JP2016531924A5 - - Google Patents
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- Publication number
- JP2016531924A5 JP2016531924A5 JP2016540383A JP2016540383A JP2016531924A5 JP 2016531924 A5 JP2016531924 A5 JP 2016531924A5 JP 2016540383 A JP2016540383 A JP 2016540383A JP 2016540383 A JP2016540383 A JP 2016540383A JP 2016531924 A5 JP2016531924 A5 JP 2016531924A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- heavy chain
- binding molecule
- igm
- chain constant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874277P | 2013-09-05 | 2013-09-05 | |
| US201361874284P | 2013-09-05 | 2013-09-05 | |
| US61/874,277 | 2013-09-05 | ||
| US61/874,284 | 2013-09-05 | ||
| PCT/US2014/054079 WO2015053887A1 (en) | 2013-09-05 | 2014-09-04 | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531924A JP2016531924A (ja) | 2016-10-13 |
| JP2016531924A5 true JP2016531924A5 (enExample) | 2017-10-12 |
| JP6721505B2 JP6721505B2 (ja) | 2020-07-15 |
Family
ID=51542496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540383A Expired - Fee Related JP6721505B2 (ja) | 2013-09-05 | 2014-09-04 | 定常領域が修飾された（ｃｏｎｓｔａｎｔ ｃｈａｉｎ ｍｏｄｉｆｉｅｄ）二重特異性五価及び六価Ｉｇ−Ｍ抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10351631B2 (enExample) |
| EP (1) | EP3041862B1 (enExample) |
| JP (1) | JP6721505B2 (enExample) |
| KR (1) | KR102306492B1 (enExample) |
| CN (1) | CN105722855B (enExample) |
| AU (1) | AU2014332458B2 (enExample) |
| CA (1) | CA2922830A1 (enExample) |
| DK (1) | DK3041862T3 (enExample) |
| WO (1) | WO2015053887A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| WO2012116926A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Antigen binding proteins |
| JP5768147B2 (ja) | 2011-02-28 | 2015-08-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 一価抗原結合タンパク質 |
| BR112016006929A2 (pt) * | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| WO2015120474A1 (en) | 2014-02-10 | 2015-08-13 | Igm Biosciences, Inc. | Iga multi-specific binding molecules |
| EP4011910A1 (en) | 2014-04-03 | 2022-06-15 | IGM Biosciences, Inc. | Modified j-chain |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) * | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| AU2016249404B2 (en) | 2015-04-17 | 2021-01-21 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| PT3355913T (pt) * | 2015-09-30 | 2024-12-18 | Igm Biosciences Inc | Moléculas de ligação com cadeia j modificada |
| ES2819870T3 (es) * | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| WO2017196867A1 (en) | 2016-05-09 | 2017-11-16 | Igm Biosciences, Inc. | Anti-pd-l1 antibodies |
| CA3055790A1 (en) | 2017-04-07 | 2018-10-11 | Igm Biosciences, Inc. | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function |
| CN111787951B (zh) | 2018-03-01 | 2025-06-17 | Igm生物科学股份有限公司 | 影响IgM血清半衰期的IgM Fc和J链突变 |
| JP2022544405A (ja) | 2019-08-15 | 2022-10-18 | アイジーエム バイオサイエンシズ インコーポレイテッド | 免疫刺激性多量体型結合分子 |
| JP2023522962A (ja) | 2020-04-22 | 2023-06-01 | アイジーエム バイオサイエンシズ インコーポレイテッド | Ｐｄ－１アゴニスト多量体結合分子 |
| CA3245061A1 (en) | 2022-04-07 | 2023-10-12 | Repertoire Immune Medicines, Inc. | T-CELL RECEIVER MULTIMERS AND THEIR USES |
| CA3268418A1 (en) * | 2022-09-28 | 2024-04-04 | Dren Bio Management, Inc. | Multispecific Antibodies and Their Methods of Use |
| CN117482225A (zh) * | 2022-12-16 | 2024-02-02 | 北京东方略生物医药科技股份有限公司 | 一种IgM抗体制剂及其用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8719963D0 (en) | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| DK1626992T3 (da) | 2003-05-23 | 2010-09-20 | Crucell Holland Bv | Produktion af rekombinant IgM i PER.C6-celler |
| EP1776383B1 (en) * | 2004-07-22 | 2014-08-20 | Erasmus University Medical Center Rotterdam | Binding molecules |
| AU2005304973A1 (en) | 2004-11-05 | 2006-05-18 | Palingen, Inc. | Antibody induced cell membrane wounding |
| US8349332B2 (en) * | 2005-04-06 | 2013-01-08 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
| EP3663318A1 (en) * | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| US9676845B2 (en) * | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US20130129723A1 (en) | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| EP2760891B1 (en) * | 2011-09-26 | 2018-11-07 | JN Biosciences LLC | Hybrid constant regions |
| US9527927B2 (en) * | 2011-12-20 | 2016-12-27 | Medimmune, Llc | Modified polypeptides for bispecific antibody scaffolds |
| WO2013120012A2 (en) | 2012-02-08 | 2013-08-15 | Igm Biosciences Inc. | Cdim binding proteins and uses thereof |
| SG10201806025TA (en) | 2014-01-16 | 2018-08-30 | Mario Umberto Francesco Mondelli | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
| WO2015120474A1 (en) | 2014-02-10 | 2015-08-13 | Igm Biosciences, Inc. | Iga multi-specific binding molecules |
| EP4011910A1 (en) | 2014-04-03 | 2022-06-15 | IGM Biosciences, Inc. | Modified j-chain |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| AU2016249404B2 (en) | 2015-04-17 | 2021-01-21 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| PT3355913T (pt) | 2015-09-30 | 2024-12-18 | Igm Biosciences Inc | Moléculas de ligação com cadeia j modificada |
| ES2819870T3 (es) | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| WO2017196867A1 (en) | 2016-05-09 | 2017-11-16 | Igm Biosciences, Inc. | Anti-pd-l1 antibodies |
| AU2017299608A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric CD137/4-1BB binding molecules and uses thereof |
| US20190338041A1 (en) | 2016-07-20 | 2019-11-07 | Igm Biosciences, Inc. | Multimeric cd40 binding molecules and uses thereof |
| US20190330374A1 (en) | 2016-07-20 | 2019-10-31 | Igm Biosciences, Inc. | Multimeric ox40 binding molecules and uses thereof |
| CA3030659A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
-
2014
- 2014-09-04 CN CN201480051238.5A patent/CN105722855B/zh not_active Expired - Fee Related
- 2014-09-04 KR KR1020167007082A patent/KR102306492B1/ko not_active Expired - Fee Related
- 2014-09-04 AU AU2014332458A patent/AU2014332458B2/en not_active Ceased
- 2014-09-04 US US14/916,166 patent/US10351631B2/en active Active
- 2014-09-04 CA CA2922830A patent/CA2922830A1/en active Pending
- 2014-09-04 WO PCT/US2014/054079 patent/WO2015053887A1/en not_active Ceased
- 2014-09-04 DK DK14766628.3T patent/DK3041862T3/da active
- 2014-09-04 EP EP14766628.3A patent/EP3041862B1/en active Active
- 2014-09-04 JP JP2016540383A patent/JP6721505B2/ja not_active Expired - Fee Related