AR089362A1 - Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico - Google Patents

Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico

Info

Publication number
AR089362A1
AR089362A1 ARP120104862A ARP120104862A AR089362A1 AR 089362 A1 AR089362 A1 AR 089362A1 AR P120104862 A ARP120104862 A AR P120104862A AR P120104862 A ARP120104862 A AR P120104862A AR 089362 A1 AR089362 A1 AR 089362A1
Authority
AR
Argentina
Prior art keywords
polypeptide
membrane
ion exchange
purification
effluent
Prior art date
Application number
ARP120104862A
Other languages
English (en)
Spanish (es)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47430154&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR089362(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR089362A1 publication Critical patent/AR089362A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/165Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
ARP120104862A 2011-12-22 2012-12-20 Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico AR089362A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161579285P 2011-12-22 2011-12-22

Publications (1)

Publication Number Publication Date
AR089362A1 true AR089362A1 (es) 2014-08-20

Family

ID=47430154

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104862A AR089362A1 (es) 2011-12-22 2012-12-20 Metodos para mejorar las etapas de purificacion de proteinas descendentes utilizando cromatografia de membranas de intercambio ionico

Country Status (21)

Country Link
US (3) US10364268B2 (enExample)
EP (2) EP3492486A1 (enExample)
JP (5) JP6605202B2 (enExample)
KR (3) KR102067075B1 (enExample)
CN (2) CN104125963B (enExample)
AR (1) AR089362A1 (enExample)
AU (3) AU2012355356B2 (enExample)
BR (1) BR112014015101A8 (enExample)
CA (1) CA2859376C (enExample)
ES (1) ES2697676T3 (enExample)
HR (1) HRP20181846T1 (enExample)
IL (2) IL267585B (enExample)
MX (2) MX360453B (enExample)
MY (1) MY172426A (enExample)
PL (1) PL2794635T3 (enExample)
RU (1) RU2648999C2 (enExample)
SG (1) SG11201403437TA (enExample)
SI (1) SI2794635T1 (enExample)
TR (1) TR201815709T4 (enExample)
WO (1) WO2013096322A1 (enExample)
ZA (2) ZA201404593B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10364268B2 (en) * 2011-12-22 2019-07-30 Genentech, Inc. Ion exchange membrane chromatography
WO2015088677A1 (en) 2013-12-12 2015-06-18 Emd Millipore Corporation Protein separations using an acrylamide containing filter
KR102344170B1 (ko) * 2013-12-27 2021-12-27 추가이 세이야쿠 가부시키가이샤 등전점이 낮은 항체의 정제방법
CN104693303B (zh) * 2015-02-28 2018-03-13 苏州金盟生物技术有限公司 一种蛋白制品中的核酸去除方法
MA42613A (fr) 2015-08-13 2018-06-20 Amgen Inc Filtration en profondeur chargée de protéines de liaison à un antigène
GB201711481D0 (en) 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
EP3546475A1 (en) * 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
US10792618B2 (en) 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
KR102140531B1 (ko) * 2018-08-07 2020-08-04 (주)휴온스 Gly-Tβ4의 제조방법
KR102893280B1 (ko) * 2018-08-14 2025-12-01 브리스톨-마이어스 스큅 컴퍼니 개선된 단백질 회수
GB201815405D0 (en) * 2018-09-21 2018-11-07 Fujifilm Mfg Europe Bv Membranes suitable for detecting, filtering and/or purifying biomolecules
WO2020128797A1 (en) * 2018-12-21 2020-06-25 3M Innovative Properties Company Method for testing a chromatography device used for ion exchange
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía
JP2023511946A (ja) * 2020-01-24 2023-03-23 アルカームス ファーマ アイルランド リミテッド 精製方法
US11416468B2 (en) * 2020-07-21 2022-08-16 International Business Machines Corporation Active-active system index management
CN116425826A (zh) * 2021-12-30 2023-07-14 广州百济神州生物制药有限公司 一种快速纯化质量样品的方法
CN116371011B (zh) * 2023-05-26 2023-08-18 湖南杰萃生物技术有限公司 一种从桑叶中提取黄酮和生物碱的方法
CN117866038B (zh) * 2024-03-11 2024-05-28 北京百力格生物科技有限公司 纯化含有宿主核酸的带亲和标签的酸性蛋白的方法

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE266710C (enExample)
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
JPS6150925A (ja) 1984-08-17 1986-03-13 Toray Ind Inc 抗原または抗体の精製方法
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU626008B2 (en) * 1987-10-23 1992-07-23 Schering Corporation Method of purifying protein
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
WO1989012463A1 (en) 1988-06-21 1989-12-28 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
DE68925971T2 (de) 1988-09-23 1996-09-05 Cetus Oncology Corp Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2844346B2 (ja) 1989-05-31 1999-01-06 昭 梶 新規ペプチドならびに新規dna
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
DK0602126T3 (da) 1991-08-14 2003-06-16 Genentech Inc Immunoglobulinvarianter til specifikke FC epsilon-receptorer
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
WO1993016185A2 (en) 1992-02-06 1993-08-19 Creative Biomolecules, Inc. Biosynthetic binding protein for cancer marker
AU687755B2 (en) 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
DK0668877T3 (da) 1993-09-21 1999-09-13 Hemosol Inc Fortrængningschromatografisk fremgangsmåde og oprenset hæmoglobinprodukt
EP0733207B1 (en) 1993-12-10 1997-08-27 Genentech, Inc. Methods for diagnosis of allergy and screening of anti-allergy therapeutics
JP3825798B2 (ja) 1994-01-18 2006-09-27 ジェネンテク,インコーポレイテッド IgEアンタゴニストを用いる寄生虫感染症の治療法
US5702946A (en) 1994-03-03 1997-12-30 Genentech, Inc. Anti-IL-8 monoclonal antibodies for treatment of inflammatory disorders
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US5641870A (en) * 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
JPH11507535A (ja) 1995-06-07 1999-07-06 イムクローン システムズ インコーポレイテッド 腫瘍の成長を抑制する抗体および抗体フラグメント類
ES2183131T3 (es) 1996-01-23 2003-03-16 Genentech Inc Anticuerpos anti-cd18 utilizados contra el ictus cerebral.
CA2242931A1 (en) 1996-01-31 1997-08-07 David Francis Elgar Production of an immunoglobulin enriched fraction from whey protein solutions
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
DK0941344T3 (da) 1996-11-27 2004-09-27 Genentech Inc Humaniserede anti-CD11a-antistoffer
IL132240A0 (en) 1997-04-07 2001-03-19 Genentech Inc Anti-vegf antibodies
EP1860187B1 (en) 1997-05-15 2011-07-13 Genentech, Inc. Apo-2 receptor
US6054293A (en) 1997-07-08 2000-04-25 The Regents Of The University Of California Semaphorin receptors
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
AT500848B1 (de) 1999-06-25 2008-01-15 Genentech Inc Humanisierte anti-erbb2-antikörper
BR0015224A (pt) 1999-10-29 2002-07-09 Genentech Inc Anticorpo anti-antìgeno de célula estaminal prostática (psca) isolado, anticorpo monoclonal anti-psca, ácido nucleico isolado, vetor de expressão, célula, célula hospedeira, método de produção de anticorpo, composição método in vitro para matar uma célula cancerosa que expresse psca, uso de uma anticorpo monoclonal anti-psca e artigo industrializado
EP1301591A4 (en) 2000-07-13 2004-05-26 Invitrogen Corp METHODS AND COMPOSITIONS FOR RAPID EXTRACTION AND ISOLATION OF PROTEINS AND PEPTIDES USING LYING MATRIX
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
CA2460819A1 (en) 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
WO2003033656A2 (en) 2001-10-16 2003-04-24 Exelixis, Inc. MSREBPs AS MODIFIERS OF THE SREBP PATHWAY AND METHODS OF USE
EP1507793A4 (en) 2001-10-17 2006-02-01 Human Genome Sciences Inc NEUTROKIN ALPHA AND NEUTROKIN ALPHA SPLICE VERSION
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
RU2004127458A (ru) 2002-02-14 2005-10-27 Иммуномедикс, Инк. (Us) Анти-cd20 антитела, их гибридные белки и способы их использования
KR20110017020A (ko) 2002-10-17 2011-02-18 젠맵 에이/에스 Cd20에 대한 인간 모노클로날 항체
EP1944320A1 (en) 2002-12-16 2008-07-16 Genentech, Inc. Immunoglobulin variants and uses thereof
CN1206240C (zh) * 2003-04-07 2005-06-15 中国科学院生态环境研究中心 高效离子交换膜色谱纯化卵黄蛋白原技术
KR101351122B1 (ko) 2003-05-09 2014-01-14 듀크 유니버시티 Cd20-특이적 항체 및 이를 이용한 방법
AR044388A1 (es) 2003-05-20 2005-09-07 Applied Molecular Evolution Moleculas de union a cd20
US20050079184A1 (en) 2003-08-08 2005-04-14 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
US8147832B2 (en) 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
US20080274501A1 (en) * 2007-05-02 2008-11-06 Chenming Zhang Method of purifying acidic proteins expressed in plants
US9433922B2 (en) 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
WO2009054226A1 (ja) 2007-10-26 2009-04-30 Asahi Kasei Chemicals Corporation たんぱく質の精製方法
CN105315323A (zh) 2007-10-30 2016-02-10 健泰科生物技术公司 通过阳离子交换层析进行的抗体纯化
WO2009135656A1 (en) * 2008-05-06 2009-11-12 Lonza Biologics Plc. A method for the purification of antibodies using displacement chromatography
ES2978373T3 (es) * 2008-08-14 2024-09-11 Genentech Inc Métodos para eliminar un contaminante usando cromatografía de membrana de intercambio iónico de desplazamiento de proteínas indígenas
GB0816242D0 (en) 2008-09-05 2008-10-15 Immunobiology Ltd Method of purifying protien complexes
AU2010292897B2 (en) 2009-08-06 2016-01-07 Genentech, Inc. Method to improve virus removal in protein purification
EP3736338A1 (en) * 2009-09-01 2020-11-11 F. Hoffmann-La Roche AG Enhanced protein purification through a modified protein a elution
CA2796633C (en) * 2010-04-23 2020-10-27 Genentech, Inc. Production of heteromultimeric proteins
EP4492053A3 (en) 2010-05-25 2025-03-19 F. Hoffmann-La Roche AG Methods of purifying polypeptides
CN103958017B (zh) * 2011-10-03 2016-01-13 塞克姆公司 用于疏水性置换色谱法的阴离子置换剂分子
US10364268B2 (en) 2011-12-22 2019-07-30 Genentech, Inc. Ion exchange membrane chromatography
WO2015198451A1 (ja) 2014-06-26 2015-12-30 楽天株式会社 情報処理装置、情報処理方法及び情報処理プログラム

Also Published As

Publication number Publication date
US11945837B2 (en) 2024-04-02
IL267585A (en) 2019-08-29
HK1203526A1 (en) 2015-10-30
CN104125963A (zh) 2014-10-29
JP2022101557A (ja) 2022-07-06
US20240247027A1 (en) 2024-07-25
JP2021169454A (ja) 2021-10-28
ZA201903994B (en) 2023-12-20
ZA201404593B (en) 2022-12-21
JP2018109024A (ja) 2018-07-12
MX2014007622A (es) 2014-09-22
AU2020201070A1 (en) 2020-03-05
SG11201403437TA (en) 2014-07-30
BR112014015101A2 (pt) 2017-06-13
BR112014015101A8 (pt) 2021-06-08
JP6605202B2 (ja) 2019-11-13
SI2794635T1 (sl) 2018-12-31
EP2794635A1 (en) 2014-10-29
WO2013096322A8 (en) 2014-02-27
EP2794635B8 (en) 2018-11-14
JP7402011B2 (ja) 2023-12-20
KR20200008022A (ko) 2020-01-22
NZ626949A (en) 2016-11-25
CA2859376C (en) 2022-04-19
RU2648999C2 (ru) 2018-03-29
TR201815709T4 (tr) 2018-11-21
JP7359807B2 (ja) 2023-10-11
CA2859376A1 (en) 2013-06-27
AU2012355356B2 (en) 2017-10-12
AU2012355356A1 (en) 2014-07-10
ES2697676T3 (es) 2019-01-25
KR20210025692A (ko) 2021-03-09
WO2013096322A9 (en) 2013-08-22
US20200102346A1 (en) 2020-04-02
IL233158A0 (en) 2014-07-31
JP2020040952A (ja) 2020-03-19
MX360453B (es) 2018-11-01
AU2018200194A1 (en) 2018-02-01
WO2013096322A1 (en) 2013-06-27
MY172426A (en) 2019-11-25
CN108892706A (zh) 2018-11-27
EP3492486A1 (en) 2019-06-05
RU2014130017A (ru) 2016-02-10
HRP20181846T1 (hr) 2018-12-28
IL233158B (en) 2019-07-31
MX2018013356A (es) 2020-09-14
PL2794635T3 (pl) 2019-02-28
AU2018200194B2 (en) 2019-11-14
US10364268B2 (en) 2019-07-30
KR20140114834A (ko) 2014-09-29
CN104125963B (zh) 2018-08-17
KR102067075B1 (ko) 2020-01-17
EP2794635B1 (en) 2018-09-12
JP2015503524A (ja) 2015-02-02
IL267585B (en) 2022-09-01
US20140348845A1 (en) 2014-11-27

Similar Documents

Publication Publication Date Title
ZA201903994B (en) Ion exchange membrane chromatography
CY1122221T1 (el) Μεθοδοι αφαιρεσης ρυπου χρησιμοποιωντας ιοντοανταλλακτικη μεμβρανικη χρωματογραφια μετατοπισης γηγενων πρωτεϊνων
MX395730B (es) Uso de lavados alcalinos durante la cromatografia para remover impurezas.
WO2011106750A3 (en) Method and apparatus for enhanced lifetime and performance of ion source in an ion implantation system
RU2014111820A (ru) Способы элиминации вируса
BR112015014751A2 (pt) anticorpos anti-tau humanos
GB2470600B (en) Charged particle analysers and methods of separating charged particles
EA201490288A1 (ru) Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b
EA201691696A1 (ru) Способы очистки матричной рнк
EA201101593A1 (ru) КОМПОЗИЦИИ И СПОСОБЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ НАПРАВЛЕННОГО ВОЗДЕЙСТВИЯ АНТИТЕЛ НА БЕЛОК С3b СИСТЕМЫ КОМПЛЕМЕНТА
BR112013002545A2 (pt) métodos, aparelho, composição e suspensão para purificação de solvente
MX2012007497A (es) Metodo para modificacion de polipeptidos para purificar multimeros de polipeptido.
EA201300137A1 (ru) Комбинированная фармацевтическая композиция и способ лечения заболеваний или состояний, связанных с нейродегенеративными зоболеваниями
EA201291225A1 (ru) Улучшенные способы получения сквалена
BR112012014060A2 (pt) métodos e reagentes para detecção aprimorada de peptídeos beta-amiloides
CL2016002434A1 (es) Proceso hidrometalúrgico de purificación de concentrado de cobre mediante la eliminación de arsénico y antimonio con regeneración concomitante y reciclado de lixiviante.
BR112017006589A2 (pt) um método de purificação de lignina por sujeição de uma pasta fluida compreendendo lignina para um campo elétrico
TR201901100T4 (tr) Saponinlerin saflaştırılması için işlem.
NZ722057A (en) Method for purifying antibody having low isoelectric point
EA201370187A1 (ru) Клеточная культуральная среда для уфс воздействия и относящиеся к ней способы
EA201391605A1 (ru) Способы очистки вирусов с использованием гельпроникающей хроматографии
EA201201127A1 (ru) Способ получения небиволола
EA201291224A1 (ru) Способ извлечения бетаина из мелассы
WO2015036917A3 (en) Methods and kits for quantifying the removal of mock virus particles from a purified solution
BR112015021142A2 (pt) purificação de xarope por deionização capacitiva

Legal Events

Date Code Title Description
FA Abandonment or withdrawal