JP2007532477A5 - - Google Patents
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- Publication number
- JP2007532477A5 JP2007532477A5 JP2006538022A JP2006538022A JP2007532477A5 JP 2007532477 A5 JP2007532477 A5 JP 2007532477A5 JP 2006538022 A JP2006538022 A JP 2006538022A JP 2006538022 A JP2006538022 A JP 2006538022A JP 2007532477 A5 JP2007532477 A5 JP 2007532477A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- protein
- substrate
- ion exchange
- hydroxyapatite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 26
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 26
- 239000000758 substrate Substances 0.000 claims description 26
- 102000004169 proteins and genes Human genes 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 22
- 239000011347 resin Substances 0.000 claims description 22
- 229920005989 resin Polymers 0.000 claims description 22
- 238000005342 ion exchange Methods 0.000 claims description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 239000011534 wash buffer Substances 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000004587 chromatography analysis Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 239000012149 elution buffer Substances 0.000 claims description 7
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 239000012160 loading buffer Substances 0.000 claims description 4
- 238000004255 ion exchange chromatography Methods 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000005349 anion exchange Methods 0.000 description 5
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 239000000872 buffer Substances 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000919 ceramic Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000006167 equilibration buffer Substances 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51401803P | 2003-10-27 | 2003-10-27 | |
| US60/514,018 | 2003-10-27 | ||
| US52333503P | 2003-11-20 | 2003-11-20 | |
| US60/523,335 | 2003-11-20 | ||
| PCT/US2004/032883 WO2005044856A2 (en) | 2003-10-27 | 2004-10-06 | Removal of high molecular weight aggregates using hydroxyapatite chromatography |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012013648A Division JP5490156B2 (ja) | 2003-10-27 | 2012-01-26 | ヒドロキシアパタイトクロマトグラフィーを用いる高分子量凝集体の取り出し |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007532477A JP2007532477A (ja) | 2007-11-15 |
| JP2007532477A5 true JP2007532477A5 (enExample) | 2012-03-22 |
| JP5004586B2 JP5004586B2 (ja) | 2012-08-22 |
Family
ID=34576743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538022A Expired - Lifetime JP5004586B2 (ja) | 2003-10-27 | 2004-10-06 | ヒドロキシアパタイトクロマトグラフィーを用いる高分子量凝集体の取り出し |
| JP2012013648A Expired - Lifetime JP5490156B2 (ja) | 2003-10-27 | 2012-01-26 | ヒドロキシアパタイトクロマトグラフィーを用いる高分子量凝集体の取り出し |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012013648A Expired - Lifetime JP5490156B2 (ja) | 2003-10-27 | 2012-01-26 | ヒドロキシアパタイトクロマトグラフィーを用いる高分子量凝集体の取り出し |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9469672B2 (enExample) |
| EP (2) | EP1678208B1 (enExample) |
| JP (2) | JP5004586B2 (enExample) |
| KR (2) | KR101221862B1 (enExample) |
| CN (2) | CN1898266B (enExample) |
| AU (1) | AU2004286938B2 (enExample) |
| BR (2) | BRPI0415887B1 (enExample) |
| CA (1) | CA2543193C (enExample) |
| CO (1) | CO5690649A2 (enExample) |
| DK (2) | DK1678208T3 (enExample) |
| EC (1) | ECSP066583A (enExample) |
| ES (2) | ES2530446T3 (enExample) |
| IL (1) | IL175229A (enExample) |
| MX (1) | MXPA06004472A (enExample) |
| NZ (1) | NZ547315A (enExample) |
| PL (2) | PL1678208T3 (enExample) |
| PT (2) | PT1678208E (enExample) |
| RU (2) | RU2409591C2 (enExample) |
| WO (1) | WO2005044856A2 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0304576D0 (en) * | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| PT1678208E (pt) * | 2003-10-27 | 2013-07-10 | Wyeth Llc | Remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatite |
| WO2006099308A2 (en) | 2005-03-11 | 2006-09-21 | Wyeth | A method of weak partitioning chromatography |
| ES2402650T3 (es) * | 2005-06-17 | 2013-05-07 | Janssen Alzheimer Immunotherapy | Métodos de purificación de anticuerpos anti A beta |
| AU2006261920A1 (en) * | 2005-06-23 | 2007-01-04 | Medimmune, Llc | Antibody formulations having optimized aggregation and fragmentation profiles |
| AR058140A1 (es) * | 2005-10-24 | 2008-01-23 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
| CN101378782A (zh) * | 2005-12-21 | 2009-03-04 | 惠氏公司 | 粘度降低的蛋白质制剂及其用途 |
| EP2012118A4 (en) | 2006-04-25 | 2009-12-16 | Tosoh Corp | ISOLENT FOR IGG PURIFICATION AND METHOD FOR PURIFYING AN IGG MONOMER THEREFOR |
| WO2009017491A1 (en) * | 2006-06-14 | 2009-02-05 | Smithkline Beecham Corporation | Methods for purifying antibodies using ceramic hydroxyapatite |
| AU2007291282B2 (en) * | 2006-08-28 | 2011-10-20 | Ares Trading S.A. | Process for the purification of Fc-fusion proteins |
| FI2061803T4 (fi) * | 2006-08-28 | 2023-03-14 | Process for the purification of fc-containing proteins | |
| CL2007002615A1 (es) * | 2006-09-08 | 2008-04-18 | Wyeth Corp | Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto. |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| BRPI0716762A2 (pt) | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
| US7691980B2 (en) * | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| US7999085B2 (en) * | 2007-01-09 | 2011-08-16 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| US20100063257A1 (en) * | 2007-01-26 | 2010-03-11 | Merck Serono Sa | Purification of FC-TACI Fusion Proteins Using the Oilbody Technology |
| TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| EP2226331A4 (en) | 2007-10-26 | 2012-02-08 | Asahi Kasei Chemicals Corp | PROCESS FOR CLEANING PROTEINS |
| JP5999899B2 (ja) * | 2008-04-08 | 2016-09-28 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 抗体のクロマトグラフィー精製法 |
| CN102149724B (zh) † | 2008-08-14 | 2014-04-09 | 健泰科生物技术公司 | 使用原地蛋白质置换离子交换膜层析清除污染物的方法 |
| TWI610936B (zh) * | 2008-10-20 | 2018-01-11 | 艾伯維有限公司 | 使用蛋白質ａ親和性層析進行抗體之分離及純化 |
| TW201028433A (en) | 2008-10-20 | 2010-08-01 | Abbott Lab | Viral inactivation during purification of antibodies |
| KR20110079693A (ko) | 2008-10-29 | 2011-07-07 | 와이어쓰 엘엘씨 | 단일 도메인 항원 결합 분자의 정제 방법 |
| EP2362767B1 (en) | 2008-10-29 | 2017-12-06 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
| US8058407B2 (en) | 2008-10-31 | 2011-11-15 | Wyeth Llc | Purification of acidic proteins using ceramic hydroxyapatite chromatography |
| KR20110139216A (ko) * | 2009-03-11 | 2011-12-28 | 와이어쓰 엘엘씨 | 소형 모듈형 면역약제 단백질의 정제 방법 |
| US8481694B2 (en) | 2009-04-29 | 2013-07-09 | Bio-Rad Laboratories, Inc. | Purification of immunoconjugates |
| US9441011B2 (en) | 2009-07-03 | 2016-09-13 | Asahi Kasei Chemicals Corporation | Method for purification of antibody using porous membrane having amino group and alkyl group both bound to graft chain immobilized on porous substrate |
| EP3037104B1 (en) | 2009-10-20 | 2020-05-27 | AbbVie Inc. | Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography |
| CA2784278C (en) | 2009-12-18 | 2019-02-26 | Novartis Ag | Wash solution and method for affinity chromatography |
| EP2519537A4 (en) * | 2009-12-29 | 2013-07-10 | Reddys Lab Ltd Dr | CLEANING PROTEINS |
| WO2011088225A1 (en) * | 2010-01-15 | 2011-07-21 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| KR20120132529A (ko) | 2010-04-14 | 2012-12-05 | 에프. 호프만-라 로슈 아게 | 면역글로불린 응집물 제거 |
| GB201006753D0 (en) | 2010-04-22 | 2010-06-09 | Biotest Ag | Process for preparing an immunolobulin composition |
| US20110301333A1 (en) * | 2010-06-08 | 2011-12-08 | Millipore Corporation | Removal of protein aggregates from biopharmaceutical preparations using calcium phosphate salts |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| MX2013004720A (es) * | 2010-11-01 | 2013-05-28 | Dsm Ip Assets Bv | Purificacion de anticuerpos mediante cromatografia de intercambio ionico de una uncia unidad. |
| EP2670704B1 (en) | 2011-02-02 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| US9809639B2 (en) * | 2011-06-08 | 2017-11-07 | Agency For Science, Technology And Research | Purification of biological products by constrained cohydration chromatography |
| AU2012269240B2 (en) * | 2011-06-16 | 2016-01-21 | Dpx Holdings B.V. | Single unit chromatography antibody purification |
| SG10201701224UA (en) * | 2012-03-12 | 2017-04-27 | Merck Patent Gmbh | Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode |
| US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| WO2014003142A1 (ja) * | 2012-06-27 | 2014-01-03 | 旭化成メディカル株式会社 | 抗体 |
| JP2014105180A (ja) * | 2012-11-27 | 2014-06-09 | Hoya Corp | モノマー化方法 |
| PL2968468T3 (pl) | 2013-03-13 | 2021-12-20 | Buzzard Pharmaceuticals AB | Preparaty chimerycznej cytokiny do dostarczania do oka |
| WO2014209508A1 (en) * | 2013-05-13 | 2014-12-31 | Medimmune, Llc | Separation of recombinant polyclonal antibody multimers with minimal separation of monomers |
| KR20160029840A (ko) | 2013-07-05 | 2016-03-15 | 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 | 친화성 크로마토그래피 매트릭스 |
| SG11201508835YA (en) | 2013-07-12 | 2015-11-27 | Merck Patent Gmbh | Removal of fragments from a sample containing a target protein using activated carbon |
| JP6479305B2 (ja) * | 2013-07-12 | 2019-03-06 | 株式会社Ｕｍｎファーマ | ウイルス様粒子の精製方法 |
| EP3698870A1 (en) | 2013-12-12 | 2020-08-26 | EMD Millipore Corporation | Protein separations using an acrylamide containing filter |
| EP4671270A3 (en) * | 2013-12-27 | 2026-03-18 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying antibody having low isoelectric point |
| US9802822B2 (en) | 2014-06-23 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| WO2015200299A2 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| US10617975B2 (en) | 2014-12-15 | 2020-04-14 | Merck Patent Gmbh | Target molecule capture from crude solutions |
| SG10201908027QA (en) | 2015-03-13 | 2019-10-30 | Bristol Myers Squibb Co | Use of alkaline washes during chromatography to remove impurities |
| ES2817751T3 (es) | 2015-12-21 | 2021-04-08 | Pfizer | Purificación de conjugados de anticuerpo-fármaco mediante el uso de un gradiente de fosfato de sodio |
| US11186858B1 (en) | 2016-03-15 | 2021-11-30 | Fresenius Kabi Deutschland Gmbh | Methods for increasing biosimilarity |
| US11919924B1 (en) * | 2016-03-15 | 2024-03-05 | Fresenius Kabi Deutschland Gmbh | Methods of purifying and producing an adalimumab antibody |
| CN106977591B (zh) * | 2017-05-04 | 2020-05-05 | 广州康盛生物科技股份有限公司 | 一种分离纯化重组葡萄球菌蛋白a的方法 |
| WO2019040671A1 (en) * | 2017-08-22 | 2019-02-28 | Biogen Ma Inc. | METHODS OF PURIFYING ANTIBODIES HAVING REDUCED AGGREGATES OF HIGH MOLECULAR WEIGHT |
| WO2019116096A1 (en) * | 2017-12-15 | 2019-06-20 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Production of fc fragments |
| TWI839347B (zh) * | 2018-02-27 | 2024-04-21 | 美商輝瑞大藥廠 | 抗體純化 |
| WO2019183334A1 (en) * | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
| WO2019192877A1 (en) | 2018-04-03 | 2019-10-10 | Merck Patent Gmbh | Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds |
| WO2019224660A1 (ja) * | 2018-05-24 | 2019-11-28 | ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 | 吸着剤の生産方法 |
| JP6704074B2 (ja) * | 2019-02-04 | 2020-06-03 | 株式会社Ｕｍｎファーマ | ウイルス様粒子の精製方法 |
| CA3162172A1 (en) | 2019-11-22 | 2021-05-27 | Morphosys Ag | Method to increase antibody yield during ion exchange chromatography |
| JP2020099909A (ja) * | 2020-03-17 | 2020-07-02 | ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 | 処理方法、生産方法およびハイドロキシアパタイト充填剤 |
| EP4126971A1 (en) | 2020-03-30 | 2023-02-08 | Ablynx N.V. | Method for the production and purification of multivalent immunoglobulin single variable domains |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US428894A (en) | 1890-05-27 | Process of making tool-handles | ||
| US419964A (en) | 1890-01-21 | Transom-lifter | ||
| US514018A (en) | 1894-02-06 | Edward j | ||
| US523335A (en) | 1894-07-24 | Air-bolt for flour-mills | ||
| US4745183A (en) * | 1984-02-21 | 1988-05-17 | Bio-Rad Laboratories, Inc. | Use of hydroxylapatite for the analysis and preparation of purified monoclonal antibodies |
| JPH03291300A (ja) * | 1989-12-28 | 1991-12-20 | Mitsui Toatsu Chem Inc | ポリクローナル抗体の分離方法 |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| PE20020574A1 (es) * | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| MXPA04006053A (es) * | 2001-12-21 | 2005-03-31 | Immunex Corp | Metodos para purificacion de proteina. |
| EP1601697B1 (en) | 2003-02-28 | 2007-05-30 | Lonza Biologics plc | Antibody purification by Protein A and ion exchange chromatography |
| PT1678208E (pt) * | 2003-10-27 | 2013-07-10 | Wyeth Llc | Remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatite |
-
2004
- 2004-10-06 PT PT47942883T patent/PT1678208E/pt unknown
- 2004-10-06 CN CN2004800387536A patent/CN1898266B/zh not_active Expired - Lifetime
- 2004-10-06 PL PL04794288T patent/PL1678208T3/pl unknown
- 2004-10-06 MX MXPA06004472A patent/MXPA06004472A/es active IP Right Grant
- 2004-10-06 NZ NZ547315A patent/NZ547315A/en unknown
- 2004-10-06 BR BRPI0415887-3A patent/BRPI0415887B1/pt not_active IP Right Cessation
- 2004-10-06 DK DK04794288.3T patent/DK1678208T3/da active
- 2004-10-06 EP EP04794288.3A patent/EP1678208B1/en not_active Expired - Lifetime
- 2004-10-06 WO PCT/US2004/032883 patent/WO2005044856A2/en not_active Ceased
- 2004-10-06 PT PT101743664T patent/PT2336172E/pt unknown
- 2004-10-06 JP JP2006538022A patent/JP5004586B2/ja not_active Expired - Lifetime
- 2004-10-06 DK DK10174366.4T patent/DK2336172T3/en active
- 2004-10-06 CN CN201110221442.5A patent/CN102276717B/zh not_active Expired - Lifetime
- 2004-10-06 PL PL10174366T patent/PL2336172T3/pl unknown
- 2004-10-06 BR BR122020007658-5A patent/BR122020007658B1/pt active IP Right Grant
- 2004-10-06 RU RU2006113695/10A patent/RU2409591C2/ru active
- 2004-10-06 ES ES10174366T patent/ES2530446T3/es not_active Expired - Lifetime
- 2004-10-06 KR KR1020067010375A patent/KR101221862B1/ko not_active Expired - Lifetime
- 2004-10-06 EP EP10174366.4A patent/EP2336172B1/en not_active Expired - Lifetime
- 2004-10-06 KR KR1020117030940A patent/KR101321876B1/ko not_active Expired - Lifetime
- 2004-10-06 US US10/958,595 patent/US9469672B2/en active Active
- 2004-10-06 AU AU2004286938A patent/AU2004286938B2/en not_active Expired
- 2004-10-06 ES ES04794288T patent/ES2418830T3/es not_active Expired - Lifetime
- 2004-10-06 CA CA2543193A patent/CA2543193C/en not_active Expired - Fee Related
-
2006
- 2006-04-26 IL IL175229A patent/IL175229A/en active IP Right Grant
- 2006-05-19 CO CO06048228A patent/CO5690649A2/es not_active Application Discontinuation
- 2006-05-25 EC EC2006006583A patent/ECSP066583A/es unknown
-
2010
- 2010-09-24 RU RU2010139827/10A patent/RU2573910C2/ru active
-
2012
- 2012-01-26 JP JP2012013648A patent/JP5490156B2/ja not_active Expired - Lifetime
-
2013
- 2013-03-14 US US13/803,071 patent/US9822143B2/en not_active Expired - Lifetime
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