CA2825651C - Apatite surface neutralization with alkali solutions - Google Patents
Apatite surface neutralization with alkali solutions Download PDFInfo
- Publication number
- CA2825651C CA2825651C CA2825651A CA2825651A CA2825651C CA 2825651 C CA2825651 C CA 2825651C CA 2825651 A CA2825651 A CA 2825651A CA 2825651 A CA2825651 A CA 2825651A CA 2825651 C CA2825651 C CA 2825651C
- Authority
- CA
- Canada
- Prior art keywords
- apatite
- solid surface
- cleaning
- apatite solid
- contacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/203—Equilibration or regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/34—Regenerating or reactivating
- B01J20/345—Regenerating or reactivating using a particular desorbing compound or mixture
- B01J20/3475—Regenerating or reactivating using a particular desorbing compound or mixture in the liquid phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438729P | 2011-02-02 | 2011-02-02 | |
| US61/438,729 | 2011-02-02 | ||
| PCT/US2012/023512 WO2012106449A1 (en) | 2011-02-02 | 2012-02-01 | Apatite surface neutralization with alkali solutions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2825651A1 CA2825651A1 (en) | 2012-08-09 |
| CA2825651C true CA2825651C (en) | 2020-03-24 |
Family
ID=46576323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2825651A Active CA2825651C (en) | 2011-02-02 | 2012-02-01 | Apatite surface neutralization with alkali solutions |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9592540B2 (enExample) |
| EP (1) | EP2670704B1 (enExample) |
| JP (1) | JP5881744B2 (enExample) |
| CA (1) | CA2825651C (enExample) |
| WO (1) | WO2012106449A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5773454B2 (ja) | 2010-01-15 | 2015-09-02 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アパタイトの表面中和方法 |
| WO2012106449A1 (en) * | 2011-02-02 | 2012-08-09 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| CN104136121B (zh) | 2012-02-14 | 2017-04-19 | 生物辐射实验室股份有限公司 | 减少离子交换色谱中的pH漂移 |
| US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| US9802822B2 (en) * | 2014-06-23 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| US10099157B2 (en) | 2014-06-23 | 2018-10-16 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| CN108348820A (zh) * | 2015-10-28 | 2018-07-31 | 生物辐射实验室股份有限公司 | 磷灰石的表面中和 |
| JP2020099909A (ja) * | 2020-03-17 | 2020-07-02 | HOYA Technosurgical株式会社 | 処理方法、生産方法およびハイドロキシアパタイト充填剤 |
| CN113351165B (zh) * | 2021-04-29 | 2023-04-14 | 中石化石油工程技术服务有限公司 | 矿区饮用水除氟工艺 |
| CN117794920A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3737516A (en) * | 1971-03-05 | 1973-06-05 | Du Pont | Calcium-deficient hydroxylapatite for use in column chromatography |
| US4053561A (en) * | 1975-08-14 | 1977-10-11 | Stauffer Chemical Company | Removal of fluorine from phosphatic solutions |
| JP2507339B2 (ja) | 1986-08-11 | 1996-06-12 | 三井東圧化学株式会社 | 粗tPAの精製方法 |
| US4859342A (en) * | 1986-10-14 | 1989-08-22 | Suntory Limited | Process for industrially separating biopolymers |
| US5332503A (en) | 1993-04-16 | 1994-07-26 | Baxter International Inc. | Process for purifying collagenase |
| JP3216436B2 (ja) * | 1994-09-06 | 2001-10-09 | 三菱マテリアル株式会社 | 塩基性タンパク質吸着剤 |
| US5744587A (en) * | 1995-06-07 | 1998-04-28 | Zymogenetics, Inc. | Method for purifying thrombopoietin |
| US5783217A (en) * | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
| TR200001580T2 (tr) | 1997-12-03 | 2000-12-21 | Roche Diagnostics Gmbh | Spesifik etkinliği yüksek eritropoyetin |
| JP4160652B2 (ja) | 1998-05-22 | 2008-10-01 | キリンファーマ株式会社 | エンド−β−N−アセチルグルコサミニダーゼ遺伝子 |
| PL347472A1 (en) | 1998-08-14 | 2002-04-08 | Merck & Co Inc | Process for purifying human papillomavirus virus-like particles |
| US6156178A (en) | 1999-07-13 | 2000-12-05 | Molecular Dynamics, Inc. | Increased throughput analysis of small compounds using multiple temporally spaced injections |
| CN1107116C (zh) | 2000-12-20 | 2003-04-30 | 华南理工大学 | 糖液脱色的离子交换树脂再生液及其再生方法 |
| US20040254267A1 (en) | 2001-07-10 | 2004-12-16 | Yoshiyuki Nagae | Coating material, paint, and process for producing coating material |
| PL374311A1 (en) | 2001-12-21 | 2005-10-03 | Immunex Corporation | Methods for purifying protein |
| FR2834227A1 (fr) | 2001-12-27 | 2003-07-04 | Chiralsep Sarl | Materiaux supports optiquement actifs, leur procede de preparation et leurs utilisations |
| CN1311076C (zh) | 2003-04-16 | 2007-04-18 | 普罗特奥姆技术公司 | 生产重组尿激酶的方法 |
| RU2409591C2 (ru) * | 2003-10-27 | 2011-01-20 | Вайет | Удаление агрегатов с высокой молекулярной массой путем хроматографии на гидроксиапатитах |
| US20090047723A1 (en) | 2005-01-14 | 2009-02-19 | Bayer Healthcare Llc | Method for purification of factor vii |
| DK1869065T3 (da) | 2005-03-11 | 2020-06-08 | Wyeth Llc | Fremgangsmåde til kromatografi med svag opdeling |
| EP1866427A4 (en) | 2005-03-30 | 2010-09-01 | Novo Nordisk As | METHOD OF MANUFACTURING PEPTIDES PRODUCED IN INSECT CELL LINES |
| JP2010510963A (ja) | 2006-06-14 | 2010-04-08 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | セラミックヒドロキシアパタイトを使用する抗体の精製方法 |
| US8513393B2 (en) | 2006-08-28 | 2013-08-20 | Ares Trading S.A. | Process for the purification of Fc-containing proteins |
| HUE028605T2 (en) | 2007-03-14 | 2016-12-28 | Takeda Vaccines Inc | Cleaning virus-like particles |
| ES2496596T3 (es) | 2007-03-23 | 2014-09-19 | Asahi Kasei Pharma Corporation | Método para producir trombomodulina soluble de gran pureza |
| EP2166093B1 (en) | 2007-05-18 | 2015-09-16 | Tokyo Metropolitan Institute of Medical Science | Pharmaceutical composition for enzyme replacement therapy |
| JP5282088B2 (ja) | 2007-06-21 | 2013-09-04 | ジェン−プロウブ インコーポレイテッド | 処理実行に使用する機器および容器 |
| US8093364B2 (en) | 2008-01-18 | 2012-01-10 | Bio-Rad Laboratories, Inc. | Enhanced purification of antibodies and antibody fragments by apatite chromatography |
| NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| JP5999899B2 (ja) * | 2008-04-08 | 2016-09-28 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 抗体のクロマトグラフィー精製法 |
| US7635791B2 (en) | 2008-04-17 | 2009-12-22 | Tpat Ip Llc | Biological buffers with wide buffering ranges |
| US20090318674A1 (en) * | 2008-06-03 | 2009-12-24 | Gagnon Peter S | Process for purification of antibodies |
| EP2334699B1 (en) | 2008-09-23 | 2013-09-11 | F. Hoffmann-La Roche AG | Purification of erythropoietin |
| WO2010051360A1 (en) | 2008-10-31 | 2010-05-06 | Wyeth Llc | Purification of acidic proteins using ceramic hydroxyapatite chromatography |
| JP5863640B2 (ja) * | 2009-04-29 | 2016-02-16 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 免疫複合体の精製 |
| KR101812813B1 (ko) | 2009-06-16 | 2017-12-27 | 젠자임 코포레이션 | 재조합 aav 벡터에 대한 개선된 정제 방법 |
| JP5773454B2 (ja) * | 2010-01-15 | 2015-09-02 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アパタイトの表面中和方法 |
| US8529859B2 (en) * | 2010-03-09 | 2013-09-10 | Lawrence Livermore National Security, Llc | Method for fabricating apatite crystals and ceramics |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| WO2012106449A1 (en) * | 2011-02-02 | 2012-08-09 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| US9815695B2 (en) * | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| US9802822B2 (en) * | 2014-06-23 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| US10099157B2 (en) * | 2014-06-23 | 2018-10-16 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| CN108348820A (zh) * | 2015-10-28 | 2018-07-31 | 生物辐射实验室股份有限公司 | 磷灰石的表面中和 |
-
2012
- 2012-02-01 WO PCT/US2012/023512 patent/WO2012106449A1/en not_active Ceased
- 2012-02-01 US US13/363,670 patent/US9592540B2/en active Active
- 2012-02-01 EP EP12742721.9A patent/EP2670704B1/en active Active
- 2012-02-01 CA CA2825651A patent/CA2825651C/en active Active
- 2012-02-01 JP JP2013552605A patent/JP5881744B2/ja active Active
-
2017
- 2017-02-14 US US15/432,755 patent/US9737829B2/en active Active
- 2017-07-19 US US15/654,275 patent/US9950279B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20120192901A1 (en) | 2012-08-02 |
| CA2825651A1 (en) | 2012-08-09 |
| EP2670704A4 (en) | 2014-08-20 |
| US9950279B2 (en) | 2018-04-24 |
| US9737829B2 (en) | 2017-08-22 |
| US20170312653A1 (en) | 2017-11-02 |
| EP2670704B1 (en) | 2018-12-12 |
| JP5881744B2 (ja) | 2016-03-09 |
| EP2670704A1 (en) | 2013-12-11 |
| US20170157533A1 (en) | 2017-06-08 |
| JP2014507368A (ja) | 2014-03-27 |
| US9592540B2 (en) | 2017-03-14 |
| WO2012106449A1 (en) | 2012-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20161222 |
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| U00 | Fee paid |
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| U11 | Full renewal or maintenance fee paid |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD Year of fee payment: 14 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260120 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260120 |