JP2019504822A5 - - Google Patents
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- JP2019504822A5 JP2019504822A5 JP2018527745A JP2018527745A JP2019504822A5 JP 2019504822 A5 JP2019504822 A5 JP 2019504822A5 JP 2018527745 A JP2018527745 A JP 2018527745A JP 2018527745 A JP2018527745 A JP 2018527745A JP 2019504822 A5 JP2019504822 A5 JP 2019504822A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- changed
- amino acid
- cd40l
- polypeptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 150000001413 amino acids Chemical group 0.000 claims 18
- 108010029697 CD40 Ligand Proteins 0.000 claims 17
- 102100032937 CD40 ligand Human genes 0.000 claims 17
- 229940024606 amino acid Drugs 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 9
- 230000027455 binding Effects 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000028622 Immune thrombocytopenia Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 4
- 101150013553 CD40 gene Proteins 0.000 claims 3
- 102000007562 Serum Albumin Human genes 0.000 claims 3
- 108010071390 Serum Albumin Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 230000003844 B-cell-activation Effects 0.000 claims 2
- 102100023804 Coagulation factor VII Human genes 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 108010023321 Factor VII Proteins 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 208000031220 Hemophilia Diseases 0.000 claims 2
- 208000009292 Hemophilia A Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 206010009887 colitis Diseases 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940012413 factor vii Drugs 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101100059511 Homo sapiens CD40LG gene Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 238000003016 alphascreen Methods 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 238000001516 cell proliferation assay Methods 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 238000012004 kinetic exclusion assay Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000010118 platelet activation Effects 0.000 claims 1
- 238000003615 platelet activation assay Methods 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260411P | 2015-11-27 | 2015-11-27 | |
| US62/260,411 | 2015-11-27 | ||
| US201662345967P | 2016-06-06 | 2016-06-06 | |
| US62/345,967 | 2016-06-06 | ||
| PCT/EP2016/079048 WO2017089618A1 (en) | 2015-11-27 | 2016-11-28 | Polypeptides inhibiting cd40l |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504822A JP2019504822A (ja) | 2019-02-21 |
| JP2019504822A5 true JP2019504822A5 (enExample) | 2020-01-16 |
| JP7256011B2 JP7256011B2 (ja) | 2023-04-11 |
Family
ID=57471837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018527745A Active JP7256011B2 (ja) | 2015-11-27 | 2016-11-28 | Ｃｄ４０ｌを阻害するポリペプチド |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US11248055B2 (enExample) |
| EP (2) | EP3380517B1 (enExample) |
| JP (1) | JP7256011B2 (enExample) |
| KR (1) | KR20180080337A (enExample) |
| CN (1) | CN108473561B (enExample) |
| AU (1) | AU2016360987A1 (enExample) |
| BR (1) | BR112018010802A2 (enExample) |
| CA (1) | CA3006398A1 (enExample) |
| CL (1) | CL2018001400A1 (enExample) |
| CO (1) | CO2018005921A2 (enExample) |
| DO (1) | DOP2018000128A (enExample) |
| EC (1) | ECSP18046820A (enExample) |
| GT (1) | GT201800102A (enExample) |
| IL (1) | IL259249A (enExample) |
| MA (1) | MA43302A (enExample) |
| MX (1) | MX2018006377A (enExample) |
| PE (1) | PE20181956A1 (enExample) |
| PH (1) | PH12018501114A1 (enExample) |
| RU (1) | RU2018122255A (enExample) |
| SG (2) | SG11201803976VA (enExample) |
| TN (1) | TN2018000180A1 (enExample) |
| WO (1) | WO2017089618A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117164710A (zh) | 2016-12-07 | 2023-12-05 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合免疫球蛋白单可变结构域 |
| SG10202108973SA (en) | 2017-01-17 | 2021-09-29 | Ablynx Nv | Improved serum albumin binders |
| ES2991459T3 (es) | 2017-01-17 | 2024-12-03 | Ablynx Nv | Ligantes de albúmina sérica mejorados |
| EP3710480A4 (en) * | 2017-11-17 | 2021-12-15 | Nanjing Legend Biotech Co., Ltd. | SINGLE-DOMAIN ANTIBODIES AND VARIANTS OF THEM DIRECTED AGAINST PD-L1 |
| AU2020400938A1 (en) * | 2019-12-09 | 2022-07-28 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting IL-13 and TSLP |
| CN114149508B (zh) * | 2021-11-25 | 2023-04-28 | 苏州普乐康医药科技有限公司 | 一种结合cd40l的融合蛋白及其应用 |
| TW202440614A (zh) | 2022-12-23 | 2024-10-16 | 比利時商艾伯霖克斯公司 | 基於蛋白質的接合載體 |
| TW202448926A (zh) | 2023-02-17 | 2024-12-16 | 比利時商艾伯霖克斯公司 | 結合新生兒fc受體之多肽 |
| US20250236673A1 (en) | 2023-12-22 | 2025-07-24 | Ablynx N.V. | Protein-based carriers for site-specific amine conjugation |
| WO2025133253A2 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based conjugation carriers for intranuclear delivery |
| WO2025235683A1 (en) | 2024-05-07 | 2025-11-13 | Eledon Pharmaceuticals, Inc. | Methods and compositions for prevention of transplant rejection |
| WO2025235670A1 (en) | 2024-05-07 | 2025-11-13 | Eledon Pharmaceuticals, Inc. | Use of anti-cd40 ligand antibodies for immunosuppression in islet cell transplantation |
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-
2016
- 2016-11-28 CA CA3006398A patent/CA3006398A1/en not_active Abandoned
- 2016-11-28 MA MA043302A patent/MA43302A/fr unknown
- 2016-11-28 US US15/778,677 patent/US11248055B2/en active Active
- 2016-11-28 EP EP16805359.3A patent/EP3380517B1/en active Active
- 2016-11-28 PE PE2018001013A patent/PE20181956A1/es unknown
- 2016-11-28 CN CN201680068704.XA patent/CN108473561B/zh active Active
- 2016-11-28 EP EP21179221.3A patent/EP3932945A1/en not_active Withdrawn
- 2016-11-28 SG SG11201803976VA patent/SG11201803976VA/en unknown
- 2016-11-28 AU AU2016360987A patent/AU2016360987A1/en not_active Abandoned
- 2016-11-28 KR KR1020187018169A patent/KR20180080337A/ko not_active Withdrawn
- 2016-11-28 MX MX2018006377A patent/MX2018006377A/es unknown
- 2016-11-28 SG SG10201913503VA patent/SG10201913503VA/en unknown
- 2016-11-28 WO PCT/EP2016/079048 patent/WO2017089618A1/en not_active Ceased
- 2016-11-28 TN TNP/2018/000180A patent/TN2018000180A1/en unknown
- 2016-11-28 BR BR112018010802A patent/BR112018010802A2/pt not_active Application Discontinuation
- 2016-11-28 RU RU2018122255A patent/RU2018122255A/ru unknown
- 2016-11-28 JP JP2018527745A patent/JP7256011B2/ja active Active
-
2018
- 2018-05-09 IL IL259249A patent/IL259249A/en unknown
- 2018-05-21 GT GT201800102A patent/GT201800102A/es unknown
- 2018-05-22 DO DO2018000128A patent/DOP2018000128A/es unknown
- 2018-05-24 CL CL2018001400A patent/CL2018001400A1/es unknown
- 2018-05-25 PH PH12018501114A patent/PH12018501114A1/en unknown
- 2018-06-08 CO CONC2018/0005921A patent/CO2018005921A2/es unknown
- 2018-06-21 EC ECSENADI201846820A patent/ECSP18046820A/es unknown