JP5881744B2 - アルカリ溶液でのアパタイトの表面中和方法 - Google Patents
アルカリ溶液でのアパタイトの表面中和方法 Download PDFInfo
- Publication number
- JP5881744B2 JP5881744B2 JP2013552605A JP2013552605A JP5881744B2 JP 5881744 B2 JP5881744 B2 JP 5881744B2 JP 2013552605 A JP2013552605 A JP 2013552605A JP 2013552605 A JP2013552605 A JP 2013552605A JP 5881744 B2 JP5881744 B2 JP 5881744B2
- Authority
- JP
- Japan
- Prior art keywords
- apatite
- target molecule
- solid surface
- contacting
- ceramic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/203—Equilibration or regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/34—Regenerating or reactivating
- B01J20/345—Regenerating or reactivating using a particular desorbing compound or mixture
- B01J20/3475—Regenerating or reactivating using a particular desorbing compound or mixture in the liquid phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438729P | 2011-02-02 | 2011-02-02 | |
| US61/438,729 | 2011-02-02 | ||
| PCT/US2012/023512 WO2012106449A1 (en) | 2011-02-02 | 2012-02-01 | Apatite surface neutralization with alkali solutions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507368A JP2014507368A (ja) | 2014-03-27 |
| JP2014507368A5 JP2014507368A5 (enExample) | 2015-12-17 |
| JP5881744B2 true JP5881744B2 (ja) | 2016-03-09 |
Family
ID=46576323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552605A Active JP5881744B2 (ja) | 2011-02-02 | 2012-02-01 | アルカリ溶液でのアパタイトの表面中和方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9592540B2 (enExample) |
| EP (1) | EP2670704B1 (enExample) |
| JP (1) | JP5881744B2 (enExample) |
| CA (1) | CA2825651C (enExample) |
| WO (1) | WO2012106449A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011088225A1 (en) | 2010-01-15 | 2011-07-21 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| EP2670704B1 (en) * | 2011-02-02 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| CN104136121B (zh) | 2012-02-14 | 2017-04-19 | 生物辐射实验室股份有限公司 | 减少离子交换色谱中的pH漂移 |
| US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| US9802822B2 (en) * | 2014-06-23 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| WO2015200299A2 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| WO2017074767A1 (en) * | 2015-10-28 | 2017-05-04 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| JP2020099909A (ja) * | 2020-03-17 | 2020-07-02 | HOYA Technosurgical株式会社 | 処理方法、生産方法およびハイドロキシアパタイト充填剤 |
| CN113351165B (zh) * | 2021-04-29 | 2023-04-14 | 中石化石油工程技术服务有限公司 | 矿区饮用水除氟工艺 |
| MA64853B1 (fr) | 2021-06-04 | 2025-11-28 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3737516A (en) * | 1971-03-05 | 1973-06-05 | Du Pont | Calcium-deficient hydroxylapatite for use in column chromatography |
| US4053561A (en) * | 1975-08-14 | 1977-10-11 | Stauffer Chemical Company | Removal of fluorine from phosphatic solutions |
| JP2507339B2 (ja) | 1986-08-11 | 1996-06-12 | 三井東圧化学株式会社 | 粗tPAの精製方法 |
| US4859342A (en) * | 1986-10-14 | 1989-08-22 | Suntory Limited | Process for industrially separating biopolymers |
| US5332503A (en) | 1993-04-16 | 1994-07-26 | Baxter International Inc. | Process for purifying collagenase |
| JP3216436B2 (ja) * | 1994-09-06 | 2001-10-09 | 三菱マテリアル株式会社 | 塩基性タンパク質吸着剤 |
| US5744587A (en) * | 1995-06-07 | 1998-04-28 | Zymogenetics, Inc. | Method for purifying thrombopoietin |
| US5783217A (en) * | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
| JP4220125B2 (ja) | 1997-12-03 | 2009-02-04 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 高い比活性を有するエリスロポエチン |
| JP4160652B2 (ja) | 1998-05-22 | 2008-10-01 | キリンファーマ株式会社 | エンド−β−N−アセチルグルコサミニダーゼ遺伝子 |
| BR9913026A (pt) | 1998-08-14 | 2001-09-25 | Merck & Co Inc | Processo de purificação de partìculas semelhantes a vìrus (vlps) de papilomavìrus recombinante, e, processo de preparação de um produto de vlp de papilomavìrus humano purificado adequado para uso em uma vacina para humano |
| US6156178A (en) | 1999-07-13 | 2000-12-05 | Molecular Dynamics, Inc. | Increased throughput analysis of small compounds using multiple temporally spaced injections |
| CN1107116C (zh) | 2000-12-20 | 2003-04-30 | 华南理工大学 | 糖液脱色的离子交换树脂再生液及其再生方法 |
| CN1547507A (zh) | 2001-07-10 | 2004-11-17 | 涂布剂、涂料和涂布剂的制造方法 | |
| MXPA04006053A (es) * | 2001-12-21 | 2005-03-31 | Immunex Corp | Metodos para purificacion de proteina. |
| FR2834227A1 (fr) | 2001-12-27 | 2003-07-04 | Chiralsep Sarl | Materiaux supports optiquement actifs, leur procede de preparation et leurs utilisations |
| CN1311076C (zh) | 2003-04-16 | 2007-04-18 | 普罗特奥姆技术公司 | 生产重组尿激酶的方法 |
| PT1678208E (pt) * | 2003-10-27 | 2013-07-10 | Wyeth Llc | Remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatite |
| DK1841863T3 (da) | 2005-01-14 | 2010-11-29 | Bayer Healthcare Llc | Fremgangsmåde til rensning af faktor VII |
| WO2006099308A2 (en) | 2005-03-11 | 2006-09-21 | Wyeth | A method of weak partitioning chromatography |
| EP1866427A4 (en) | 2005-03-30 | 2010-09-01 | Novo Nordisk As | METHOD OF MANUFACTURING PEPTIDES PRODUCED IN INSECT CELL LINES |
| WO2009017491A1 (en) | 2006-06-14 | 2009-02-05 | Smithkline Beecham Corporation | Methods for purifying antibodies using ceramic hydroxyapatite |
| FI2061803T4 (fi) | 2006-08-28 | 2023-03-14 | Process for the purification of fc-containing proteins | |
| CA2683977C (en) | 2007-03-14 | 2017-04-25 | Ligocyte Pharmaceuticals, Inc. | A method of norovirus virus-like particle purification comprising ion exchange chromatography |
| EP2138505B1 (en) | 2007-03-23 | 2014-08-06 | Asahi Kasei Pharma Corporation | Method for producing soluble thrombomodulin of high purity |
| JP5507242B2 (ja) | 2007-05-18 | 2014-05-28 | 公益財団法人東京都医学総合研究所 | 酵素補充療法用医薬組成物 |
| CA2691197C (en) | 2007-06-21 | 2013-03-12 | Gen-Probe Incorporated | Instrument and receptacles for use in performing processes |
| WO2009092014A1 (en) * | 2008-01-18 | 2009-07-23 | Gagnon Peter S | Enhanced purification of antibodies and antibody fragments by apatite chromatography |
| US9938333B2 (en) | 2008-02-08 | 2018-04-10 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
| JP5999899B2 (ja) * | 2008-04-08 | 2016-09-28 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 抗体のクロマトグラフィー精製法 |
| US7635791B2 (en) | 2008-04-17 | 2009-12-22 | Tpat Ip Llc | Biological buffers with wide buffering ranges |
| CA2726823A1 (en) | 2008-06-03 | 2009-12-10 | Patrys Limited | Process for purification of antibodies |
| EP2334699B1 (en) | 2008-09-23 | 2013-09-11 | F. Hoffmann-La Roche AG | Purification of erythropoietin |
| US8058407B2 (en) | 2008-10-31 | 2011-11-15 | Wyeth Llc | Purification of acidic proteins using ceramic hydroxyapatite chromatography |
| US8481694B2 (en) * | 2009-04-29 | 2013-07-09 | Bio-Rad Laboratories, Inc. | Purification of immunoconjugates |
| HUE040636T2 (hu) | 2009-06-16 | 2019-03-28 | Genzyme Corp | Javított eljárások rekombináns AAV-vektorok tisztítására |
| WO2011088225A1 (en) * | 2010-01-15 | 2011-07-21 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| US8529859B2 (en) * | 2010-03-09 | 2013-09-10 | Lawrence Livermore National Security, Llc | Method for fabricating apatite crystals and ceramics |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| EP2670704B1 (en) * | 2011-02-02 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| US9815695B2 (en) * | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| WO2015200299A2 (en) * | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| US9802822B2 (en) * | 2014-06-23 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| WO2017074767A1 (en) * | 2015-10-28 | 2017-05-04 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
-
2012
- 2012-02-01 EP EP12742721.9A patent/EP2670704B1/en active Active
- 2012-02-01 US US13/363,670 patent/US9592540B2/en active Active
- 2012-02-01 JP JP2013552605A patent/JP5881744B2/ja active Active
- 2012-02-01 CA CA2825651A patent/CA2825651C/en active Active
- 2012-02-01 WO PCT/US2012/023512 patent/WO2012106449A1/en not_active Ceased
-
2017
- 2017-02-14 US US15/432,755 patent/US9737829B2/en active Active
- 2017-07-19 US US15/654,275 patent/US9950279B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9737829B2 (en) | 2017-08-22 |
| JP2014507368A (ja) | 2014-03-27 |
| US20170312653A1 (en) | 2017-11-02 |
| US20170157533A1 (en) | 2017-06-08 |
| WO2012106449A1 (en) | 2012-08-09 |
| CA2825651A1 (en) | 2012-08-09 |
| CA2825651C (en) | 2020-03-24 |
| EP2670704B1 (en) | 2018-12-12 |
| EP2670704A4 (en) | 2014-08-20 |
| US9950279B2 (en) | 2018-04-24 |
| EP2670704A1 (en) | 2013-12-11 |
| US20120192901A1 (en) | 2012-08-02 |
| US9592540B2 (en) | 2017-03-14 |
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