RU2564569C2 - Промывочный раствор и способ промывки для аффинной хроматографии - Google Patents

Промывочный раствор и способ промывки для аффинной хроматографии Download PDF

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Publication number
RU2564569C2
RU2564569C2 RU2012130151/10A RU2012130151A RU2564569C2 RU 2564569 C2 RU2564569 C2 RU 2564569C2 RU 2012130151/10 A RU2012130151/10 A RU 2012130151/10A RU 2012130151 A RU2012130151 A RU 2012130151A RU 2564569 C2 RU2564569 C2 RU 2564569C2
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Russia
Prior art keywords
protein
arginine
washing
concentration
antibody
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RU2012130151/10A
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English (en)
Russian (ru)
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RU2012130151A (ru
Inventor
ФРАУЕНШУХ Ахим
БИЛЛЬ Курт
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Новартис Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43598315&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2564569(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2012130151A publication Critical patent/RU2012130151A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2012130151/10A 2009-12-18 2010-12-17 Промывочный раствор и способ промывки для аффинной хроматографии RU2564569C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28805909P 2009-12-18 2009-12-18
US61/288,059 2009-12-18
PCT/EP2010/070076 WO2011073389A1 (en) 2009-12-18 2010-12-17 Wash solution and method for affinity chromatography

Publications (2)

Publication Number Publication Date
RU2012130151A RU2012130151A (ru) 2014-01-27
RU2564569C2 true RU2564569C2 (ru) 2015-10-10

Family

ID=43598315

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012130151/10A RU2564569C2 (ru) 2009-12-18 2010-12-17 Промывочный раствор и способ промывки для аффинной хроматографии

Country Status (18)

Country Link
US (3) US9505803B2 (enExample)
EP (2) EP3272764B1 (enExample)
JP (2) JP5909450B2 (enExample)
KR (1) KR101858266B1 (enExample)
CN (1) CN102725304B (enExample)
AU (1) AU2010332778B2 (enExample)
BR (1) BR112012014937B1 (enExample)
CA (1) CA2784278C (enExample)
DK (2) DK3272764T3 (enExample)
ES (2) ES2982297T3 (enExample)
IL (1) IL220164B (enExample)
LT (2) LT2513134T (enExample)
MX (1) MX2012007103A (enExample)
PL (2) PL2513134T3 (enExample)
PT (2) PT2513134T (enExample)
RU (1) RU2564569C2 (enExample)
SG (2) SG10201408384PA (enExample)
WO (1) WO2011073389A1 (enExample)

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US12528835B2 (en) 2017-12-21 2026-01-20 Genzyme Corporation Methods for enhanced removal of impurities during protein a chromatography

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CN107793469B (zh) * 2017-10-16 2021-07-30 上海药明生物技术有限公司 一种去除宿主细胞蛋白含量的亲和纯化工艺
US11155575B2 (en) 2018-03-21 2021-10-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
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CN112105927B (zh) * 2018-05-08 2024-06-25 沃特世科技公司 可用于pH梯度阳离子交换色谱法的方法、组合物和试剂盒
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JP7817945B2 (ja) * 2020-03-27 2026-02-19 ハエマロジックス・リミテッド 組成物および方法
US20230143163A1 (en) * 2020-04-27 2023-05-11 Alexion Pharmaceuticals, Inc. Protein a chromatography purification of an antibody
CN112827217A (zh) * 2020-12-29 2021-05-25 苏州良辰生物医药科技有限公司 一种层析柱清洗液及其应用
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EP4729534A1 (en) 2024-10-21 2026-04-22 Technische Universität München, in Vertretung des Freistaats Bayern Polypeptides comprising protein domains linked via rigid amino acid linkers

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KR101953405B1 (ko) 2011-06-01 2019-02-28 노파르티스 아게 친화성 크로마토그래피를 위한 세척 용액 및 방법

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2773852C2 (ru) * 2017-12-21 2022-06-14 Джензим Корпорейшн Способы улучшенного удаления примесей при проведении хроматографии на основе связывания с белком а
US12528835B2 (en) 2017-12-21 2026-01-20 Genzyme Corporation Methods for enhanced removal of impurities during protein a chromatography

Also Published As

Publication number Publication date
BR112012014937B1 (pt) 2021-01-19
CN102725304A (zh) 2012-10-10
PL3272764T3 (pl) 2024-06-10
LT2513134T (lt) 2017-11-27
IL220164A0 (en) 2012-07-31
JP5909450B2 (ja) 2016-04-26
LT3272764T (lt) 2024-05-10
US20190233469A1 (en) 2019-08-01
PT3272764T (pt) 2024-04-24
KR20120109506A (ko) 2012-10-08
IL220164B (en) 2019-02-28
MX2012007103A (es) 2012-07-17
SG10201408384PA (en) 2015-01-29
PL2513134T3 (pl) 2018-02-28
WO2011073389A1 (en) 2011-06-23
BR112012014937A2 (pt) 2016-03-08
DK2513134T3 (en) 2017-12-18
EP3272764A1 (en) 2018-01-24
AU2010332778B2 (en) 2015-03-19
ES2651065T3 (es) 2018-01-24
KR101858266B1 (ko) 2018-05-15
US20120283416A1 (en) 2012-11-08
EP2513134A1 (en) 2012-10-24
US9505803B2 (en) 2016-11-29
EP3272764B1 (en) 2024-02-07
JP2013514073A (ja) 2013-04-25
RU2012130151A (ru) 2014-01-27
US20170044211A1 (en) 2017-02-16
EP2513134B1 (en) 2017-09-06
JP2016128495A (ja) 2016-07-14
ES2982297T3 (es) 2024-10-15
PT2513134T (pt) 2017-12-14
AU2010332778A1 (en) 2012-07-19
CA2784278A1 (en) 2011-06-23
CA2784278C (en) 2019-02-26
DK3272764T3 (da) 2024-05-06
CN102725304B (zh) 2015-12-09
SG181771A1 (en) 2012-07-30

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