|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
WO1992002551A1
(en)
|
1990-08-02 |
1992-02-20 |
B.R. Centre Limited |
Methods for the production of proteins with a desired function
|
|
DE69231223T3
(de)
|
1991-03-29 |
2008-01-17 |
Genentech, Inc., South San Francisco |
Menschliche pf4a rezeptoren und ihre verwendung
|
|
US5440021A
(en)
|
1991-03-29 |
1995-08-08 |
Chuntharapai; Anan |
Antibodies to human IL-8 type B receptor
|
|
US5374506A
(en)
|
1991-09-13 |
1994-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Amino acid sequence for a functional human interleukin-8 receptor
|
|
EP0651805B1
(en)
|
1992-07-17 |
2006-12-13 |
Dana Farber Cancer Institute |
Method of intracellular binding of target molecules
|
|
EP0656946B2
(en)
|
1992-08-21 |
2010-03-31 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
DK0702721T3
(da)
|
1993-06-09 |
2001-05-21 |
Unilever Nv |
Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvamp
|
|
US6091639A
(en)
|
1993-08-27 |
2000-07-18 |
Kabushiki Kaisha Toshiba |
Non-volatile semiconductor memory device and data programming method
|
|
US6448379B1
(en)
|
1993-09-14 |
2002-09-10 |
Chiron Corporation |
IL8 inhibitors
|
|
US5595756A
(en)
*
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
EP0745134A1
(en)
|
1994-02-22 |
1996-12-04 |
Danafarber Cancer Institute |
Nucleic acid delivery system, method of synthesis and uses thereof
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
AU7298398A
(en)
|
1996-11-19 |
1998-06-10 |
Sangstat Medical Corporation |
Enhanced effects for hapten conjugated therapeutics
|
|
US6329516B1
(en)
|
1997-04-28 |
2001-12-11 |
Fmc Corporation |
Lepidopteran GABA-gated chloride channels
|
|
BR9813276A
(pt)
|
1997-10-27 |
2000-08-22 |
Unilever Nv |
Proteìna multivalente de ligação de antìgeno, sequências de nucleotìdeos, vetor de expressão, célula hospedeira, processo para preparação de proteìna multivalente de ligação de antìgeno, e, uso da mesma
|
|
US20020155604A1
(en)
|
1998-02-19 |
2002-10-24 |
Jeffrey A. Ledbetter |
Compositions and methods for regulating lymphocyte activation
|
|
EP0967284A1
(en)
|
1998-05-28 |
1999-12-29 |
Pfizer Limited |
Phosphodiesterases
|
|
GB9824632D0
(en)
|
1998-11-10 |
1999-01-06 |
Celltech Therapeutics Ltd |
Biological compounds
|
|
EP1157119A1
(en)
|
1999-02-05 |
2001-11-28 |
Rijksuniversiteit Leiden |
Method of modulating metabolite biosynthesis in recombinant cells
|
|
DE60035163T2
(de)
|
1999-03-15 |
2008-02-21 |
University Of British Columbia, Vancouver |
Abc1 polypeptide und verfahren und reagenzien zur modulation des cholesterolgehalts
|
|
WO2000078972A2
(en)
|
1999-06-18 |
2000-12-28 |
Cv Therapeutics, Inc. |
Regulation with binding cassette transporter protein abc1
|
|
IL147920A0
(en)
|
1999-08-02 |
2002-08-14 |
Keygene Nv |
Method for generating cgmmv resistant plants, genetic constructs, and the obtained cgmmv-resistant plants
|
|
US20040214783A1
(en)
|
2002-05-08 |
2004-10-28 |
Terman David S. |
Compositions and methods for treatment of neoplastic disease
|
|
GB9922124D0
(en)
|
1999-09-17 |
1999-11-17 |
Pfizer Ltd |
Phosphodiesterase enzymes
|
|
DE19955408A1
(de)
|
1999-11-18 |
2001-05-23 |
Bayer Ag |
GABA-B-Rezeptoren
|
|
WO2001045746A2
(en)
|
1999-12-24 |
2001-06-28 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
WO2001072830A2
(de)
|
2000-03-31 |
2001-10-04 |
Ipf Pharmaceuticals Gmbh |
Diagnostik- und arzneimittel zur untersuchung des zelloberflächenproteoms von tumor- und entzündungszellen sowie zur behandlung von tumorerkrankungen und entzündlichen erkrankungen vorzugsweise mit hilfe einer spezifischen chemokinrezeptor-analyse und der chemokinrezeptor-ligand-interaktion
|
|
CA2405550A1
(en)
|
2000-04-12 |
2001-10-25 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
WO2002057445A1
(en)
|
2000-05-26 |
2002-07-25 |
National Research Council Of Canada |
Single-domain brain-targeting antibody fragments derived from llama antibodies
|
|
US6741957B1
(en)
|
2000-07-21 |
2004-05-25 |
Daimlerchrysler Corporation |
Analytical tire model for vehicle durability and ride comfort analysis
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
NZ527591A
(en)
|
2001-01-17 |
2006-04-28 |
Trubion Pharmaceuticals Inc |
Binding domain-immunoglobulin fusion proteins
|
|
CA2440582A1
(en)
|
2001-03-09 |
2002-10-03 |
Dyax Corp. |
Serum albumin binding moieties
|
|
EP1379275A4
(en)
|
2001-03-14 |
2005-12-21 |
Centocor Inc |
IMMUNOGLOBULIN-ASSOCIATED PROTEINS ASSOCIATED WITH OBSTRUCTIVE CHRONIC BRONCHOPNEUMOPATHY, COMPOSITIONS, METHODS AND USES
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
DE60237282D1
(de)
|
2001-06-28 |
2010-09-23 |
Domantis Ltd |
Doppelspezifischer ligand und dessen verwendung
|
|
JP2004538324A
(ja)
|
2001-08-03 |
2004-12-24 |
メディカル リサーチ カウンシル |
細胞内抗体
|
|
EP1427829A4
(en)
|
2001-08-31 |
2005-10-12 |
Abmaxis Inc |
MULTIVALENT PROTEIN CONJUGATE WITH SEVERAL LIGANDEN BINDING RECORDORDOMAS
|
|
KR100599789B1
(ko)
|
2001-12-03 |
2006-07-12 |
삼성에스디아이 주식회사 |
방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법
|
|
JP2005517674A
(ja)
|
2002-01-03 |
2005-06-16 |
フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー |
腫瘍の処置に有用な新規免疫コンジュゲート
|
|
DK1517921T3
(da)
|
2002-06-28 |
2006-10-09 |
Domantis Ltd |
Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf
|
|
US7004940B2
(en)
|
2002-10-10 |
2006-02-28 |
Ethicon, Inc. |
Devices for performing thermal ablation having movable ultrasound transducers
|
|
AU2003284891A1
(en)
|
2002-10-23 |
2004-05-13 |
Ludwig Institute For Cancer Research |
A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same
|
|
WO2004041170A2
(en)
|
2002-11-01 |
2004-05-21 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
EP3299393A1
(en)
|
2002-11-08 |
2018-03-28 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
EP1558647B1
(en)
|
2002-11-08 |
2015-06-10 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
GB0228210D0
(en)
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
|
EP1570267B1
(en)
|
2002-12-03 |
2011-10-12 |
UCB Pharma, S.A. |
Assay for identifying antibody producing cells
|
|
ES2373947T3
(es)
|
2002-12-16 |
2012-02-10 |
Genmab A/S |
Anticuerpos monoclonales humanos contra interleucina 8 (il-8).
|
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
KR101025143B1
(ko)
|
2002-12-31 |
2011-04-01 |
넥타르 테라퓨틱스 |
가수분해상으로 안정한 말레이미드－종결 중합체
|
|
GB0312481D0
(en)
|
2003-05-30 |
2003-07-09 |
Celltech R&D Ltd |
Antibodies
|
|
DK1639011T3
(da)
|
2003-06-30 |
2009-02-16 |
Domantis Ltd |
Pegylerede enkelt-domæne antistoffer (dAb)
|
|
US20060263353A1
(en)
|
2003-08-20 |
2006-11-23 |
Lawson Alastair D G |
Methods for obtaining antibodies
|
|
WO2005103702A2
(en)
|
2004-04-20 |
2005-11-03 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with cxc chemokine receptor 2 (cxcr2)
|
|
US7882839B2
(en)
|
2004-06-25 |
2011-02-08 |
Ambis Jr Edward J |
Custom mouthguard
|
|
US20060008601A1
(en)
|
2004-06-25 |
2006-01-12 |
Zeik Douglas B |
Flexible laminate having an integrated pressure release valve
|
|
WO2006008548A2
(en)
|
2004-07-22 |
2006-01-26 |
Erasmus University Medical Centre Rotterdam |
Binding molecules
|
|
BRPI0518151A2
(pt)
|
2004-10-13 |
2009-06-16 |
Ablynx Nv |
polipetìdeos contra amiloide-beta, ácido nucléico que codifica tal polipetìdeo, composição compreendendo tal polipetìdeo, método para produzir um polipetìdeo e uso do mesmo
|
|
WO2006040154A2
(en)
|
2004-10-14 |
2006-04-20 |
Dublin City University |
Prokaryotic two hybrid system
|
|
CA2595682A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
CN103254309B
(zh)
|
2005-05-18 |
2017-09-26 |
埃博灵克斯股份有限公司 |
针对肿瘤坏死因子α的改进的纳米体TM
|
|
CN101213214B
(zh)
|
2005-05-20 |
2014-06-25 |
埃博灵克斯股份有限公司 |
针对冯威勒布兰特因子的单一结构域vhh抗体
|
|
WO2007005605A2
(en)
|
2005-07-01 |
2007-01-11 |
Washington University In St. Louis |
Phosphospecific chemokine receptor antibodies
|
|
TWI323734B
(en)
|
2005-08-19 |
2010-04-21 |
Abbott Lab |
Dual variable domain immunoglobulin and uses thereof
|
|
WO2007112940A2
(en)
|
2006-03-31 |
2007-10-11 |
Ablynx N.V. |
Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same
|
|
EP2010568A1
(en)
|
2006-04-14 |
2009-01-07 |
Ablynx N.V. |
Dp-78-like nanobodies
|
|
CN101070346A
(zh)
*
|
2006-05-08 |
2007-11-14 |
陈正贤 |
一种制备双功能抗体的方法
|
|
EP2040995A1
(en)
|
2006-06-26 |
2009-04-01 |
Aida Centre, S.L. |
Blister package integrating rfid based tags
|
|
EP2046383B1
(en)
|
2006-07-04 |
2014-11-19 |
Genmab A/S |
Cd20 binding molecules for the treatment of copd
|
|
EP2057191A1
(en)
|
2006-08-18 |
2009-05-13 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
|
WO2008028044A2
(en)
|
2006-08-30 |
2008-03-06 |
Centocor, Inc. |
Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel
|
|
AU2007293614A1
(en)
|
2006-09-08 |
2008-03-13 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
ATE536369T1
(de)
|
2006-10-11 |
2011-12-15 |
Ablynx Nv |
Im wesentlichen ph-wert-unabhängigerweise an serumproteine bindende aminosäuresequenzen, verbindungen, die diese enthalten, und deren verwendung
|
|
EP2115004A2
(en)
|
2006-12-19 |
2009-11-11 |
Ablynx N.V. |
Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
|
|
JP2010518842A
(ja)
|
2007-02-22 |
2010-06-03 |
ノボ ノルディスク ヘルス ケア アーゲー |
改善された特異性を有するトランスグルタミナーゼ変異体
|
|
EP2185188B1
(en)
|
2007-08-22 |
2014-08-06 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
|
|
JP5373823B2
(ja)
|
2008-01-29 |
2013-12-18 |
アブリンクス エン．ヴェー． |
タンパク質及びポリペプチドを安定化する方法
|
|
US9212226B2
(en)
|
2008-05-16 |
2015-12-15 |
Ablynx N.V. |
Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same
|
|
EP2352764B1
(en)
|
2008-10-14 |
2018-03-28 |
Ablynx N.V. |
AMINO ACID SEQUENCES TARGETING HUMAN CD4 and CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN,BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND/OR CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY
|
|
MX2011007049A
(es)
|
2009-02-24 |
2011-08-03 |
Esbatech Alcon Biomed Res Unit |
Metodos para identificar inmunoligadores de los antegenos de la superficie celular.
|
|
HUE051430T2
(hu)
|
2009-07-10 |
2021-03-01 |
Ablynx Nv |
Eljárás variábilis domének elõállítására
|
|
CA2773978A1
(en)
*
|
2009-09-23 |
2011-03-31 |
Carolus Therapeutics, Inc. |
Methods of treating inflammation
|
|
MA33930B1
(fr)
|
2009-12-18 |
2013-01-02 |
Sanofi Sa |
Nouveaux anticorps antagonistes contre gpvi et leurs fragments fab et utilisations de ceux-ci
|
|
EP3498731A1
(en)
|
2009-12-23 |
2019-06-19 |
ESBATech, an Alcon Biomedical Research Unit LLC |
Method for decreasing immunogenicity
|
|
WO2011083140A1
(en)
*
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Immunoglobulin single variable domain directed against human cxcr4
|
|
KR101650995B1
(ko)
|
2010-11-08 |
2016-08-25 |
노파르티스 아게 |
Ｃｘｃｒ２ 결합 폴리펩티드
|
|
NZ780183A
(en)
|
2011-06-23 |
2024-12-20 |
Ablynx Nv |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
PE20141522A1
(es)
|
2011-08-17 |
2014-11-17 |
Glaxo Group Ltd |
Proteinas y peptidos modificados
|
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
|
WO2015100459A2
(en)
|
2013-12-27 |
2015-07-02 |
Merrimack Pharmaceuticals, Inc. |
Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
|