JP2019531055A5 - - Google Patents
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- Publication number
- JP2019531055A5 JP2019531055A5 JP2019505354A JP2019505354A JP2019531055A5 JP 2019531055 A5 JP2019531055 A5 JP 2019531055A5 JP 2019505354 A JP2019505354 A JP 2019505354A JP 2019505354 A JP2019505354 A JP 2019505354A JP 2019531055 A5 JP2019531055 A5 JP 2019531055A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- binding protein
- isoleucine
- binding
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000014914 Carrier Proteins Human genes 0.000 claims 21
- 108091008324 binding proteins Proteins 0.000 claims 21
- 150000001413 amino acids Chemical group 0.000 claims 20
- 229940024606 amino acid Drugs 0.000 claims 17
- 235000001014 amino acid Nutrition 0.000 claims 17
- 229960000310 isoleucine Drugs 0.000 claims 12
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 12
- 235000014705 isoleucine Nutrition 0.000 claims 12
- 239000011159 matrix material Substances 0.000 claims 9
- 108060003951 Immunoglobulin Proteins 0.000 claims 8
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 8
- 102000018358 immunoglobulin Human genes 0.000 claims 8
- 238000000926 separation method Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 239000004475 Arginine Substances 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 4
- 238000001261 affinity purification Methods 0.000 claims 3
- 229940072221 immunoglobulins Drugs 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229940099472 immunoglobulin a Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022112299A JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183710.9 | 2016-08-11 | ||
| EP16183710 | 2016-08-11 | ||
| EP16205707.9 | 2016-12-21 | ||
| EP16205707 | 2016-12-21 | ||
| PCT/EP2017/069976 WO2018029157A1 (en) | 2016-08-11 | 2017-08-07 | Novel alkaline stable immunoglobulin-binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022112299A Division JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531055A JP2019531055A (ja) | 2019-10-31 |
| JP2019531055A5 true JP2019531055A5 (enExample) | 2020-08-13 |
| JP7181612B2 JP7181612B2 (ja) | 2022-12-01 |
Family
ID=59631752
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507171A Active JP6951417B2 (ja) | 2016-08-11 | 2017-08-07 | アフィニティークロマトグラフィーのためのＦＣ−結合タンパク質、並びにＦｃ−結合タンパク質を含むアフィニティー分離マトリックスおよびその使用 |
| JP2019505354A Active JP7181612B2 (ja) | 2016-08-11 | 2017-08-07 | アルカリ安定性免疫グロブリン結合タンパク質 |
| JP2022112299A Pending JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507171A Active JP6951417B2 (ja) | 2016-08-11 | 2017-08-07 | アフィニティークロマトグラフィーのためのＦＣ−結合タンパク質、並びにＦｃ−結合タンパク質を含むアフィニティー分離マトリックスおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022112299A Pending JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11230576B2 (enExample) |
| EP (4) | EP4324840A3 (enExample) |
| JP (3) | JP6951417B2 (enExample) |
| KR (3) | KR20230133943A (enExample) |
| CN (4) | CN109963864B (enExample) |
| AU (2) | AU2017311541B2 (enExample) |
| CA (2) | CA3031858A1 (enExample) |
| DK (1) | DK3497117T5 (enExample) |
| LT (1) | LT3497117T (enExample) |
| SG (1) | SG11201901066UA (enExample) |
| WO (2) | WO2018029157A1 (enExample) |
Families Citing this family (32)
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|---|---|---|---|---|
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| PL3322721T4 (pl) | 2015-07-16 | 2022-06-06 | Navigo Proteins Gmbh | Nowe białka wiążące immunoglobulinę i ich zastosowanie w oczyszczaniu na bazie powinowactwa |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| AU2017311541B2 (en) | 2016-08-11 | 2020-08-13 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin-binding proteins |
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| EP3521304B9 (en) | 2018-02-01 | 2023-10-04 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| KR102798502B1 (ko) * | 2017-08-07 | 2025-04-23 | 리플리겐 코포레이션 | C-말단 나선형 영역에 시스테인을 갖는 fc 결합 단백질 |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| EP3650465A1 (en) * | 2018-11-12 | 2020-05-13 | Navigo Proteins Gmbh | Novel populations of polypeptides having a triple-helical structure |
| JP7591284B2 (ja) * | 2018-11-12 | 2024-11-28 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫グロブリンＦｃドメインに対する結合親和性を持たない新規三重らせんポリペプチド及び同ポリペプチドの使用 |
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| AU2020213921B2 (en) * | 2019-02-01 | 2022-06-16 | Navigo Proteins Gmbh | Immunoglobulin binding proteins for affinity purification |
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| EP3875472A1 (en) * | 2020-03-06 | 2021-09-08 | Navigo Proteins Gmbh | Novel immunoglobulin binding polypeptides |
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| JP6881760B2 (ja) | 2015-07-20 | 2021-06-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質に基づくＨｅｒ２結合タンパク質 |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| AU2017311541B2 (en) | 2016-08-11 | 2020-08-13 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin-binding proteins |
| EP3521304B9 (en) | 2018-02-01 | 2023-10-04 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| KR102798502B1 (ko) | 2017-08-07 | 2025-04-23 | 리플리겐 코포레이션 | C-말단 나선형 영역에 시스테인을 갖는 fc 결합 단백질 |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
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2017
- 2017-08-07 AU AU2017311541A patent/AU2017311541B2/en active Active
- 2017-08-07 KR KR1020237030862A patent/KR20230133943A/ko not_active Ceased
- 2017-08-07 JP JP2019507171A patent/JP6951417B2/ja active Active
- 2017-08-07 EP EP23218805.2A patent/EP4324840A3/en active Pending
- 2017-08-07 LT LTEPPCT/EP2017/069976T patent/LT3497117T/lt unknown
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- 2017-08-07 CN CN201780050413.2A patent/CN109963864B/zh active Active
- 2017-08-07 WO PCT/EP2017/069976 patent/WO2018029157A1/en not_active Ceased
- 2017-08-07 DK DK17752349.5T patent/DK3497117T5/da active
- 2017-08-07 KR KR1020197003966A patent/KR102573370B1/ko active Active
- 2017-08-07 SG SG11201901066UA patent/SG11201901066UA/en unknown
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- 2017-08-07 CN CN202210871980.7A patent/CN116333065A/zh active Pending
- 2017-08-07 KR KR1020197003790A patent/KR102578256B1/ko active Active
- 2017-08-07 CN CN202311795884.XA patent/CN117736281A/zh active Pending
- 2017-08-07 WO PCT/EP2017/069979 patent/WO2018029158A1/en not_active Ceased
- 2017-08-07 EP EP22193930.9A patent/EP4177260A1/en active Pending
- 2017-08-07 CN CN201780044905.0A patent/CN109476712B/zh active Active
- 2017-08-07 JP JP2019505354A patent/JP7181612B2/ja active Active
- 2017-08-07 US US16/324,842 patent/US11014967B2/en active Active
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2021
- 2021-03-23 US US17/209,455 patent/US20210206815A1/en not_active Abandoned
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2022
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2024
- 2024-09-03 US US18/822,867 patent/US20250051400A1/en active Pending
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