Right Cessation
- 2013-06-18 RU RU2014146707A patent/RU2014146707A/ru not_active Application Discontinuation
- 2013-06-18 US US14/411,356 patent/US9408922B2/en not_active Expired - Fee Related
- 2013-06-18 AU AU2013282863A patent/AU2013282863A1/en not_active Abandoned
- 2013-06-18 EP EP13752676.0A patent/EP2866840A1/en not_active Withdrawn
- 2013-06-18 KR KR1020147036168A patent/KR20150014996A/ko not_active Application Discontinuation
- 2013-06-18 CA CA2873192A patent/CA2873192A1/en not_active Abandoned
- 2013-06-18 MX MX2014015088A patent/MX2014015088A/es unknown
- 2013-06-18 WO PCT/IB2013/055008 patent/WO2014001967A1/en active Application Filing
- 2013-06-18 JP JP2015519413A patent/JP2015527987A/ja not_active Withdrawn
- 2013-06-18 CN CN201380034143.8A patent/CN104411336A/zh active Pending
-
2014
- 2014-12-15 IL IL236291A patent/IL236291A0/en unknown
-
2015
- 2015-08-19 HK HK15108023.7A patent/HK1207309A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR20150014996A (ko) | 2015-02-09 |
HK1207309A1 (en) | 2016-01-29 |
JP2015527987A (ja) | 2015-09-24 |
AU2013282863A1 (en) | 2014-11-20 |
EP2866840A1 (en) | 2015-05-06 |
IL236291A0 (en) | 2015-02-26 |
WO2014001967A1 (en) | 2014-01-03 |
CN104411336A (zh) | 2015-03-11 |
US9408922B2 (en) | 2016-08-09 |
US20150337054A1 (en) | 2015-11-26 |
BR112014032916A2 (pt) | 2017-08-01 |
CA2873192A1 (en) | 2014-01-03 |
RU2014146707A (ru) | 2016-08-20 |
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