HRP20151024T1 - Polipeptidi, varijabilne domene protutijela i antagonisti - Google Patents
Polipeptidi, varijabilne domene protutijela i antagonisti Download PDFInfo
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- HRP20151024T1 HRP20151024T1 HRP20151024TT HRP20151024T HRP20151024T1 HR P20151024 T1 HRP20151024 T1 HR P20151024T1 HR P20151024T T HRP20151024T T HR P20151024TT HR P20151024 T HRP20151024 T HR P20151024T HR P20151024 T1 HRP20151024 T1 HR P20151024T1
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- Prior art keywords
- variable domain
- antagonist
- immunoglobulin
- tnfr1
- specified
- Prior art date
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- 239000005557 antagonist Substances 0.000 title claims 11
- 229920001184 polypeptide Polymers 0.000 title claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 7
- 102000018358 immunoglobulin Human genes 0.000 claims 7
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 6
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 6
- 206010035664 Pneumonia Diseases 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A61K2039/543—Mucosal route intranasal
-
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
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Claims (16)
1. Pojedinačna varijabilna domena imunoglobulina protiv receptora tip 1 za TNFα, naznačena time što sadrži sljedeći aminokiselinski slijed:
EVQLLESGGGLVQPGGSLRLSCAASGFTFAHETMVWVRQAPGKGLEWV
SHIPPDGQDPFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYHCAL
LPKRGPWFDYWGQGTLVTVSS.
2. Pojedinačna varijabilna domena imunoglobulina protiv receptora tip 1 za TNFα u skladu s patentnim zahtjevom 1, naznačena time što je kodira slijed istovjetan nukleotidnom slijedu DOM1h-131-206, prikazanom na slici 19.
3. Antagonist receptora tip 1 za TNFα, naznačen time što sadrži pojedinačnu varijabilnu domenu imunoglobulina protiv TNFR1 u skladu s bilo kojim prethodnim patentnim zahtjevom.
4. Antagonist u skladu s patentnim zahtjevom 3, naznačen time što sadrži prvu i drugu pojedinačnu varijabilnu domenu imunoglobulina, gdje je svaka varijabilna domena u skladu s bilo kojim od patentnih zahtjeva 1-2.
5. Antagonist u skladu s patentnim zahtjevom 3 ili 4, naznačen time što antagonist sadrži monomer navedene pojedinačne varijabilne domene ili homodimer navedene pojedinačne varijabilne domene, gdje je navedena varijabilna domena istovjetna aminokiselinskom slijedu DOM1h-131-206.
6. Antagonist TNFR1 u skladu s patentnim zahtjevima 3-5 namijenjen upotrebi u medicini, naznačen time što se primjenjuje oralno, putem GI sustava, ili unosom preko pluća.
7. Antagonist TNFR1 u skladu s patentnim zahtjevima 3-5, naznačen time što je namijenjen upotrebi u liječenju i/ili profilaksi upalnog stanja.
8. Antagonist TNFR1 u skladu s patentnim zahtjevom 7, naznačen time što se navedeno upalno stanje bira između: plućne bolesti, psorijaze, artritisa, upalne bolesti crijeva.
9. Antagonist TNFR1 u skladu s patentnim zahtjevima 3-5, naznačen time što je namijenjen upotrebi u liječenju i/ili profilaksi bolesti dišnog sustava kod ljudskog subjekta.
10. Antagonist TNFR1 u skladu s patentnim zahtjevom 9, naznačen time što se navedenu bolest dišnog sustava se bira između: upale pluća, COPD, astme, pneumonije, cistične fibroze, intersticijske bolesti pluća, alergije, plućne upale.
11. Dvojni specifični ligand, naznačen time što sadrži varijabilnu domenu u skladu s bilo kojim od patentnih zahtjeva 1-2.
12. Izolirana ili rekombinantna nukleinska kiselina, naznačena time što kodira polipeptid koji sadrži pojedinačnu varijabilnu domenu imunoglobulina u skladu s bilo kojim od patentnih zahtjeva 1-2.
13. Vektor, naznačen time što sadrži nukleinsku kiselinau u skladu s patentnim zahtjevom 12.
14. Stanica domaćin, naznačena time što sadrži nukleinsku kiselinu u skladu s patentnim zahtjevom 12, ili vektor u skladu s patentnim zahtjevom 13.
15. Farmaceutski pripravak, naznačen time što sadrži pojedinačnu varijabilnu domenu imunoglobulina u skladu s bilo kojim od patentnih zahtjeva 1 do 2, ili antagonist u skladu s bilo kojim od patentnih zahtjeva 3 do 5, kao i farmaceutski prihvatljiv nosač, pomoćnu tvar ili razrjeđivač.
16. Pojedinačna varijabilna domena imunoglobulina u skladu s bilo kojim od patentnih zahtjeva 1 do 2 ili antagonist u skladu s bilo kojim od patentnih zahtjeva 3 do 5, naznačeni time što sadrže konstantnu domenu protutijela.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93363207P | 2007-06-06 | 2007-06-06 | |
| GBGB0724331.4A GB0724331D0 (en) | 2007-12-13 | 2007-12-13 | Compositions for pulmonary delivery |
| EP08750800.8A EP2162467B1 (en) | 2007-06-06 | 2008-06-04 | Polypeptides, antibody variable domains & antagonists |
| PCT/GB2008/050405 WO2008149148A2 (en) | 2007-06-06 | 2008-06-04 | Polypeptides, antibody variable domains and antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151024T1 true HRP20151024T1 (hr) | 2015-11-06 |
Family
ID=39791116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151024TT HRP20151024T1 (hr) | 2007-06-06 | 2015-09-28 | Polipeptidi, varijabilne domene protutijela i antagonisti |
Country Status (32)
| Country | Link |
|---|---|
| US (5) | US20100247515A1 (hr) |
| EP (5) | EP2164867A2 (hr) |
| JP (3) | JP2010530364A (hr) |
| KR (4) | KR20100018040A (hr) |
| CN (4) | CN101883788A (hr) |
| AR (3) | AR066847A1 (hr) |
| AU (4) | AU2008259590A1 (hr) |
| BR (3) | BRPI0813899A2 (hr) |
| CA (6) | CA2688434A1 (hr) |
| CL (3) | CL2008001674A1 (hr) |
| CO (2) | CO6251322A2 (hr) |
| CR (2) | CR11195A (hr) |
| CY (1) | CY1116762T1 (hr) |
| DK (1) | DK2162467T3 (hr) |
| DO (1) | DOP2009000268A (hr) |
| EA (5) | EA200901494A1 (hr) |
| ES (1) | ES2546943T3 (hr) |
| HK (1) | HK1138022A1 (hr) |
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| TW (6) | TW200907128A (hr) |
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2009
- 2009-10-11 IL IL201398A patent/IL201398A0/en unknown
- 2009-11-04 US US13/130,656 patent/US20110256122A1/en not_active Abandoned
- 2009-11-04 EA EA201100546A patent/EA201100546A1/ru unknown
- 2009-11-18 IL IL202204A patent/IL202204A0/en unknown
- 2009-11-27 DO DO2009000268A patent/DOP2009000268A/es unknown
- 2009-11-30 ZA ZA2009/08470A patent/ZA200908470B/en unknown
- 2009-11-30 MA MA32388A patent/MA31403B1/fr unknown
- 2009-12-14 CO CO09142782A patent/CO6251322A2/es not_active Application Discontinuation
- 2009-12-14 CO CO09142781A patent/CO6251321A2/es not_active Application Discontinuation
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2010
- 2010-01-04 MA MA32475A patent/MA31668B1/fr unknown
- 2010-01-06 CR CR11195A patent/CR11195A/es unknown
- 2010-01-06 CR CR11194A patent/CR11194A/es not_active Application Discontinuation
- 2010-05-24 HK HK10105002.3A patent/HK1138022A1/xx not_active IP Right Cessation
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2011
- 2011-11-17 US US13/299,030 patent/US20120134982A1/en not_active Abandoned
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2015
- 2015-09-28 HR HRP20151024TT patent/HRP20151024T1/hr unknown
- 2015-10-06 CY CY20151100886T patent/CY1116762T1/el unknown
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