JP2014500311A5 - - Google Patents
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- Publication number
- JP2014500311A5 JP2014500311A5 JP2013546072A JP2013546072A JP2014500311A5 JP 2014500311 A5 JP2014500311 A5 JP 2014500311A5 JP 2013546072 A JP2013546072 A JP 2013546072A JP 2013546072 A JP2013546072 A JP 2013546072A JP 2014500311 A5 JP2014500311 A5 JP 2014500311A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- ligand
- domain
- asparagine
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000018102 proteins Nutrition 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 239000003446 ligand Substances 0.000 claims 14
- 108010025221 plasma protein Z Proteins 0.000 claims 13
- 238000000034 method Methods 0.000 claims 9
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 5
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 5
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 5
- 229960001230 asparagine Drugs 0.000 claims 5
- 235000009582 asparagine Nutrition 0.000 claims 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 5
- 239000011159 matrix material Substances 0.000 claims 5
- 239000000178 monomer Substances 0.000 claims 5
- 108010088160 Staphylococcal Protein A Proteins 0.000 claims 4
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 3
- 238000010828 elution Methods 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 102100035971 Molybdopterin molybdenumtransferase Human genes 0.000 claims 1
- 101710119577 Molybdopterin molybdenumtransferase Proteins 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000003480 eluent Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424698P | 2010-12-20 | 2010-12-20 | |
| US61/424,698 | 2010-12-20 | ||
| PCT/SE2011/051537 WO2012087231A1 (en) | 2010-12-20 | 2011-12-19 | Affinity chromatography matrix |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500311A JP2014500311A (ja) | 2014-01-09 |
| JP2014500311A5 true JP2014500311A5 (enExample) | 2015-02-05 |
| JP5974343B2 JP5974343B2 (ja) | 2016-08-23 |
Family
ID=46314246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546072A Active JP5974343B2 (ja) | 2010-12-20 | 2011-12-19 | アフィニティークロマトグラフィーマトリックス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9187555B2 (enExample) |
| EP (1) | EP2654914B1 (enExample) |
| JP (1) | JP5974343B2 (enExample) |
| CN (1) | CN103269762B (enExample) |
| WO (1) | WO2012087231A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013081540A1 (en) * | 2011-11-30 | 2013-06-06 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
| EP2831096B1 (en) * | 2012-03-28 | 2020-04-29 | GE Healthcare BioProcess R&D AB | Affinity chromatography matrix |
| ES2868093T3 (es) | 2012-09-17 | 2021-10-21 | Grace W R & Co | Medio y dispositivos de cromatografía |
| CN105377880B (zh) | 2013-07-10 | 2020-08-07 | 通用电气医疗集团生物工艺研发股份公司 | 突变的免疫球蛋白结合多肽 |
| WO2015109068A1 (en) | 2014-01-16 | 2015-07-23 | W. R. Grace & Co.-Conn. | Affinity chromatography media and chromatography devices |
| WO2015168383A1 (en) | 2014-05-02 | 2015-11-05 | W. R. Grace & Co.-Conn. | Functionalized support material and methods of making and using functionalized support material |
| US11566082B2 (en) * | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10695744B2 (en) | 2015-06-05 | 2020-06-30 | W. R. Grace & Co.-Conn. | Adsorbent biprocessing clarification agents and methods of making and using the same |
| JP6891114B2 (ja) * | 2015-07-22 | 2021-06-18 | 株式会社カネカ | 酸性ｐＨ領域での抗体結合能が低下した抗体結合性タンパク質 |
| JP6512308B2 (ja) * | 2015-12-28 | 2019-05-15 | 株式会社島津製作所 | クロマトグラフ |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| CN109071613A (zh) | 2016-05-11 | 2018-12-21 | 通用电气医疗集团生物工艺研发股份公司 | 分离基质 |
| CN109311949B (zh) | 2016-05-11 | 2022-09-16 | 思拓凡生物工艺研发有限公司 | 储存分离基质的方法 |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| JP6987424B2 (ja) | 2016-05-11 | 2022-01-05 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを洗浄および／または消毒する方法 |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| CN106543274B (zh) * | 2016-10-18 | 2020-10-27 | 天津大学 | 一种对抗体具有特异性结合作用的a蛋白结构域z的衍生物及其应用 |
| CA3046561A1 (en) | 2016-12-12 | 2018-06-21 | Hurrah S.A R.L. | Compositions and methods for increasing the immunoglobulin binding capacities of immunoglobulin-binding polypeptides and oligopeptides |
| GB201703116D0 (en) * | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
| EP4229068A1 (en) | 2020-10-13 | 2023-08-23 | Avitide LLC | Affinity ligand libraries of three-helix bundle proteins and uses thereof |
| CN117241866A (zh) | 2021-02-19 | 2023-12-15 | 艾维泰有限责任公司 | Aav2亲和剂 |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
| CN114939400B (zh) * | 2022-06-28 | 2024-11-22 | 上海兆维科技发展有限公司 | 一种亲和层析填料及其制备方法以及亲和纯化工艺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| US6602977B1 (en) | 1999-04-19 | 2003-08-05 | Biovitrum Ab | Receptor structures |
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| US7709209B2 (en) | 2002-03-25 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Protein ligands |
| SE0301987D0 (sv) * | 2003-07-04 | 2003-07-04 | Affibody Ab | New polypeptide |
| SE0400274D0 (sv) | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
| ATE490268T1 (de) | 2005-03-01 | 2010-12-15 | Affibody Ab | Tnf-alhpa-bindendes polypeptid, anwendungen davon und verfahren, bei denen dieses verwendet wird |
| JP5229888B2 (ja) * | 2008-09-30 | 2013-07-03 | 独立行政法人産業技術総合研究所 | 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤 |
| WO2010080065A1 (en) * | 2009-01-12 | 2010-07-15 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
-
2011
- 2011-12-19 JP JP2013546072A patent/JP5974343B2/ja active Active
- 2011-12-19 US US13/995,977 patent/US9187555B2/en active Active
- 2011-12-19 WO PCT/SE2011/051537 patent/WO2012087231A1/en not_active Ceased
- 2011-12-19 CN CN201180061115.6A patent/CN103269762B/zh active Active
- 2011-12-19 EP EP11850306.9A patent/EP2654914B1/en active Active
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