JP2015503524A5 - - Google Patents
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- Publication number
- JP2015503524A5 JP2015503524A5 JP2014549204A JP2014549204A JP2015503524A5 JP 2015503524 A5 JP2015503524 A5 JP 2015503524A5 JP 2014549204 A JP2014549204 A JP 2014549204A JP 2014549204 A JP2014549204 A JP 2014549204A JP 2015503524 A5 JP2015503524 A5 JP 2015503524A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- membrane
- eluate
- interest
- ion exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012528 membrane Substances 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 30
- 239000000356 contaminant Substances 0.000 claims description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 238000000746 purification Methods 0.000 claims description 12
- 238000005341 cation exchange Methods 0.000 claims description 11
- 229920000831 ionic polymer Polymers 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 239000003011 anion exchange membrane Substances 0.000 claims description 7
- 239000003014 ion exchange membrane Substances 0.000 claims description 7
- 239000000872 buffer Substances 0.000 claims description 6
- 229920002873 Polyethylenimine Polymers 0.000 claims description 5
- 238000011210 chromatographic step Methods 0.000 claims description 5
- 238000005349 anion exchange Methods 0.000 claims description 4
- 238000005571 anion exchange chromatography Methods 0.000 claims description 4
- 238000005277 cation exchange chromatography Methods 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 3
- 239000003463 adsorbent Substances 0.000 claims description 2
- 238000004255 ion exchange chromatography Methods 0.000 claims 6
- 238000011091 antibody purification Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 108091008038 CHOP Proteins 0.000 description 8
- 102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 101100075829 Caenorhabditis elegans mab-3 gene Proteins 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 4
- 229930182566 Gentamicin Natural products 0.000 description 4
- 229960002518 gentamicin Drugs 0.000 description 4
- 238000001042 affinity chromatography Methods 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 238000001742 protein purification Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 101100476210 Caenorhabditis elegans rnt-1 gene Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- -1 salt ions Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579285P | 2011-12-22 | 2011-12-22 | |
| US61/579,285 | 2011-12-22 | ||
| PCT/US2012/070373 WO2013096322A1 (en) | 2011-12-22 | 2012-12-18 | Ion exchange membrane chromatography |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023128A Division JP2018109024A (ja) | 2011-12-22 | 2018-02-13 | イオン交換膜クロマトグラフィー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015503524A JP2015503524A (ja) | 2015-02-02 |
| JP2015503524A5 true JP2015503524A5 (enExample) | 2017-06-15 |
| JP6605202B2 JP6605202B2 (ja) | 2019-11-13 |
Family
ID=47430154
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549204A Active JP6605202B2 (ja) | 2011-12-22 | 2012-12-18 | イオン交換膜クロマトグラフィー |
| JP2018023128A Withdrawn JP2018109024A (ja) | 2011-12-22 | 2018-02-13 | イオン交換膜クロマトグラフィー |
| JP2019193276A Active JP7402011B2 (ja) | 2011-12-22 | 2019-10-24 | イオン交換膜クロマトグラフィー |
| JP2021102974A Active JP7359807B2 (ja) | 2011-12-22 | 2021-06-22 | イオン交換膜クロマトグラフィー |
| JP2022050501A Pending JP2022101557A (ja) | 2011-12-22 | 2022-03-25 | イオン交換膜クロマトグラフィー |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023128A Withdrawn JP2018109024A (ja) | 2011-12-22 | 2018-02-13 | イオン交換膜クロマトグラフィー |
| JP2019193276A Active JP7402011B2 (ja) | 2011-12-22 | 2019-10-24 | イオン交換膜クロマトグラフィー |
| JP2021102974A Active JP7359807B2 (ja) | 2011-12-22 | 2021-06-22 | イオン交換膜クロマトグラフィー |
| JP2022050501A Pending JP2022101557A (ja) | 2011-12-22 | 2022-03-25 | イオン交換膜クロマトグラフィー |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10364268B2 (enExample) |
| EP (2) | EP3492486A1 (enExample) |
| JP (5) | JP6605202B2 (enExample) |
| KR (3) | KR20210025692A (enExample) |
| CN (2) | CN108892706A (enExample) |
| AR (1) | AR089362A1 (enExample) |
| AU (3) | AU2012355356B2 (enExample) |
| BR (1) | BR112014015101A8 (enExample) |
| CA (1) | CA2859376C (enExample) |
| ES (1) | ES2697676T3 (enExample) |
| HR (1) | HRP20181846T1 (enExample) |
| IL (2) | IL267585B (enExample) |
| MX (2) | MX360453B (enExample) |
| MY (1) | MY172426A (enExample) |
| PL (1) | PL2794635T3 (enExample) |
| RU (1) | RU2648999C2 (enExample) |
| SG (1) | SG11201403437TA (enExample) |
| SI (1) | SI2794635T1 (enExample) |
| TR (1) | TR201815709T4 (enExample) |
| WO (1) | WO2013096322A1 (enExample) |
| ZA (2) | ZA201404593B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL267585B (en) * | 2011-12-22 | 2022-09-01 | Genentech Inc | Ion exchange membrane chromatography |
| CN110054661A (zh) | 2013-12-12 | 2019-07-26 | Emd密理博公司 | 使用含丙烯酰胺的过滤器分离蛋白 |
| CN106029682B (zh) | 2013-12-27 | 2021-04-13 | 中外制药株式会社 | 等电点低的抗体的纯化方法 |
| CN104693303B (zh) * | 2015-02-28 | 2018-03-13 | 苏州金盟生物技术有限公司 | 一种蛋白制品中的核酸去除方法 |
| EP3334747B1 (en) | 2015-08-13 | 2023-09-27 | Amgen Inc. | Charged depth filtration of antigen-binding proteins |
| GB201711481D0 (en) | 2017-07-17 | 2017-08-30 | Ucb Biopharma Sprl | Protein purification |
| EP3546475A1 (en) * | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| US10792618B2 (en) | 2018-06-19 | 2020-10-06 | Sartorius Stedim Biotech Gmbh | Particle separation and/or purification of a fluid |
| KR102140531B1 (ko) * | 2018-08-07 | 2020-08-04 | (주)휴온스 | Gly-Tβ4의 제조방법 |
| EP3837273B1 (en) * | 2018-08-14 | 2025-09-24 | Bristol-Myers Squibb Company | Improved protein recovery |
| GB201815405D0 (en) * | 2018-09-21 | 2018-11-07 | Fujifilm Mfg Europe Bv | Membranes suitable for detecting, filtering and/or purifying biomolecules |
| US12306152B2 (en) | 2018-12-21 | 2025-05-20 | Solventum Intellectual Properties Company | Method for testing a chromatography device used for ion exchange |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CN115335394A (zh) * | 2020-01-24 | 2022-11-11 | 奥克梅斯制药爱尔兰有限公司 | 纯化方法 |
| US11416468B2 (en) * | 2020-07-21 | 2022-08-16 | International Business Machines Corporation | Active-active system index management |
| CN116371011B (zh) * | 2023-05-26 | 2023-08-18 | 湖南杰萃生物技术有限公司 | 一种从桑叶中提取黄酮和生物碱的方法 |
| CN117866038B (zh) * | 2024-03-11 | 2024-05-28 | 北京百力格生物科技有限公司 | 纯化含有宿主核酸的带亲和标签的酸性蛋白的方法 |
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-
2012
- 2012-12-18 IL IL267585A patent/IL267585B/en unknown
- 2012-12-18 EP EP18193475.3A patent/EP3492486A1/en active Pending
- 2012-12-18 SI SI201231443T patent/SI2794635T1/sl unknown
- 2012-12-18 SG SG11201403437TA patent/SG11201403437TA/en unknown
- 2012-12-18 KR KR1020217005616A patent/KR20210025692A/ko not_active Ceased
- 2012-12-18 PL PL12806322T patent/PL2794635T3/pl unknown
- 2012-12-18 BR BR112014015101A patent/BR112014015101A8/pt not_active Application Discontinuation
- 2012-12-18 WO PCT/US2012/070373 patent/WO2013096322A1/en not_active Ceased
- 2012-12-18 MY MYPI2014701665A patent/MY172426A/en unknown
- 2012-12-18 CN CN201810818291.3A patent/CN108892706A/zh active Pending
- 2012-12-18 MX MX2014007622A patent/MX360453B/es active IP Right Grant
- 2012-12-18 EP EP12806322.9A patent/EP2794635B8/en active Active
- 2012-12-18 US US14/365,449 patent/US10364268B2/en active Active
- 2012-12-18 AU AU2012355356A patent/AU2012355356B2/en active Active
- 2012-12-18 CA CA2859376A patent/CA2859376C/en active Active
- 2012-12-18 KR KR1020147019968A patent/KR102067075B1/ko active Active
- 2012-12-18 ES ES12806322T patent/ES2697676T3/es active Active
- 2012-12-18 TR TR2018/15709T patent/TR201815709T4/tr unknown
- 2012-12-18 JP JP2014549204A patent/JP6605202B2/ja active Active
- 2012-12-18 KR KR1020207000846A patent/KR20200008022A/ko not_active Ceased
- 2012-12-18 HR HRP20181846TT patent/HRP20181846T1/hr unknown
- 2012-12-18 CN CN201280070369.9A patent/CN104125963B/zh active Active
- 2012-12-18 RU RU2014130017A patent/RU2648999C2/ru active
- 2012-12-20 AR ARP120104862A patent/AR089362A1/es not_active Application Discontinuation
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2014
- 2014-06-16 IL IL233158A patent/IL233158B/en active IP Right Grant
- 2014-06-20 MX MX2018013356A patent/MX2018013356A/es unknown
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