JP2014502253A5 - - Google Patents
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- Publication number
- JP2014502253A5 JP2014502253A5 JP2013532271A JP2013532271A JP2014502253A5 JP 2014502253 A5 JP2014502253 A5 JP 2014502253A5 JP 2013532271 A JP2013532271 A JP 2013532271A JP 2013532271 A JP2013532271 A JP 2013532271A JP 2014502253 A5 JP2014502253 A5 JP 2014502253A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- antibody
- acid sequence
- sequence
- difficile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1016742.7A GB201016742D0 (en) | 2010-10-05 | 2010-10-05 | Clostridium difficile antigens |
| GB1016742.7 | 2010-10-05 | ||
| PCT/GB2011/051910 WO2012046061A2 (en) | 2010-10-05 | 2011-10-05 | Clostridium difficile antigens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502253A JP2014502253A (ja) | 2014-01-30 |
| JP2014502253A5 true JP2014502253A5 (enExample) | 2014-11-13 |
| JP6377907B2 JP6377907B2 (ja) | 2018-08-22 |
Family
ID=43243528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532271A Active JP6377907B2 (ja) | 2010-10-05 | 2011-10-05 | クロストリジウム・ディフィシル（Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ）抗原 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10369206B2 (enExample) |
| EP (1) | EP2625193B1 (enExample) |
| JP (1) | JP6377907B2 (enExample) |
| CN (1) | CN103237807B (enExample) |
| AU (1) | AU2011311321B2 (enExample) |
| BR (1) | BR112013008407A2 (enExample) |
| CA (1) | CA2812731C (enExample) |
| GB (1) | GB201016742D0 (enExample) |
| SG (1) | SG189058A1 (enExample) |
| WO (1) | WO2012046061A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201016742D0 (en) | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| AR086199A1 (es) | 2011-04-22 | 2013-11-27 | Wyeth Llc | Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos |
| US9290565B2 (en) * | 2011-05-27 | 2016-03-22 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| AU2012349753A1 (en) * | 2011-12-08 | 2014-06-19 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| GB201206070D0 (en) | 2012-04-04 | 2012-05-16 | Health Prot Agency | Clostridium difficile antigens |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| JP2016501877A (ja) * | 2012-11-28 | 2016-01-21 | シーエヌジェー ホールディングス，インコーポレイテッド | クロストリジウム・ディフィシルに対する抗体 |
| CN103865938B (zh) * | 2012-12-16 | 2016-10-05 | 山东国际生物科技园发展有限公司 | 艰难梭菌外毒素a羧基端序列密码子优化基因片段、表达载体构建方法及其表达蛋白的应用 |
| US9493518B2 (en) * | 2013-03-14 | 2016-11-15 | National Health Research Institutes | Compositions and methods for treating clostridium difficile-associated diseases |
| CN105451762A (zh) * | 2013-04-22 | 2016-03-30 | 俄克拉荷马州大学评议会 | 艰难梭菌疫苗及使用方法 |
| GB201309421D0 (en) * | 2013-05-24 | 2013-07-10 | Imp Innovations Ltd | Polypeptides |
| CN103772509B (zh) * | 2014-01-20 | 2017-01-11 | 山东国际生物科技园发展有限公司 | 一种艰难梭菌毒素a/b的融合蛋白及其编码基因与应用 |
| EP3344276B1 (en) * | 2015-09-03 | 2020-04-22 | The Board of Regents of the University of Oklahoma | Peptide inhibitors of clostridium difficile tcdb toxin |
| CN112512556A (zh) * | 2018-01-16 | 2021-03-16 | 儿童医学中心公司 | 用于抑制wnt信号传导的组合物和方法 |
| US11136360B2 (en) * | 2018-12-19 | 2021-10-05 | Tsinghua University | Fusion proteins comprising a Mtu ΔI-CM intein variant and methods of protein purification |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| WO2022174229A1 (en) * | 2021-02-09 | 2022-08-18 | Joby Aero, Inc. | Aircraft propulsion unit |
| CN113717263B (zh) * | 2021-08-04 | 2022-06-07 | 河北医科大学第二医院 | 一种艰难梭菌特异性抗原肽 |
| CN115093470B (zh) * | 2022-06-30 | 2023-03-24 | 广州市乾相生物科技有限公司 | 内含肽Mtu RecA突变体及其在生产谷胱甘肽GSH中的应用 |
| CN120484111B (zh) * | 2025-05-14 | 2025-10-28 | 广州海绿生物技术有限公司 | 一种包含益生菌的组合物及其在治疗肠胃疾病中的用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| JP2002514886A (ja) * | 1994-10-24 | 2002-05-21 | プロメガ コーポレーション | クロストリジウム・ディフィシル疾患の治療及び予防のためのワクチン及び抗トキシン |
| US5919463A (en) | 1995-07-07 | 1999-07-06 | Oravax, Inc. | Clostridium difficle toxins as mucosal adjuvants |
| AU746859B2 (en) | 1997-06-20 | 2002-05-02 | Imperial College Of Science, Technology And Medicine | Immonogenic fragments of toxin a of clostridium difficile |
| EP1169456B1 (en) | 1999-04-09 | 2012-07-11 | Intercell USA, Inc. | Recombinant production of Clostridium difficile Toxin A or Toxin B |
| EP1358331A2 (en) | 2001-02-09 | 2003-11-05 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Clostridium difficile vaccine |
| ES2366626T3 (es) * | 2004-02-06 | 2011-10-24 | University Of Massachusetts | Anticuerpos contra toxinas de clostridium difficile y usos de los mismos. |
| CN101500581B (zh) | 2006-06-08 | 2013-10-30 | 科内尔研究基金会 | 编码艰难梭菌毒素a和毒素b受体结合域的密码子优化dna分子及其使用方法 |
| WO2010017383A1 (en) | 2008-08-06 | 2010-02-11 | Emergent Product Development Uk Limited | Vaccines against clostridium difficile and methods of use |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| GB201016742D0 (en) | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| AR086199A1 (es) * | 2011-04-22 | 2013-11-27 | Wyeth Llc | Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos |
-
2010
- 2010-10-05 GB GBGB1016742.7A patent/GB201016742D0/en not_active Ceased
-
2011
- 2011-10-05 AU AU2011311321A patent/AU2011311321B2/en active Active
- 2011-10-05 US US13/878,150 patent/US10369206B2/en active Active
- 2011-10-05 JP JP2013532271A patent/JP6377907B2/ja active Active
- 2011-10-05 CA CA2812731A patent/CA2812731C/en active Active
- 2011-10-05 WO PCT/GB2011/051910 patent/WO2012046061A2/en not_active Ceased
- 2011-10-05 SG SG2013021506A patent/SG189058A1/en unknown
- 2011-10-05 BR BR112013008407A patent/BR112013008407A2/pt not_active IP Right Cessation
- 2011-10-05 EP EP11769913.2A patent/EP2625193B1/en active Active
- 2011-10-05 CN CN201180047913.3A patent/CN103237807B/zh active Active
-
2019
- 2019-07-15 US US16/511,503 patent/US20190328859A1/en not_active Abandoned
-
2021
- 2021-04-07 US US17/224,404 patent/US20210369830A1/en active Pending
-
2022
- 2022-08-23 US US17/821,730 patent/US12491239B2/en active Active
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