BR122020006918B8 - Anticorpo de domínio único anti-stat3 e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado - Google Patents
Anticorpo de domínio único anti-stat3 e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isoladoInfo
- Publication number
- BR122020006918B8 BR122020006918B8 BR122020006918A BR122020006918A BR122020006918B8 BR 122020006918 B8 BR122020006918 B8 BR 122020006918B8 BR 122020006918 A BR122020006918 A BR 122020006918A BR 122020006918 A BR122020006918 A BR 122020006918A BR 122020006918 B8 BR122020006918 B8 BR 122020006918B8
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- isolated polypeptide
- sdabs
- single domain
- diagnosing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108010003723 Single-Domain Antibodies Proteins 0.000 title abstract 2
- 230000003834 intracellular effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- C—CHEMISTRY; METALLURGY
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Abstract
A presente invenção fornece composições e métodos para tratar uma condição ou uma doença sem o uso de sequências de direcionamento exógenas ou composições químicas. A presente invenção refere-se a anticorpos de domínio único (sdAbs), proteínas e polipeptídeos compreendendo os sdAbs que são direcionados contra componentes intracelulares que causam uma condição ou doença. A invenção também inclui ácidos nucleicos que codificam os sdAbs, proteínas e polipeptídeos, e composições compreendendo os sdAbs. A invenção inclui o uso das composições, sdAbs, e ácidos nucleicos que codificam os sdAbs para fins profiláticos, terapêuticos ou de diagnóstico.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462067908P | 2014-10-23 | 2014-10-23 | |
US62/067,908 | 2014-10-23 | ||
US201562148656P | 2015-04-16 | 2015-04-16 | |
US62/148,656 | 2015-04-16 | ||
US201562188353P | 2015-07-02 | 2015-07-02 | |
US62/188,353 | 2015-07-02 | ||
US201562210795P | 2015-08-27 | 2015-08-27 | |
US62/210,795 | 2015-08-27 | ||
PCT/US2015/057223 WO2016065323A2 (en) | 2014-10-23 | 2015-10-23 | Single domain antibodies directed against intracellular antigens |
BR112017008165A BR112017008165B8 (pt) | 2014-10-23 | 2015-10-23 | anticorpo de domínio único direcionado contra um componente intracelular e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
Publications (2)
Publication Number | Publication Date |
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BR122020006918B1 BR122020006918B1 (pt) | 2022-03-15 |
BR122020006918B8 true BR122020006918B8 (pt) | 2023-01-31 |
Family
ID=55761757
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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BR122020006907A BR122020006907B8 (pt) | 2014-10-23 | 2015-10-23 | Anticorpo de domínio único anti-kras e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipetídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
BR122020006914A BR122020006914B8 (pt) | 2014-10-23 | 2015-10-23 | Anticorpo de domínio único anti-tnf-alfa e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
BR112017008165A BR112017008165B8 (pt) | 2014-10-23 | 2015-10-23 | anticorpo de domínio único direcionado contra um componente intracelular e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
BR122020006918A BR122020006918B8 (pt) | 2014-10-23 | 2015-10-23 | Anticorpo de domínio único anti-stat3 e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122020006907A BR122020006907B8 (pt) | 2014-10-23 | 2015-10-23 | Anticorpo de domínio único anti-kras e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipetídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
BR122020006914A BR122020006914B8 (pt) | 2014-10-23 | 2015-10-23 | Anticorpo de domínio único anti-tnf-alfa e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
BR112017008165A BR112017008165B8 (pt) | 2014-10-23 | 2015-10-23 | anticorpo de domínio único direcionado contra um componente intracelular e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado |
Country Status (23)
Country | Link |
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US (4) | US9695234B2 (pt) |
EP (3) | EP4006052A1 (pt) |
JP (5) | JP2017538671A (pt) |
KR (4) | KR102023289B1 (pt) |
CN (2) | CN106852148B (pt) |
AU (4) | AU2015335600B2 (pt) |
BR (4) | BR122020006907B8 (pt) |
CA (3) | CA3052777C (pt) |
CY (2) | CY1122035T1 (pt) |
DK (2) | DK3209685T3 (pt) |
ES (2) | ES2900253T3 (pt) |
HR (2) | HRP20211889T1 (pt) |
HU (2) | HUE057605T2 (pt) |
IL (2) | IL289769B1 (pt) |
LT (2) | LT3590962T (pt) |
MX (2) | MX2017003268A (pt) |
PL (2) | PL3209685T3 (pt) |
PT (2) | PT3590962T (pt) |
RS (2) | RS62694B1 (pt) |
RU (1) | RU2017116710A (pt) |
SI (2) | SI3209685T1 (pt) |
TW (1) | TWI664289B (pt) |
WO (1) | WO2016065323A2 (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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US20180072815A1 (en) | 2014-10-23 | 2018-03-15 | Singh Biotechnology, Llc | Single Domain Antibodies Directed Against Intracellular Antigens |
LT3590962T (lt) | 2014-10-23 | 2021-12-27 | Singh Molecular Medicine, Llc | Vieno domeno antikūnai, nukreipti prieš viduląstelinius antigenus |
US20170267784A1 (en) * | 2014-10-23 | 2017-09-21 | Singh Molecular Medicine, Llc | Single domain antibodies directed against intracellular antigens |
BR112017020275A8 (pt) | 2015-03-31 | 2023-01-31 | Sorriso Pharmaceuticals Inc | Polipeptídeos |
EA201890618A1 (ru) | 2015-09-01 | 2018-10-31 | Ферст Вэйв Байо, Инк. | Способы и композиции для лечения состояний, ассоциированных с аномальными воспалительными ответами |
TWI746473B (zh) | 2015-11-02 | 2021-11-21 | 美商辛分子醫藥有限公司 | 針對細胞內抗原之單域抗體 |
CN112274649A (zh) * | 2015-12-10 | 2021-01-29 | 希望之城 | 细胞穿透花青偶联抗体 |
EP3519438A1 (en) | 2016-09-30 | 2019-08-07 | VHsquared Limited | Compositions |
CN110520436A (zh) | 2017-03-15 | 2019-11-29 | 潘迪恩治疗公司 | 靶向免疫耐受性 |
EP3630163A4 (en) | 2017-05-24 | 2021-06-09 | Pandion Operations, Inc. | TARGETED IMMUNTOLERANCE |
TW201922780A (zh) | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗il12/il23抗體治療狼瘡之安全且有效之方法 |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
KR20190076354A (ko) * | 2017-12-22 | 2019-07-02 | 주식회사 로피바이오 | 세포 내 침투능을 갖는 항 stat3 이중특이 항체를 포함하는, 염증성 질환 치료용 약학적 조성물 |
WO2019125033A1 (ko) * | 2017-12-22 | 2019-06-27 | (주)로피바이오 | 세포 내 침투능을 갖는 항 stat3 이중특이 항체 및 이를 포함하는 약학적 조성물 |
JP2021523115A (ja) * | 2018-05-04 | 2021-09-02 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | 炎症性疾患または障害を治療するための方法および組成物 |
KR102101561B1 (ko) * | 2018-07-25 | 2020-04-20 | 가톨릭대학교 산학협력단 | 신생혈관 표적용 조영제 조성물 및 이의 제조방법 |
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