JP2018516229A5 - - Google Patents
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- Publication number
- JP2018516229A5 JP2018516229A5 JP2017546779A JP2017546779A JP2018516229A5 JP 2018516229 A5 JP2018516229 A5 JP 2018516229A5 JP 2017546779 A JP2017546779 A JP 2017546779A JP 2017546779 A JP2017546779 A JP 2017546779A JP 2018516229 A5 JP2018516229 A5 JP 2018516229A5
- Authority
- JP
- Japan
- Prior art keywords
- dsba
- polypeptide
- antibody
- sample
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 238000000034 method Methods 0.000 claims 28
- 239000000463 material Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 13
- 238000003018 immunoassay Methods 0.000 claims 12
- 241000588724 Escherichia coli Species 0.000 claims 10
- 238000001514 detection method Methods 0.000 claims 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 238000003556 assay Methods 0.000 claims 8
- 238000005349 anion exchange Methods 0.000 claims 7
- 239000013592 cell lysate Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 238000005571 anion exchange chromatography Methods 0.000 claims 5
- 238000005341 cation exchange Methods 0.000 claims 5
- 238000005277 cation exchange chromatography Methods 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 4
- 229920002873 Polyethylenimine Polymers 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 239000012535 impurity Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000006166 lysate Substances 0.000 claims 2
- 238000007670 refining Methods 0.000 claims 2
- 238000001542 size-exclusion chromatography Methods 0.000 claims 2
- -1 sulfopropyl moiety Chemical group 0.000 claims 2
- 238000000954 titration curve Methods 0.000 claims 2
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 239000007993 MOPS buffer Substances 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000013628 high molecular weight specie Substances 0.000 claims 1
- 239000013627 low molecular weight specie Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000012264 purified product Substances 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562129701P | 2015-03-06 | 2015-03-06 | |
| US62/129,701 | 2015-03-06 | ||
| PCT/US2016/021059 WO2016144824A1 (en) | 2015-03-06 | 2016-03-04 | Ultrapurified dsba and dsbc and methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021001186A Division JP7191132B2 (ja) | 2015-03-06 | 2021-01-07 | 超精製ＤｓｂＡ及びＤｓｂＣ、ならびにそれらの作製及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516229A JP2018516229A (ja) | 2018-06-21 |
| JP2018516229A5 true JP2018516229A5 (enExample) | 2019-04-11 |
| JP6865689B2 JP6865689B2 (ja) | 2021-04-28 |
Family
ID=55637452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546779A Active JP6865689B2 (ja) | 2015-03-06 | 2016-03-04 | 超精製ＤｓｂＡ及びＤｓｂＣ、ならびにそれらの作製及び使用方法 |
| JP2021001186A Active JP7191132B2 (ja) | 2015-03-06 | 2021-01-07 | 超精製ＤｓｂＡ及びＤｓｂＣ、ならびにそれらの作製及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021001186A Active JP7191132B2 (ja) | 2015-03-06 | 2021-01-07 | 超精製ＤｓｂＡ及びＤｓｂＣ、ならびにそれらの作製及び使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10073098B2 (enExample) |
| EP (2) | EP3265557B1 (enExample) |
| JP (2) | JP6865689B2 (enExample) |
| KR (1) | KR20170122216A (enExample) |
| CN (1) | CN107531749A (enExample) |
| AR (1) | AR103852A1 (enExample) |
| AU (1) | AU2016230018A1 (enExample) |
| CA (1) | CA2978256A1 (enExample) |
| ES (1) | ES2761726T3 (enExample) |
| HK (1) | HK1247936A1 (enExample) |
| HR (1) | HRP20192217T1 (enExample) |
| IL (1) | IL254166A0 (enExample) |
| MX (2) | MX387454B (enExample) |
| PL (1) | PL3265557T3 (enExample) |
| SG (2) | SG10202005917SA (enExample) |
| SI (1) | SI3265557T1 (enExample) |
| WO (1) | WO2016144824A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| ES2761726T3 (es) | 2015-03-06 | 2020-05-20 | Hoffmann La Roche | DsbA y DsbC ultrapurificadas y procedimientos de preparación y uso de las mismas |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| KR20220166814A (ko) | 2020-04-09 | 2022-12-19 | 싸이톰스 테라퓨틱스, 인크. | 활성화 가능한 항체를 함유하는 조성물 |
| CN115028691B (zh) * | 2022-06-29 | 2024-09-10 | 青岛硕景生物科技有限公司 | 一种检测试纸用的独立质控系统、杂交瘤细胞株、质控线用包被单克隆抗体及其应用 |
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-
2016
- 2016-03-04 ES ES16712126T patent/ES2761726T3/es active Active
- 2016-03-04 EP EP16712126.8A patent/EP3265557B1/en active Active
- 2016-03-04 CA CA2978256A patent/CA2978256A1/en not_active Abandoned
- 2016-03-04 SG SG10202005917SA patent/SG10202005917SA/en unknown
- 2016-03-04 CN CN201680026013.3A patent/CN107531749A/zh active Pending
- 2016-03-04 US US15/061,943 patent/US10073098B2/en active Active
- 2016-03-04 MX MX2021000153A patent/MX387454B/es unknown
- 2016-03-04 HR HRP20192217TT patent/HRP20192217T1/hr unknown
- 2016-03-04 SG SG11201707186YA patent/SG11201707186YA/en unknown
- 2016-03-04 SI SI201630544T patent/SI3265557T1/sl unknown
- 2016-03-04 KR KR1020177026459A patent/KR20170122216A/ko not_active Ceased
- 2016-03-04 WO PCT/US2016/021059 patent/WO2016144824A1/en not_active Ceased
- 2016-03-04 MX MX2017011189A patent/MX381844B/es unknown
- 2016-03-04 AU AU2016230018A patent/AU2016230018A1/en not_active Abandoned
- 2016-03-04 HK HK18107289.5A patent/HK1247936A1/zh unknown
- 2016-03-04 PL PL16712126T patent/PL3265557T3/pl unknown
- 2016-03-04 EP EP19195777.8A patent/EP3636749B1/en active Active
- 2016-03-04 AR ARP160100573A patent/AR103852A1/es not_active Application Discontinuation
- 2016-03-04 JP JP2017546779A patent/JP6865689B2/ja active Active
-
2017
- 2017-08-27 IL IL254166A patent/IL254166A0/en unknown
-
2018
- 2018-07-24 US US16/044,360 patent/US10690671B2/en active Active
-
2021
- 2021-01-07 JP JP2021001186A patent/JP7191132B2/ja active Active
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