JP5881744B2 - アルカリ溶液でのアパタイトの表面中和方法 - Google Patents

アルカリ溶液でのアパタイトの表面中和方法 Download PDF

Info

Publication number
JP5881744B2
JP5881744B2 JP2013552605A JP2013552605A JP5881744B2 JP 5881744 B2 JP5881744 B2 JP 5881744B2 JP 2013552605 A JP2013552605 A JP 2013552605A JP 2013552605 A JP2013552605 A JP 2013552605A JP 5881744 B2 JP5881744 B2 JP 5881744B2
Authority
JP
Japan
Prior art keywords
apatite
target molecule
solid surface
contacting
ceramic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013552605A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014507368A (ja
JP2014507368A5 (enExample
Inventor
ラリー ジェイ． カミングス
ラリー ジェイ． カミングス
Original Assignee
バイオ−ラッド ラボラトリーズ インコーポレーティッド
バイオ−ラッド ラボラトリーズ インコーポレーティッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオ−ラッド ラボラトリーズ インコーポレーティッド, バイオ−ラッド ラボラトリーズ インコーポレーティッド filed Critical バイオ−ラッド ラボラトリーズ インコーポレーティッド
Publication of JP2014507368A publication Critical patent/JP2014507368A/ja
Publication of JP2014507368A5 publication Critical patent/JP2014507368A5/ja
Application granted granted Critical
Publication of JP5881744B2 publication Critical patent/JP5881744B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203—Equilibration or regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B01J20/345—Regenerating or reactivating using a particular desorbing compound or mixture
    • B01J20/3475—Regenerating or reactivating using a particular desorbing compound or mixture in the liquid phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
JP2013552605A 2011-02-02 2012-02-01 アルカリ溶液でのアパタイトの表面中和方法 Active JP5881744B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161438729P 2011-02-02 2011-02-02
US61/438,729 2011-02-02
PCT/US2012/023512 WO2012106449A1 (en) 2011-02-02 2012-02-01 Apatite surface neutralization with alkali solutions

Publications (3)

Publication Number Publication Date
JP2014507368A JP2014507368A (ja) 2014-03-27
JP2014507368A5 JP2014507368A5 (enExample) 2015-12-17
JP5881744B2 true JP5881744B2 (ja) 2016-03-09

Family

ID=46576323

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013552605A Active JP5881744B2 (ja) 2011-02-02 2012-02-01 アルカリ溶液でのアパタイトの表面中和方法

Country Status (5)

Country Link
US (3) US9592540B2 (enExample)
EP (1) EP2670704B1 (enExample)
JP (1) JP5881744B2 (enExample)
CA (1) CA2825651C (enExample)
WO (1) WO2012106449A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
JP5881744B2 (ja) * 2011-02-02 2016-03-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド アルカリ溶液でのアパタイトの表面中和方法
WO2013122834A1 (en) 2012-02-14 2013-08-22 Bio-Rad Laboratories, Inc. REDUCING pH EXCURSIONS IN ION EXCHANGE CHROMATOGRAPHY
US9815695B2 (en) 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
CN105392569B (zh) * 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
EP3157863B1 (en) 2014-06-23 2023-06-21 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
WO2017074767A1 (en) * 2015-10-28 2017-05-04 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
JP2020099909A (ja) * 2020-03-17 2020-07-02 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 処理方法、生産方法およびハイドロキシアパタイト充填剤
CN113351165B (zh) * 2021-04-29 2023-04-14 中石化石油工程技术服务有限公司 矿区饮用水除氟工艺
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3737516A (en) * 1971-03-05 1973-06-05 Du Pont Calcium-deficient hydroxylapatite for use in column chromatography
US4053561A (en) * 1975-08-14 1977-10-11 Stauffer Chemical Company Removal of fluorine from phosphatic solutions
JP2507339B2 (ja) 1986-08-11 1996-06-12 三井東圧化学株式会社 粗ｔＰＡの精製方法
US4859342A (en) * 1986-10-14 1989-08-22 Suntory Limited Process for industrially separating biopolymers
US5332503A (en) 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
JP3216436B2 (ja) * 1994-09-06 2001-10-09 三菱マテリアル株式会社 塩基性タンパク質吸着剤
US5744587A (en) * 1995-06-07 1998-04-28 Zymogenetics, Inc. Method for purifying thrombopoietin
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
AU744086B2 (en) 1997-12-03 2002-02-14 Roche Diagnostics Gmbh Erythropoietin with high specific activity
JP4160652B2 (ja) 1998-05-22 2008-10-01 キリンファーマ株式会社 エンド−β−Ｎ−アセチルグルコサミニダーゼ遺伝子
EP1105466B1 (en) 1998-08-14 2006-04-26 Merck & Co., Inc. Process for purifying human papillomavirus virus-like particles
US6156178A (en) 1999-07-13 2000-12-05 Molecular Dynamics, Inc. Increased throughput analysis of small compounds using multiple temporally spaced injections
CN1107116C (zh) 2000-12-20 2003-04-30 华南理工大学 糖液脱色的离子交换树脂再生液及其再生方法
JP4260005B2 (ja) 2001-07-10 2009-04-30 良行 永江 コーティング剤
JP4363986B2 (ja) * 2001-12-21 2009-11-11 イミュネックス・コーポレーション タンパク質の精製方法
FR2834227A1 (fr) 2001-12-27 2003-07-04 Chiralsep Sarl Materiaux supports optiquement actifs, leur procede de preparation et leurs utilisations
CN1311076C (zh) 2003-04-16 2007-04-18 普罗特奥姆技术公司 生产重组尿激酶的方法
BRPI0415887B1 (pt) 2003-10-27 2021-01-26 Wyeth métodos para a remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatita
ES2349112T3 (es) 2005-01-14 2010-12-28 Bayer Healthcare Llc Método de purificación de factor vii.
BRPI0608584B8 (pt) 2005-03-11 2021-05-25 Wyeth Corp métodos de recuperar um produto purificado
US20060246544A1 (en) 2005-03-30 2006-11-02 Neose Technologies,Inc. Manufacturing process for the production of peptides grown in insect cell lines
EP2069387A4 (en) 2006-06-14 2011-02-02 Glaxosmithkline Llc METHODS OF PURIFYING ANTIBODIES USING HYDROXYAPATITE CERAMIC
JP2010501623A (ja) 2006-08-28 2010-01-21 アレス トレーディング ソシエテ アノニム Ｆｃ含有タンパク質の精製法
CA2683977C (en) 2007-03-14 2017-04-25 Ligocyte Pharmaceuticals, Inc. A method of norovirus virus-like particle purification comprising ion exchange chromatography
CA2681294C (en) 2007-03-23 2014-05-06 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
US8569032B2 (en) 2007-05-18 2013-10-29 Tokyo Metropolitan Institute Of Medical Science Proteins having acquired A-galactosidase activity
CN103157400B (zh) 2007-06-21 2014-12-24 简·探针公司 用于将容器暴露于多个热区的仪器和方法
US8093364B2 (en) 2008-01-18 2012-01-10 Bio-Rad Laboratories, Inc. Enhanced purification of antibodies and antibody fragments by apatite chromatography
SG188143A1 (en) 2008-02-08 2013-03-28 Ambrx Inc Modified leptin polypeptides and their uses
WO2009126603A1 (en) * 2008-04-08 2009-10-15 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
US7635791B2 (en) 2008-04-17 2009-12-22 Tpat Ip Llc Biological buffers with wide buffering ranges
EP2291388A4 (en) * 2008-06-03 2013-02-13 Patrys Ltd METHOD FOR PURIFYING ANTIBODIES
CA2736141C (en) 2008-09-23 2018-03-20 F. Hoffmann-La Roche Ag Purification of erythropoietin
EP2350130B1 (en) 2008-10-31 2018-10-03 Wyeth LLC Purification of acidic proteins using ceramic hydroxyapatite chromatography
JP5863640B2 (ja) * 2009-04-29 2016-02-16 バイオ−ラッド ラボラトリーズ インコーポレーティッド 免疫複合体の精製
JP5956331B2 (ja) 2009-06-16 2016-07-27 ジェンザイム・コーポレーション 組換えａａｖベクターの改良された精製方法
CA2787009C (en) * 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
US8529859B2 (en) * 2010-03-09 2013-09-10 Lawrence Livermore National Security, Llc Method for fabricating apatite crystals and ceramics
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
JP5881744B2 (ja) * 2011-02-02 2016-03-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド アルカリ溶液でのアパタイトの表面中和方法
US9815695B2 (en) * 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
EP3157863B1 (en) * 2014-06-23 2023-06-21 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN105392569B (zh) * 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
WO2017074767A1 (en) * 2015-10-28 2017-05-04 Bio-Rad Laboratories, Inc. Surface neutralization of apatite

Also Published As

Publication number Publication date
EP2670704A4 (en) 2014-08-20
US20170312653A1 (en) 2017-11-02
CA2825651C (en) 2020-03-24
JP2014507368A (ja) 2014-03-27
US20120192901A1 (en) 2012-08-02
WO2012106449A1 (en) 2012-08-09
US9737829B2 (en) 2017-08-22
CA2825651A1 (en) 2012-08-09
US9950279B2 (en) 2018-04-24
EP2670704B1 (en) 2018-12-12
US20170157533A1 (en) 2017-06-08
US9592540B2 (en) 2017-03-14
EP2670704A1 (en) 2013-12-11

Similar Documents

Publication Publication Date Title
US9950279B2 (en) Apatite surface neutralization with alkali solutions
JP5773454B2 (ja) アパタイトの表面中和方法
JP5624476B2 (ja) アパタイトクロマトグラフィーによるリン酸化生体分子および非リン酸化生体分子の向上した精製法
JP5064225B2 (ja) 抗体精製法
JP5793080B2 (ja) セラミックヒドロキシアパタイトクロマトグラフィーを使用する酸性タンパク質の精製
JP2023145727A (ja) プロテインａクロマトグラフィー中の不純物の除去を促進する方法
JP2014507368A5 (enExample)
CN108348820A (zh) 磷灰石的表面中和

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141205

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141205

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150603

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150619

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150729

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20151026

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151130

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151201

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160106

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160202

R150 Certificate of patent or registration of utility model

Ref document number: 5881744

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250