AR089362A1 - Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico - Google Patents

Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico

Info

Publication number
AR089362A1
AR089362A1 ARP120104862A ARP120104862A AR089362A1 AR 089362 A1 AR089362 A1 AR 089362A1 AR P120104862 A ARP120104862 A AR P120104862A AR P120104862 A ARP120104862 A AR P120104862A AR 089362 A1 AR089362 A1 AR 089362A1
Authority
AR
Argentina
Prior art keywords
polypeptide
membrane
ion exchange
purification
effluent
Prior art date
Application number
ARP120104862A
Other languages
English (en)
Spanish (es)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47430154&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR089362(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR089362A1 publication Critical patent/AR089362A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
ARP120104862A 2011-12-22 2012-12-20 Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico AR089362A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161579285P 2011-12-22 2011-12-22

Publications (1)

Publication Number Publication Date
AR089362A1 true AR089362A1 (es) 2014-08-20

Family

ID=47430154

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104862A AR089362A1 (es) 2011-12-22 2012-12-20 Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico

Country Status (21)

Country Link
US (3) US10364268B2 (enExample)
EP (2) EP3492486A1 (enExample)
JP (5) JP6605202B2 (enExample)
KR (3) KR20200008022A (enExample)
CN (2) CN104125963B (enExample)
AR (1) AR089362A1 (enExample)
AU (3) AU2012355356B2 (enExample)
BR (1) BR112014015101A8 (enExample)
CA (1) CA2859376C (enExample)
ES (1) ES2697676T3 (enExample)
HR (1) HRP20181846T1 (enExample)
IL (2) IL267585B (enExample)
MX (2) MX360453B (enExample)
MY (1) MY172426A (enExample)
PL (1) PL2794635T3 (enExample)
RU (1) RU2648999C2 (enExample)
SG (1) SG11201403437TA (enExample)
SI (1) SI2794635T1 (enExample)
TR (1) TR201815709T4 (enExample)
WO (1) WO2013096322A1 (enExample)
ZA (2) ZA201404593B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX360453B (es) * 2011-12-22 2018-11-01 Genentech Inc Cromatografia de membrana de intercambio ionico.
CN105980047B (zh) 2013-12-12 2019-01-04 Emd密理博公司 使用含丙烯酰胺的过滤器分离蛋白
MY181081A (en) * 2013-12-27 2020-12-17 Chugai Pharmaceutical Co Ltd Method for purifying antibody having low isoelectric point
CN104693303B (zh) * 2015-02-28 2018-03-13 苏州金盟生物技术有限公司 一种蛋白制品中的核酸去除方法
SG10202101105XA (en) 2015-08-13 2021-03-30 Amgen Inc Charged depth filtration of antigen-binding proteins
GB201711481D0 (en) 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
EP3546475A1 (en) 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
US10792618B2 (en) 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
KR102140531B1 (ko) * 2018-08-07 2020-08-04 (주)휴온스 Gly-Tβ4의 제조방법
KR102893280B1 (ko) * 2018-08-14 2025-12-01 브리스톨-마이어스 스큅 컴퍼니 개선된 단백질 회수
GB201815405D0 (en) * 2018-09-21 2018-11-07 Fujifilm Mfg Europe Bv Membranes suitable for detecting, filtering and/or purifying biomolecules
WO2020128797A1 (en) * 2018-12-21 2020-06-25 3M Innovative Properties Company Method for testing a chromatography device used for ion exchange
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía
IL294901A (en) * 2020-01-24 2022-09-01 Alkermes Pharma Ireland Ltd Methods of purification
US11416468B2 (en) * 2020-07-21 2022-08-16 International Business Machines Corporation Active-active system index management
CN116371011B (zh) * 2023-05-26 2023-08-18 湖南杰萃生物技术有限公司 一种从桑叶中提取黄酮和生物碱的方法
CN117866038B (zh) * 2024-03-11 2024-05-28 北京百力格生物科技有限公司 纯化含有宿主核酸的带亲和标签的酸性蛋白的方法

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE266710C (enExample)
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
JPS6150925A (ja) * 1984-08-17 1986-03-13 Toray Ind Inc 抗原または抗体の精製方法
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
ES2070855T5 (es) * 1987-10-23 2004-03-01 Schering Corporation Metodo para purificar una proteina.
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
ATE113846T1 (de) 1988-06-21 1994-11-15 Genentech Inc Therapeutische zusammensetzungen für die behandlung von myocard-infarkten.
WO1990003430A1 (en) 1988-09-23 1990-04-05 Cetus Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2844346B2 (ja) * 1989-05-31 1999-01-06 昭 梶 新規ペプチドならびに新規ｄｎａ
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
DK1260521T3 (da) 1991-08-14 2008-03-25 Genentech Inc Immunoglobulinvarianter af specifikke Fc-epsilonreceptorer
ATE297465T1 (de) 1991-11-25 2005-06-15 Enzon Inc Verfahren zur herstellung von multivalenten antigenbindenden proteinen
WO1993016185A2 (en) 1992-02-06 1993-08-19 Creative Biomolecules, Inc. Biosynthetic binding protein for cancer marker
DK0656789T3 (da) 1992-08-21 1998-08-24 Genentech Inc Fremgangsmåde til behandling af en LFA-1-medieretforstyrrelse.
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
RU2145873C1 (ru) * 1993-09-21 2000-02-27 Хемосол Инк. Способ очистки гемоглобина в коммерческом масштабе
ES2108566T3 (es) 1993-12-10 1997-12-16 Genentech Inc Procedimientos para diagnosticar alergias y para seleccionar agentes terapeuticos antialergicos.
JP3825798B2 (ja) 1994-01-18 2006-09-27 ジェネンテク，インコーポレイテッド ＩｇＥアンタゴニストを用いる寄生虫感染症の治療法
US5677426A (en) 1994-03-03 1997-10-14 Genentech, Inc. Anti-IL-8 antibody fragments
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
CA2222231A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
EP1297847A3 (en) 1996-01-23 2003-05-07 Genentech, Inc. Anti-CD18 antibodies in stroke
US6592905B1 (en) * 1996-01-31 2003-07-15 Massey University Production of an immunoglobulin enriched fraction from whey protein solutions
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
DK0941344T3 (da) 1996-11-27 2004-09-27 Genentech Inc Humaniserede anti-CD11a-antistoffer
ES2236634T3 (es) 1997-04-07 2005-07-16 Genentech, Inc. Anticuerpos anti-vegf.
ATE516354T1 (de) 1997-05-15 2011-07-15 Genentech Inc Apo-2-rezeptor
US6054293A (en) 1997-07-08 2000-04-25 The Regents Of The University Of California Semaphorin receptors
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
HU226742B1 (en) 1999-06-25 2009-08-28 Genentech Inc Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
ES2309012T3 (es) 1999-10-29 2008-12-16 Genentech, Inc. Composiciones del anticuerpo anti-psca y a sus procedimientos contra celulas cancerigenas que expresen psca.
WO2002006456A1 (en) * 2000-07-13 2002-01-24 Invitrogen Corporation Methods and compositions for rapid protein and peptide extraction and isolation using a lysis matrix
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
AU2002325755A1 (en) 2001-09-18 2003-04-01 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
WO2003033656A2 (en) 2001-10-16 2003-04-24 Exelixis, Inc. MSREBPs AS MODIFIERS OF THE SREBP PATHWAY AND METHODS OF USE
EP1507793A4 (en) 2001-10-17 2006-02-01 Human Genome Sciences Inc NEUTROKIN ALPHA AND NEUTROKIN ALPHA SPLICE VERSION
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
JP4498746B2 (ja) 2002-02-14 2010-07-07 イミューノメディクス、インコーポレイテッド 抗ｃｄ２０抗体およびその融合タンパク質ならびに使用法
MXPA05004022A (es) 2002-10-17 2005-10-05 Genmab As Anticuerpos monoclonales humanos contra cd20.
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
CN1206240C (zh) * 2003-04-07 2005-06-15 中国科学院生态环境研究中心 高效离子交换膜色谱纯化卵黄蛋白原技术
CA2897608C (en) 2003-05-09 2018-07-31 Duke University Cd20-specific antibodies and methods employing same
AR044388A1 (es) 2003-05-20 2005-09-07 Applied Molecular Evolution Moleculas de union a cd20
US20050079184A1 (en) 2003-08-08 2005-04-14 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
US8147832B2 (en) 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
US20080274501A1 (en) * 2007-05-02 2008-11-06 Chenming Zhang Method of purifying acidic proteins expressed in plants
US9433922B2 (en) 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
EP2719705B1 (en) 2007-10-26 2020-07-29 Asahi Kasei Kabushiki Kaisha Method for purifying protein
EP3441402A1 (en) 2007-10-30 2019-02-13 Genentech, Inc. Antibody purification by cation exchange chromatography
WO2009135656A1 (en) * 2008-05-06 2009-11-12 Lonza Biologics Plc. A method for the purification of antibodies using displacement chromatography
PL3604324T3 (pl) 2008-08-14 2024-07-01 Genentech, Inc. Sposoby usuwania zanieczyszczeń za pomocą chromatografii membranowej jonowymiennej z zastąpieniem macierzystego białka
GB0816242D0 (en) 2008-09-05 2008-10-15 Immunobiology Ltd Method of purifying protien complexes
NZ597809A (en) 2009-08-06 2014-05-30 Genentech Inc Method to improve virus removal in protein purification
EP3736338A1 (en) * 2009-09-01 2020-11-11 F. Hoffmann-La Roche AG Enhanced protein purification through a modified protein a elution
ES2617777T5 (es) * 2010-04-23 2022-10-13 Hoffmann La Roche Producción de proteínas heteromultiméricas
KR101976853B1 (ko) 2010-05-25 2019-05-09 제넨테크, 인크. 폴리펩티드의 정제 방법
WO2013052537A2 (en) * 2011-10-03 2013-04-11 Sachem, Inc. Anionic displacer molecules for hydrophobic displacement chromatography
MX360453B (es) 2011-12-22 2018-11-01 Genentech Inc Cromatografia de membrana de intercambio ionico.
US9813410B2 (en) 2014-06-26 2017-11-07 Rakuten, Inc. Information processing apparatus, information processing method, and information processing program

Also Published As

Publication number Publication date
JP7359807B2 (ja) 2023-10-11
MY172426A (en) 2019-11-25
BR112014015101A2 (pt) 2017-06-13
US20200102346A1 (en) 2020-04-02
CN104125963A (zh) 2014-10-29
WO2013096322A8 (en) 2014-02-27
JP2020040952A (ja) 2020-03-19
US20240247027A1 (en) 2024-07-25
JP6605202B2 (ja) 2019-11-13
AU2012355356B2 (en) 2017-10-12
AU2012355356A1 (en) 2014-07-10
IL233158A0 (en) 2014-07-31
JP7402011B2 (ja) 2023-12-20
IL233158B (en) 2019-07-31
JP2018109024A (ja) 2018-07-12
KR102067075B1 (ko) 2020-01-17
EP3492486A1 (en) 2019-06-05
CN104125963B (zh) 2018-08-17
HK1203526A1 (en) 2015-10-30
PL2794635T3 (pl) 2019-02-28
BR112014015101A8 (pt) 2021-06-08
EP2794635B8 (en) 2018-11-14
AU2020201070A1 (en) 2020-03-05
US11945837B2 (en) 2024-04-02
ES2697676T3 (es) 2019-01-25
IL267585A (en) 2019-08-29
MX2014007622A (es) 2014-09-22
CN108892706A (zh) 2018-11-27
KR20210025692A (ko) 2021-03-09
TR201815709T4 (tr) 2018-11-21
IL267585B (en) 2022-09-01
ZA201404593B (en) 2022-12-21
SG11201403437TA (en) 2014-07-30
AU2018200194B2 (en) 2019-11-14
EP2794635B1 (en) 2018-09-12
CA2859376A1 (en) 2013-06-27
KR20200008022A (ko) 2020-01-22
MX360453B (es) 2018-11-01
JP2021169454A (ja) 2021-10-28
HRP20181846T1 (hr) 2018-12-28
JP2022101557A (ja) 2022-07-06
AU2018200194A1 (en) 2018-02-01
WO2013096322A9 (en) 2013-08-22
JP2015503524A (ja) 2015-02-02
KR20140114834A (ko) 2014-09-29
WO2013096322A1 (en) 2013-06-27
US20140348845A1 (en) 2014-11-27
EP2794635A1 (en) 2014-10-29
CA2859376C (en) 2022-04-19
NZ626949A (en) 2016-11-25
MX2018013356A (es) 2020-09-14
ZA201903994B (en) 2023-12-20
RU2014130017A (ru) 2016-02-10
SI2794635T1 (sl) 2018-12-31
US10364268B2 (en) 2019-07-30
RU2648999C2 (ru) 2018-03-29

Similar Documents

Publication Publication Date Title
AR089362A1 (es) Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico
CY1122221T1 (el) Μεθοδοι αφαιρεσης ρυπου χρησιμοποιωντας ιοντοανταλλακτικη μεμβρανικη χρωματογραφια μετατοπισης γηγενων πρωτεϊνων
MX395730B (es) Uso de lavados alcalinos durante la cromatografia para remover impurezas.
MX2020004603A (es) Metodos de purificacion de arn mensajero.
WO2011106750A3 (en) Method and apparatus for enhanced lifetime and performance of ion source in an ion implantation system
BR112015014751A2 (pt) anticorpos anti-tau humanos
GB2470600B (en) Charged particle analysers and methods of separating charged particles
EA201490288A1 (ru) Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b
EA201101593A1 (ru) КОМПОЗИЦИИ И СПОСОБЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ НАПРАВЛЕННОГО ВОЗДЕЙСТВИЯ АНТИТЕЛ НА БЕЛОК С3b СИСТЕМЫ КОМПЛЕМЕНТА
MX2012007497A (es) Metodo para modificacion de polipeptidos para purificar multimeros de polipeptido.
EA201590719A1 (ru) Фоллистатин в лечении мышечной дистрофии дюшенна
BR112012014060A2 (pt) métodos e reagentes para detecção aprimorada de peptídeos beta-amiloides
CO7061040A2 (es) Anticuerpos contra la metaloproteinasa de la matriz 9
MX2017008410A (es) Reduccion selectiva de residuos cisteina en anticuerpos il-17.
EA201492177A1 (ru) Очистка идуронат-2-сульфатазы
CL2016002434A1 (es) Proceso hidrometalúrgico de purificación de concentrado de cobre mediante la eliminación de arsénico y antimonio con regeneración concomitante y reciclado de lixiviante.
TR201901100T4 (tr) Saponinlerin saflaştırılması için işlem.
NZ722057A (en) Method for purifying antibody having low isoelectric point
EA201370187A1 (ru) Клеточная культуральная среда для уфс воздействия и относящиеся к ней способы
EA201201127A1 (ru) Способ получения небиволола
EA201590720A1 (ru) АНТИ-Flt-1-АНТИТЕЛА В ЛЕЧЕНИИ МЫШЕЧНОЙ ДИСТРОФИИ ДЮШЕНА
EA201291224A1 (ru) Способ извлечения бетаина из мелассы
BR112017006589A2 (pt) um método de purificação de lignina por sujeição de uma pasta fluida compreendendo lignina para um campo elétrico
WO2015036917A3 (en) Methods and kits for quantifying the removal of mock virus particles from a purified solution
BR112015021142A2 (pt) purificação de xarope por deionização capacitiva

Legal Events

Date Code Title Description
FA Abandonment or withdrawal