HRP20190303T1 - Liječenje raka - Google Patents
Liječenje raka Download PDFInfo
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- HRP20190303T1 HRP20190303T1 HRP20190303TT HRP20190303T HRP20190303T1 HR P20190303 T1 HRP20190303 T1 HR P20190303T1 HR P20190303T T HRP20190303T T HR P20190303TT HR P20190303 T HRP20190303 T HR P20190303T HR P20190303 T1 HRP20190303 T1 HR P20190303T1
- Authority
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- Croatia
- Prior art keywords
- compound
- phase
- use according
- total weekly
- cell lymphoma
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- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 17
- 230000003442 weekly effect Effects 0.000 claims 6
- 239000002777 nucleoside Substances 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 230000003042 antagnostic effect Effects 0.000 claims 3
- 230000000692 anti-sense effect Effects 0.000 claims 3
- 125000003835 nucleoside group Chemical group 0.000 claims 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- 101000826373 Homo sapiens Signal transducer and activator of transcription 3 Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000008094 contradictory effect Effects 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- -1 ethyl nucleoside Chemical class 0.000 claims 1
- 102000051841 human STAT3 Human genes 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4718—Cytokine-induced proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (9)
1. Protusmisleni spoj komplementaran s ljudskim STAT3 za uporabu u postupku liječenja B- staničnog limfoma kod ljudskog subjekta kojem je to potrebno, naznačen time što postupak uključuje davanje subjektu protusmislenog spoja u prvoj fazi i zatim u drugoj fazi, pri čemu prva faza uključuje davanje ukupne tjedne doze spoja u rasponu od 100-750 mg (±12%) tijekom prvih 1-10 tjedana, i druga faza uključuje davanje ukupne tjedne doze u rasponu od 100-250 mg (±12%) tijekom barem 1 tjedan nakon prve faze; i pri čemu je protusmisleni spoj jednolančani modificirani oligonukleotid koji se sastoji od 16 povezanih nukleozida koji imaju nukleobaznu sekvencu koja se sastoji od SEQ ID NO: 12, te sadrži:
segment razmaka koji se sastoji od deset povezanih deoksinukleozida;
5' krilni segment koji se sastoji od 3 povezana nukleozida; i
3' krilni segment koji se sastoji od 3 povezana nukleozida;
pri čemu je segment razmaka smješten između 5' krilnog segmenta i 3' krilnog segmenta; pri čemu svaki nukleozid svakog krilnog segmenta sadrži ograničeni etilni nukleozid; pri čemu svaka internukleozidna veza modificiranog oligonukleotida je fosforotioatna veza; i pri čemu svaki citozin modificiranog oligonukleotida je 5-metilcitozin.
2. Spoj za uporabu prema zahtjevu 1, naznačen time što B-stanični limfom je ne-Hodgkinov B-stanični limfom.
3. Spoj za uporabu prema zahtjevu 2, naznačen time što ne-Hodgkinov B-stanični limfom je difuzni B velikostanični limfom (DLBCL).
4. Spoj za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time što prva faza iznosi 1 tjedan.
5. Spoj za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time što prva faza uključuje davanje spoja u 3 jednake doze unutar tjedan dana.
6. Spoj za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time što je ukupna tjedna doza protusmislenog spoja u prvoj fazi količina bilo kojeg od 100 mg (±12%), 125 mg (±12%), 150 mg (±12%), 175 mg (±12%), 200 mg (±12%), 225 mg (±12%), 250 mg (±12%), 275 mg (±12%), 300 mg (±12%), 325 mg (±12%), 350 mg (±12%), 375 mg (±12%), 400 mg (±12%), 425 mg (±12%), 450 mg (±12%), 475 mg (±12%), 500 mg (±12%), 525 mg (±12%), 550 mg (±12%), 575 mg (±12%), 600 mg (±12%), 625 mg (±12%), 650 mg (±12%), 675 mg (±12%), 700 mg (±12%), 725 mg (±12%), ili 750 mg (±12%).
7. Spoj za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time što je ukupna tjedna doza protusmislenog spoja u drugoj fazi količina bilo kojeg od 100 mg (±12%), 110 mg (±12%), 120 mg (±12%), 130 mg (±12%), 140 mg (±12%), 150 mg (±12%), 160 mg (±12%), 170 mg (±12%), 180 mg (±12%), 190 mg (±12%), 200 mg (±12%), 210 mg (±12%), 220 mg (±12%), 230 mg (±12%), 240 mg (±12%), ili 250 mg (±12%).
8. Spoj za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time što je ukupna tjedna doza protusmislenog spoja u prvoj fazi količina od 600 mg (±12%).
9. Spoj za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time što je ukupna tjedna doza protusmislenog spoja u drugoj fazi količina od 200 mg (±12%).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261720939P | 2012-10-31 | 2012-10-31 | |
US201361777875P | 2013-03-12 | 2013-03-12 | |
PCT/US2013/067469 WO2014070868A1 (en) | 2012-10-31 | 2013-10-30 | Cancer treatment |
EP13850047.5A EP2920308B1 (en) | 2012-10-31 | 2013-10-30 | Cancer treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20190303T1 true HRP20190303T1 (hr) | 2019-05-17 |
Family
ID=50628028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190303TT HRP20190303T1 (hr) | 2012-10-31 | 2019-02-14 | Liječenje raka |
Country Status (24)
Country | Link |
---|---|
US (4) | US9540641B2 (hr) |
EP (2) | EP3483273A1 (hr) |
JP (2) | JP6542669B2 (hr) |
CN (1) | CN104755621A (hr) |
BR (1) | BR112015009559A2 (hr) |
CA (1) | CA2889630C (hr) |
CY (1) | CY1121873T1 (hr) |
DK (1) | DK2920308T3 (hr) |
ES (1) | ES2718082T3 (hr) |
HK (1) | HK1211982A1 (hr) |
HR (1) | HRP20190303T1 (hr) |
HU (1) | HUE041632T2 (hr) |
IL (2) | IL238249B (hr) |
LT (1) | LT2920308T (hr) |
ME (1) | ME03363B (hr) |
MX (1) | MX365158B (hr) |
NZ (1) | NZ706540A (hr) |
PH (2) | PH12015500935B1 (hr) |
PL (1) | PL2920308T3 (hr) |
PT (1) | PT2920308T (hr) |
RS (1) | RS58576B1 (hr) |
RU (1) | RU2689548C2 (hr) |
SI (1) | SI2920308T1 (hr) |
WO (1) | WO2014070868A1 (hr) |
Families Citing this family (18)
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HUE042173T2 (hu) | 2011-04-01 | 2019-06-28 | Ionis Pharmaceuticals Inc | 'Signal transducer and activator of transcription 3' (stat3) expresszió modulálása |
EP3483273A1 (en) | 2012-10-31 | 2019-05-15 | Ionis Pharmaceuticals, Inc. | Cancer treatment |
CA3226825A1 (en) * | 2014-06-19 | 2015-12-23 | Quercis Pharma AG | Method for treating cancer with a combination of quercetin and a chemotherapy agent |
CA2958524A1 (en) * | 2014-08-20 | 2016-02-25 | Lifesplice Pharma Llc | Splice modulating oligonucleotides and methods of use thereof |
RS59063B1 (sr) * | 2014-10-23 | 2019-08-30 | Singh Biotechnology Llc | Antitela sa jednim domenom usmerena protiv intracelularnih antigena |
US20180072815A1 (en) | 2014-10-23 | 2018-03-15 | Singh Biotechnology, Llc | Single Domain Antibodies Directed Against Intracellular Antigens |
WO2016062722A1 (en) | 2014-10-24 | 2016-04-28 | Astrazeneca Ab | Combination |
EP3316894A4 (en) | 2015-07-02 | 2019-06-19 | City of Hope | COMPOUNDS AND COMPOSITIONS USING PHOSPHOROIDED OLIGODESOXYNUCLEOTIDE AND METHOD OF USE THEREOF |
US20170049709A1 (en) | 2015-08-21 | 2017-02-23 | Pfizer Inc. | Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same |
US9990779B2 (en) * | 2016-05-13 | 2018-06-05 | Meta Company | System and method for modifying virtual objects in a virtual environment in response to user interactions |
SG10201607303YA (en) * | 2016-09-01 | 2018-04-27 | Agency Science Tech & Res | Antisense oligonucleotides to induce exon skipping |
AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
US10366263B2 (en) * | 2016-12-30 | 2019-07-30 | Accenture Global Solutions Limited | Object detection for video camera self-calibration |
CA3052038C (en) * | 2017-01-31 | 2023-08-01 | Curigin Co., Ltd. | Nucleic acid simultaneously inhibiting expression of mtor gene and stat3 gene |
EP3407613A1 (en) * | 2017-05-23 | 2018-11-28 | Thomson Licensing | Control of display device content |
EP3752613A1 (en) * | 2018-02-14 | 2020-12-23 | Ionis Pharmaceuticals, Inc. | Methods of modulating antisense activity |
CN113164440A (zh) | 2018-11-30 | 2021-07-23 | 贝斯以色列女执事医疗中心有限公司 | 减少癌症患者的主要血栓事件的组合物和方法 |
US20220354880A1 (en) | 2019-09-30 | 2022-11-10 | Astrazeneca Ab | Combination treatment for cancer |
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2013
- 2013-10-30 EP EP18206571.4A patent/EP3483273A1/en not_active Withdrawn
- 2013-10-30 PL PL13850047T patent/PL2920308T3/pl unknown
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- 2013-10-30 LT LTEP13850047.5T patent/LT2920308T/lt unknown
- 2013-10-30 DK DK13850047.5T patent/DK2920308T3/en active
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- 2013-10-30 WO PCT/US2013/067469 patent/WO2014070868A1/en active Application Filing
- 2013-10-30 MX MX2015005587A patent/MX365158B/es active IP Right Grant
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- 2013-10-30 US US14/439,363 patent/US9540641B2/en active Active
- 2013-10-30 CN CN201380056691.0A patent/CN104755621A/zh active Pending
- 2013-10-30 HU HUE13850047A patent/HUE041632T2/hu unknown
- 2013-10-30 RU RU2015113231A patent/RU2689548C2/ru active
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- 2013-10-30 JP JP2015540744A patent/JP6542669B2/ja active Active
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2015
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2016
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2017
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