BR112015014718A2 - métodos de uso de cromatografia de troca iônica para controlar níveis de glicoformas ricas em manose - Google Patents

métodos de uso de cromatografia de troca iônica para controlar níveis de glicoformas ricas em manose

Info

Publication number
BR112015014718A2
BR112015014718A2 BR112015014718A BR112015014718A BR112015014718A2 BR 112015014718 A2 BR112015014718 A2 BR 112015014718A2 BR 112015014718 A BR112015014718 A BR 112015014718A BR 112015014718 A BR112015014718 A BR 112015014718A BR 112015014718 A2 BR112015014718 A2 BR 112015014718A2
Authority
BR
Brazil
Prior art keywords
mannose
rich
ion exchange
methods
control
Prior art date
Application number
BR112015014718A
Other languages
English (en)
Inventor
Wang Jihong
Rajendran Saravanamoorthy
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of BR112015014718A2 publication Critical patent/BR112015014718A2/pt

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/28—Interference filters
    • G02B5/281—Interference filters designed for the infrared light
    • G02B5/282—Interference filters designed for the infrared light reflecting for infrared and transparent for visible light, e.g. heat reflectors, laser protection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

resumo patente de invenção: "métodos de uso de cromatografia de troca iônica para controlar níveis de glicoformas ricas em manose". são proporcionados métodos de uso de cromatografia baseada em troca iônica para controlar os níveis de glicoformas ricas em manose em uma amostra de glicoproteína, como uma amostra de anticorpo. as glicoformas ricas em manose podem ser removidas da amostra ou isoladas e enriquecidas. também é proporcionada uma composição compreendendo uma glicoproteína, como um anticorpo, de onde as glicoformas ricas em manose foram reduzidas ou removidas ou isoladas ou enriquecidas usando uma etapa de cromatografia baseada em troca iônica.
BR112015014718A 2012-12-20 2013-12-18 métodos de uso de cromatografia de troca iônica para controlar níveis de glicoformas ricas em manose BR112015014718A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261740238P 2012-12-20 2012-12-20
PCT/US2013/076002 WO2014100117A2 (en) 2012-12-20 2013-12-18 Methods of using ion exchange chromatograpy to control levels of high mannose glycoforms

Publications (1)

Publication Number Publication Date
BR112015014718A2 true BR112015014718A2 (pt) 2017-10-10

Family

ID=50979391

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015014718A BR112015014718A2 (pt) 2012-12-20 2013-12-18 métodos de uso de cromatografia de troca iônica para controlar níveis de glicoformas ricas em manose

Country Status (11)

Country Link
US (1) US20150361128A1 (pt)
EP (1) EP2935610A4 (pt)
JP (1) JP2016504337A (pt)
KR (1) KR20150099805A (pt)
CN (1) CN105229498A (pt)
AU (1) AU2013361559A1 (pt)
BR (1) BR112015014718A2 (pt)
CA (1) CA2895330A1 (pt)
HK (1) HK1216654A1 (pt)
SG (1) SG11201504738PA (pt)
WO (1) WO2014100117A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114007737B (zh) * 2019-07-03 2024-07-05 默克专利股份公司 抗体药物缀合物纯化
EP3993887B1 (en) * 2019-07-03 2023-07-26 Merck Patent GmbH Glycoform purification
US20230193339A1 (en) * 2020-05-19 2023-06-22 Momenta Pharmaceuticals, Inc. Preparation and Purification of Hypersialylated IGG

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US20070190057A1 (en) * 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
KR20110014607A (ko) * 2008-04-29 2011-02-11 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
US20110105725A1 (en) * 2008-05-15 2011-05-05 Novo Nordisk A/S Antibody purification process
US20120263722A1 (en) * 2010-11-04 2012-10-18 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof

Also Published As

Publication number Publication date
JP2016504337A (ja) 2016-02-12
CA2895330A1 (en) 2014-06-26
WO2014100117A2 (en) 2014-06-26
EP2935610A4 (en) 2016-08-31
US20150361128A1 (en) 2015-12-17
WO2014100117A3 (en) 2015-07-16
EP2935610A2 (en) 2015-10-28
KR20150099805A (ko) 2015-09-01
CN105229498A (zh) 2016-01-06
WO2014100117A9 (en) 2015-09-03
SG11201504738PA (en) 2015-07-30
HK1216654A1 (zh) 2016-11-25
AU2013361559A1 (en) 2015-07-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]