JP2013514073A5 - - Google Patents
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- Publication number
- JP2013514073A5 JP2013514073A5 JP2012543787A JP2012543787A JP2013514073A5 JP 2013514073 A5 JP2013514073 A5 JP 2013514073A5 JP 2012543787 A JP2012543787 A JP 2012543787A JP 2012543787 A JP2012543787 A JP 2012543787A JP 2013514073 A5 JP2013514073 A5 JP 2013514073A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- matrix
- arginine
- antibody fragment
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28805909P | 2009-12-18 | 2009-12-18 | |
| US61/288,059 | 2009-12-18 | ||
| PCT/EP2010/070076 WO2011073389A1 (en) | 2009-12-18 | 2010-12-17 | Wash solution and method for affinity chromatography |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016021798A Division JP2016128495A (ja) | 2009-12-18 | 2016-02-08 | 洗浄溶液及びアフィニティークロマトグラフィーの方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514073A JP2013514073A (ja) | 2013-04-25 |
| JP2013514073A5 true JP2013514073A5 (enExample) | 2014-02-13 |
| JP5909450B2 JP5909450B2 (ja) | 2016-04-26 |
Family
ID=43598315
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543787A Active JP5909450B2 (ja) | 2009-12-18 | 2010-12-17 | 洗浄溶液及びアフィニティークロマトグラフィーの方法 |
| JP2016021798A Pending JP2016128495A (ja) | 2009-12-18 | 2016-02-08 | 洗浄溶液及びアフィニティークロマトグラフィーの方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016021798A Pending JP2016128495A (ja) | 2009-12-18 | 2016-02-08 | 洗浄溶液及びアフィニティークロマトグラフィーの方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9505803B2 (enExample) |
| EP (2) | EP2513134B1 (enExample) |
| JP (2) | JP5909450B2 (enExample) |
| KR (1) | KR101858266B1 (enExample) |
| CN (1) | CN102725304B (enExample) |
| AU (1) | AU2010332778B2 (enExample) |
| BR (1) | BR112012014937B1 (enExample) |
| CA (1) | CA2784278C (enExample) |
| DK (2) | DK3272764T3 (enExample) |
| ES (2) | ES2651065T3 (enExample) |
| IL (1) | IL220164B (enExample) |
| LT (2) | LT2513134T (enExample) |
| MX (1) | MX2012007103A (enExample) |
| PL (2) | PL2513134T3 (enExample) |
| PT (2) | PT2513134T (enExample) |
| RU (1) | RU2564569C2 (enExample) |
| SG (2) | SG181771A1 (enExample) |
| WO (1) | WO2011073389A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX353340B (es) | 2006-09-13 | 2018-01-09 | Abbvie Inc | Mejoras de cultivos celulares. |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| TW201024318A (en) * | 2008-10-20 | 2010-07-01 | Abbott Lab | Isolation and purification of antibodies using protein A affinity chromatography |
| SG195577A1 (en) | 2008-10-20 | 2013-12-30 | Abbott Lab | Viral inactivation during purification of antibodies |
| DK3272764T3 (da) | 2009-12-18 | 2024-05-06 | Novartis Ag | Fremgangsmåde til affinitetskromatografi |
| KR101753569B1 (ko) * | 2010-01-22 | 2017-07-04 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｆｃ―함유 단백질을 정제하는 크로마토그래피 방법 |
| ES2688348T3 (es) * | 2011-06-01 | 2018-11-02 | Novartis Ag | Solución y método de lavado para cromatografía de afinidad |
| HRP20240230T1 (hr) | 2011-10-11 | 2024-04-26 | F. Hoffmann - La Roche Ag | Poboljšani sklop bispecifičnih protutijela |
| JP2016519145A (ja) * | 2013-05-15 | 2016-06-30 | メディミューン リミテッド | 組換え産生ポリペプチドの精製 |
| JP6602765B2 (ja) * | 2013-09-05 | 2019-11-06 | ジェネンテック， インコーポレイテッド | クロマトグラフィー再使用のための方法 |
| CN105407905B (zh) | 2014-01-03 | 2020-03-03 | 生物辐射实验室股份有限公司 | 蛋白a洗脱产物中杂质的去除 |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| EP3268100A1 (en) | 2015-03-13 | 2018-01-17 | Bristol-Myers Squibb Company | Use of alkaline washes during chromatography to remove impurities |
| WO2017032610A1 (en) * | 2015-08-21 | 2017-03-02 | F. Hoffmann-La Roche Ag | Affinity chromatography purification with low conductivity wash buffer |
| ES2877532T3 (es) | 2015-08-21 | 2021-11-17 | Hoffmann La Roche | Procedimiento para la reducción de proteínas de célula huésped en cromatografía de afinidad |
| ES2874974T3 (es) | 2016-05-11 | 2021-11-05 | Cytiva Bioprocess R & D Ab | Matriz de separación |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| ES2909833T3 (es) | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
| JP7106187B2 (ja) | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
| US10688412B2 (en) * | 2016-07-25 | 2020-06-23 | Cehpalon, Inc. | Affinity chromatography wash buffer |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| ES2887046T3 (es) | 2017-08-17 | 2021-12-21 | Just Evotec Biologics Inc | Método de purificación de proteína glicosilada a partir de galectinas de las células hospedadoras y otros contaminantes |
| CN107793469B (zh) * | 2017-10-16 | 2021-07-30 | 上海药明生物技术有限公司 | 一种去除宿主细胞蛋白含量的亲和纯化工艺 |
| JP7786876B2 (ja) | 2017-12-21 | 2025-12-16 | ジェンザイム・コーポレーション | プロテインａクロマトグラフィー中の不純物の除去を促進する方法 |
| WO2019183334A1 (en) | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
| EP3774881A1 (en) | 2018-04-02 | 2021-02-17 | Amgen Inc. | Erenumab compositions and uses thereof |
| US11612885B2 (en) * | 2018-05-08 | 2023-03-28 | Waters Technologies Corporation | Methods, compositions and kits useful for pH gradient cation exchange chromatography |
| KR102893280B1 (ko) * | 2018-08-14 | 2025-12-01 | 브리스톨-마이어스 스큅 컴퍼니 | 개선된 단백질 회수 |
| US20230399358A1 (en) * | 2019-10-08 | 2023-12-14 | North Carolina State University | Immunoglobulin purification peptides and their use |
| US20240262928A1 (en) * | 2020-03-27 | 2024-08-08 | Haemalogix Pty Ltd | Composition and Method |
| WO2021222120A1 (en) * | 2020-04-27 | 2021-11-04 | Alexion Pharmaceuticals, Inc. | Protein a chromatography purification of an antibody |
| CN112827217A (zh) * | 2020-12-29 | 2021-05-25 | 苏州良辰生物医药科技有限公司 | 一种层析柱清洗液及其应用 |
| AU2023394724A1 (en) * | 2022-12-12 | 2025-07-31 | H. Lundbeck A/S | Arginine wash in protein purification |
| WO2024233992A2 (en) * | 2023-05-11 | 2024-11-14 | Trophogen, Inc. | Methods of manufacturing highly glycosylated glycoprotein hormones and their analogs |
| EP4729534A1 (en) | 2024-10-21 | 2026-04-22 | Technische Universität München, in Vertretung des Freistaats Bayern | Polypeptides comprising protein domains linked via rigid amino acid linkers |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704366A (en) | 1984-06-22 | 1987-11-03 | Bio-Rad Laboratories, Inc. | Process for binding IgG to protein A |
| US4857320A (en) * | 1987-02-19 | 1989-08-15 | Monsanto Company | Method of enhancing the solubility of tissue plasminogen activator |
| JPH01238534A (ja) * | 1988-03-17 | 1989-09-22 | Mitsui Toatsu Chem Inc | エンドトキシンの除去方法 |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| ES2337091T3 (es) | 1996-11-27 | 2010-04-20 | Genentech, Inc. | Purificacion por afinidad de polipeptido en una matriz de proteina. |
| BRPI9910332B8 (pt) | 1998-05-06 | 2021-05-25 | Genentech Inc | método para purificação de um polipeptídio a partir de uma composição |
| EP1084136B1 (en) | 1998-06-01 | 2004-08-25 | Genentech, Inc. | Separation of antibody monomers from its multimers by use of ion-exchange chromatography |
| EP3088412B1 (en) | 2001-03-09 | 2021-05-05 | Chugai Seiyaku Kabushiki Kaisha | Protein purification method |
| ES2266535T3 (es) | 2001-06-05 | 2007-03-01 | Genetics Institute, Llc | Procedimientos relativos a la purificacion de proteinas altamente anionicas. |
| CA2473144C (en) | 2002-02-05 | 2013-05-28 | Genentech, Inc. | Protein purification |
| ES2626268T3 (es) | 2002-09-11 | 2017-07-24 | Chugai Seiyaku Kabushiki Kaisha | Método de purificación de proteínas |
| JP2006514100A (ja) * | 2002-10-24 | 2006-04-27 | イーノス・ファーマシューティカルス・インコーポレーテッド | 徐放性ｌ−アルギニン製剤並びに製造方法および使用方法 |
| EP1575516B1 (en) * | 2002-11-26 | 2012-05-30 | Abbott Biotherapeutics Corp. | Chimeric and humanized antibodies to alpha5 beta1 integrin that modulate angiogenesis |
| DK1599222T3 (da) * | 2003-01-08 | 2009-04-27 | Novartis Vaccines & Diagnostic | Stabiliserede vandige pr parater omfattende v vsfaktorvej-inhibitor (TFPI) eller v vsfaktorvej-inhibitorvariant |
| GB0304576D0 (en) | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| CA2516518A1 (en) | 2003-02-28 | 2004-09-10 | Lonza Biologics Plc. | Antibody purification by protein a and ion exchange chromatography |
| RU2409591C2 (ru) | 2003-10-27 | 2011-01-20 | Вайет | Удаление агрегатов с высокой молекулярной массой путем хроматографии на гидроксиапатитах |
| US8084032B2 (en) | 2004-01-21 | 2011-12-27 | Ajinomoto Co., Inc. | Purification method which prevents denaturation of an antibody |
| EP1698637B1 (en) | 2005-03-03 | 2008-10-15 | Ajinomoto Co., Inc. | A method for improving recovery yield in protein purification with gel filtration chromatography using arginine |
| DK1869065T3 (da) | 2005-03-11 | 2020-06-08 | Wyeth Llc | Fremgangsmåde til kromatografi med svag opdeling |
| CN101365948B (zh) | 2006-01-06 | 2012-11-07 | Emd密理博公司 | 亲和层析基质及其制备和使用方法 |
| US8263750B2 (en) | 2006-03-16 | 2012-09-11 | Amgen Inc. | Method for purifying a protein using protein-A affinity chromatography using an intermediate wash step |
| EP2001898A1 (en) | 2006-03-20 | 2008-12-17 | Medarex Inc. | Protein purification |
| MX2008015263A (es) * | 2006-06-02 | 2008-12-17 | Wyeth Corp | Uso de proteinas y pepetidos de la superfamilia del factor beta transformador de crecimiento para purificacion y metodos terapeuticos. |
| US7754689B2 (en) | 2006-06-02 | 2010-07-13 | Wyeth Llc | Finger-1 peptide analogs of the TGF-β superfamily |
| US8513393B2 (en) | 2006-08-28 | 2013-08-20 | Ares Trading S.A. | Process for the purification of Fc-containing proteins |
| AR062711A1 (es) * | 2006-09-08 | 2008-11-26 | Wyeth Corp | Lavado de arginina en l a purificacion de proteinas usando cromatografia de afinidad |
| JP2010516651A (ja) | 2007-01-17 | 2010-05-20 | メルク セローノ ソシエテ アノニム | Ｆｃ含有タンパク質の精製のための方法 |
| MX2009012786A (es) | 2007-06-01 | 2009-12-10 | Hoffmann La Roche | Purificacion de inmunoglobulina. |
| EP2281000A2 (en) | 2008-05-15 | 2011-02-09 | Novo Nordisk A/S | Antibody purification process |
| WO2010019493A1 (en) | 2008-08-14 | 2010-02-18 | Merck Sharp & Dohme Corp. | Methods for purifying antibodies using protein a affinity chromatography |
| DK3272764T3 (da) | 2009-12-18 | 2024-05-06 | Novartis Ag | Fremgangsmåde til affinitetskromatografi |
| ES2688348T3 (es) | 2011-06-01 | 2018-11-02 | Novartis Ag | Solución y método de lavado para cromatografía de afinidad |
-
2010
- 2010-12-17 DK DK17188657.5T patent/DK3272764T3/da active
- 2010-12-17 CA CA2784278A patent/CA2784278C/en active Active
- 2010-12-17 EP EP10790452.6A patent/EP2513134B1/en not_active Revoked
- 2010-12-17 SG SG2012044707A patent/SG181771A1/en unknown
- 2010-12-17 PT PT107904526T patent/PT2513134T/pt unknown
- 2010-12-17 PL PL10790452T patent/PL2513134T3/pl unknown
- 2010-12-17 RU RU2012130151/10A patent/RU2564569C2/ru active
- 2010-12-17 EP EP17188657.5A patent/EP3272764B1/en active Active
- 2010-12-17 BR BR112012014937-7A patent/BR112012014937B1/pt active IP Right Grant
- 2010-12-17 AU AU2010332778A patent/AU2010332778B2/en active Active
- 2010-12-17 LT LTEP10790452.6T patent/LT2513134T/lt unknown
- 2010-12-17 SG SG10201408384PA patent/SG10201408384PA/en unknown
- 2010-12-17 ES ES10790452.6T patent/ES2651065T3/es active Active
- 2010-12-17 KR KR1020127015524A patent/KR101858266B1/ko active Active
- 2010-12-17 ES ES17188657T patent/ES2982297T3/es active Active
- 2010-12-17 CN CN201080057457.6A patent/CN102725304B/zh active Active
- 2010-12-17 JP JP2012543787A patent/JP5909450B2/ja active Active
- 2010-12-17 MX MX2012007103A patent/MX2012007103A/es unknown
- 2010-12-17 PT PT171886575T patent/PT3272764T/pt unknown
- 2010-12-17 LT LTEP17188657.5T patent/LT3272764T/lt unknown
- 2010-12-17 WO PCT/EP2010/070076 patent/WO2011073389A1/en not_active Ceased
- 2010-12-17 US US13/516,960 patent/US9505803B2/en active Active
- 2010-12-17 DK DK10790452.6T patent/DK2513134T3/en active
- 2010-12-17 PL PL17188657.5T patent/PL3272764T3/pl unknown
-
2012
- 2012-06-04 IL IL220164A patent/IL220164B/en active IP Right Grant
-
2016
- 2016-02-08 JP JP2016021798A patent/JP2016128495A/ja active Pending
- 2016-10-28 US US15/336,878 patent/US20170044211A1/en not_active Abandoned
-
2019
- 2019-03-25 US US16/363,170 patent/US20190233469A1/en not_active Abandoned
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