BR112015009559A2 - uso de composto antissenso na preparação de medicamento para tratamento de cãncer, composto antissenso e composição farmacêutica - Google Patents

uso de composto antissenso na preparação de medicamento para tratamento de cãncer, composto antissenso e composição farmacêutica

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Publication number
BR112015009559A2
BR112015009559A2 BR112015009559A BR112015009559A BR112015009559A2 BR 112015009559 A2 BR112015009559 A2 BR 112015009559A2 BR 112015009559 A BR112015009559 A BR 112015009559A BR 112015009559 A BR112015009559 A BR 112015009559A BR 112015009559 A2 BR112015009559 A2 BR 112015009559A2
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BR
Brazil
Prior art keywords
antisense compound
cancer treatment
preparation
pharmaceutical composition
treatment medicament
Prior art date
Application number
BR112015009559A
Other languages
English (en)
Inventor
Yamashita Mason
T Crooke Stanley
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of BR112015009559A2 publication Critical patent/BR112015009559A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/3233—Morpholino-type ring
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

resumo patente de invenção: "tratamento de câncer". em certas concretizações, métodos, compostos, e composições para tratamento de linfoma de célula b ou carcinoma hepatocelular por inibição da expressão de mrna de stat3 ou proteína em um animal, são aqui proporcionados. tais métodos, compostos, e composições são úteis para tratar, prevenir, ou melhorar linfoma de célula b, ou carcinoma hepatocelular.
BR112015009559A 2012-10-31 2013-10-30 uso de composto antissenso na preparação de medicamento para tratamento de cãncer, composto antissenso e composição farmacêutica BR112015009559A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261720939P 2012-10-31 2012-10-31
US201361777875P 2013-03-12 2013-03-12
PCT/US2013/067469 WO2014070868A1 (en) 2012-10-31 2013-10-30 Cancer treatment

Publications (1)

Publication Number Publication Date
BR112015009559A2 true BR112015009559A2 (pt) 2017-11-14

Family

ID=50628028

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BR112015009559A BR112015009559A2 (pt) 2012-10-31 2013-10-30 uso de composto antissenso na preparação de medicamento para tratamento de cãncer, composto antissenso e composição farmacêutica

Country Status (24)

Country Link
US (4) US9540641B2 (pt)
EP (2) EP2920308B1 (pt)
JP (2) JP6542669B2 (pt)
CN (1) CN104755621A (pt)
BR (1) BR112015009559A2 (pt)
CA (1) CA2889630C (pt)
CY (1) CY1121873T1 (pt)
DK (1) DK2920308T3 (pt)
ES (1) ES2718082T3 (pt)
HK (1) HK1211982A1 (pt)
HR (1) HRP20190303T1 (pt)
HU (1) HUE041632T2 (pt)
IL (2) IL238249B (pt)
LT (1) LT2920308T (pt)
ME (1) ME03363B (pt)
MX (1) MX365158B (pt)
NZ (1) NZ706540A (pt)
PH (2) PH12015500935B1 (pt)
PL (1) PL2920308T3 (pt)
PT (1) PT2920308T (pt)
RS (1) RS58576B1 (pt)
RU (1) RU2689548C2 (pt)
SI (1) SI2920308T1 (pt)
WO (1) WO2014070868A1 (pt)

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MX365158B (es) 2019-05-24
CN104755621A (zh) 2015-07-01
JP2018118999A (ja) 2018-08-02
PH12018501827A1 (en) 2019-04-15
US20200318112A1 (en) 2020-10-08
ES2718082T3 (es) 2019-06-27
DK2920308T3 (en) 2019-04-01
US9873876B2 (en) 2018-01-23
HUE041632T2 (hu) 2019-05-28
CY1121873T1 (el) 2020-10-14
US20160002625A1 (en) 2016-01-07
EP2920308B1 (en) 2018-12-12
CA2889630A1 (en) 2014-05-08
US9540641B2 (en) 2017-01-10
JP6542669B2 (ja) 2019-07-10
WO2014070868A1 (en) 2014-05-08
HK1211982A1 (en) 2016-06-03
PL2920308T3 (pl) 2019-06-28
US20180346907A1 (en) 2018-12-06
SI2920308T1 (sl) 2019-05-31
IL267242A (en) 2019-08-29
EP3483273A1 (en) 2019-05-15
RS58576B1 (sr) 2019-05-31
ME03363B (me) 2019-10-20
RU2689548C2 (ru) 2019-05-28
PH12015500935A1 (en) 2015-06-29
US10619157B2 (en) 2020-04-14
MX2015005587A (es) 2015-08-14
RU2015113231A (ru) 2016-12-20
NZ706540A (en) 2018-11-30
PT2920308T (pt) 2019-03-20
IL267242B (en) 2020-08-31
HRP20190303T1 (hr) 2019-05-17
EP2920308A4 (en) 2016-06-29
IL238249B (en) 2019-09-26
EP2920308A1 (en) 2015-09-23
US20170145413A1 (en) 2017-05-25
PH12015500935B1 (en) 2015-06-29
IL238249A0 (en) 2015-06-30
LT2920308T (lt) 2019-04-25
CA2889630C (en) 2020-09-01
JP2016502516A (ja) 2016-01-28

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