|
FI903489A7
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
CA2090126C
(en)
|
1990-08-02 |
2002-10-22 |
John W. Schrader |
Methods for the production of proteins with a desired function
|
|
US5440021A
(en)
|
1991-03-29 |
1995-08-08 |
Chuntharapai; Anan |
Antibodies to human IL-8 type B receptor
|
|
DE69231223T3
(de)
|
1991-03-29 |
2008-01-17 |
Genentech, Inc., South San Francisco |
Menschliche pf4a rezeptoren und ihre verwendung
|
|
US5374506A
(en)
|
1991-09-13 |
1994-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Amino acid sequence for a functional human interleukin-8 receptor
|
|
WO1994002610A1
(en)
|
1992-07-17 |
1994-02-03 |
Dana-Farber Cancer Institute |
Method of intracellular binding of target molecules
|
|
DE69334275D1
(de)
|
1992-08-21 |
2009-05-20 |
Univ Bruxelles |
Immunoglobuline ohne Leichtkette
|
|
CA2162878A1
(en)
|
1993-06-09 |
1994-12-22 |
Leon Gerardus Joseph Frenken |
Process for producing fusion proteins comprising scfv fragments by a transformed mould
|
|
US6091639A
(en)
|
1993-08-27 |
2000-07-18 |
Kabushiki Kaisha Toshiba |
Non-volatile semiconductor memory device and data programming method
|
|
US6448379B1
(en)
|
1993-09-14 |
2002-09-10 |
Chiron Corporation |
IL8 inhibitors
|
|
US5595756A
(en)
*
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
JPH10501681A
(ja)
|
1994-02-22 |
1998-02-17 |
ダナ−ファーバー キャンサー インスティチュート |
核酸送達システムならびにその合成および使用方法
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
EP1027073A2
(en)
|
1996-11-19 |
2000-08-16 |
Sangstat Medical Corporation |
Enhanced effects for hapten conjugated therapeutics
|
|
US6329516B1
(en)
|
1997-04-28 |
2001-12-11 |
Fmc Corporation |
Lepidopteran GABA-gated chloride channels
|
|
DK1027439T3
(da)
|
1997-10-27 |
2010-05-10 |
Bac Ip Bv |
Multivalente antigenbindende proteiner
|
|
ID26964A
(id)
|
1998-02-19 |
2001-02-22 |
Xcyte Therapies Inc |
Komposisi dan metode untuk pengaturan pengaktifan limfosit
|
|
EP0967284A1
(en)
|
1998-05-28 |
1999-12-29 |
Pfizer Limited |
Phosphodiesterases
|
|
GB9824632D0
(en)
|
1998-11-10 |
1999-01-06 |
Celltech Therapeutics Ltd |
Biological compounds
|
|
NZ513356A
(en)
|
1999-02-05 |
2004-01-30 |
Univ Leiden |
Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate
|
|
WO2000055318A2
(en)
|
1999-03-15 |
2000-09-21 |
University Of British Columbia |
Abc1 polypeptide and methods and reagents for modulating cholesterol levels
|
|
EP1190065A2
(en)
|
1999-06-18 |
2002-03-27 |
Cv Therapeutics, Inc. |
Atp binding cassette transporter protein abc1 polypeptides
|
|
WO2001009300A2
(en)
|
1999-08-02 |
2001-02-08 |
Keygene N.V. |
Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants
|
|
US20040214783A1
(en)
|
2002-05-08 |
2004-10-28 |
Terman David S. |
Compositions and methods for treatment of neoplastic disease
|
|
GB9922124D0
(en)
|
1999-09-17 |
1999-11-17 |
Pfizer Ltd |
Phosphodiesterase enzymes
|
|
DE19955408A1
(de)
|
1999-11-18 |
2001-05-23 |
Bayer Ag |
GABA-B-Rezeptoren
|
|
US7608681B2
(en)
|
1999-12-24 |
2009-10-27 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
US20030186889A1
(en)
*
|
2000-03-31 |
2003-10-02 |
Wolf-Georg Forssmann |
Diagnostic and medicament for analysing the cell surface proteome of tumour and inflammatory cells and for treating tumorous and inflammatory diseases, preferably using a specific chemokine receptor analysis and the chemokine receptor-ligand interaction
|
|
US6926898B2
(en)
|
2000-04-12 |
2005-08-09 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
CA2441903C
(en)
|
2000-05-26 |
2012-07-31 |
National Research Council Of Canada |
Single-domain brain-targeting antibody fragments derived from llama antibodies
|
|
US6741957B1
(en)
|
2000-07-21 |
2004-05-25 |
Daimlerchrysler Corporation |
Analytical tire model for vehicle durability and ride comfort analysis
|
|
EP1361892A4
(en)
|
2001-01-17 |
2004-10-13 |
Trubion Pharmaceuticals Inc |
BINDING DOMAIN FUSION PROTEIN Immunoglobulin
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US7211395B2
(en)
|
2001-03-09 |
2007-05-01 |
Dyax Corp. |
Serum albumin binding moieties
|
|
US20030017150A1
(en)
|
2001-03-14 |
2003-01-23 |
Torphy Theodore J. |
Chronic obstructive pulmonary disease-related immunglobulin derived proteins, compositions, methods and uses
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
JP4303105B2
(ja)
|
2001-06-28 |
2009-07-29 |
ドマンティス リミテッド |
二重特異性リガンドとその利用
|
|
CA2456121A1
(en)
|
2001-08-03 |
2003-02-20 |
Medical Research Council |
Intracellular antibodies
|
|
WO2003020906A2
(en)
|
2001-08-31 |
2003-03-13 |
Abmaxis, Inc. |
Multivalent protein conjugate with multiple ligand-binding domains of receptors
|
|
KR100599789B1
(ko)
|
2001-12-03 |
2006-07-12 |
삼성에스디아이 주식회사 |
방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법
|
|
WO2003055527A2
(en)
|
2002-01-03 |
2003-07-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Immunoconjugates useful for treatment of tumours
|
|
CN1678634A
(zh)
|
2002-06-28 |
2005-10-05 |
多曼蒂斯有限公司 |
免疫球蛋白单个变体抗原结合区及其特异性构建体
|
|
US7004940B2
(en)
|
2002-10-10 |
2006-02-28 |
Ethicon, Inc. |
Devices for performing thermal ablation having movable ultrasound transducers
|
|
EP1565482B1
(en)
|
2002-10-23 |
2014-04-30 |
Ludwig Institute for Cancer Research Ltd. |
A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same
|
|
AU2003284357A1
(en)
|
2002-11-01 |
2004-06-07 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
NZ540194A
(en)
|
2002-11-08 |
2008-07-31 |
Ablynx Nv |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
EP1558645B1
(en)
|
2002-11-08 |
2011-07-27 |
Ablynx N.V. |
Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
|
|
GB0228210D0
(en)
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
|
WO2004051268A1
(en)
|
2002-12-03 |
2004-06-17 |
Celltech R & D Limited |
Assay for identifying antibody producing cells
|
|
NZ541050A
(en)
|
2002-12-16 |
2010-06-25 |
Genmab As |
Human monoclonal antibodies against interleukin 8 (IL-8)
|
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
ATE444984T1
(de)
|
2002-12-31 |
2009-10-15 |
Nektar Therapeutics Al Corp |
Hydrolysestabile maleimidendgruppen-enthaltende polymere
|
|
GB0312481D0
(en)
|
2003-05-30 |
2003-07-09 |
Celltech R&D Ltd |
Antibodies
|
|
JP5087274B2
(ja)
|
2003-06-30 |
2012-12-05 |
ドマンティス リミテッド |
ポリペプチド
|
|
ES2385829T3
(es)
|
2003-08-20 |
2012-08-01 |
Ucb Pharma, S.A. |
Métodos para obtener anticuerpos
|
|
WO2005103702A2
(en)
|
2004-04-20 |
2005-11-03 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with cxc chemokine receptor 2 (cxcr2)
|
|
US7882839B2
(en)
|
2004-06-25 |
2011-02-08 |
Ambis Jr Edward J |
Custom mouthguard
|
|
US20060008601A1
(en)
|
2004-06-25 |
2006-01-12 |
Zeik Douglas B |
Flexible laminate having an integrated pressure release valve
|
|
EP1776383B1
(en)
|
2004-07-22 |
2014-08-20 |
Erasmus University Medical Center Rotterdam |
Binding molecules
|
|
WO2006040153A2
(en)
|
2004-10-13 |
2006-04-20 |
Ablynx N.V. |
Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
|
|
WO2006040154A2
(en)
|
2004-10-14 |
2006-04-20 |
Dublin City University |
Prokaryotic two hybrid system
|
|
JP2008528010A
(ja)
|
2005-01-31 |
2008-07-31 |
アブリンクス ナームローゼ フェンノートシャップ |
重鎖抗体の可変ドメイン配列を作出する方法
|
|
AU2006249144B2
(en)
|
2005-05-18 |
2011-11-17 |
Ablynx Nv |
Improved NanobodiesTM against Tumor Necrosis Factor-alpha
|
|
LT2444424T
(lt)
|
2005-05-20 |
2018-10-25 |
Ablynx N.V. |
Pagerintos tm nanodalelės, skirtos agregacijos sąlygotų sutrikimų gydymui
|
|
WO2007005605A2
(en)
|
2005-07-01 |
2007-01-11 |
Washington University In St. Louis |
Phosphospecific chemokine receptor antibodies
|
|
KR20140053410A
(ko)
|
2005-08-19 |
2014-05-07 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
WO2007112940A2
(en)
|
2006-03-31 |
2007-10-11 |
Ablynx N.V. |
Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same
|
|
AU2007237501A1
(en)
|
2006-04-14 |
2007-10-25 |
Ablynx N.V. |
DP-78-like nanobodies
|
|
CN101070346A
(zh)
*
|
2006-05-08 |
2007-11-14 |
陈正贤 |
一种制备双功能抗体的方法
|
|
WO2008000279A1
(en)
|
2006-06-26 |
2008-01-03 |
Aida Centre, S.L. |
Blister package integrating rfid based tags
|
|
US20130004480A1
(en)
|
2006-07-04 |
2013-01-03 |
Paul Parren |
CD20 Binding Molecules for the Treatment of Copd
|
|
JP2010500876A
(ja)
|
2006-08-18 |
2010-01-14 |
アブリンクス エン．ヴェー． |
Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド
|
|
US7943310B2
(en)
|
2006-08-30 |
2011-05-17 |
Centocor Ortho Biotech Inc. |
Methods for assessing response to therapy in subjects having ulcerative colitis
|
|
US20100113339A1
(en)
|
2006-09-08 |
2010-05-06 |
Ablynx N. V. |
Serum albumin binding proteins with long half-lives
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
US20100129368A9
(en)
|
2006-10-11 |
2010-05-27 |
Ablynx N.V. |
Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and uses thereof
|
|
AU2007336242B2
(en)
|
2006-12-19 |
2012-08-30 |
Ablynx N.V. |
Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
|
WO2008102007A1
(en)
|
2007-02-22 |
2008-08-28 |
Novo Nordisk Health Care Ag |
Transglutaminase variants with improved specificity
|
|
EP2185188B1
(en)
|
2007-08-22 |
2014-08-06 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
|
|
CA2712432C
(en)
|
2008-01-29 |
2018-09-25 |
Ablynx N.V. |
Methods to stabilize single variable domains
|
|
US9212226B2
(en)
*
|
2008-05-16 |
2015-12-15 |
Ablynx N.V. |
Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same
|
|
WO2010043650A2
(en)
|
2008-10-14 |
2010-04-22 |
Ablynx Nv |
Amino acid sequences directed against cellular receptors for viruses and bacteria
|
|
CA2744103C
(en)
|
2009-02-24 |
2018-01-02 |
Esbatech, An Alcon Biomedical Research Unit Llc |
Methods for identifying immunobinders of cell-surface antigens
|
|
ES2804450T3
(es)
|
2009-07-10 |
2021-02-08 |
Ablynx Nv |
Método para la producción de dominios variables
|
|
WO2011038149A2
(en)
*
|
2009-09-23 |
2011-03-31 |
Carolus Therapeutics, Inc. |
Methods of treating inflammation
|
|
JP5843783B2
(ja)
|
2009-12-18 |
2016-01-13 |
サノフイ |
ＧＰＶＩに対する新規アンタゴニスト抗体および該抗体のＦａｂフラグメントならびにこれらの使用
|
|
CA2777527C
(en)
|
2009-12-23 |
2020-06-23 |
Esbatech, An Alcon Biomedical Research Unit Llc |
Method for decreasing immunogenicity
|
|
WO2011083140A1
(en)
*
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Immunoglobulin single variable domain directed against human cxcr4
|
|
PY1147875A
(es)
|
2010-11-08 |
2015-08-03 |
Novartis Ag |
Polipéptidos de enlace de los receptores de quimiocina
|
|
CA3141978A1
(en)
|
2011-06-23 |
2012-12-27 |
Ablynx Nv |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
MY167125A
(en)
|
2011-08-17 |
2018-08-13 |
Glaxo Group Ltd |
Modified proteins and peptides
|
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
|
WO2015100459A2
(en)
|
2013-12-27 |
2015-07-02 |
Merrimack Pharmaceuticals, Inc. |
Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
|