JP2016519932A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016519932A5 JP2016519932A5 JP2016513127A JP2016513127A JP2016519932A5 JP 2016519932 A5 JP2016519932 A5 JP 2016519932A5 JP 2016513127 A JP2016513127 A JP 2016513127A JP 2016513127 A JP2016513127 A JP 2016513127A JP 2016519932 A5 JP2016519932 A5 JP 2016519932A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- human
- sortase
- antibody
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000005260 human cell Anatomy 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 3
- 210000000987 immune system Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019079111A JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822092P | 2013-05-10 | 2013-05-10 | |
| US61/822,092 | 2013-05-10 | ||
| US201461943094P | 2014-02-21 | 2014-02-21 | |
| US61/943,094 | 2014-02-21 | ||
| PCT/US2014/037545 WO2014183066A2 (en) | 2013-05-10 | 2014-05-09 | Protein modification of living cells using sortase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019079111A Division JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519932A JP2016519932A (ja) | 2016-07-11 |
| JP2016519932A5 true JP2016519932A5 (enExample) | 2017-06-22 |
| JP6603209B2 JP6603209B2 (ja) | 2019-11-06 |
Family
ID=51867884
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513127A Expired - Fee Related JP6603209B2 (ja) | 2013-05-10 | 2014-05-09 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| JP2019079111A Expired - Fee Related JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| JP2021043795A Active JP7306731B2 (ja) | 2013-05-10 | 2021-03-17 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019079111A Expired - Fee Related JP6901154B2 (ja) | 2013-05-10 | 2019-04-18 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| JP2021043795A Active JP7306731B2 (ja) | 2013-05-10 | 2021-03-17 | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10260038B2 (enExample) |
| EP (2) | EP2994530A4 (enExample) |
| JP (3) | JP6603209B2 (enExample) |
| AU (3) | AU2014262469B2 (enExample) |
| WO (1) | WO2014183066A2 (enExample) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012275390A1 (en) | 2011-06-28 | 2014-01-16 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| EP3546485A1 (en) | 2013-05-10 | 2019-10-02 | Whitehead Institute for Biomedical Research | In vitro production of red blood cells with sortaggable proteins |
| AU2014262469B2 (en) | 2013-05-10 | 2019-11-14 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| EP3049442A4 (en) * | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| WO2015073746A2 (en) | 2013-11-13 | 2015-05-21 | Whitehead Institute For Biomedical Research | 18f labeling of proteins using sortases |
| WO2015073587A2 (en) | 2013-11-18 | 2015-05-21 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| KR20230097209A (ko) | 2014-03-12 | 2023-06-30 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소 |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10869898B2 (en) | 2014-04-01 | 2020-12-22 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
| US20150307620A1 (en) * | 2014-04-16 | 2015-10-29 | University Of Connecticut | Linked immunotherapeutic agonists that costimulate multiple pathways |
| EP3194585A1 (en) * | 2014-07-21 | 2017-07-26 | Novartis AG | Sortase molecules and uses thereof |
| US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| GB201417288D0 (en) * | 2014-09-30 | 2014-11-12 | Univ Dundee | Cysteine labelling |
| US10053683B2 (en) * | 2014-10-03 | 2018-08-21 | Whitehead Institute For Biomedical Research | Intercellular labeling of ligand-receptor interactions |
| EP3789403A1 (en) * | 2014-11-11 | 2021-03-10 | MedImmune Limited | Therapeutic combinations comprising anti-cd73 antibodies and a2a receptor inhibitor and uses thereof |
| JP6800154B2 (ja) | 2014-12-17 | 2020-12-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 結合形成酵素の活性アッセイ |
| SG11201704627XA (en) | 2014-12-17 | 2017-07-28 | Hoffmann La Roche | Enzymatic one-pot reaction for double polypeptide conjugation in a single step using sortase |
| CA2975729A1 (en) * | 2015-02-12 | 2016-08-18 | Beyondspring Pharmaceuticals, Inc. | Use of plinabulin in combination with immune checkpoint inhibitors |
| JP6336684B2 (ja) | 2015-03-02 | 2018-06-06 | イノベイティブ セルラー セラピューティクス シーオー．，エルティディ．Ｉｎｎｏｖａｔｉｖｅ Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．，Ｌｔｄ． | Ｐｄ−ｌ１によって誘導される免疫寛容の低減 |
| EP3292511B1 (en) * | 2015-05-04 | 2020-08-19 | Smith, Andrew Dennis | Computer-assisted tumor response assessment and evaluation of the vascular tumor burden |
| EP3291679B1 (en) | 2015-05-06 | 2021-12-15 | SNIPR Technologies Limited | Altering microbial populations & modifying microbiota |
| US20200079860A1 (en) * | 2015-08-06 | 2020-03-12 | Memorial Sloan Kettering Cancer Center | Methods and compositions for tumor therapy |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
| JP2017043547A (ja) * | 2015-08-24 | 2017-03-02 | 国立研究開発法人理化学研究所 | ポリペプチドを結合した成長因子及びその利用 |
| EP3353310B1 (en) | 2015-09-25 | 2020-04-29 | H. Hoffnabb-La Roche Ag | Process for producing thioesters employing a sortase a |
| WO2017050866A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Novel soluble sortase a |
| CN108026560A (zh) | 2015-09-25 | 2018-05-11 | 豪夫迈·罗氏有限公司 | 在低共熔溶剂中使用分选酶的转酰胺反应 |
| ES2941968T3 (es) | 2015-10-01 | 2023-05-29 | The Whitehead Institute For Biomedical Res | Marcaje de anticuerpos |
| EP4046655A1 (en) * | 2015-11-03 | 2022-08-24 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
| CN105400773B (zh) * | 2015-12-14 | 2018-06-26 | 同济大学 | 应用于大规模筛选癌症基因的CRISPR/Cas9富集测序方法 |
| CA3009063A1 (en) * | 2016-01-11 | 2017-07-20 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for cancer indications |
| CN105821039B (zh) * | 2016-03-09 | 2020-02-07 | 李旭 | 联合免疫基因抑制HBV复制的特异性sgRNA、表达载体及其应用 |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| US11229642B2 (en) | 2016-06-06 | 2022-01-25 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing neutropenia |
| JP7295795B2 (ja) * | 2016-07-29 | 2023-06-21 | ジュノー セラピューティクス インコーポレイテッド | 免疫調節ポリペプチドならびに関連する組成物および方法 |
| WO2018039810A1 (en) * | 2016-08-29 | 2018-03-08 | Pdi Pharm Development International Ag | Provision of a therapeutically active cell product |
| EP4372002A3 (en) * | 2016-09-14 | 2024-08-14 | The Trustees Of The University Of Pennsylvania | Proximity-based sortase-mediated protein purification and ligation |
| WO2018068201A1 (en) * | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| GB2607227B (en) * | 2016-10-27 | 2023-05-10 | Intima Bioscience Inc | Viral methods of T cell therapy |
| WO2018085208A1 (en) | 2016-11-02 | 2018-05-11 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction |
| JP2019536793A (ja) | 2016-12-02 | 2019-12-19 | ルビウス セラピューティクス， インコーポレイテッド | 固形腫瘍に浸透させるための細胞系に関連する組成物および方法 |
| JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
| US20190375815A1 (en) * | 2017-01-31 | 2019-12-12 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| MY201811A (en) | 2017-02-01 | 2024-03-19 | Beyondspring Pharmaceuticals Inc | Method of reducing neutropenia |
| US20200038484A1 (en) * | 2017-02-06 | 2020-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Bioconjugation Methods for Targeted in Situ Therapeutic Delivery |
| US11020435B2 (en) | 2017-02-17 | 2021-06-01 | Rubius Therapeutics, Inc. | Functionalized erythroid cells |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| WO2018161026A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il15 compositions and methods for immunotherapy |
| KR20190129077A (ko) | 2017-03-15 | 2019-11-19 | 팬디온 테라퓨틱스, 인코포레이티드 | 표적화된 면역관용 |
| CA3064435A1 (en) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| EP3654992A1 (en) | 2017-07-19 | 2020-05-27 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for cardiometabolic disease |
| US20200172868A1 (en) | 2017-07-19 | 2020-06-04 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for infectious disease |
| EP3672602A1 (en) | 2017-08-22 | 2020-07-01 | Rubius Therapeutics, Inc. | Lipid nanoparticle methods and compositions for producing engineered erythroid cells |
| WO2019135816A2 (en) * | 2017-10-23 | 2019-07-11 | The Broad Institute, Inc. | Novel nucleic acid modifiers |
| WO2019090148A2 (en) | 2017-11-03 | 2019-05-09 | Rubius Therapeutics, Inc. | Compositions and methods related to therapeutic cell systems for tumor growth inhibition |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US20190201548A1 (en) | 2017-12-29 | 2019-07-04 | Rubius Therapeutics, Inc. | Gene editing and targeted transcriptional modulation for engineering erythroid cells |
| US20190330591A1 (en) | 2018-01-10 | 2019-10-31 | Rubius Therapeutics, Inc. | Amplifiable rnas for therapeutic cell systems |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| WO2019173798A1 (en) | 2018-03-08 | 2019-09-12 | Rubius Therapeutics, Inc. | Therapeutic cell systems and methods for treating cancer and infectious diseases |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| SG11202010233XA (en) * | 2018-04-27 | 2020-11-27 | Crispr Therapeutics Ag | Anti-bcma car-t-cells for plasma cell depletion |
| CN110499291B (zh) * | 2018-05-16 | 2023-11-24 | 上海赛比曼生物科技有限公司 | 无血清培养制备嵌合抗原受体t细胞的方法 |
| RU2677264C1 (ru) * | 2018-05-24 | 2019-01-16 | Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") | Иммунотоксин для терапии рассеянного склероза, способ его получения и применения |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| WO2020007899A1 (en) * | 2018-07-03 | 2020-01-09 | Technische Universität München | Means and methods for site-specific protein modification using transpeptidases |
| JP2022513312A (ja) * | 2018-09-21 | 2022-02-07 | シティー・ユニバーシティー・オブ・ホンコン | 表面修飾細胞外小胞 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3864143A4 (en) * | 2018-10-12 | 2022-08-17 | The Trustees of The University of Pennsylvania | Compositions and methods for switchable car t cells using surface-bound sortase transpeptidase |
| US20220023430A1 (en) * | 2018-11-13 | 2022-01-27 | Lipoxen Technologies Limited | Glycopolysialylation of blinatumomab |
| WO2020117852A1 (en) | 2018-12-03 | 2020-06-11 | Rubius Therapeutics, Inc. | Artificial antigen presenting cells including hla-e and hla-g molecules and methods of use |
| BR112021016451A2 (pt) | 2019-02-20 | 2021-11-09 | Rubius Therapeutics Inc | Célula eritroide projetada incluindo polipeptídeos apresentadores de antígeno carregáveis e métodos de uso |
| EP3938784A1 (en) * | 2019-03-13 | 2022-01-19 | Merck Patent GmbH | Process for the preparation of lipidated proteinaceous structures |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| WO2020220016A1 (en) * | 2019-04-26 | 2020-10-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells comprising ligands for nkg2d for expanding immune cells for immunotherapy |
| TW202106315A (zh) | 2019-04-26 | 2021-02-16 | 美商盧比亞斯治療公司 | 包括去核類紅血球之組成物 |
| TW202110885A (zh) | 2019-05-20 | 2021-03-16 | 美商潘迪恩治療公司 | 靶向ＭＡｄＣＡＭ之免疫耐受性 |
| AU2020283752A1 (en) | 2019-05-24 | 2021-12-23 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells |
| US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| WO2021092052A1 (en) | 2019-11-04 | 2021-05-14 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells using myo-inositol |
| JP2023500325A (ja) | 2019-11-04 | 2023-01-05 | ルビウス セラピューティクス， インコーポレイテッド | タウリンまたはヒポタウリンを使用して除核赤芽球細胞を生成する方法 |
| US20230050813A1 (en) | 2020-01-13 | 2023-02-16 | Carmine Therapeutics Pte. Ltd. | Nucleic acid loaded red blood cell extracellular vesicles |
| US20210246426A1 (en) | 2020-02-10 | 2021-08-12 | Rubius Therapeutics, Inc. | Engineered Erythroid Cells Including HLA-G Polypeptides and Methods of Use Thereof |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| WO2021185359A1 (en) * | 2020-03-20 | 2021-09-23 | Westlake Therapeutics (Hangzhou) Co. Limited | Modified red blood cells and uses thereof for delivering agents |
| CA3178252A1 (en) | 2020-05-11 | 2021-11-18 | Erytech Pharma | Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof |
| USD980069S1 (en) | 2020-07-14 | 2023-03-07 | Ball Corporation | Metallic dispensing lid |
| CN111848816B (zh) * | 2020-07-24 | 2021-06-08 | 斯普迈(北京)生物科技有限公司 | 融合蛋白及其用途 |
| WO2022089605A1 (en) * | 2020-10-30 | 2022-05-05 | Westlake Therapeutics (Hangzhou) Co. Limited | Modified red blood cells and uses thereof for delivering agents |
| EP4243839A1 (en) | 2020-11-13 | 2023-09-20 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| TW202241471A (zh) | 2021-01-08 | 2022-11-01 | 美商盧比亞斯治療公司 | 提高個體中NKp30陽性淋巴球的方法及其用途 |
| WO2022150578A1 (en) | 2021-01-08 | 2022-07-14 | Rubius Therapeutics, Inc. | Methods of treating a tumor in a human subject |
| CN116917484A (zh) | 2021-01-28 | 2023-10-20 | 启德医药科技（苏州）有限公司 | 连接酶融合蛋白及其应用 |
| US12168551B2 (en) | 2021-03-01 | 2024-12-17 | Ball Corporation | Metal container and end closure with seal |
| WO2022197548A1 (en) | 2021-03-14 | 2022-09-22 | Rubius Therapeutics, Inc. | Methods of increasing nkg2d-positive lymphocytes in a subject and uses thereof |
| WO2022211740A1 (en) | 2021-03-31 | 2022-10-06 | Carmine Therapeutics Pte. Ltd. | Extracellular vesicles loaded with at least two different nucleic acids |
| JP2024513505A (ja) | 2021-04-09 | 2024-03-25 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | 腫瘍を治療するための組成物及び方法 |
| TW202317179A (zh) | 2021-06-03 | 2023-05-01 | 美商盧比亞斯治療公司 | 在個體中治療ｈｐｖ１６－陽性或ｈｐｖ１６－相關的癌症之方法 |
| US20250276013A1 (en) * | 2021-07-13 | 2025-09-04 | Westlake Therapeutics (Hangzhou) Co. Limited | Cells Modified by Conjugated N-Terminal Glycine and Uses Thereof |
| IL313360A (en) * | 2021-12-10 | 2024-08-01 | Georgiamune Inc | Polypeptide modulators |
| WO2023134573A1 (en) * | 2022-01-12 | 2023-07-20 | Westlake Therapeutics (Shanghai) Co., Limited | Modified cells and uses thereof |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| CN120380136A (zh) * | 2022-09-28 | 2025-07-25 | 西湖生物医药科技(杭州)有限公司 | 修饰的红细胞及其用于递送药物的用途 |
| WO2024126293A1 (en) * | 2022-12-13 | 2024-06-20 | Evotec International Gmbh | Interferon-associated antigen binding proteins for use for the treatment or prevention of respiratory syncytial virus infection |
| WO2024126294A1 (en) * | 2022-12-13 | 2024-06-20 | Evotec International Gmbh | Interferon-associated antigen binding proteins for use for the treatment or prevention of parainfluenza virus infection |
| WO2024126289A1 (en) * | 2022-12-13 | 2024-06-20 | Evotec International Gmbh | Interferon-associated antigen binding proteins for use for the treatment or prevention of influenza virus infection |
| WO2025120230A1 (en) * | 2023-12-07 | 2025-06-12 | T-Curx Gmbh | Method of producing leukocytes expressing artificial antigen receptors |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5670132A (en) | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
| US5728369A (en) | 1994-10-05 | 1998-03-17 | Immunomedics, Inc. | Radioactive phosphorus labeling of proteins for targeted radiotherapy |
| US5891680A (en) | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| CA2365523A1 (en) | 1999-04-15 | 2000-10-26 | The Regents Of The University Of California | Identification of sortase gene |
| US20030119185A1 (en) | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| CA2413538A1 (en) | 2000-07-06 | 2002-01-17 | Bristol-Myers Squibb Pharma Company | Stable radiopharmaceutical compositions and methods for preparation thereof |
| GB0025307D0 (en) | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
| US6808905B2 (en) | 2001-05-14 | 2004-10-26 | Cell Genesys, Inc. | Lentiviral vectors encoding clotting factors for gene therapy |
| WO2004022722A2 (en) | 2002-09-06 | 2004-03-18 | Massachusetts Institute Of Technology | Lentiviral vectors, related reagents, and methods of use thereof |
| ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| US6960473B2 (en) | 2003-02-27 | 2005-11-01 | Istituto Superiore Di Sanita | In vitro mass production of human erythroid cells from the blood of normal donors and thalassemic patients |
| AU2003264053A1 (en) | 2003-08-12 | 2005-03-10 | William M. Yarbrough | Treatment for acne vulgaris and method of use |
| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| WO2005051976A2 (en) | 2003-11-20 | 2005-06-09 | Ansata Therapeutics, Inc. | Protein and peptide ligation processes and one-step purification processes |
| JP5139799B2 (ja) | 2004-06-04 | 2013-02-06 | ユニベルシテ ピエール エ マリー キュリー（パリ シズエム） | 赤血球細胞の生産方法 |
| US7767453B2 (en) | 2004-10-20 | 2010-08-03 | Whitehead Institute For Biomedical Research | Cultured hematopoietic stem cells and method for expansion and analysis thereof |
| US8444973B2 (en) | 2005-02-15 | 2013-05-21 | Duke University | Anti-CD19 antibodies and uses in B cell disorders |
| US7807464B2 (en) | 2005-05-24 | 2010-10-05 | Whitehead Institute For Biomedical Research | Methods for expansion and analysis of cultured hematopoietic stem cells |
| EP1739165A1 (en) | 2005-06-29 | 2007-01-03 | Cellution Biotech B.V. | Method and apparatus for cultivating cells utilizing wave motion |
| RU2008151516A (ru) | 2006-05-31 | 2010-07-10 | Нвента Биофармасьютиклз Корпорейшн (Us) | СПОСОБ УВЕЛИЧЕНИЯ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ ОЧИЩЕННОГО БЕЛКА HspE7 |
| US8398956B2 (en) | 2007-01-11 | 2013-03-19 | Immunomedics, Inc. | In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents |
| WO2008137641A2 (en) | 2007-05-04 | 2008-11-13 | Whitehead Institute For Biomedical Research | Ex vivo expansion of human hematopoietic stem cells |
| CA2691357C (en) | 2007-06-18 | 2014-09-23 | N.V. Organon | Antibodies to human programmed death receptor pd-1 |
| EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| US8282942B2 (en) | 2007-10-29 | 2012-10-09 | Trustees Of Dartmouth College | Toxoplasma gondii vaccines and uses thereof |
| US9757440B2 (en) | 2007-10-29 | 2017-09-12 | Trustees Of Dartmouth College | Method for treating cancer with Toxoplasma gondii vaccine |
| EP2247308A4 (en) | 2008-01-10 | 2012-04-18 | Nventa Biopharmaceuticals Corp | ADJUVANT COMPOSITIONS COMPRISING POLY-IC AND CATIONIC POLYMER |
| CA2722907C (en) | 2008-05-05 | 2016-07-12 | Wilson Wolf Manufacturing Corporation | Cell container |
| WO2010006055A2 (en) | 2008-07-08 | 2010-01-14 | Wilson Wolf Manufacturing Corporation | Improved gas permeable cell culture device and method of use |
| US20120034155A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| HUE027525T2 (en) | 2008-08-25 | 2016-11-28 | Amplimmune Inc | PD-1 Antagonist preparations and their use |
| MX2011002250A (es) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Antagonistas de muerte celular programada-1 y métodos de uso de los mismos. |
| US8822647B2 (en) | 2008-08-26 | 2014-09-02 | City Of Hope | Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells |
| US20100092470A1 (en) | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| PL2342226T3 (pl) | 2008-09-26 | 2017-01-31 | Dana-Farber Cancer Institute, Inc. | Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania |
| JP2010115136A (ja) | 2008-11-12 | 2010-05-27 | Teruyuki Nagamune | Ｎ末端標識膜蛋白質の作製方法、及びｎ末端標識膜蛋白質を表層に有する細胞 |
| WO2010078376A2 (en) | 2008-12-30 | 2010-07-08 | Ventana Medical Systems, Inc. | Fc-specific polymer-conjugated antibodies and their diagnostic use |
| EP2391714B2 (en) | 2009-01-30 | 2019-07-24 | Whitehead Institute for Biomedical Research | Methods for ligation and uses thereof |
| EP3192811A1 (en) | 2009-02-09 | 2017-07-19 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| JP2012521215A (ja) | 2009-03-26 | 2012-09-13 | アヴァリス・アクチエボラーグ | Ｎｋ細胞の増殖 |
| RU2012111349A (ru) | 2009-08-24 | 2013-10-27 | Байлор Колледж Оф Медсин | Генерация линий ctl со специфичностью против множества опухолевых антигенов или множества вирусов |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| US20110151551A1 (en) | 2009-12-22 | 2011-06-23 | Ge Healthcare Bio-Sciences Corp. | Bioreactors |
| AU2011213242B2 (en) | 2010-02-08 | 2015-01-29 | Sangamo Therapeutics, Inc. | Engineered cleavage half-domains |
| EP2533810B1 (en) | 2010-02-10 | 2016-10-12 | ImmunoGen, Inc. | Cd20 antibodies and uses thereof |
| PT2539441T (pt) | 2010-02-22 | 2017-01-05 | Assist Publique Hôpitaux De Paris | Meio de cultura de células para o crescimento e diferenciação de células da linhagem hematopoiética |
| CA2791116A1 (en) | 2010-02-26 | 2011-09-01 | Olivier Danos | Use of endonucleases for inserting transgenes into safe harbor loci |
| EP2545078A1 (en) | 2010-03-11 | 2013-01-16 | UCB Pharma, S.A. | Pd-1 antibody |
| EP3072961A1 (en) | 2010-04-16 | 2016-09-28 | Children's Medical Center Corporation | Sustained polypeptide expression from synthetic, modified rnas and uses thereof |
| EP2593469A4 (en) | 2010-04-20 | 2015-07-15 | Whitehead Biomedical Inst | MODIFIED POLYPEPTIDES AND PROTEINS AND ITS APPLICATION |
| EP2614077B1 (en) | 2010-09-08 | 2016-08-17 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012142659A1 (en) | 2011-04-19 | 2012-10-26 | Baker Idi Heart And Diabetes Institute Holdings Limited | Site-selective modification of proteins |
| US20130071414A1 (en) | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| AU2012275390A1 (en) * | 2011-06-28 | 2014-01-16 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| EP2546329A1 (en) | 2011-07-11 | 2013-01-16 | Lonza Cologne GmbH | Scale up of cell cultures |
| CN102559600A (zh) * | 2011-12-29 | 2012-07-11 | 上海交通大学医学院 | 一种人工抗原递呈细胞及其在nk细胞扩增中的应用 |
| WO2013132317A1 (en) | 2012-03-07 | 2013-09-12 | Aurigene Discovery Technologies Limited | Peptidomimetic compounds as immunomodulators |
| EP2836507A4 (en) | 2012-04-13 | 2016-08-24 | Whitehead Biomedical Inst | SORTAS-MODIFIED VHH DOMAINS AND USES THEREOF |
| US20140030697A1 (en) | 2012-06-14 | 2014-01-30 | Massachusetts Institute Of Technology | Sortase-mediated modification of viral surface proteins |
| US9267127B2 (en) | 2012-06-21 | 2016-02-23 | President And Fellows Of Harvard College | Evolution of bond-forming enzymes |
| US9511350B2 (en) | 2013-05-10 | 2016-12-06 | Clean Diesel Technologies, Inc. (Cdti) | ZPGM Diesel Oxidation Catalysts and methods of making and using same |
| AU2014262469B2 (en) | 2013-05-10 | 2019-11-14 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| EP3546485A1 (en) | 2013-05-10 | 2019-10-02 | Whitehead Institute for Biomedical Research | In vitro production of red blood cells with sortaggable proteins |
| WO2015051188A1 (en) | 2013-10-02 | 2015-04-09 | Washington University | Heterocyclic molecules for biomedical imaging and therapeutic applications |
| US9878045B2 (en) | 2013-10-15 | 2018-01-30 | Regents Of The University Of Minnesota | Triorthogonal reagents for dual protein conjugation |
| WO2015073746A2 (en) | 2013-11-13 | 2015-05-21 | Whitehead Institute For Biomedical Research | 18f labeling of proteins using sortases |
| US10053683B2 (en) | 2014-10-03 | 2018-08-21 | Whitehead Institute For Biomedical Research | Intercellular labeling of ligand-receptor interactions |
| ES2941968T3 (es) | 2015-10-01 | 2023-05-29 | The Whitehead Institute For Biomedical Res | Marcaje de anticuerpos |
| AU2020283752A1 (en) | 2019-05-24 | 2021-12-23 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells |
-
2014
- 2014-05-09 AU AU2014262469A patent/AU2014262469B2/en not_active Expired - Fee Related
- 2014-05-09 EP EP14795120.6A patent/EP2994530A4/en not_active Withdrawn
- 2014-05-09 WO PCT/US2014/037545 patent/WO2014183066A2/en not_active Ceased
- 2014-05-09 US US14/890,296 patent/US10260038B2/en active Active
- 2014-05-09 EP EP22173120.1A patent/EP4119662A1/en not_active Withdrawn
- 2014-05-09 JP JP2016513127A patent/JP6603209B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-15 US US16/277,721 patent/US12331311B2/en active Active
- 2019-04-11 US US16/381,654 patent/US11492590B2/en active Active
- 2019-04-18 JP JP2019079111A patent/JP6901154B2/ja not_active Expired - Fee Related
-
2020
- 2020-02-11 AU AU2020200962A patent/AU2020200962B2/en not_active Ceased
-
2021
- 2021-03-17 JP JP2021043795A patent/JP7306731B2/ja active Active
-
2022
- 2022-09-14 AU AU2022231702A patent/AU2022231702A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016519932A5 (enExample) | ||
| HRP20201770T1 (hr) | Nova imunoterapija protiv raznih vrsta karcinoma, uključujući gastrointestinalni karcinom i gastrični karcinom | |
| BR112022001923A2 (pt) | Proteína de ligação ao antígeno, ácido nucleico isolado, célula hospedeira recombinante, composição farmacêutica, método de produção da proteína de ligação ao antígeno | |
| JP2012143232A5 (enExample) | ||
| JP2020530285A5 (enExample) | ||
| NZ701444A (en) | Antibodies to matrix metalloproteinase 9 | |
| JP2014528696A5 (enExample) | ||
| HRP20220918T1 (hr) | Anti-transtiretinska antitijela | |
| JP2020516603A5 (enExample) | ||
| RU2021124437A (ru) | Конструкции, направленные на комплексы пептида afp/mhc, и виды их использования | |
| JP2014502253A5 (enExample) | ||
| RU2017107773A (ru) | Антитела, специфичные к ммр9 | |
| RU2015146419A (ru) | Выделение терапевтических доменов vnar, специфичных по отношению к мишени icosl | |
| PH12018502451A1 (en) | Brain delivery protein | |
| EA201790341A1 (ru) | Анти-ск8 антитела для применения в лечении рака | |
| HRP20192262T1 (hr) | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) | |
| JP2017529870A5 (enExample) | ||
| JP2018507254A5 (enExample) | ||
| JP2018537117A5 (enExample) | ||
| EA201100741A1 (ru) | Антитела к модифицированным пептидам ифр-1/е человека | |
| JP2012523221A5 (enExample) | ||
| HRP20211753T1 (hr) | Novi peptidi i kombinacije peptida za upotrebu u imunoterapiji protiv hepatocelularnog karcinoma (hcc) i drugih rakova | |
| CN109890839A (zh) | 识别sage1抗原短肽的t细胞受体 | |
| CN115362171A (zh) | 用于治疗冠状病毒的抗体、融合蛋白及其应用 | |
| JP2017524358A5 (enExample) |