JP2014501758A5 - - Google Patents
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- Publication number
- JP2014501758A5 JP2014501758A5 JP2013546071A JP2013546071A JP2014501758A5 JP 2014501758 A5 JP2014501758 A5 JP 2014501758A5 JP 2013546071 A JP2013546071 A JP 2013546071A JP 2013546071 A JP2013546071 A JP 2013546071A JP 2014501758 A5 JP2014501758 A5 JP 2014501758A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- ligand
- domain
- domains
- asparagine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010025221 plasma protein Z Proteins 0.000 claims 15
- 235000018102 proteins Nutrition 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 239000003446 ligand Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 8
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 5
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 5
- 229960001230 asparagine Drugs 0.000 claims 5
- 235000009582 asparagine Nutrition 0.000 claims 5
- 239000011159 matrix material Substances 0.000 claims 5
- 239000000178 monomer Substances 0.000 claims 5
- 108010088160 Staphylococcal Protein A Proteins 0.000 claims 4
- 238000010828 elution Methods 0.000 claims 4
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 102100035971 Molybdopterin molybdenumtransferase Human genes 0.000 claims 1
- 101710119577 Molybdopterin molybdenumtransferase Proteins 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000003480 eluent Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424725P | 2010-12-20 | 2010-12-20 | |
| US61/424,725 | 2010-12-20 | ||
| PCT/SE2011/051536 WO2012087230A1 (en) | 2010-12-20 | 2011-12-19 | Affinity chromatography matrix |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501758A JP2014501758A (ja) | 2014-01-23 |
| JP2014501758A5 true JP2014501758A5 (enExample) | 2015-02-05 |
| JP5974342B2 JP5974342B2 (ja) | 2016-08-23 |
Family
ID=46314245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546071A Active JP5974342B2 (ja) | 2010-12-20 | 2011-12-19 | アフィニティークロマトグラフィーマトリックス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9683013B2 (enExample) |
| EP (1) | EP2654915B1 (enExample) |
| JP (1) | JP5974342B2 (enExample) |
| CN (1) | CN103269761B (enExample) |
| WO (1) | WO2012087230A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG195555A1 (en) | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
| SG186552A1 (en) | 2011-06-08 | 2013-01-30 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| JPWO2013018880A1 (ja) * | 2011-08-04 | 2015-03-05 | 独立行政法人産業技術総合研究所 | プロテインｇの細胞膜外ドメイン変異体のタンデム型多量体から成る新規な改変型タンパク質 |
| US9657055B2 (en) * | 2011-11-30 | 2017-05-23 | Ge Healthcare Bioprocess R&D Ab | Affinity chromatography matrix |
| US10189891B2 (en) * | 2012-03-28 | 2019-01-29 | Ge Healthcare Bioprocess R&D Ab | Affinity chromatography matrix |
| MY178616A (en) | 2012-09-17 | 2020-10-19 | Grace W R & Co | Chromatography media and devices |
| SG11201605712SA (en) | 2014-01-16 | 2016-08-30 | Grace W R & Co | Affinity chromatography media and chromatography devices |
| CN104945488B (zh) * | 2014-03-27 | 2020-02-18 | 迈格生物医药（上海）有限公司 | 一种具有免疫球蛋白结合能力的多肽 |
| US11389783B2 (en) | 2014-05-02 | 2022-07-19 | W.R. Grace & Co.-Conn. | Functionalized support material and methods of making and using functionalized support material |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| CN107108701B (zh) * | 2014-12-17 | 2022-02-11 | 思拓凡生物工艺研发有限公司 | 修饰的κ轻链-结合多肽 |
| KR102566292B1 (ko) | 2015-06-05 | 2023-08-10 | 더블유.알. 그레이스 앤드 캄파니-콘. | 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법 |
| GB201515339D0 (en) * | 2015-08-28 | 2015-10-14 | Ge Healthcare Bio Sciences Ab | A seperation matrix and a method of seperating antibodies |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US11753438B2 (en) | 2016-05-11 | 2023-09-12 | Cytiva Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| WO2017194592A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of storing a separation matrix |
| CN109071613A (zh) | 2016-05-11 | 2018-12-21 | 通用电气医疗集团生物工艺研发股份公司 | 分离基质 |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| KR101857953B1 (ko) * | 2016-07-06 | 2018-05-16 | 아미코젠주식회사 | 알칼리 내성이 증가된 변이 면역글로불린 결합 단백질 |
| GB201615254D0 (en) | 2016-09-08 | 2016-11-23 | Ge Healthcare Bio Sciences Ab | Novel Ligand and use thereof |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| WO2018151743A1 (en) | 2017-02-15 | 2018-08-23 | Bioprocessia Technologies Llc | Affinity chromatography ligands with mild elution ph |
| GB201708277D0 (en) | 2017-05-24 | 2017-07-05 | Ge Healthcare | A Recombinant protein |
| EP3875472A1 (en) * | 2020-03-06 | 2021-09-08 | Navigo Proteins Gmbh | Novel immunoglobulin binding polypeptides |
| WO2022081779A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Affinity ligand libraries of three-helix bundle proteins and uses thereof |
| GB202018588D0 (en) | 2020-11-26 | 2021-01-13 | Cytiva Bioprocess R & D Ab | Separation matrix |
| EP4294542A1 (en) | 2021-02-19 | 2023-12-27 | Avitide LLC | Aav2 affinity agents |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| US6602977B1 (en) | 1999-04-19 | 2003-08-05 | Biovitrum Ab | Receptor structures |
| US7709209B2 (en) | 2002-03-25 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Protein ligands |
| SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| DK1641818T3 (da) * | 2003-07-04 | 2009-03-16 | Affibody Ab | Polypeptider der har bindingsaffinitet for HER2 |
| SE0400274D0 (sv) | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
| ATE490268T1 (de) * | 2005-03-01 | 2010-12-15 | Affibody Ab | Tnf-alhpa-bindendes polypeptid, anwendungen davon und verfahren, bei denen dieses verwendet wird |
| CN102989018A (zh) * | 2005-08-03 | 2013-03-27 | Rq生物科技有限公司 | 用于诊断IgA和IgM介导的肾脏疾病的方法和组合物 |
| JP5229888B2 (ja) * | 2008-09-30 | 2013-07-03 | 独立行政法人産業技術総合研究所 | 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤 |
| CN102272145B (zh) | 2009-01-12 | 2014-07-30 | 通用电气健康护理生物科学股份公司 | 亲和色谱基质 |
-
2011
- 2011-12-19 CN CN201180061114.1A patent/CN103269761B/zh active Active
- 2011-12-19 US US13/996,023 patent/US9683013B2/en active Active
- 2011-12-19 JP JP2013546071A patent/JP5974342B2/ja active Active
- 2011-12-19 EP EP11850413.3A patent/EP2654915B1/en active Active
- 2011-12-19 WO PCT/SE2011/051536 patent/WO2012087230A1/en not_active Ceased
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