JP2012515160A5 - - Google Patents
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- Publication number
- JP2012515160A5 JP2012515160A5 JP2011545323A JP2011545323A JP2012515160A5 JP 2012515160 A5 JP2012515160 A5 JP 2012515160A5 JP 2011545323 A JP2011545323 A JP 2011545323A JP 2011545323 A JP2011545323 A JP 2011545323A JP 2012515160 A5 JP2012515160 A5 JP 2012515160A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- immunoglobulin
- ligand
- mutating
- spa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 11
- 108060003951 Immunoglobulin Proteins 0.000 claims 10
- 102000018358 immunoglobulin Human genes 0.000 claims 10
- 235000018102 proteins Nutrition 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 9
- 108010088160 Staphylococcal Protein A Proteins 0.000 claims 6
- 108010025221 plasma protein Z Proteins 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 3
- 239000003480 eluent Substances 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 2
- 125000003630 glycyl group Chemical class [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0900029 | 2009-01-12 | ||
| SE0900029-0 | 2009-01-12 | ||
| PCT/SE2010/050016 WO2010080065A1 (en) | 2009-01-12 | 2010-01-11 | Affinity chromatography matrix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515160A JP2012515160A (ja) | 2012-07-05 |
| JP2012515160A5 true JP2012515160A5 (enExample) | 2013-02-21 |
Family
ID=42316657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011545323A Pending JP2012515160A (ja) | 2009-01-12 | 2010-01-11 | アフィニティークロマトグラフィーマトリックス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20120149875A1 (enExample) |
| EP (1) | EP2389386A4 (enExample) |
| JP (1) | JP2012515160A (enExample) |
| CN (1) | CN102272145B (enExample) |
| WO (1) | WO2010080065A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| US8592555B2 (en) | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| CN105152939A (zh) * | 2008-11-10 | 2015-12-16 | 阿尔尼拉姆医药品有限公司 | 用于递送治疗剂的脂质和组合物 |
| SG162687A1 (en) | 2008-12-24 | 2010-07-29 | Millipore Corp | Caustic stable chromatography ligands |
| KR20230098713A (ko) * | 2009-06-10 | 2023-07-04 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| CA2791918C (en) * | 2010-03-05 | 2019-11-19 | Boehringer Ingelheim International Gmbh | Selective enrichment of antibodies |
| CN103228328A (zh) | 2010-11-29 | 2013-07-31 | 通用电气健康护理生物科学股份公司 | 亲和色谱基质 |
| LT2647707T (lt) | 2010-11-30 | 2018-11-12 | Chugai Seiyaku Kabushiki Kaisha | Citotoksiškumą indukuojantis terapinis agentas |
| EP2654914B1 (en) | 2010-12-20 | 2018-05-30 | GE Healthcare BioProcess R&D AB | Affinity chromatography matrix |
| WO2012087230A1 (en) * | 2010-12-20 | 2012-06-28 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
| SG10201604554WA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| US20140221613A1 (en) * | 2011-08-04 | 2014-08-07 | Daicel Corporation | Novel modified protein comprising tandem-type multimer of mutant extracellular domain of protein g |
| EP2831096B1 (en) * | 2012-03-28 | 2020-04-29 | GE Healthcare BioProcess R&D AB | Affinity chromatography matrix |
| US8921113B2 (en) | 2012-12-21 | 2014-12-30 | Dionex Corporation | Buffer kit and method of generating a linear pH gradient |
| US9896486B2 (en) * | 2013-07-10 | 2018-02-20 | Ge Healthcare Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US20160215026A1 (en) | 2013-09-06 | 2016-07-28 | Kaneka Corporation | Dissociation capacity-boosted ligand for affinity dissociation matrix |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| JP7219005B2 (ja) | 2015-12-28 | 2023-02-07 | 中外製薬株式会社 | Ｆｃ領域含有ポリペプチドの精製を効率化するための方法 |
| JP7320943B2 (ja) | 2016-04-28 | 2023-08-04 | 中外製薬株式会社 | 抗体含有製剤 |
| ES2909833T3 (es) | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| EP3455243B1 (en) | 2016-05-11 | 2021-03-24 | Cytiva BioProcess R&D AB | Separation matrix |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US11708390B2 (en) | 2016-05-11 | 2023-07-25 | Cytiva Bioprocess R&D Ab | Method of storing a separation matrix |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| CN106543274B (zh) * | 2016-10-18 | 2020-10-27 | 天津大学 | 一种对抗体具有特异性结合作用的a蛋白结构域z的衍生物及其应用 |
| GB201703116D0 (en) * | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
| AU2018361430B2 (en) | 2017-11-01 | 2025-08-14 | Chugai Seiyaku Kabushiki Kaisha | Antibody variant and isoform with lowered biological activity |
| JP7335881B2 (ja) * | 2018-08-24 | 2023-08-30 | Jsr株式会社 | イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体 |
| CN109182364A (zh) * | 2018-08-30 | 2019-01-11 | 武汉百意欣生物技术有限公司 | 一种特异性识别蛋白a的多克隆抗体及其制备方法和应用 |
| US11022585B2 (en) | 2019-06-09 | 2021-06-01 | Dionex Corporation | Methods and systems for optimizing buffer conditions with liquid chromatography |
| EP4541444A1 (en) * | 2023-10-20 | 2025-04-23 | Cytiva BioProcess R&D AB | Fusion protein for affinity capture |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1714982T3 (da) * | 2001-06-05 | 2009-05-04 | Genetics Inst Llc | Fremgangsmåde til rensning af stærkt anioniske proteiner |
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| US7709209B2 (en) * | 2002-03-25 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Protein ligands |
| US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| SG162687A1 (en) * | 2008-12-24 | 2010-07-29 | Millipore Corp | Caustic stable chromatography ligands |
-
2010
- 2010-01-11 JP JP2011545323A patent/JP2012515160A/ja active Pending
- 2010-01-11 CN CN201080004708.4A patent/CN102272145B/zh active Active
- 2010-01-11 WO PCT/SE2010/050016 patent/WO2010080065A1/en not_active Ceased
- 2010-01-11 US US13/143,996 patent/US20120149875A1/en not_active Abandoned
- 2010-01-11 EP EP10729367.2A patent/EP2389386A4/en not_active Withdrawn
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