MX342271B - Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. - Google Patents
Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor.Info
- Publication number
- MX342271B MX342271B MX2012000384A MX2012000384A MX342271B MX 342271 B MX342271 B MX 342271B MX 2012000384 A MX2012000384 A MX 2012000384A MX 2012000384 A MX2012000384 A MX 2012000384A MX 342271 B MX342271 B MX 342271B
- Authority
- MX
- Mexico
- Prior art keywords
- nanobodies
- polypeptides
- alpha
- nanobodiesâ
- improved
- Prior art date
Links
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title abstract 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 abstract 6
- 229920001184 polypeptide Polymers 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C07—ORGANIC CHEMISTRY
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Abstract
La presente invención se refiere a un dominio variable de inmunoglobulina aislado que se enlaza a TNFa, el domino que comprende cuatro regiones de estructura (FR1 a FR4) y 3 regiones que determinan la complementariedad (CDR1 a CDR3), en donde: a. CDR1 comprende la secuencia de aminoácidos (SEC ID NO: 193); b. CDR2 comprende la secuencia de aminoácidos (SEC ID NO: 261); y c.CDR3 comprende la secuencia de aminoácidos (SEC. ID NO: 239).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68233205P | 2005-05-18 | 2005-05-18 | |
PCT/EP2006/004678 WO2006122786A2 (en) | 2005-05-18 | 2006-05-17 | Improved nanobodies™ against tumor necrosis factor-alpha |
Publications (1)
Publication Number | Publication Date |
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MX342271B true MX342271B (es) | 2016-09-21 |
Family
ID=36954329
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007014359A MX2007014359A (es) | 2005-05-18 | 2006-05-17 | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
MX2012000384A MX342271B (es) | 2005-05-18 | 2006-05-17 | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
MX2016001166A MX363423B (es) | 2005-05-18 | 2006-05-17 | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
Family Applications Before (1)
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- 2007-10-25 IL IL186941A patent/IL186941A/en active IP Right Grant
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- 2007-11-14 CR CR9519A patent/CR9519A/es not_active Application Discontinuation
- 2007-11-15 ZA ZA200709867A patent/ZA200709867B/xx unknown
- 2007-11-19 EC EC2007007910A patent/ECSP077910A/es unknown
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2008
- 2008-08-15 HK HK08109098.4A patent/HK1113685A1/xx unknown
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2009
- 2009-02-12 ZA ZA200901011A patent/ZA200901011B/xx unknown
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2011
- 2011-01-14 ZA ZA2011/00385A patent/ZA201100385B/en unknown
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2012
- 2012-05-02 JP JP2012105089A patent/JP5788359B2/ja active Active
- 2012-06-26 RU RU2012126722A patent/RU2634381C2/ru active
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2013
- 2013-03-20 IL IL225347A patent/IL225347A/en active IP Right Grant
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2014
- 2014-02-27 US US14/191,907 patent/US9067991B2/en active Active
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2015
- 2015-05-07 JP JP2015094805A patent/JP6420200B2/ja active Active
- 2015-05-12 US US14/709,870 patent/US20150353635A1/en not_active Abandoned
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2016
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2017
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2019
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2022
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