JP2014528696A5 - - Google Patents
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- Publication number
- JP2014528696A5 JP2014528696A5 JP2014517736A JP2014517736A JP2014528696A5 JP 2014528696 A5 JP2014528696 A5 JP 2014528696A5 JP 2014517736 A JP2014517736 A JP 2014517736A JP 2014517736 A JP2014517736 A JP 2014517736A JP 2014528696 A5 JP2014528696 A5 JP 2014528696A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- peptide
- psca
- amino acid
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 230000027455 binding Effects 0.000 claims description 3
- 101000972485 Homo sapiens Lupus La protein Proteins 0.000 claims description 2
- 102000052972 human La Human genes 0.000 claims description 2
- 239000012636 effector Substances 0.000 description 8
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 6
- 102100036735 Prostate stem cell antigen Human genes 0.000 description 6
- 108010032595 Antibody Binding Sites Proteins 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 239000012634 fragment Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000000139 costimulatory effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011118022.6A DE102011118022B4 (de) | 2011-06-30 | 2011-06-30 | Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung |
| DE102011118022.6 | 2011-06-30 | ||
| PCT/EP2012/062716 WO2013001065A1 (de) | 2011-06-30 | 2012-06-29 | Antikörper gegen das prostata-spezifische stammzellantigen und dessen verwendung |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017002983A Division JP6549622B2 (ja) | 2011-06-30 | 2017-01-12 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014528696A JP2014528696A (ja) | 2014-10-30 |
| JP2014528696A5 true JP2014528696A5 (enExample) | 2015-10-01 |
Family
ID=46384405
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517736A Pending JP2014528696A (ja) | 2011-06-30 | 2012-06-29 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
| JP2017002983A Expired - Fee Related JP6549622B2 (ja) | 2011-06-30 | 2017-01-12 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
| JP2019117977A Active JP6886491B2 (ja) | 2011-06-30 | 2019-06-26 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
| JP2021081553A Active JP7341185B2 (ja) | 2011-06-30 | 2021-05-13 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017002983A Expired - Fee Related JP6549622B2 (ja) | 2011-06-30 | 2017-01-12 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
| JP2019117977A Active JP6886491B2 (ja) | 2011-06-30 | 2019-06-26 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
| JP2021081553A Active JP7341185B2 (ja) | 2011-06-30 | 2021-05-13 | 前立腺特異幹細胞抗原に対する抗体およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9200078B2 (enExample) |
| EP (2) | EP3505536B1 (enExample) |
| JP (4) | JP2014528696A (enExample) |
| AU (1) | AU2012277784B2 (enExample) |
| CY (1) | CY1121249T1 (enExample) |
| DE (1) | DE102011118022B4 (enExample) |
| DK (1) | DK2726507T3 (enExample) |
| ES (2) | ES2711978T3 (enExample) |
| HR (1) | HRP20190289T1 (enExample) |
| HU (1) | HUE042008T2 (enExample) |
| LT (1) | LT2726507T (enExample) |
| PL (1) | PL2726507T3 (enExample) |
| PT (1) | PT2726507T (enExample) |
| RS (1) | RS58448B1 (enExample) |
| SI (1) | SI2726507T1 (enExample) |
| SM (1) | SMT201900085T1 (enExample) |
| TR (1) | TR201901991T4 (enExample) |
| WO (1) | WO2013001065A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011118022B4 (de) * | 2011-06-30 | 2018-01-18 | Gemoab Monoclonals Gmbh | Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung |
| EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
| US11834506B2 (en) | 2017-02-08 | 2023-12-05 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind NKG2D, CD16, and a tumor-associated antigen for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| ES2955074T3 (es) | 2017-02-20 | 2023-11-28 | Dragonfly Therapeutics Inc | Proteínas que se unen a HER2, NKG2D Y CD16 |
| WO2019066093A1 (ko) * | 2017-09-26 | 2019-04-04 | 주식회사 와이바이오로직스 | Scf 특이적 항체 |
| ES2986967T3 (es) | 2018-02-08 | 2024-11-13 | Dragonfly Therapeutics Inc | Combinaciones de dominios variables de anticuerpos dirigidas al receptor NKG2D |
| MX2020008333A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales. |
| BR112020016939A2 (pt) | 2018-02-20 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Proteínas de ligação multiespecíficas que se ligam a cd33, nkg2d, e cd16 e métodos de uso |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| SG11202100883SA (en) | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics Inc | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| AU2021268340A1 (en) | 2020-05-06 | 2022-12-08 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and CLEC12A |
| AU2021276327A1 (en) * | 2020-05-19 | 2022-12-01 | City Of Hope | Engineered anti-prostate stem cell antigen fusion proteins and uses thereof |
| US12377144B2 (en) | 2021-03-03 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen |
| WO2024233662A2 (en) * | 2023-05-09 | 2024-11-14 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Molecules that bind to psca polypeptides |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541212B2 (en) | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
| EP2343085B1 (en) * | 1997-03-10 | 2014-12-10 | The Regents of The University of California | Antibody against prostate stem cell antigen (PSCA) |
| ES2309012T3 (es) * | 1999-10-29 | 2008-12-16 | Genentech, Inc. | Composiciones del anticuerpo anti-psca y a sus procedimientos contra celulas cancerigenas que expresen psca. |
| MXPA06004035A (es) * | 2003-10-16 | 2006-08-31 | Micromet Ag | Aglutinantes cd3 de-inmunizados multi-especificos. |
| AU2005250370B2 (en) * | 2004-05-28 | 2010-04-01 | Agensys, Inc. | Antibodies and related molecules that bind to PSCA proteins |
| JP6126773B2 (ja) * | 2007-09-04 | 2017-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原（ｐｓｃａ）抗体 |
| SG194399A1 (en) * | 2008-10-01 | 2013-11-29 | Amgen Res Munich Gmbh | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxcd3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody |
| US20110142811A1 (en) * | 2009-12-16 | 2011-06-16 | Deutsches Krebsforschungszentrum | Measles virus for the elimination of unwanted cell populations |
| DE102011118022B4 (de) * | 2011-06-30 | 2018-01-18 | Gemoab Monoclonals Gmbh | Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung |
-
2011
- 2011-06-30 DE DE102011118022.6A patent/DE102011118022B4/de not_active Expired - Fee Related
-
2012
- 2012-06-29 RS RS20190218A patent/RS58448B1/sr unknown
- 2012-06-29 ES ES12729996T patent/ES2711978T3/es active Active
- 2012-06-29 US US14/129,933 patent/US9200078B2/en active Active
- 2012-06-29 LT LTEP12729996.4T patent/LT2726507T/lt unknown
- 2012-06-29 SI SI201231523T patent/SI2726507T1/sl unknown
- 2012-06-29 TR TR2019/01991T patent/TR201901991T4/tr unknown
- 2012-06-29 HU HUE12729996A patent/HUE042008T2/hu unknown
- 2012-06-29 EP EP18207370.0A patent/EP3505536B1/de active Active
- 2012-06-29 PT PT12729996T patent/PT2726507T/pt unknown
- 2012-06-29 SM SM20190085T patent/SMT201900085T1/it unknown
- 2012-06-29 HR HRP20190289TT patent/HRP20190289T1/hr unknown
- 2012-06-29 ES ES18207370T patent/ES2989975T3/es active Active
- 2012-06-29 WO PCT/EP2012/062716 patent/WO2013001065A1/de not_active Ceased
- 2012-06-29 EP EP12729996.4A patent/EP2726507B1/de active Active
- 2012-06-29 JP JP2014517736A patent/JP2014528696A/ja active Pending
- 2012-06-29 DK DK12729996.4T patent/DK2726507T3/en active
- 2012-06-29 PL PL12729996T patent/PL2726507T3/pl unknown
- 2012-06-29 AU AU2012277784A patent/AU2012277784B2/en not_active Ceased
-
2017
- 2017-01-12 JP JP2017002983A patent/JP6549622B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-11 CY CY20191100176T patent/CY1121249T1/el unknown
- 2019-06-26 JP JP2019117977A patent/JP6886491B2/ja active Active
-
2021
- 2021-05-13 JP JP2021081553A patent/JP7341185B2/ja active Active
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