MX2017008410A - Reduccion selectiva de residuos cisteina en anticuerpos il-17. - Google Patents

Reduccion selectiva de residuos cisteina en anticuerpos il-17.

Info

Publication number
MX2017008410A
MX2017008410A MX2017008410A MX2017008410A MX2017008410A MX 2017008410 A MX2017008410 A MX 2017008410A MX 2017008410 A MX2017008410 A MX 2017008410A MX 2017008410 A MX2017008410 A MX 2017008410A MX 2017008410 A MX2017008410 A MX 2017008410A
Authority
MX
Mexico
Prior art keywords
antibodies
secukinumab
preparation
antigen binding
binding fragments
Prior art date
Application number
MX2017008410A
Other languages
English (en)
Inventor
Heitzmann Markus
Winkler Johann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2017008410A publication Critical patent/MX2017008410A/es

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente divulgación se refiere a métodos para reducir selectivamente CysL97 en una preparación de anticuerpos IL-17 o fragmentos de unión a antígeno de los mismos (p. ej., una preparación de anticuerpos secukinumab), que ha sido producida de forma recombinante por células de mamíferos. También se proporcionan preparaciones purificadas de anticuerpos IL-17 o fragmentos de unión a antígeno de los mismos producidos por estos métodos, p. ej., preparaciones purificadas de secukinumab, en donde el nivel de anticuerpos IL-17 intactos o fragmentos de unión a antígeno de los mismos (p. ej., secukinumab) en la preparación es alto, p. ej., al menos aproximadamente 90%, tal como se mide mediante electroforesis capilar con dodecil-sulfato de sodio (CE-SDS) y en donde el nivel de actividad de anticuerpos IL-17 o fragmentos de unión a antígeno de los mismos (p. ej., secukinumab) en la preparación es alta, p. ej., al menos aproximadamente 92%, tal como se mide mediante cromatografía de intercambio catiónico (CEX).
MX2017008410A 2014-12-22 2015-12-21 Reduccion selectiva de residuos cisteina en anticuerpos il-17. MX2017008410A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462095361P 2014-12-22 2014-12-22
PCT/IB2015/059824 WO2016103146A1 (en) 2014-12-22 2015-12-21 Selective reduction of cysteine residues in il-17 antibodies

Publications (1)

Publication Number Publication Date
MX2017008410A true MX2017008410A (es) 2017-10-19

Family

ID=55135470

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008410A MX2017008410A (es) 2014-12-22 2015-12-21 Reduccion selectiva de residuos cisteina en anticuerpos il-17.

Country Status (15)

Country Link
US (2) US11292833B2 (es)
EP (2) EP4389143A2 (es)
JP (3) JP7021950B2 (es)
KR (2) KR20230159617A (es)
CN (4) CN114316044A (es)
AR (1) AR103172A1 (es)
AU (1) AU2015370515B2 (es)
BR (1) BR112017010069A2 (es)
CA (1) CA2971541A1 (es)
IL (2) IL298761A (es)
MX (1) MX2017008410A (es)
PH (1) PH12017500967A1 (es)
RU (2) RU2765307C2 (es)
SG (1) SG11201703639QA (es)
WO (1) WO2016103146A1 (es)

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CA3041533A1 (en) 2016-11-07 2018-05-11 Seattle Genetics, Inc. Distribution of engineered-cysteine caps
WO2020037016A1 (en) * 2018-08-15 2020-02-20 Bristol-Myers Squibb Company Protein fragmentation control strategy by re-oxidation in downstream chromatography
CN109369806B (zh) * 2019-01-14 2019-04-19 迈威(上海)生物科技有限公司 苏金单抗制品中半胱氨酸化变异体的去除方法
EP4255927A1 (en) * 2020-12-02 2023-10-11 Fresenius Kabi Deutschland GmbH Methods of selectively reducing antibodies
CA3205650A1 (en) * 2020-12-22 2022-06-30 Novartis Ag Methods for reducing the oxidation level of cysteine residues in a secreted recombinantly-expressed protein during cell culture
CN113189184B (zh) * 2021-04-28 2022-09-09 浙江大学 含有半胱氨酸的毛细管凝胶电泳样品缓冲液
WO2023067626A1 (en) * 2021-10-20 2023-04-27 Dr. Reddy's Laboratories Limited A cell culture process to produce an antibody composition

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GB0513852D0 (en) 2005-07-06 2005-08-10 Celltech R&D Ltd Biological products
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JP5364382B2 (ja) 2006-02-07 2013-12-11 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 遊離チオール部分を有するタンパク質の安定化された組成物
LT3327026T (lt) 2007-07-09 2019-11-11 Genentech Inc Disulfidinio ryšio redukcijos prevencija rekombinantinių polipeptidų gaminimo metu
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Also Published As

Publication number Publication date
US20170369567A1 (en) 2017-12-28
EP3237445A1 (en) 2017-11-01
RU2719563C2 (ru) 2020-04-21
CN114010780B (zh) 2022-08-02
IL251893B2 (en) 2023-11-01
BR112017010069A2 (pt) 2018-02-06
WO2016103146A1 (en) 2016-06-30
CN107001460A (zh) 2017-08-01
RU2017126025A3 (es) 2019-11-12
US20220315650A1 (en) 2022-10-06
IL298761A (en) 2023-02-01
KR20170088906A (ko) 2017-08-02
CN107001460B (zh) 2022-01-21
AU2015370515A1 (en) 2017-05-18
CA2971541A1 (en) 2016-06-30
KR102643328B1 (ko) 2024-03-11
AU2015370515B2 (en) 2018-11-22
JP2022062194A (ja) 2022-04-19
CN114316044A (zh) 2022-04-12
AR103172A1 (es) 2017-04-19
RU2017126025A (ru) 2019-01-24
JP7021950B2 (ja) 2022-02-17
IL251893A0 (en) 2017-06-29
RU2020113344A (ru) 2020-09-02
JP2023110026A (ja) 2023-08-08
IL251893B1 (en) 2023-02-01
RU2020113344A3 (es) 2021-11-29
US11292833B2 (en) 2022-04-05
CN114249826B (zh) 2024-02-02
CN114249826A (zh) 2022-03-29
EP4389143A2 (en) 2024-06-26
CN114010780A (zh) 2022-02-08
PH12017500967A1 (en) 2017-10-18
RU2765307C2 (ru) 2022-01-28
JP2018507250A (ja) 2018-03-15
KR20230159617A (ko) 2023-11-21
SG11201703639QA (en) 2017-07-28

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