JP2018537415A5 - - Google Patents
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- Publication number
- JP2018537415A5 JP2018537415A5 JP2018519031A JP2018519031A JP2018537415A5 JP 2018537415 A5 JP2018537415 A5 JP 2018537415A5 JP 2018519031 A JP2018519031 A JP 2018519031A JP 2018519031 A JP2018519031 A JP 2018519031A JP 2018537415 A5 JP2018537415 A5 JP 2018537415A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- antibody
- multivalent
- terminus
- variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15189665.1 | 2015-10-13 | ||
| EP15189665.1A EP3156417A1 (en) | 2015-10-13 | 2015-10-13 | Multivalent fv antibodies |
| PCT/EP2016/074642 WO2017064221A1 (en) | 2015-10-13 | 2016-10-13 | Multivalent fv antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537415A JP2018537415A (ja) | 2018-12-20 |
| JP2018537415A5 true JP2018537415A5 (enExample) | 2019-11-21 |
| JP6936497B2 JP6936497B2 (ja) | 2021-09-15 |
Family
ID=54325413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519031A Active JP6936497B2 (ja) | 2015-10-13 | 2016-10-13 | 多価Ｆｖ抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11572415B2 (enExample) |
| EP (2) | EP3156417A1 (enExample) |
| JP (1) | JP6936497B2 (enExample) |
| KR (1) | KR20180057720A (enExample) |
| CN (1) | CN108473577A (enExample) |
| AU (1) | AU2016336866B2 (enExample) |
| BR (1) | BR112018007445A2 (enExample) |
| CA (1) | CA3001765A1 (enExample) |
| IL (1) | IL258638B2 (enExample) |
| MX (1) | MX2018004547A (enExample) |
| SG (2) | SG10202004094VA (enExample) |
| WO (1) | WO2017064221A1 (enExample) |
| ZA (1) | ZA201802543B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201890041A1 (ru) | 2015-06-15 | 2018-07-31 | Нумаб Инновейшн Аг | Гетеродимерный полиспецифичный формат антител |
| JP7474193B2 (ja) * | 2017-06-25 | 2024-04-24 | システィミューン， インク． | 多重特異性抗体とその作製及び使用方法 |
| KR102924742B1 (ko) | 2018-03-14 | 2026-02-10 | 아피메트 게엠베하 | 이중특이적 egfr/cd16 항원-결합 단백질 |
| JP2021519289A (ja) * | 2018-03-27 | 2021-08-10 | システィミューン， インク．Ｓｙｓｔｉｍｍｕｎｅ， Ｉｎｃ． | ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 |
| US20240132626A1 (en) * | 2018-04-13 | 2024-04-25 | Eli Lilly And Company | Fab-Based Trispecific Antibodies |
| EP3774914A2 (en) * | 2018-04-13 | 2021-02-17 | Affimed GmbH | Nk cell engaging antibody fusion constructs |
| WO2019204398A1 (en) * | 2018-04-17 | 2019-10-24 | Invenra Inc. | Trivalent trispecific antibody constructs |
| RS65658B1 (sr) | 2018-08-27 | 2024-07-31 | Affimed Gmbh | Kriokonzervirane nk ćelije prethodno punjene konstruktom antitela |
| US20220396635A1 (en) * | 2019-09-25 | 2022-12-15 | Universität Stuttgart | Trivalent binding molecules |
| CN118420771A (zh) * | 2019-11-06 | 2024-08-02 | 西雅图免疫公司 | 制导和导航控制蛋白及其制备和使用方法 |
| AU2020414409A1 (en) | 2019-12-27 | 2022-06-16 | Affimed Gmbh | Method for the production of bispecific FcyRIIl x CD30 antibody construct |
| TWI908779B (zh) * | 2020-03-17 | 2025-12-21 | 美商西雅圖免疫公司 | 引導及導航控制(gnc)抗體樣蛋白質及製造與使用其之方法 |
| CN116368154A (zh) | 2020-10-08 | 2023-06-30 | 阿菲姆德股份有限公司 | 三特异性结合剂 |
| WO2022120033A1 (en) * | 2020-12-03 | 2022-06-09 | Amgen Inc. | Immunoglobuline constructs with multiple binding domains |
| JP2024510098A (ja) * | 2021-02-19 | 2024-03-06 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | 抗ＧＰＲＣ５ＤｘＢＣＭＡｘＣＤ３三重特異性抗体およびその使用 |
| AU2022320948A1 (en) | 2021-07-30 | 2024-01-18 | Affimed Gmbh | Duplexbodies |
| KR20240099224A9 (ko) * | 2021-09-29 | 2025-12-10 | 모덱스 테라퓨틱스, 인크. | 항원 결합 폴리펩티드, 항원 결합 폴리펩티드 복합체 및 이의 사용 방법 |
| CN114316060B (zh) * | 2021-12-15 | 2023-06-13 | 北京市肿瘤防治研究所 | 抗人cd19与cd206双特异性抗体及其制备方法和应用 |
| US20230272069A1 (en) * | 2022-02-28 | 2023-08-31 | Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences | Chimeric Antigen Receptor Targeting CD22 and CD19 and Application thereof |
| WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| IL327045A (en) | 2023-10-05 | 2026-05-01 | Capstan Therapeutics Inc | Structure-restricted ionizable cationic lipids and lipid nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025235413A1 (en) * | 2024-05-05 | 2025-11-13 | Duke University | Compositions targeting cancer antigens and methods of use thereof |
| WO2026087751A1 (en) | 2024-10-24 | 2026-04-30 | Affimed Gmbh | Combination of immune cell engager and nk cell products |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
| NZ279108A (en) * | 1994-01-07 | 1997-06-24 | Immunex Corp | Human fas (tgf/ngf receptor) ligand proteins coding sequences and production |
| WO1997014719A1 (en) | 1995-10-16 | 1997-04-24 | Unilever N.V. | A bifunctional or bivalent antibody fragment analogue |
| WO2002002781A1 (en) * | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Heterodimeric fusion proteins |
| ES2276735T3 (es) | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
| JP2005514030A (ja) * | 2001-12-26 | 2005-05-19 | イミューノメディクス、インコーポレイテッド | Ｖｈおよびｖｌドメインから多重特異性多価薬剤を製造する方法 |
| US20120237442A1 (en) | 2005-04-06 | 2012-09-20 | Ibc Pharmaceuticals, Inc. | Design and Construction of Novel Multivalent Antibodies |
| GB0510790D0 (en) * | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| CL2007002057A1 (es) * | 2006-07-13 | 2008-01-11 | Chugai Pharmaceutical Co Ltd | Diacuerpo anti-antigeno leucocitario humano (hla), usos del diacuerpo para preparar un medicamento util como inductor de muerte celular, supresor del crecimeinto celular o como agente antitumoral. |
| EP2014680A1 (en) * | 2007-07-10 | 2009-01-14 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Recombinant, single-chain, trivalent tri-specific or bi-specific antibody derivatives |
| GB201003701D0 (en) * | 2010-03-05 | 2010-04-21 | Cilian Ag | System for the expression of a protein |
| FR2959416B1 (fr) * | 2010-05-03 | 2012-06-22 | Monoclonal Antibodies Therapeutics Mat Biopharma | Utilisation d'anticorps anti-cd71 pour la preparation d'un medicament |
| WO2012088290A2 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Tri-variable domain binding proteins and uses thereof |
| TWI838039B (zh) * | 2011-03-28 | 2024-04-01 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| EP4706769A2 (en) * | 2012-12-03 | 2026-03-11 | NovImmune SA | Anti-cd47 antibodies and methods of use thereof |
| HK1216894A1 (zh) | 2012-12-28 | 2016-12-09 | Abbvie Inc. | 多價結合蛋白組合物 |
| US20150017120A1 (en) * | 2013-06-13 | 2015-01-15 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il-2 and adoptive cell therapy |
| EP2930188A1 (en) | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| EA201890041A1 (ru) * | 2015-06-15 | 2018-07-31 | Нумаб Инновейшн Аг | Гетеродимерный полиспецифичный формат антител |
-
2015
- 2015-10-13 EP EP15189665.1A patent/EP3156417A1/en not_active Withdrawn
-
2016
- 2016-10-13 BR BR112018007445A patent/BR112018007445A2/pt not_active Application Discontinuation
- 2016-10-13 CN CN201680073236.5A patent/CN108473577A/zh active Pending
- 2016-10-13 WO PCT/EP2016/074642 patent/WO2017064221A1/en not_active Ceased
- 2016-10-13 SG SG10202004094VA patent/SG10202004094VA/en unknown
- 2016-10-13 CA CA3001765A patent/CA3001765A1/en active Pending
- 2016-10-13 AU AU2016336866A patent/AU2016336866B2/en not_active Ceased
- 2016-10-13 KR KR1020187013310A patent/KR20180057720A/ko not_active Ceased
- 2016-10-13 SG SG11201803083XA patent/SG11201803083XA/en unknown
- 2016-10-13 IL IL258638A patent/IL258638B2/en unknown
- 2016-10-13 MX MX2018004547A patent/MX2018004547A/es unknown
- 2016-10-13 JP JP2018519031A patent/JP6936497B2/ja active Active
- 2016-10-13 EP EP16791328.4A patent/EP3362478A1/en not_active Withdrawn
-
2018
- 2018-04-11 US US15/950,733 patent/US11572415B2/en active Active
- 2018-04-17 ZA ZA2018/02543A patent/ZA201802543B/en unknown
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