RU2648999C2 - Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии - Google Patents

Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии Download PDF

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RU2648999C2
RU2648999C2 RU2014130017A RU2014130017A RU2648999C2 RU 2648999 C2 RU2648999 C2 RU 2648999C2 RU 2014130017 A RU2014130017 A RU 2014130017A RU 2014130017 A RU2014130017 A RU 2014130017A RU 2648999 C2 RU2648999 C2 RU 2648999C2
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antibody
membrane
antibodies
interest
eluate
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RU2014130017A
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RU2014130017A (ru
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Джером Джозеф Мл. БИЛЛ
Арик Майкл БРАУН
Кристофер Джон ДАУД
Брук Эллен ТЭЙЕР
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Дженентек, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
RU2014130017A 2011-12-22 2012-12-18 Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии RU2648999C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579285P 2011-12-22 2011-12-22
US61/579,285 2011-12-22
PCT/US2012/070373 WO2013096322A1 (en) 2011-12-22 2012-12-18 Ion exchange membrane chromatography

Publications (2)

Publication Number Publication Date
RU2014130017A RU2014130017A (ru) 2016-02-10
RU2648999C2 true RU2648999C2 (ru) 2018-03-29

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RU2014130017A RU2648999C2 (ru) 2011-12-22 2012-12-18 Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии

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US (3) US10364268B2 (enExample)
EP (2) EP3492486A1 (enExample)
JP (5) JP6605202B2 (enExample)
KR (3) KR102067075B1 (enExample)
CN (2) CN104125963B (enExample)
AR (1) AR089362A1 (enExample)
AU (3) AU2012355356B2 (enExample)
BR (1) BR112014015101A8 (enExample)
CA (1) CA2859376C (enExample)
ES (1) ES2697676T3 (enExample)
HR (1) HRP20181846T1 (enExample)
IL (2) IL267585B (enExample)
MX (2) MX360453B (enExample)
MY (1) MY172426A (enExample)
PL (1) PL2794635T3 (enExample)
RU (1) RU2648999C2 (enExample)
SG (1) SG11201403437TA (enExample)
SI (1) SI2794635T1 (enExample)
TR (1) TR201815709T4 (enExample)
WO (1) WO2013096322A1 (enExample)
ZA (2) ZA201404593B (enExample)

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CN116425826A (zh) * 2021-12-30 2023-07-14 广州百济神州生物制药有限公司 一种快速纯化质量样品的方法
CN116371011B (zh) * 2023-05-26 2023-08-18 湖南杰萃生物技术有限公司 一种从桑叶中提取黄酮和生物碱的方法
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US11945837B2 (en) 2024-04-02
AR089362A1 (es) 2014-08-20
IL267585A (en) 2019-08-29
HK1203526A1 (en) 2015-10-30
CN104125963A (zh) 2014-10-29
JP2022101557A (ja) 2022-07-06
US20240247027A1 (en) 2024-07-25
JP2021169454A (ja) 2021-10-28
ZA201903994B (en) 2023-12-20
ZA201404593B (en) 2022-12-21
JP2018109024A (ja) 2018-07-12
MX2014007622A (es) 2014-09-22
AU2020201070A1 (en) 2020-03-05
SG11201403437TA (en) 2014-07-30
BR112014015101A2 (pt) 2017-06-13
BR112014015101A8 (pt) 2021-06-08
JP6605202B2 (ja) 2019-11-13
SI2794635T1 (sl) 2018-12-31
EP2794635A1 (en) 2014-10-29
WO2013096322A8 (en) 2014-02-27
EP2794635B8 (en) 2018-11-14
JP7402011B2 (ja) 2023-12-20
KR20200008022A (ko) 2020-01-22
NZ626949A (en) 2016-11-25
CA2859376C (en) 2022-04-19
TR201815709T4 (tr) 2018-11-21
JP7359807B2 (ja) 2023-10-11
CA2859376A1 (en) 2013-06-27
AU2012355356B2 (en) 2017-10-12
AU2012355356A1 (en) 2014-07-10
ES2697676T3 (es) 2019-01-25
KR20210025692A (ko) 2021-03-09
WO2013096322A9 (en) 2013-08-22
US20200102346A1 (en) 2020-04-02
IL233158A0 (en) 2014-07-31
JP2020040952A (ja) 2020-03-19
MX360453B (es) 2018-11-01
AU2018200194A1 (en) 2018-02-01
WO2013096322A1 (en) 2013-06-27
MY172426A (en) 2019-11-25
CN108892706A (zh) 2018-11-27
EP3492486A1 (en) 2019-06-05
RU2014130017A (ru) 2016-02-10
HRP20181846T1 (hr) 2018-12-28
IL233158B (en) 2019-07-31
MX2018013356A (es) 2020-09-14
PL2794635T3 (pl) 2019-02-28
AU2018200194B2 (en) 2019-11-14
US10364268B2 (en) 2019-07-30
KR20140114834A (ko) 2014-09-29
CN104125963B (zh) 2018-08-17
KR102067075B1 (ko) 2020-01-17
EP2794635B1 (en) 2018-09-12
JP2015503524A (ja) 2015-02-02
IL267585B (en) 2022-09-01
US20140348845A1 (en) 2014-11-27

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