JP2016519932A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016519932A5 JP2016519932A5 JP2016513127A JP2016513127A JP2016519932A5 JP 2016519932 A5 JP2016519932 A5 JP 2016519932A5 JP 2016513127 A JP2016513127 A JP 2016513127A JP 2016513127 A JP2016513127 A JP 2016513127A JP 2016519932 A5 JP2016519932 A5 JP 2016519932A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- human
- sortase
- antibody
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000005260 human cell Anatomy 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 3
- 210000000987 immune system Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019079111A JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822092P | 2013-05-10 | 2013-05-10 | |
| US61/822,092 | 2013-05-10 | ||
| US201461943094P | 2014-02-21 | 2014-02-21 | |
| US61/943,094 | 2014-02-21 | ||
| PCT/US2014/037545 WO2014183066A2 (en) | 2013-05-10 | 2014-05-09 | Protein modification of living cells using sortase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019079111A Division JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519932A JP2016519932A (ja) | 2016-07-11 |
| JP2016519932A5 true JP2016519932A5 (enExample) | 2017-06-22 |
| JP6603209B2 JP6603209B2 (ja) | 2019-11-06 |
Family
ID=51867884
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513127A Expired - Fee Related JP6603209B2 (ja) | 2013-05-10 | 2014-05-09 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| JP2019079111A Expired - Fee Related JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| JP2021043795A Active JP7306731B2 (ja) | 2013-05-10 | 2021-03-17 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019079111A Expired - Fee Related JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| JP2021043795A Active JP7306731B2 (ja) | 2013-05-10 | 2021-03-17 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10260038B2 (enExample) |
| EP (2) | EP4119662A1 (enExample) |
| JP (3) | JP6603209B2 (enExample) |
| AU (3) | AU2014262469B2 (enExample) |
| WO (1) | WO2014183066A2 (enExample) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10081684B2 (en) | 2011-06-28 | 2018-09-25 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| AU2014262469B2 (en) | 2013-05-10 | 2019-11-14 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| JP6599848B2 (ja) | 2013-05-10 | 2019-10-30 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ソルタギング可能なタンパク質を有する赤血球のｉｎｖｉｔｒｏ生成 |
| WO2015048312A1 (en) * | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| US10556024B2 (en) | 2013-11-13 | 2020-02-11 | Whitehead Institute For Biomedical Research | 18F labeling of proteins using sortases |
| BR112016011195A2 (pt) | 2013-11-18 | 2017-09-19 | Rubius Therapeutics Inc | Células eritroides enucleadas e seus métodos de fabricação, composição farmacêutica e seu uso, uso de uma população de células eritroides, biorreator, mistura de células e dispositivo médico |
| US10144778B2 (en) | 2014-03-12 | 2018-12-04 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| WO2015153102A1 (en) | 2014-04-01 | 2015-10-08 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
| US20150307620A1 (en) * | 2014-04-16 | 2015-10-29 | University Of Connecticut | Linked immunotherapeutic agonists that costimulate multiple pathways |
| US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| US20170226495A1 (en) * | 2014-07-21 | 2017-08-10 | Novartis Ag | Sortase molecules and uses thereof |
| GB201417288D0 (en) * | 2014-09-30 | 2014-11-12 | Univ Dundee | Cysteine labelling |
| US10053683B2 (en) * | 2014-10-03 | 2018-08-21 | Whitehead Institute For Biomedical Research | Intercellular labeling of ligand-receptor interactions |
| EP3789403A1 (en) * | 2014-11-11 | 2021-03-10 | MedImmune Limited | Therapeutic combinations comprising anti-cd73 antibodies and a2a receptor inhibitor and uses thereof |
| SG11201704627XA (en) | 2014-12-17 | 2017-07-28 | Hoffmann La Roche | Enzymatic one-pot reaction for double polypeptide conjugation in a single step using sortase |
| CN107109463B (zh) | 2014-12-17 | 2020-12-29 | 豪夫迈·罗氏有限公司 | 键形成酶的活性测定 |
| EP3256130A4 (en) * | 2015-02-12 | 2018-08-01 | Beyondspring Pharmaceuticals, Inc. | Use of plinabulin in combination with immune checkpoint inhibitors |
| EP3089761B1 (en) * | 2015-03-02 | 2019-06-12 | Innovative Cellular Therapeutics Co., Ltd. | Reducing immune tolerance induced by pd l1 |
| EP3770807B1 (en) * | 2015-05-04 | 2023-11-01 | Smith, Andrew Dennis | Computer-assisted tumor response assessment and evaluation of the vascular tumor burden |
| RU2017142352A (ru) | 2015-05-06 | 2019-06-06 | Снипр Текнолоджиз Лимитед | Изменение популяций микроорганизмов и модификация микробиоты |
| WO2017024296A1 (en) * | 2015-08-06 | 2017-02-09 | Memorial Sloan Kettering Cancer Center | Methods and compositions for tumor therapy |
| US11667691B2 (en) | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
| JP2017043547A (ja) * | 2015-08-24 | 2017-03-02 | 国立研究開発法人理化学研究所 | ポリペプチドを結合した成長因子及びその利用 |
| EP3353314A1 (en) | 2015-09-25 | 2018-08-01 | H. Hoffnabb-La Roche Ag | Transamidation employing sortase a in deep eutectic solvents |
| EP3353310B1 (en) | 2015-09-25 | 2020-04-29 | H. Hoffnabb-La Roche Ag | Process for producing thioesters employing a sortase a |
| CN108138158B (zh) * | 2015-09-25 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 可溶性分选酶a |
| EP4218833A1 (en) | 2015-10-01 | 2023-08-02 | Whitehead Institute for Biomedical Research | Labeling of antibodies |
| HRP20220436T1 (hr) * | 2015-11-03 | 2022-05-27 | Janssen Biotech, Inc. | Protutijela koja se specifično vežu na pd-1 i njihove uporabe |
| CN105400773B (zh) * | 2015-12-14 | 2018-06-26 | 同济大学 | 应用于大规模筛选癌症基因的CRISPR/Cas9富集测序方法 |
| RS62939B1 (sr) | 2016-01-11 | 2022-03-31 | Rubius Therapeutics Inc | Kompozicije i metode u vezi sa multimodalnim terapijskim ćelijskim sistemima u indikacijama kancera |
| CN105821039B (zh) * | 2016-03-09 | 2020-02-07 | 李旭 | 联合免疫基因抑制HBV复制的特异性sgRNA、表达载体及其应用 |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| SG11201810872UA (en) | 2016-06-06 | 2019-01-30 | Beyondspring Pharmaceuticals Inc | Composition and method for reducing neutropenia |
| JP7295795B2 (ja) * | 2016-07-29 | 2023-06-21 | ジュノー セラピューティクス インコーポレイテッド | 免疫調節ポリペプチドならびに関連する組成物および方法 |
| SG11201903644VA (en) * | 2016-08-29 | 2019-05-30 | Pdi Pharm Development Int Ag | Provision of a therapeutically active cell product |
| EP3512564B1 (en) * | 2016-09-14 | 2024-01-17 | The Trustees of The University of Pennsylvania | Proximity-based sortase-mediated protein purification and ligation |
| WO2018068201A1 (en) * | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| JP2019531755A (ja) * | 2016-10-27 | 2019-11-07 | インティマ バイオサイエンス， インコーポレイテッド | 遺伝子改変細胞を作製するウイルス法 |
| US12059413B2 (en) | 2016-11-02 | 2024-08-13 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction |
| BR112019011138A2 (pt) | 2016-12-02 | 2019-10-01 | Rubius Therapeutics Inc | composições e métodos relacionados com sistemas celulares para penetração em tumores sólidos |
| CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
| US20190375815A1 (en) * | 2017-01-31 | 2019-12-12 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| CN110381938A (zh) | 2017-02-01 | 2019-10-25 | 大连万春布林医药有限公司 | 减少中性粒细胞缺乏症的方法 |
| WO2018144966A1 (en) * | 2017-02-06 | 2018-08-09 | The Board Of Trustees Of The Leland Stanford Junior University | Bioconjugation methods for targeted in situ therapeutic delivery |
| CN110520522A (zh) | 2017-02-17 | 2019-11-29 | 鲁比厄斯治疗法股份有限公司 | 功能化红系细胞 |
| WO2018161026A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il15 compositions and methods for immunotherapy |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| CA3064435A1 (en) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| US20200172867A1 (en) | 2017-07-19 | 2020-06-04 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for cardiometabolic disease |
| US20200172868A1 (en) | 2017-07-19 | 2020-06-04 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for infectious disease |
| EP4328314A3 (en) | 2017-08-22 | 2024-03-20 | Tessera Therapeutics, Inc. | Lipid nanoparticle methods and compositions for producing engineered erythroid cells |
| US12227742B2 (en) | 2017-10-23 | 2025-02-18 | The Broad Institute, Inc. | Nucleic acid modifiers |
| WO2019090148A2 (en) | 2017-11-03 | 2019-05-09 | Rubius Therapeutics, Inc. | Compositions and methods related to therapeutic cell systems for tumor growth inhibition |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US20190201548A1 (en) | 2017-12-29 | 2019-07-04 | Rubius Therapeutics, Inc. | Gene editing and targeted transcriptional modulation for engineering erythroid cells |
| WO2019140116A2 (en) | 2018-01-10 | 2019-07-18 | Rubius Therapeutics, Inc. | Amplifiable rnas for therapeutic cell systems |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| US11141433B2 (en) | 2018-03-08 | 2021-10-12 | Rubius Therapeutics, Inc. | Therapeutic cell systems and methods for treating cancer and infectious diseases |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| AU2019257789A1 (en) * | 2018-04-27 | 2020-11-12 | Crispr Therapeutics Ag | Anti-BCMA CAR-T-cells for plasma cell depletion |
| CN110499291B (zh) * | 2018-05-16 | 2023-11-24 | 上海赛比曼生物科技有限公司 | 无血清培养制备嵌合抗原受体t细胞的方法 |
| RU2677264C1 (ru) * | 2018-05-24 | 2019-01-16 | Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") | Иммунотоксин для терапии рассеянного склероза, способ его получения и применения |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3818072A1 (en) * | 2018-07-03 | 2021-05-12 | Technische Universität München | Means and methods for site-specific protein modification using transpeptidases |
| JP2022513312A (ja) * | 2018-09-21 | 2022-02-07 | シティー・ユニバーシティー・オブ・ホンコン | 表面修飾細胞外小胞 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3154589A1 (en) * | 2018-10-12 | 2020-04-16 | Mauro CASTELLARIN | Compositions and methods for switchable car t cells using surface-bound sortase transpeptidase |
| WO2020099513A1 (en) * | 2018-11-13 | 2020-05-22 | Lipoxen Technologies Limited | Glycopolysialylation of blinatumomab |
| WO2020117852A1 (en) | 2018-12-03 | 2020-06-11 | Rubius Therapeutics, Inc. | Artificial antigen presenting cells including hla-e and hla-g molecules and methods of use |
| SG11202109073VA (en) | 2019-02-20 | 2021-09-29 | Rubius Therapeutics Inc | Engineered erythroid cells including loadable antigen-presenting polypeptides and methods of use |
| EP3938784A1 (en) * | 2019-03-13 | 2022-01-19 | Merck Patent GmbH | Process for the preparation of lipidated proteinaceous structures |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| TW202106315A (zh) | 2019-04-26 | 2021-02-16 | 美商盧比亞斯治療公司 | 包括去核類紅血球之組成物 |
| US20220154144A1 (en) * | 2019-04-26 | 2022-05-19 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells comprising ligands for nkg2d for expanding immune cells for immunotherapy |
| BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
| KR20220016480A (ko) | 2019-05-24 | 2022-02-09 | 루비우스 테라퓨틱스, 아이엔씨. | 탈핵 적혈구를 생성하는 방법 |
| US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| WO2021092047A1 (en) | 2019-11-04 | 2021-05-14 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells using taurine or hypotaurine |
| KR20220110192A (ko) | 2019-11-04 | 2022-08-05 | 루비우스 테라퓨틱스, 아이엔씨. | 미오-이노시톨을 사용하여 제혁 적혈구를 생성하는 방법 |
| US20230050813A1 (en) | 2020-01-13 | 2023-02-16 | Carmine Therapeutics Pte. Ltd. | Nucleic acid loaded red blood cell extracellular vesicles |
| WO2021162731A1 (en) | 2020-02-10 | 2021-08-19 | Rubius Therapeutics, Inc. | Engineered erythroid cells including hla-g polypeptides and methods of use thereof |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| WO2021185360A1 (en) * | 2020-03-20 | 2021-09-23 | Westlake Therapeutics (Hangzhou) Co., Limited | Novel truncated sortase variants |
| WO2021228832A1 (en) | 2020-05-11 | 2021-11-18 | Erytech Pharma | Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof |
| USD980069S1 (en) | 2020-07-14 | 2023-03-07 | Ball Corporation | Metallic dispensing lid |
| CN111848816B (zh) * | 2020-07-24 | 2021-06-08 | 斯普迈(北京)生物科技有限公司 | 融合蛋白及其用途 |
| WO2022089605A1 (en) * | 2020-10-30 | 2022-05-05 | Westlake Therapeutics (Hangzhou) Co. Limited | Modified red blood cells and uses thereof for delivering agents |
| IL302728A (en) | 2020-11-13 | 2023-07-01 | Catamaran Bio Inc | Genetically modified natural killer cells and methods of use thereof |
| TW202241471A (zh) | 2021-01-08 | 2022-11-01 | 美商盧比亞斯治療公司 | 提高個體中NKp30陽性淋巴球的方法及其用途 |
| TW202241470A (zh) | 2021-01-08 | 2022-11-01 | 美商盧比亞斯治療公司 | 治療人類個體腫瘤之方法 |
| AU2021423664A1 (en) | 2021-01-28 | 2023-09-07 | Genequantum Healthcare (Suzhou) Co., Ltd. | Ligase fusion proteins and applications thereof |
| US12168551B2 (en) | 2021-03-01 | 2024-12-17 | Ball Corporation | Metal container and end closure with seal |
| TW202304482A (zh) | 2021-03-14 | 2023-02-01 | 美商盧比亞斯治療公司 | 於個體中增加nkg2d陽性淋巴球之方法及其用途 |
| CN117202894A (zh) | 2021-03-31 | 2023-12-08 | 胭脂红治疗私人有限公司 | 负载至少两个不同核酸的细胞外囊泡 |
| EP4319751A4 (en) | 2021-04-09 | 2025-02-26 | Beyondspring Pharmaceuticals, Inc. | THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS |
| TW202317179A (zh) | 2021-06-03 | 2023-05-01 | 美商盧比亞斯治療公司 | 在個體中治療ｈｐｖ１６－陽性或ｈｐｖ１６－相關的癌症之方法 |
| WO2023284742A1 (en) * | 2021-07-13 | 2023-01-19 | Westlake Therapeutics (Hangzhou) Co. Limited | Cells modified by conjugated n-terminal glycine and uses thereof |
| CA3241913A1 (en) * | 2021-12-10 | 2023-06-15 | Georgiamune Inc. | Polypeptide modulators |
| WO2023134573A1 (en) * | 2022-01-12 | 2023-07-20 | Westlake Therapeutics (Shanghai) Co., Limited | Modified cells and uses thereof |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| WO2024067295A1 (zh) * | 2022-09-28 | 2024-04-04 | 西湖生物医药科技(杭州)有限公司 | 修饰的红细胞及其用于递送药物的用途 |
| WO2024126294A1 (en) * | 2022-12-13 | 2024-06-20 | Evotec International Gmbh | Interferon-associated antigen binding proteins for use for the treatment or prevention of parainfluenza virus infection |
| WO2024126293A1 (en) * | 2022-12-13 | 2024-06-20 | Evotec International Gmbh | Interferon-associated antigen binding proteins for use for the treatment or prevention of respiratory syncytial virus infection |
| WO2024126289A1 (en) * | 2022-12-13 | 2024-06-20 | Evotec International Gmbh | Interferon-associated antigen binding proteins for use for the treatment or prevention of influenza virus infection |
| WO2025120230A1 (en) * | 2023-12-07 | 2025-06-12 | T-Curx Gmbh | Method of producing leukocytes expressing artificial antigen receptors |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5670132A (en) | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
| US5728369A (en) | 1994-10-05 | 1998-03-17 | Immunomedics, Inc. | Radioactive phosphorus labeling of proteins for targeted radiotherapy |
| US5891680A (en) | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| EP1233780A4 (en) | 1999-04-15 | 2004-09-22 | Univ California | IDENTIFICATION OF THE SORTASE GENE |
| US20030119185A1 (en) | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| EP1311301A2 (en) | 2000-07-06 | 2003-05-21 | Bristol-Myers Squibb Pharma Company | Stable radiopharmaceutical compositions and methods for preparation thereof |
| GB0025307D0 (en) | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
| ATE437221T1 (de) | 2001-05-14 | 2009-08-15 | Gbp Ip Llc | Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie |
| WO2004022722A2 (en) | 2002-09-06 | 2004-03-18 | Massachusetts Institute Of Technology | Lentiviral vectors, related reagents, and methods of use thereof |
| MXPA05006828A (es) | 2002-12-23 | 2005-09-08 | Wyeth Corp | Anticuerpos contra pd-1, y sus usos. |
| US6960473B2 (en) | 2003-02-27 | 2005-11-01 | Istituto Superiore Di Sanita | In vitro mass production of human erythroid cells from the blood of normal donors and thalassemic patients |
| CA2535550A1 (en) | 2003-08-12 | 2005-03-03 | William M. Yarbrough | Treatment for acne vulgaris and method of use |
| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| WO2005051976A2 (en) | 2003-11-20 | 2005-06-09 | Ansata Therapeutics, Inc. | Protein and peptide ligation processes and one-step purification processes |
| EP1753859B1 (en) | 2004-06-04 | 2014-07-30 | Université Pierre et Marie Curie (Paris 6) | A method for producing red blood cells |
| WO2006045064A2 (en) | 2004-10-20 | 2006-04-27 | Whitehead Institute For Biomedical Research | Cultured hematopoietic stem cells and method for expansion and analysis thereof |
| US8444973B2 (en) | 2005-02-15 | 2013-05-21 | Duke University | Anti-CD19 antibodies and uses in B cell disorders |
| JP5139271B2 (ja) | 2005-05-24 | 2013-02-06 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | 培養した造血幹細胞を拡大しかつ分析する方法 |
| EP1739165A1 (en) | 2005-06-29 | 2007-01-03 | Cellution Biotech B.V. | Method and apparatus for cultivating cells utilizing wave motion |
| KR20090021295A (ko) | 2006-05-31 | 2009-03-02 | 엔벤타 바이오파마슈티칼스 코퍼레이션 | 생물활성 정제된 ＨｓｐＥ7 조성물 |
| US8398956B2 (en) | 2007-01-11 | 2013-03-19 | Immunomedics, Inc. | In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents |
| WO2008137641A2 (en) | 2007-05-04 | 2008-11-13 | Whitehead Institute For Biomedical Research | Ex vivo expansion of human hematopoietic stem cells |
| NZ582150A (en) | 2007-06-18 | 2012-08-31 | Msd Oss Bv | Antibodies to human programmed death receptor pd-1 |
| US8865875B2 (en) | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
| US9757440B2 (en) | 2007-10-29 | 2017-09-12 | Trustees Of Dartmouth College | Method for treating cancer with Toxoplasma gondii vaccine |
| US8282942B2 (en) | 2007-10-29 | 2012-10-09 | Trustees Of Dartmouth College | Toxoplasma gondii vaccines and uses thereof |
| WO2009086640A1 (en) | 2008-01-10 | 2009-07-16 | Nventa Biopharmaceuticals Corporation | Adjuvant compositions comprising poly-ic and a cationic polymer |
| JP2011519557A (ja) | 2008-05-05 | 2011-07-14 | ウィルソン ウォルフ マニュファクチャリング コーポレイション | 細胞容器 |
| JP5395171B2 (ja) | 2008-07-08 | 2014-01-22 | ウィルソン ウォルフ マニュファクチャリング コーポレイション | 気体透過性の細胞培養装置および使用方法 |
| US20120034156A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| JP2012510429A (ja) | 2008-08-25 | 2012-05-10 | アンプリミューン、インコーポレーテッド | Ｐｄ−１アンタゴニストおよびその使用方法 |
| CN102203132A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂的组合物和使用方法 |
| PT3006459T (pt) | 2008-08-26 | 2021-11-26 | Hope City | Método e composições para funcionamento melhorado de efetores antitumorais de células t |
| WO2010033913A1 (en) | 2008-09-22 | 2010-03-25 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| AU2009296392B2 (en) | 2008-09-26 | 2016-06-02 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor |
| JP2010115136A (ja) | 2008-11-12 | 2010-05-27 | Teruyuki Nagamune | Ｎ末端標識膜蛋白質の作製方法、及びｎ末端標識膜蛋白質を表層に有する細胞 |
| WO2010078376A2 (en) | 2008-12-30 | 2010-07-08 | Ventana Medical Systems, Inc. | Fc-specific polymer-conjugated antibodies and their diagnostic use |
| EP2391714B2 (en) | 2009-01-30 | 2019-07-24 | Whitehead Institute for Biomedical Research | Methods for ligation and uses thereof |
| JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ | Ｐｄ−１抗体およびｐｄ−ｌ１抗体ならびにその使用 |
| JP2012521215A (ja) | 2009-03-26 | 2012-09-13 | アヴァリス・アクチエボラーグ | Ｎｋ細胞の増殖 |
| WO2011028531A1 (en) | 2009-08-24 | 2011-03-10 | Baylor College Of Medicine | Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| US20110151551A1 (en) | 2009-12-22 | 2011-06-23 | Ge Healthcare Bio-Sciences Corp. | Bioreactors |
| EP2534173B1 (en) | 2010-02-08 | 2019-09-11 | Sangamo Therapeutics, Inc. | Engineered cleavage half-domains |
| BR112012020102A2 (pt) | 2010-02-10 | 2016-11-29 | Immunogen Inc | anticorpos cd20 e usos dos mesmos. |
| DK2539441T3 (en) | 2010-02-22 | 2017-01-09 | Univ Pierre Et Marie Curie Paris 6 | Cell culture medium for the growth and differentiation of cells of hematopoietic lineage |
| CN103097527A (zh) | 2010-02-26 | 2013-05-08 | 塞勒克提斯公司 | 用于将转基因插入安全港座位的内切核酸酶的用途 |
| CA2791930A1 (en) | 2010-03-11 | 2011-09-15 | Kerry Louise Tyson | Pd-1 antibody |
| WO2011130624A2 (en) | 2010-04-16 | 2011-10-20 | Immune Disease Institute, Inc. | Sustained polypeptide expression from synthetic, modified rnas and uses thereof |
| WO2011133704A2 (en) | 2010-04-20 | 2011-10-27 | Whitehead Institute For Biomedical Researh | Modified polypeptides and proteins and uses thereof |
| ES2602743T3 (es) | 2010-09-08 | 2017-02-22 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Receptores de antígenos quiméricos con una región bisagra optimizada |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012142659A1 (en) | 2011-04-19 | 2012-10-26 | Baker Idi Heart And Diabetes Institute Holdings Limited | Site-selective modification of proteins |
| US20130071414A1 (en) | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| US10081684B2 (en) | 2011-06-28 | 2018-09-25 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| EP2546329A1 (en) | 2011-07-11 | 2013-01-16 | Lonza Cologne GmbH | Scale up of cell cultures |
| CN102559600A (zh) * | 2011-12-29 | 2012-07-11 | 上海交通大学医学院 | 一种人工抗原递呈细胞及其在nk细胞扩增中的应用 |
| EP2822957A1 (en) | 2012-03-07 | 2015-01-14 | Aurigene Discovery Technologies Limited | Peptidomimetic compounds as immunomodulators |
| AU2013245645A1 (en) | 2012-04-13 | 2014-11-13 | Whitehead Institute For Biomedical Research | Sortase- modified VHH domains and uses thereof |
| US20140030697A1 (en) | 2012-06-14 | 2014-01-30 | Massachusetts Institute Of Technology | Sortase-mediated modification of viral surface proteins |
| US9267127B2 (en) | 2012-06-21 | 2016-02-23 | President And Fellows Of Harvard College | Evolution of bond-forming enzymes |
| US9511350B2 (en) | 2013-05-10 | 2016-12-06 | Clean Diesel Technologies, Inc. (Cdti) | ZPGM Diesel Oxidation Catalysts and methods of making and using same |
| JP6599848B2 (ja) | 2013-05-10 | 2019-10-30 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ソルタギング可能なタンパク質を有する赤血球のｉｎｖｉｔｒｏ生成 |
| AU2014262469B2 (en) | 2013-05-10 | 2019-11-14 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| WO2015051188A1 (en) | 2013-10-02 | 2015-04-09 | Washington University | Heterocyclic molecules for biomedical imaging and therapeutic applications |
| WO2015057863A1 (en) | 2013-10-15 | 2015-04-23 | Regents Of The University Of Minnesota | Triorthogonal reagents for dual protein conjugation |
| US10556024B2 (en) | 2013-11-13 | 2020-02-11 | Whitehead Institute For Biomedical Research | 18F labeling of proteins using sortases |
| US10053683B2 (en) | 2014-10-03 | 2018-08-21 | Whitehead Institute For Biomedical Research | Intercellular labeling of ligand-receptor interactions |
| EP4218833A1 (en) | 2015-10-01 | 2023-08-02 | Whitehead Institute for Biomedical Research | Labeling of antibodies |
| KR20220016480A (ko) | 2019-05-24 | 2022-02-09 | 루비우스 테라퓨틱스, 아이엔씨. | 탈핵 적혈구를 생성하는 방법 |
-
2014
- 2014-05-09 AU AU2014262469A patent/AU2014262469B2/en not_active Expired - Fee Related
- 2014-05-09 US US14/890,296 patent/US10260038B2/en active Active
- 2014-05-09 WO PCT/US2014/037545 patent/WO2014183066A2/en not_active Ceased
- 2014-05-09 EP EP22173120.1A patent/EP4119662A1/en not_active Withdrawn
- 2014-05-09 EP EP14795120.6A patent/EP2994530A4/en not_active Withdrawn
- 2014-05-09 JP JP2016513127A patent/JP6603209B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-15 US US16/277,721 patent/US12331311B2/en active Active
- 2019-04-11 US US16/381,654 patent/US11492590B2/en active Active
- 2019-04-18 JP JP2019079111A patent/JP6901154B2/ja not_active Expired - Fee Related
-
2020
- 2020-02-11 AU AU2020200962A patent/AU2020200962B2/en not_active Ceased
-
2021
- 2021-03-17 JP JP2021043795A patent/JP7306731B2/ja active Active
-
2022
- 2022-09-14 AU AU2022231702A patent/AU2022231702A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016519932A5 (enExample) | ||
| HRP20201770T1 (hr) | Nova imunoterapija protiv raznih vrsta karcinoma, uključujući gastrointestinalni karcinom i gastrični karcinom | |
| BR112022001923A2 (pt) | Proteína de ligação ao antígeno, ácido nucleico isolado, célula hospedeira recombinante, composição farmacêutica, método de produção da proteína de ligação ao antígeno | |
| JP2012143232A5 (enExample) | ||
| NZ701444A (en) | Antibodies to matrix metalloproteinase 9 | |
| JP2014528696A5 (enExample) | ||
| JOP20190248A1 (ar) | بروتينات ربط مولد ضد trem2 واستخداماته | |
| JP2014502253A5 (enExample) | ||
| RU2017107773A (ru) | Антитела, специфичные к ммр9 | |
| RU2015146419A (ru) | Выделение терапевтических доменов vnar, специфичных по отношению к мишени icosl | |
| JP2017532005A5 (enExample) | ||
| EA201790341A1 (ru) | Анти-ск8 антитела для применения в лечении рака | |
| PH12018502451A1 (en) | Brain delivery protein | |
| HRP20192262T1 (hr) | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) | |
| CN110869390A (zh) | 抗pd-l1抗体及其用途 | |
| JP2013511996A5 (enExample) | ||
| JP2017529870A5 (enExample) | ||
| JP2018507254A5 (enExample) | ||
| EA201290671A1 (ru) | Антигенсвязывающие белки, специфические в отношении сывороточного амилоидного компонента р | |
| EA201100741A1 (ru) | Антитела к модифицированным пептидам ифр-1/е человека | |
| JP2012523221A5 (enExample) | ||
| HRP20211753T1 (hr) | Novi peptidi i kombinacije peptida za upotrebu u imunoterapiji protiv hepatocelularnog karcinoma (hcc) i drugih rakova | |
| CN109890839A (zh) | 识别sage1抗原短肽的t细胞受体 | |
| JP2017524358A5 (enExample) | ||
| RU2017104910A (ru) | Новый аллерген |