AR088108A1 - METODO PARA DETECTAR ANTICUERPOS ESPECIFICOS Ab EN UNA MUESTRA BIOLOGICA - Google Patents
METODO PARA DETECTAR ANTICUERPOS ESPECIFICOS Ab EN UNA MUESTRA BIOLOGICAInfo
- Publication number
- AR088108A1 AR088108A1 ARP120103680A ARP120103680A AR088108A1 AR 088108 A1 AR088108 A1 AR 088108A1 AR P120103680 A ARP120103680 A AR P120103680A AR P120103680 A ARP120103680 A AR P120103680A AR 088108 A1 AR088108 A1 AR 088108A1
- Authority
- AR
- Argentina
- Prior art keywords
- aggregates
- biological sample
- specific antibodies
- detecting specific
- antibodies
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Se divulga un método para detectar anticuerpos específicos Ab en una muestra biológica que comprende los siguientes pasos: poner la muestra en contacto con agregados Ab o con partículas que comprenden superficies similares a los agregados Ab y permitir que los anticuerpos específicos Ab se unan con los agregados Ab, y detectar anticuerpos específicos Ab unidos con los agregados Ab mediante una única técnica de detección de partículas, preferentemente mediante clasificación celular activada por fluorescencia FACS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11183842.1A EP2579042B1 (en) | 2011-10-04 | 2011-10-04 | Method for detecting Aß-specific antibodies in a biological sample |
Publications (1)
Publication Number | Publication Date |
---|---|
AR088108A1 true AR088108A1 (es) | 2014-05-07 |
Family
ID=46888451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120103680A AR088108A1 (es) | 2011-10-04 | 2012-10-03 | METODO PARA DETECTAR ANTICUERPOS ESPECIFICOS Ab EN UNA MUESTRA BIOLOGICA |
Country Status (24)
Country | Link |
---|---|
US (2) | US20140234877A1 (es) |
EP (3) | EP2579042B1 (es) |
JP (2) | JP6162127B2 (es) |
KR (2) | KR20140069346A (es) |
CN (2) | CN103842824A (es) |
AR (1) | AR088108A1 (es) |
AU (2) | AU2012320766B2 (es) |
BR (2) | BR112014008089A2 (es) |
CA (2) | CA2850840A1 (es) |
CY (1) | CY1115624T1 (es) |
DK (2) | DK2579042T3 (es) |
ES (2) | ES2496341T3 (es) |
HK (1) | HK1178601A1 (es) |
HR (1) | HRP20140937T1 (es) |
IL (2) | IL231057A0 (es) |
MX (2) | MX2014003983A (es) |
PL (2) | PL2579042T3 (es) |
PT (1) | PT2579042E (es) |
RS (1) | RS53496B1 (es) |
RU (2) | RU2014117671A (es) |
SG (2) | SG11201400229XA (es) |
SI (1) | SI2579042T1 (es) |
SM (1) | SMT201400145B (es) |
WO (2) | WO2013050248A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2787349A1 (en) | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting proteinopathy-specific antibodies in a biological sample |
EP2787347A1 (en) * | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting Aß-specific antibodies in a biological sample |
WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
KR101658620B1 (ko) * | 2014-12-02 | 2016-09-23 | 주식회사 피플바이오 | 응집형-형성 폴리펩타이드의 응집형을 검출하는 방법 |
KR20170108203A (ko) | 2016-03-16 | 2017-09-27 | 주식회사 피플바이오 | 응집형-형성 폴리펩타이드의 응집형을 검출하는 방법 |
KR101871895B1 (ko) * | 2016-04-20 | 2018-06-28 | 한국과학기술연구원 | 응집 단백질의 고감도 광 산화 증폭 면역 분석을 통한 체액기반의 퇴행성 신경질환 진단 방법 |
EP3242134A1 (en) * | 2016-05-04 | 2017-11-08 | Euroimmun Medizinische Labordiagnostika AG | Assay for the diagnosis of a neurological disease |
KR101989383B1 (ko) * | 2017-04-04 | 2019-06-14 | 조선대학교산학협력단 | 알츠하이머성 치매의 조기진단을 위한 펩타이드 프로브 |
WO2020045962A1 (ko) * | 2018-08-27 | 2020-03-05 | 광주과학기술원 | 알츠하이머성 치매 진단용 펩타이드 바이오마커 |
KR102108171B1 (ko) * | 2018-08-27 | 2020-05-08 | 광주과학기술원 | 알츠하이머성 치매 진단용 펩타이드 바이오마커 |
CN113075398A (zh) * | 2021-03-23 | 2021-07-06 | 中国医学科学院输血研究所 | 一种血浆中特异性IgG抗体的定量测定方法 |
CN113063949A (zh) * | 2021-03-23 | 2021-07-02 | 中国医学科学院输血研究所 | 一种血浆中特异性IgM抗体的定量测定方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262332A (en) | 1989-04-05 | 1993-11-16 | Brigham And Women's Hospital | Diagnostic method for Alzheimer's disease: examination of non-neural tissue |
AU8083094A (en) * | 1994-10-19 | 1996-05-15 | General Hospital Corporation, The | A diagnostic assay for alzheimer's disease: assessment of abeta abnormalities |
US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
UA81216C2 (en) * | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
DE60033530T2 (de) | 1999-08-24 | 2007-10-31 | Medarex Inc. | Humane antikörper gegen ctla-4 und deren verwendungen |
AT413945B (de) | 2003-01-14 | 2006-07-15 | Mattner Frank Dr | Impfstoff für die alzheimer-krankheit |
KR100595494B1 (ko) * | 2003-02-24 | 2006-07-03 | (주) 디지탈바이오텍 | 혈액 내 베타-아밀로이드 항체 농도를 이용한 알츠하이머병 진단키트 |
AT413336B (de) | 2003-09-12 | 2006-02-15 | Mattner Frank Dr | Apherese-vorrichtung |
AT500483B1 (de) | 2004-07-13 | 2006-01-15 | Mattner Frank Dr | Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung |
AT413946B (de) | 2004-07-13 | 2006-07-15 | Mattner Frank Dr | Impfstoff gegen die alzheimer-krankheit |
DE102005006217B4 (de) * | 2005-02-07 | 2007-08-16 | Universitätsklinikum Hamburg-Eppendorf | Diagnose von allergischen Erkrankungen und/oder atopischen Erkrankungen durch Nachweis von Autoantikörpern gegen CD28 in humanem Serum |
TW200700432A (en) * | 2005-03-05 | 2007-01-01 | Abbott Gmbh & Co Kg | Screening method, process for purifying of non-diffusible a β oligomers, selective antibodies against said non-diffusible a β oligomers and a process for manufacturing of said antibodies |
TW200726774A (en) | 2005-06-30 | 2007-07-16 | Merck & Co Inc | Composition and method for producing stable amyloid beta oligomers |
AU2006269405B2 (en) | 2005-07-08 | 2013-01-17 | Dsm Ip Assets B.V. | Polyunsaturated fatty acids for treatment of dementia and pre-dementia-related conditions |
RU2551782C2 (ru) * | 2005-12-12 | 2015-05-27 | Ац Иммуне Са | Специфические в отношении амилоида бета (а бета) 1-42 моноклональные антитела, обладающие терапевтическими свойствами |
US7939075B2 (en) * | 2007-01-11 | 2011-05-10 | Philipps-Universitaet Marburg | Human monoclonal anti-amyloid-beta antibodies |
WO2009051599A1 (en) * | 2007-10-19 | 2009-04-23 | The Regents Of The University Of California | Use of biomarkers of alzheimer's disease for diagnostic tests and drug screening |
US7771957B2 (en) * | 2007-10-19 | 2010-08-10 | The Regents Of The University Of California | Method for diagnosing alzheimer's disease |
AT506535B1 (de) | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
AT506820B1 (de) | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
KR20110036809A (ko) | 2008-06-12 | 2011-04-11 | 아피리스 아게 | 파킨슨병과 관련된 증상을 치료하기 위한 화합물 |
AT506819B1 (de) | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
CA2753586A1 (en) * | 2009-02-24 | 2010-09-02 | Winton G. Gibbons | Detection of complexes of tau and amyloid |
WO2010128139A1 (en) | 2009-05-08 | 2010-11-11 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Biomarkers and methods for diagnosing alzheimer's disease and/ or mild cognitive impairment |
AT508638B1 (de) | 2009-08-21 | 2011-08-15 | Affiris Ag | Verwendung von peptiden und polypeptiden zur behandlung und/oder prävention von synukleinopathien |
WO2011106732A1 (en) * | 2010-02-25 | 2011-09-01 | Wyeth Llc | Pet monitoring of ab-directed immunotherapy |
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2011
- 2011-10-04 PT PT111838421T patent/PT2579042E/pt unknown
- 2011-10-04 SI SI201130248T patent/SI2579042T1/sl unknown
- 2011-10-04 ES ES11183842.1T patent/ES2496341T3/es active Active
- 2011-10-04 EP EP11183842.1A patent/EP2579042B1/en not_active Not-in-force
- 2011-10-04 PL PL11183842T patent/PL2579042T3/pl unknown
- 2011-10-04 RS RSP20140412 patent/RS53496B1/en unknown
- 2011-10-04 DK DK11183842.1T patent/DK2579042T3/da active
-
2012
- 2012-09-20 RU RU2014117671/15A patent/RU2014117671A/ru not_active Application Discontinuation
- 2012-09-20 KR KR1020147012156A patent/KR20140069346A/ko not_active Application Discontinuation
- 2012-09-20 WO PCT/EP2012/068493 patent/WO2013050248A1/en active Application Filing
- 2012-09-20 US US14/348,788 patent/US20140234877A1/en not_active Abandoned
- 2012-09-20 CA CA2850840A patent/CA2850840A1/en not_active Abandoned
- 2012-09-20 EP EP12761989.8A patent/EP2764367B1/en not_active Not-in-force
- 2012-09-20 RU RU2014117677/15A patent/RU2014117677A/ru not_active Application Discontinuation
- 2012-09-20 CA CA2850843A patent/CA2850843A1/en not_active Abandoned
- 2012-09-20 ES ES12761989.8T patent/ES2692185T3/es active Active
- 2012-09-20 SG SG11201400229XA patent/SG11201400229XA/en unknown
- 2012-09-20 AU AU2012320766A patent/AU2012320766B2/en not_active Ceased
- 2012-09-20 JP JP2014533825A patent/JP6162127B2/ja not_active Expired - Fee Related
- 2012-09-20 DK DK12761989.8T patent/DK2764367T3/en active
- 2012-09-20 CN CN201280049115.9A patent/CN103842824A/zh active Pending
- 2012-09-20 BR BR112014008089A patent/BR112014008089A2/pt not_active IP Right Cessation
- 2012-09-20 KR KR1020147012158A patent/KR20140073568A/ko not_active Application Discontinuation
- 2012-09-20 EP EP12762576.2A patent/EP2764368A1/en not_active Withdrawn
- 2012-09-20 BR BR112014008088A patent/BR112014008088A2/pt not_active IP Right Cessation
- 2012-09-20 US US14/346,910 patent/US9625459B2/en not_active Expired - Fee Related
- 2012-09-20 JP JP2014533826A patent/JP2014529088A/ja not_active Withdrawn
- 2012-09-20 MX MX2014003983A patent/MX2014003983A/es not_active Application Discontinuation
- 2012-09-20 SG SG11201400223SA patent/SG11201400223SA/en unknown
- 2012-09-20 MX MX2014003984A patent/MX2014003984A/es not_active Application Discontinuation
- 2012-09-20 WO PCT/EP2012/068494 patent/WO2013050249A1/en active Application Filing
- 2012-09-20 AU AU2012320767A patent/AU2012320767A1/en not_active Abandoned
- 2012-09-20 CN CN201280049131.8A patent/CN103842825B/zh not_active Expired - Fee Related
- 2012-09-20 PL PL12761989T patent/PL2764367T3/pl unknown
- 2012-10-03 AR ARP120103680A patent/AR088108A1/es unknown
-
2013
- 2013-05-06 HK HK13105371.3A patent/HK1178601A1/xx not_active IP Right Cessation
-
2014
- 2014-02-20 IL IL231057A patent/IL231057A0/en unknown
- 2014-03-20 IL IL231620A patent/IL231620A0/en unknown
- 2014-09-30 HR HRP20140937AT patent/HRP20140937T1/hr unknown
- 2014-10-03 CY CY20141100799T patent/CY1115624T1/el unknown
- 2014-10-09 SM SM201400145T patent/SMT201400145B/xx unknown
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