JP2014507368A5 - - Google Patents

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Publication number
JP2014507368A5
JP2014507368A5 JP2013552605A JP2013552605A JP2014507368A5 JP 2014507368 A5 JP2014507368 A5 JP 2014507368A5 JP 2013552605 A JP2013552605 A JP 2013552605A JP 2013552605 A JP2013552605 A JP 2013552605A JP 2014507368 A5 JP2014507368 A5 JP 2014507368A5
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JP
Japan
Prior art keywords
apatite
solid surface
target molecule
contacting
washing
Prior art date
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JP2013552605A
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English (en)
Japanese (ja)
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JP5881744B2 (ja
JP2014507368A (ja
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Priority claimed from PCT/US2012/023512 external-priority patent/WO2012106449A1/en
Publication of JP2014507368A publication Critical patent/JP2014507368A/ja
Publication of JP2014507368A5 publication Critical patent/JP2014507368A5/ja
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Publication of JP5881744B2 publication Critical patent/JP5881744B2/ja
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JP2013552605A 2011-02-02 2012-02-01 アルカリ溶液でのアパタイトの表面中和方法 Active JP5881744B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161438729P 2011-02-02 2011-02-02
US61/438,729 2011-02-02
PCT/US2012/023512 WO2012106449A1 (en) 2011-02-02 2012-02-01 Apatite surface neutralization with alkali solutions

Publications (3)

Publication Number Publication Date
JP2014507368A JP2014507368A (ja) 2014-03-27
JP2014507368A5 true JP2014507368A5 (enExample) 2015-12-17
JP5881744B2 JP5881744B2 (ja) 2016-03-09

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ID=46576323

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JP2013552605A Active JP5881744B2 (ja) 2011-02-02 2012-02-01 アルカリ溶液でのアパタイトの表面中和方法

Country Status (5)

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US (3) US9592540B2 (enExample)
EP (1) EP2670704B1 (enExample)
JP (1) JP5881744B2 (enExample)
CA (1) CA2825651C (enExample)
WO (1) WO2012106449A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5773454B2 (ja) 2010-01-15 2015-09-02 バイオ−ラッド ラボラトリーズ インコーポレーティッド アパタイトの表面中和方法
WO2012106449A1 (en) * 2011-02-02 2012-08-09 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
CN104136121B (zh) 2012-02-14 2017-04-19 生物辐射实验室股份有限公司 减少离子交换色谱中的pH漂移
US9815695B2 (en) 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
US9802822B2 (en) * 2014-06-23 2017-10-31 Bio-Rad Laboratories, Inc. Apatite pretreatment
US10099157B2 (en) 2014-06-23 2018-10-16 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN108348820A (zh) * 2015-10-28 2018-07-31 生物辐射实验室股份有限公司 磷灰石的表面中和
JP2020099909A (ja) * 2020-03-17 2020-07-02 HOYA Technosurgical株式会社 処理方法、生産方法およびハイドロキシアパタイト充填剤
CN113351165B (zh) * 2021-04-29 2023-04-14 中石化石油工程技术服务有限公司 矿区饮用水除氟工艺
CN117794920A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3737516A (en) * 1971-03-05 1973-06-05 Du Pont Calcium-deficient hydroxylapatite for use in column chromatography
US4053561A (en) * 1975-08-14 1977-10-11 Stauffer Chemical Company Removal of fluorine from phosphatic solutions
JP2507339B2 (ja) 1986-08-11 1996-06-12 三井東圧化学株式会社 粗tPAの精製方法
US4859342A (en) * 1986-10-14 1989-08-22 Suntory Limited Process for industrially separating biopolymers
US5332503A (en) 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
JP3216436B2 (ja) * 1994-09-06 2001-10-09 三菱マテリアル株式会社 塩基性タンパク質吸着剤
US5744587A (en) * 1995-06-07 1998-04-28 Zymogenetics, Inc. Method for purifying thrombopoietin
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
TR200001580T2 (tr) 1997-12-03 2000-12-21 Roche Diagnostics Gmbh Spesifik etkinliği yüksek eritropoyetin
JP4160652B2 (ja) 1998-05-22 2008-10-01 キリンファーマ株式会社 エンド−β−N−アセチルグルコサミニダーゼ遺伝子
PL347472A1 (en) 1998-08-14 2002-04-08 Merck & Co Inc Process for purifying human papillomavirus virus-like particles
US6156178A (en) 1999-07-13 2000-12-05 Molecular Dynamics, Inc. Increased throughput analysis of small compounds using multiple temporally spaced injections
CN1107116C (zh) 2000-12-20 2003-04-30 华南理工大学 糖液脱色的离子交换树脂再生液及其再生方法
US20040254267A1 (en) 2001-07-10 2004-12-16 Yoshiyuki Nagae Coating material, paint, and process for producing coating material
PL374311A1 (en) 2001-12-21 2005-10-03 Immunex Corporation Methods for purifying protein
FR2834227A1 (fr) 2001-12-27 2003-07-04 Chiralsep Sarl Materiaux supports optiquement actifs, leur procede de preparation et leurs utilisations
CN1311076C (zh) 2003-04-16 2007-04-18 普罗特奥姆技术公司 生产重组尿激酶的方法
RU2409591C2 (ru) * 2003-10-27 2011-01-20 Вайет Удаление агрегатов с высокой молекулярной массой путем хроматографии на гидроксиапатитах
US20090047723A1 (en) 2005-01-14 2009-02-19 Bayer Healthcare Llc Method for purification of factor vii
DK1869065T3 (da) 2005-03-11 2020-06-08 Wyeth Llc Fremgangsmåde til kromatografi med svag opdeling
EP1866427A4 (en) 2005-03-30 2010-09-01 Novo Nordisk As METHOD OF MANUFACTURING PEPTIDES PRODUCED IN INSECT CELL LINES
JP2010510963A (ja) 2006-06-14 2010-04-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー セラミックヒドロキシアパタイトを使用する抗体の精製方法
US8513393B2 (en) 2006-08-28 2013-08-20 Ares Trading S.A. Process for the purification of Fc-containing proteins
HUE028605T2 (en) 2007-03-14 2016-12-28 Takeda Vaccines Inc Cleaning virus-like particles
ES2496596T3 (es) 2007-03-23 2014-09-19 Asahi Kasei Pharma Corporation Método para producir trombomodulina soluble de gran pureza
EP2166093B1 (en) 2007-05-18 2015-09-16 Tokyo Metropolitan Institute of Medical Science Pharmaceutical composition for enzyme replacement therapy
JP5282088B2 (ja) 2007-06-21 2013-09-04 ジェン−プロウブ インコーポレイテッド 処理実行に使用する機器および容器
US8093364B2 (en) 2008-01-18 2012-01-10 Bio-Rad Laboratories, Inc. Enhanced purification of antibodies and antibody fragments by apatite chromatography
NZ602170A (en) 2008-02-08 2014-03-28 Ambrx Inc Modified leptin polypeptides and their uses
JP5999899B2 (ja) * 2008-04-08 2016-09-28 バイオ−ラッド ラボラトリーズ インコーポレーティッド 抗体のクロマトグラフィー精製法
US7635791B2 (en) 2008-04-17 2009-12-22 Tpat Ip Llc Biological buffers with wide buffering ranges
US20090318674A1 (en) * 2008-06-03 2009-12-24 Gagnon Peter S Process for purification of antibodies
EP2334699B1 (en) 2008-09-23 2013-09-11 F. Hoffmann-La Roche AG Purification of erythropoietin
WO2010051360A1 (en) 2008-10-31 2010-05-06 Wyeth Llc Purification of acidic proteins using ceramic hydroxyapatite chromatography
JP5863640B2 (ja) * 2009-04-29 2016-02-16 バイオ−ラッド ラボラトリーズ インコーポレーティッド 免疫複合体の精製
KR101812813B1 (ko) 2009-06-16 2017-12-27 젠자임 코포레이션 재조합 aav 벡터에 대한 개선된 정제 방법
JP5773454B2 (ja) * 2010-01-15 2015-09-02 バイオ−ラッド ラボラトリーズ インコーポレーティッド アパタイトの表面中和方法
US8529859B2 (en) * 2010-03-09 2013-09-10 Lawrence Livermore National Security, Llc Method for fabricating apatite crystals and ceramics
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
WO2012106449A1 (en) * 2011-02-02 2012-08-09 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
US9815695B2 (en) * 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
US9802822B2 (en) * 2014-06-23 2017-10-31 Bio-Rad Laboratories, Inc. Apatite pretreatment
US10099157B2 (en) * 2014-06-23 2018-10-16 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN108348820A (zh) * 2015-10-28 2018-07-31 生物辐射实验室股份有限公司 磷灰石的表面中和

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