PL2424889T3 - Sposób wytwarzania przeciwciał domenowych - Google Patents
Sposób wytwarzania przeciwciał domenowychInfo
- Publication number
- PL2424889T3 PL2424889T3 PL10719752T PL10719752T PL2424889T3 PL 2424889 T3 PL2424889 T3 PL 2424889T3 PL 10719752 T PL10719752 T PL 10719752T PL 10719752 T PL10719752 T PL 10719752T PL 2424889 T3 PL2424889 T3 PL 2424889T3
- Authority
- PL
- Poland
- Prior art keywords
- production
- domain antibodies
- antibodies
- domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17418409P | 2009-04-30 | 2009-04-30 | |
| US30483410P | 2010-02-16 | 2010-02-16 | |
| EP10719752.7A EP2424889B1 (en) | 2009-04-30 | 2010-04-30 | Method for the production of domain antibodies |
| PCT/EP2010/055916 WO2010125187A2 (en) | 2009-04-30 | 2010-04-30 | Method for the production of domain antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2424889T3 true PL2424889T3 (pl) | 2016-01-29 |
Family
ID=42332495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10719752T PL2424889T3 (pl) | 2009-04-30 | 2010-04-30 | Sposób wytwarzania przeciwciał domenowych |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9464138B2 (pl) |
| EP (3) | EP2424889B1 (pl) |
| AU (1) | AU2010243551B2 (pl) |
| CA (1) | CA2759370C (pl) |
| CY (1) | CY1124137T1 (pl) |
| DK (2) | DK2424889T3 (pl) |
| ES (2) | ES2551854T3 (pl) |
| HU (1) | HUE053480T2 (pl) |
| PL (1) | PL2424889T3 (pl) |
| PT (1) | PT2424889E (pl) |
| WO (1) | WO2010125187A2 (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008252853B2 (en) | 2007-05-24 | 2011-12-01 | Ablynx N.V. | Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders |
| ES2713864T3 (es) | 2008-06-05 | 2019-05-24 | Ablynx Nv | Secuencias de aminoácidos dirigidas contra proteínas de la envuelta de un virus y polipéptidos que comprenden las mismas para el tratamiento de enfermedades virales |
| AU2010243551B2 (en) | 2009-04-30 | 2015-03-26 | Ablynx Nv | Method for the production of domain antibodies |
| EP2438087B1 (en) | 2009-06-05 | 2017-05-10 | Ablynx N.V. | Trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
| AU2015200057B9 (en) * | 2009-06-05 | 2017-03-09 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hRSV) Nanobody constructs for the prevention and/or treatment of respiratory tract infections |
| WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| WO2011161266A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
| ES2996232T3 (en) | 2010-10-29 | 2025-02-12 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
| ES2560470T3 (es) | 2011-04-29 | 2016-02-19 | Biocon Research Limited | Un método para reducir la heterogeneidad de anticuerpos y un proceso de producción de dichos anticuerpos |
| CN105189735B (zh) * | 2011-04-29 | 2019-04-12 | 拜康研究有限公司 | 在培养期间减少乳酸累积的方法和生产多肽的方法 |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| US9534039B2 (en) | 2011-05-09 | 2017-01-03 | Ablynx N.V. | Method for the production of immunoglobulin single variable domains |
| CN108329391A (zh) * | 2011-05-27 | 2018-07-27 | 埃博灵克斯股份有限公司 | 使用rankl结合肽抑制骨质吸收 |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| KR20250099289A (ko) * | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| HUE050007T2 (hu) | 2014-05-16 | 2020-11-30 | Ablynx Nv | Immunglobulin variábilis domének |
| CA2971278C (en) * | 2014-12-19 | 2023-09-19 | Ablynx N.V. | Cysteine linked nanobody dimers |
| CN107667113B (zh) * | 2015-02-05 | 2022-05-03 | 埃博灵克斯股份有限公司 | 通过c端改造的半胱氨酸连接的纳米抗体二聚体 |
| GB201506869D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| PL3294319T3 (pl) | 2015-05-13 | 2024-10-07 | Ablynx Nv | Polipeptydy rekrutujące komórki t na podstawie reaktywności cd3 |
| ES2754427T3 (es) | 2015-05-13 | 2020-04-17 | Ablynx Nv | Polipéptidos de reclutamiento de células T basados en la reactividad de TCR alfa/beta |
| MA42613A (fr) | 2015-08-13 | 2018-06-20 | Amgen Inc | Filtration en profondeur chargée de protéines de liaison à un antigène |
| RU2018119732A (ru) | 2015-10-30 | 2019-12-03 | Аблинкс Нв | Полипептиды против il-23 |
| CN108699151B (zh) | 2016-02-12 | 2022-08-12 | 埃博灵克斯股份有限公司 | 用于制备免疫球蛋白单可变结构域的方法 |
| CA3043515A1 (en) | 2016-11-16 | 2018-05-24 | Ablynx Nv | T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta |
| BR112019024333A2 (pt) | 2017-06-02 | 2020-07-28 | Merck Patent Gmbh | imunoglobulinas de ligação adamts |
| US20210170342A1 (en) * | 2017-12-13 | 2021-06-10 | King Abdullah University Of Science And Technology | Functionalized polymeric membranes for the separation, recovery, and/or purification of antibodies |
| AU2019356564A1 (en) * | 2018-10-11 | 2021-04-29 | Amgen Inc. | Downstream processing of bispecific antibody constructs |
| WO2020144164A1 (en) | 2019-01-07 | 2020-07-16 | Bactolife Aps | Pathogen binding proteins |
| EP4126971A1 (en) | 2020-03-30 | 2023-02-08 | Ablynx N.V. | Method for the production and purification of multivalent immunoglobulin single variable domains |
| PH12023500009A1 (en) | 2020-12-18 | 2024-03-11 | Ablynx Nv | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| US20240117038A1 (en) | 2022-07-18 | 2024-04-11 | Ablynx N.V. | Cx3cr1-binding compounds, methods and uses thereof |
| JP2025526384A (ja) | 2022-07-27 | 2025-08-13 | アブリンクス エン．ヴェー． | 新生児型Ｆｃ受容体の特異的エピトープに結合するポリペプチド |
| EP4665755A1 (en) | 2023-02-17 | 2025-12-24 | Ablynx N.V. | Polypeptides binding to the neonatal fc receptor |
| WO2025008537A1 (en) | 2023-07-05 | 2025-01-09 | Ablynx Nv | Improved fcrn antagonists for treatment of igg-related diseases and disorders |
| AR133903A1 (es) | 2023-09-22 | 2025-11-12 | Ablynx Nv | Agentes de unión de albúmina bi- y multivalentes |
| WO2025207946A1 (en) | 2024-03-28 | 2025-10-02 | Genzyme Corporation | Polypeptides binding to a specific epitope of the transferrin receptor 1 |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4572798A (en) | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
| FI903489A0 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna. |
| US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| GB2270076A (en) | 1992-08-18 | 1994-03-02 | Univ Manchester | Human HSP 90 Epitopes |
| EP1498427B1 (en) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| DK0698097T3 (da) | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| AU740043B2 (en) | 1996-06-27 | 2001-10-25 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Recognition molecules interacting specifically with the active site or cleft of a target molecule |
| EP1027439B1 (en) | 1997-10-27 | 2010-03-17 | Bac Ip B.V. | Multivalent antigen-binding proteins |
| BR9907241A (pt) | 1998-01-26 | 2000-10-17 | Unilever Nv | Biblioteca de expressão, processo para preparar a mesma, uso de uma fonte não imunizada de sequências de ácido nucleico, e, processos para preparar fragmentos de anticorpos e, para preparar um anticorpo |
| WO2000040968A1 (en) | 1999-01-05 | 2000-07-13 | Unilever Plc | Binding of antibody fragments to solid supports |
| WO2000043507A1 (en) | 1999-01-19 | 2000-07-27 | Unilever Plc | Method for producing antibody fragments |
| ID30380A (id) | 1999-04-22 | 2001-11-29 | Unilever Nv | Penghambatan infeksi virus menggunakan protein pengikat antigen bervalensi tunggal |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| DK1233987T3 (da) | 1999-11-29 | 2009-09-28 | Bac Ip B V | Immobiliserede enkelt-domæne antigenbindende molekyler |
| EP1242460B1 (en) | 1999-11-29 | 2006-10-18 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
| EP1134231B1 (en) | 2000-03-14 | 2009-04-15 | Unilever N.V. | Antibody heavy chain variable domains against human dietary lipases, and their uses |
| CA2380443C (en) | 2000-05-26 | 2013-03-12 | Ginette Dubuc | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| US20040053340A1 (en) | 2000-12-13 | 2004-03-18 | De Haard Johannes Joseph | Protein arrays |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| EP1433793A4 (en) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| AU2002351896A1 (en) | 2001-12-11 | 2003-06-23 | Ablynx N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| AU2002360068B2 (en) | 2001-12-21 | 2009-09-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Method for cloning of variable domain sequences |
| JP2005517674A (ja) | 2002-01-03 | 2005-06-16 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー | 腫瘍の処置に有用な新規免疫コンジュゲート |
| US20040157514A1 (en) | 2002-11-01 | 2004-08-12 | Courtney William L. | Variably configured inflatable personal flotation device also serving as an emergency distress marker |
| WO2004041862A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| RU2357974C2 (ru) | 2003-01-10 | 2009-06-10 | Аблинкс Н.В. | Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами |
| US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
| JP2007521234A (ja) | 2003-08-12 | 2007-08-02 | ウィリアム エム ヤーブロー | 尋常性ざ瘡の治療薬及び使用方法 |
| ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| AU2005293752A1 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease |
| NZ554520A (en) * | 2004-10-22 | 2010-03-26 | Amgen Inc | Methods for refolding of recombinant antibodies |
| WO2006058890A2 (en) | 2004-11-30 | 2006-06-08 | Novo Nordisk A/S | Method of producing antibodies |
| AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| RU2464276C2 (ru) | 2005-05-18 | 2012-10-20 | Аблинкс Н.В. | Улучшенные нанотела против фактора некроза опухоли-альфа |
| DK2444424T3 (en) | 2005-05-20 | 2018-12-03 | Ablynx Nv | IMPROVED NANOL BODIES (TM) FOR TREATING AGGREGATED MEDICINAL DISORDERS |
| GT200600240A (es) * | 2005-06-06 | 2007-03-14 | Anticuerpos monoclonales anti-trkb y usos de los mismos | |
| ES2402650T3 (es) * | 2005-06-17 | 2013-05-07 | Janssen Alzheimer Immunotherapy | Métodos de purificación de anticuerpos anti A beta |
| WO2007136463A2 (en) | 2006-04-07 | 2007-11-29 | Dow Global Technologies Incorporated | Processes for improved disulfide bond formation in recombinant systems |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| CA2666607C (en) * | 2006-11-01 | 2015-02-10 | Biogen Idec Ma Inc. | Method of isolating biomacromolecules using low ph and divalent cations |
| CA2678218A1 (en) | 2007-02-21 | 2008-08-28 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| AU2008252853B2 (en) * | 2007-05-24 | 2011-12-01 | Ablynx N.V. | Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders |
| MX354993B (es) | 2007-07-09 | 2018-03-28 | Genentech Inc | Prevención de reducción de enlaces de disulfuro durante la producción recombinante de polipéptidos. |
| CN101970490A (zh) | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| AU2010243551B2 (en) | 2009-04-30 | 2015-03-26 | Ablynx Nv | Method for the production of domain antibodies |
-
2010
- 2010-04-30 AU AU2010243551A patent/AU2010243551B2/en active Active
- 2010-04-30 EP EP10719752.7A patent/EP2424889B1/en active Active
- 2010-04-30 WO PCT/EP2010/055916 patent/WO2010125187A2/en not_active Ceased
- 2010-04-30 EP EP15174570.0A patent/EP2982690B1/en active Active
- 2010-04-30 CA CA2759370A patent/CA2759370C/en active Active
- 2010-04-30 HU HUE15174570A patent/HUE053480T2/hu unknown
- 2010-04-30 DK DK10719752.7T patent/DK2424889T3/en active
- 2010-04-30 ES ES10719752.7T patent/ES2551854T3/es active Active
- 2010-04-30 ES ES15174570T patent/ES2864956T3/es active Active
- 2010-04-30 US US13/266,503 patent/US9464138B2/en active Active
- 2010-04-30 EP EP20216389.5A patent/EP3828201A1/en active Pending
- 2010-04-30 PL PL10719752T patent/PL2424889T3/pl unknown
- 2010-04-30 PT PT107197527T patent/PT2424889E/pt unknown
- 2010-04-30 DK DK15174570.0T patent/DK2982690T3/da active
-
2016
- 2016-09-01 US US15/254,027 patent/US12116607B2/en active Active
-
2021
- 2021-04-07 CY CY20211100300T patent/CY1124137T1/el unknown
-
2024
- 2024-09-17 US US18/887,126 patent/US20250122547A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK2424889T3 (en) | 2015-11-02 |
| EP2424889B1 (en) | 2015-08-12 |
| AU2010243551B2 (en) | 2015-03-26 |
| PT2424889E (pt) | 2015-11-12 |
| WO2010125187A3 (en) | 2011-01-20 |
| CA2759370C (en) | 2020-02-11 |
| EP3828201A1 (en) | 2021-06-02 |
| US9464138B2 (en) | 2016-10-11 |
| EP2982690B1 (en) | 2021-01-27 |
| EP2982690A1 (en) | 2016-02-10 |
| US20120157664A1 (en) | 2012-06-21 |
| DK2982690T3 (da) | 2021-04-12 |
| US12116607B2 (en) | 2024-10-15 |
| HK1219741A1 (en) | 2017-04-13 |
| AU2010243551A1 (en) | 2011-11-10 |
| EP2424889A2 (en) | 2012-03-07 |
| ES2551854T3 (es) | 2015-11-24 |
| US20170081692A1 (en) | 2017-03-23 |
| ES2864956T3 (es) | 2021-10-14 |
| HUE053480T2 (hu) | 2021-06-28 |
| CA2759370A1 (en) | 2010-11-04 |
| CY1124137T1 (el) | 2022-05-27 |
| WO2010125187A2 (en) | 2010-11-04 |
| US20250122547A1 (en) | 2025-04-17 |
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