PT2424889E - Método de produção de anticorpos de domínio - Google Patents
Método de produção de anticorpos de domínio Download PDFInfo
- Publication number
- PT2424889E PT2424889E PT107197527T PT10719752T PT2424889E PT 2424889 E PT2424889 E PT 2424889E PT 107197527 T PT107197527 T PT 107197527T PT 10719752 T PT10719752 T PT 10719752T PT 2424889 E PT2424889 E PT 2424889E
- Authority
- PT
- Portugal
- Prior art keywords
- production
- domain antibodies
- antibodies
- domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17418409P | 2009-04-30 | 2009-04-30 | |
US30483410P | 2010-02-16 | 2010-02-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2424889E true PT2424889E (pt) | 2015-11-12 |
Family
ID=42332495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT107197527T PT2424889E (pt) | 2009-04-30 | 2010-04-30 | Método de produção de anticorpos de domínio |
Country Status (12)
Country | Link |
---|---|
US (2) | US9464138B2 (pt) |
EP (3) | EP2424889B1 (pt) |
AU (1) | AU2010243551B2 (pt) |
CA (1) | CA2759370C (pt) |
CY (1) | CY1124137T1 (pt) |
DK (2) | DK2982690T3 (pt) |
ES (2) | ES2864956T3 (pt) |
HK (1) | HK1219741A1 (pt) |
HU (1) | HUE053480T2 (pt) |
PL (1) | PL2424889T3 (pt) |
PT (1) | PT2424889E (pt) |
WO (1) | WO2010125187A2 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101264473B1 (ko) | 2007-05-24 | 2013-05-29 | 아블린쓰 엔.브이. | Rank-l에 대한 아미노산 서열, 및 이를 포함하는 골 질환 및 장애 치료용 폴리펩티드 |
EP3424526A1 (en) | 2008-06-05 | 2019-01-09 | Ablynx NV | Immunoglobulin single variable domains binding to the g envelope protein of rabies virus and uses thereof for the treatment and prevention of rabies |
PT2438087T (pt) | 2009-06-05 | 2017-08-04 | Ablynx Nv | Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório |
AU2015200057B9 (en) * | 2009-06-05 | 2017-03-09 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hRSV) Nanobody constructs for the prevention and/or treatment of respiratory tract infections |
EP2507262A1 (en) | 2009-11-30 | 2012-10-10 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
WO2011161266A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
EP3279214A1 (en) | 2010-10-29 | 2018-02-07 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
WO2012147053A1 (en) * | 2011-04-29 | 2012-11-01 | Biocon Research Limited | A method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof |
RU2592680C2 (ru) * | 2011-04-29 | 2016-07-27 | Биокон Рисерч Лимитед | Способ снижения накопления лактата при культивировании и способ получения антитела |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
WO2012152823A1 (en) | 2011-05-09 | 2012-11-15 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
AU2012264809B2 (en) * | 2011-05-27 | 2017-05-04 | Ablynx Nv | Inhibition of bone resorption with RANKL binding peptides |
WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
KR20230145503A (ko) * | 2014-05-16 | 2023-10-17 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
JP6862343B2 (ja) | 2014-12-19 | 2021-04-21 | アブリンクス エン.ヴェー. | システイン結合ナノボディダイマー |
EP3262068A1 (en) * | 2015-02-05 | 2018-01-03 | Ablynx N.V. | Nanobody dimers linked via c-terminally engineered cysteins |
GB201506869D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
CA2985698C (en) | 2015-05-13 | 2023-02-28 | Ablynx N.V. | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
WO2016180982A1 (en) | 2015-05-13 | 2016-11-17 | Ablynx N.V. | T cell recruiting polypeptides based on cd3 reactivity |
HRP20231544T1 (hr) * | 2015-08-13 | 2024-03-15 | Amgen Inc. | Nabijena dubinska filtracija proteina koji vežu antigene |
AU2016347610A1 (en) | 2015-10-30 | 2018-05-10 | Ablynx Nv | Polypeptides against IL-23 |
WO2017137579A1 (en) | 2016-02-12 | 2017-08-17 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
US11840569B2 (en) | 2016-11-16 | 2023-12-12 | Ablynx N.V. | T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta |
EP3630847A1 (en) | 2017-06-02 | 2020-04-08 | Merck Patent GmbH | Adamts binding immunoglobulins |
US20210170342A1 (en) * | 2017-12-13 | 2021-06-10 | King Abdullah University Of Science And Technology | Functionalized polymeric membranes for the separation, recovery, and/or purification of antibodies |
AU2019356564A1 (en) * | 2018-10-11 | 2021-04-29 | Amgen Inc. | Downstream processing of bispecific antibody constructs |
CN115397868A (zh) | 2020-03-30 | 2022-11-25 | 埃博灵克斯股份有限公司 | 用于产生和纯化多价免疫球蛋白单可变域的方法 |
MX2023007299A (es) | 2020-12-18 | 2023-07-04 | Ablynx Nv | Polipeptidos de reclutamiento de celulas t basados en la reactividad de tcr alfa/beta. |
US20240117038A1 (en) | 2022-07-18 | 2024-04-11 | Ablynx N.V. | Cx3cr1-binding compounds, methods and uses thereof |
WO2024023271A1 (en) | 2022-07-27 | 2024-02-01 | Ablynx Nv | Polypeptides binding to a specific epitope of the neonatal fc receptor |
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US4572798A (en) | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
GB2270076A (en) | 1992-08-18 | 1994-03-02 | Univ Manchester | Human HSP 90 Epitopes |
ES2162823T5 (es) | 1992-08-21 | 2010-08-09 | Vrije Universiteit Brussel | Inmunoglobulinas desprovistas de cadenas ligeras. |
DK0698097T3 (da) | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
ATE374248T1 (de) | 1996-06-27 | 2007-10-15 | Vlaams Interuniv Inst Biotech | Antikörpermoleküle, die spezifisch mit dem aktiven zentrum oder dem aktiven spalt eines zielmoleküls interagieren |
AU2152299A (en) | 1997-10-27 | 1999-05-24 | Unilever Plc | Multivalent antigen-binding proteins |
AU3596599A (en) | 1998-01-26 | 1999-08-09 | Unilever Plc | Method for producing antibody fragments |
AU3041100A (en) | 1999-01-05 | 2000-07-24 | Unilever Plc | Binding of antibody fragments to solid supports |
ATE276359T1 (de) | 1999-01-19 | 2004-10-15 | Unilever Nv | Verfahren zur herstellung von antikörperfragmenten |
WO2000065057A1 (en) | 1999-04-22 | 2000-11-02 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins |
US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
AU1859201A (en) | 1999-11-29 | 2001-06-12 | Unilever Plc | Immobilisation of proteins |
DE60042789D1 (de) | 1999-11-29 | 2009-10-01 | Bac Ip B V | Immobilisierte antigenbindende moleküle aus einer domäne |
DE60138333D1 (de) | 2000-03-14 | 2009-05-28 | Unilever Nv | Variabele Domänen der schweren Kette eines Antikörpers gegen menschliche Ernährungslipasen und deren Verwendungen |
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EP1360207B1 (en) | 2000-12-13 | 2011-06-22 | Bac Ip B.V. | Protein arrays of camelid heavy-chain immunoglobulin variable domains |
US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
EP1433793A4 (en) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY |
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CA2471645A1 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
AU2003301812A1 (en) | 2002-11-01 | 2004-06-07 | William L. Courtney | Variably configured inflatable personal flotation device also serving as an emergency distress marker |
EP1558646A2 (en) | 2002-11-08 | 2005-08-03 | Ablynx N.V. | Single domain antibodies directed against interferon- gamma and uses thereof |
EP2316852B1 (en) | 2002-11-08 | 2014-03-05 | Ablynx N.V. | Stabilized single domain antibodies |
US20060228355A1 (en) | 2003-11-07 | 2006-10-12 | Toon Laeremans | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
KR20050092029A (ko) | 2003-01-10 | 2005-09-16 | 아블린쓰 엔.브이. | 폰 빌레브란트 인자(vWF) 또는 콜라겐에 대한낙타과로부터의 재조합 VHH 단일 도메인 항체 |
US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
JP2007521234A (ja) | 2003-08-12 | 2007-08-02 | ウィリアム エム ヤーブロー | 尋常性ざ瘡の治療薬及び使用方法 |
US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
AU2005293752A1 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease |
NZ554520A (en) * | 2004-10-22 | 2010-03-26 | Amgen Inc | Methods for refolding of recombinant antibodies |
US20080305516A1 (en) * | 2004-11-30 | 2008-12-11 | Kristian Kjaergaard | Method of Producing Antibodies |
EP1844073A1 (en) | 2005-01-31 | 2007-10-17 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
PL1888640T3 (pl) | 2005-05-18 | 2012-08-31 | Ablynx Nv | Ulepszone nanociała skierowane przeciwko czynnikowi martwicy nowotworów typu alfa |
PT2444424T (pt) | 2005-05-20 | 2018-11-09 | Ablynx Nv | Nanocorpos tm aperfeiçoados para o tratamento de distúrbios mediados por agregação |
CA2610771A1 (en) * | 2005-06-06 | 2006-12-14 | Wyeth | Anti-trkb monoclonal antibodies and uses thereof |
MY144484A (en) * | 2005-06-17 | 2011-09-30 | Wyeth Corp | Methods of purifying anti a beta antibodies |
EP2004804A2 (en) | 2006-04-07 | 2008-12-24 | Dow Global Technologies Inc. | Processes for improved disulfide bond formation in recombinant systems |
WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
EP2078039B1 (en) * | 2006-11-01 | 2017-09-13 | Biogen MA Inc. | Method of isolating biomacromolecules using low ph and divalent cations |
US20110118185A9 (en) | 2007-02-21 | 2011-05-19 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
KR101264473B1 (ko) | 2007-05-24 | 2013-05-29 | 아블린쓰 엔.브이. | Rank-l에 대한 아미노산 서열, 및 이를 포함하는 골 질환 및 장애 치료용 폴리펩티드 |
ES2751022T3 (es) * | 2007-07-09 | 2020-03-30 | Genentech Inc | Prevención de la reducción de enlaces disulfuro durante la producción recombinante de polipéptidos |
EP2215125A1 (en) | 2007-11-27 | 2010-08-11 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
-
2010
- 2010-04-30 PT PT107197527T patent/PT2424889E/pt unknown
- 2010-04-30 AU AU2010243551A patent/AU2010243551B2/en active Active
- 2010-04-30 EP EP10719752.7A patent/EP2424889B1/en active Active
- 2010-04-30 WO PCT/EP2010/055916 patent/WO2010125187A2/en active Application Filing
- 2010-04-30 HU HUE15174570A patent/HUE053480T2/hu unknown
- 2010-04-30 DK DK15174570.0T patent/DK2982690T3/da active
- 2010-04-30 ES ES15174570T patent/ES2864956T3/es active Active
- 2010-04-30 DK DK10719752.7T patent/DK2424889T3/en active
- 2010-04-30 US US13/266,503 patent/US9464138B2/en active Active
- 2010-04-30 EP EP15174570.0A patent/EP2982690B1/en active Active
- 2010-04-30 CA CA2759370A patent/CA2759370C/en active Active
- 2010-04-30 EP EP20216389.5A patent/EP3828201A1/en active Pending
- 2010-04-30 PL PL10719752T patent/PL2424889T3/pl unknown
- 2010-04-30 ES ES10719752.7T patent/ES2551854T3/es active Active
-
2016
- 2016-07-04 HK HK16107739.3A patent/HK1219741A1/zh unknown
- 2016-09-01 US US15/254,027 patent/US20170081692A1/en active Pending
-
2021
- 2021-04-07 CY CY20211100300T patent/CY1124137T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010243551B2 (en) | 2015-03-26 |
DK2982690T3 (da) | 2021-04-12 |
HUE053480T2 (hu) | 2021-06-28 |
WO2010125187A2 (en) | 2010-11-04 |
EP2424889B1 (en) | 2015-08-12 |
WO2010125187A3 (en) | 2011-01-20 |
EP2982690A1 (en) | 2016-02-10 |
US9464138B2 (en) | 2016-10-11 |
ES2864956T3 (es) | 2021-10-14 |
ES2551854T3 (es) | 2015-11-24 |
DK2424889T3 (en) | 2015-11-02 |
US20170081692A1 (en) | 2017-03-23 |
EP2982690B1 (en) | 2021-01-27 |
CA2759370A1 (en) | 2010-11-04 |
CY1124137T1 (el) | 2022-05-27 |
PL2424889T3 (pl) | 2016-01-29 |
HK1219741A1 (zh) | 2017-04-13 |
US20120157664A1 (en) | 2012-06-21 |
AU2010243551A1 (en) | 2011-11-10 |
CA2759370C (en) | 2020-02-11 |
EP3828201A1 (en) | 2021-06-02 |
EP2424889A2 (en) | 2012-03-07 |
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