JP2017509323A5 - - Google Patents
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- JP2017509323A5 JP2017509323A5 JP2016549449A JP2016549449A JP2017509323A5 JP 2017509323 A5 JP2017509323 A5 JP 2017509323A5 JP 2016549449 A JP2016549449 A JP 2016549449A JP 2016549449 A JP2016549449 A JP 2016549449A JP 2017509323 A5 JP2017509323 A5 JP 2017509323A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- binding molecule
- molecule according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 43
- 239000012634 fragment Substances 0.000 claims 19
- 235000001014 amino acid Nutrition 0.000 claims 15
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 7
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 7
- 239000005557 antagonist Substances 0.000 claims 7
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 6
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 6
- 239000000710 homodimer Substances 0.000 claims 6
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 5
- 230000004927 fusion Effects 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 101100425758 Mus musculus Tnfrsf1b gene Proteins 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 101150111783 NTRK1 gene Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 2
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 102000046917 human NGF Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461934828P | 2014-02-02 | 2014-02-02 | |
| US61/934,828 | 2014-02-02 | ||
| PCT/EP2015/052098 WO2015114150A1 (en) | 2014-02-02 | 2015-02-02 | Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020065513A Division JP7074792B2 (ja) | 2014-02-02 | 2020-04-01 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509323A JP2017509323A (ja) | 2017-04-06 |
| JP2017509323A5 true JP2017509323A5 (enExample) | 2018-03-08 |
| JP6687526B2 JP6687526B2 (ja) | 2020-04-22 |
Family
ID=52440681
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549449A Active JP6687526B2 (ja) | 2014-02-02 | 2015-02-02 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
| JP2020065513A Active JP7074792B2 (ja) | 2014-02-02 | 2020-04-01 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
| JP2022077858A Active JP7520070B2 (ja) | 2014-02-02 | 2022-05-11 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
| JP2024109298A Pending JP2024133644A (ja) | 2014-02-02 | 2024-07-08 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020065513A Active JP7074792B2 (ja) | 2014-02-02 | 2020-04-01 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
| JP2022077858A Active JP7520070B2 (ja) | 2014-02-02 | 2022-05-11 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
| JP2024109298A Pending JP2024133644A (ja) | 2014-02-02 | 2024-07-08 | ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US9884911B2 (enExample) |
| EP (2) | EP3099713B1 (enExample) |
| JP (4) | JP6687526B2 (enExample) |
| KR (1) | KR102489452B1 (enExample) |
| CN (2) | CN106459190A (enExample) |
| AU (3) | AU2015212787B2 (enExample) |
| CA (1) | CA2938066C (enExample) |
| CY (1) | CY1123248T1 (enExample) |
| DK (1) | DK3099713T3 (enExample) |
| ES (1) | ES2784238T3 (enExample) |
| HR (1) | HRP20200477T1 (enExample) |
| HU (1) | HUE048478T2 (enExample) |
| LT (1) | LT3099713T (enExample) |
| MX (1) | MX382763B (enExample) |
| PL (1) | PL3099713T3 (enExample) |
| PT (1) | PT3099713T (enExample) |
| RS (1) | RS60156B1 (enExample) |
| RU (1) | RU2678810C2 (enExample) |
| SI (1) | SI3099713T1 (enExample) |
| SM (1) | SMT202000182T1 (enExample) |
| WO (1) | WO2015114150A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3099713B1 (en) * | 2014-02-02 | 2020-01-15 | MedImmune Limited | Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain |
| US9862760B2 (en) | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
| AU2018337686B2 (en) | 2017-09-21 | 2023-04-20 | Merck Patent Gmbh | Fusion protein comprising an FGF-18 moiety |
| WO2021142573A1 (zh) * | 2020-01-13 | 2021-07-22 | 丁邦 | 一种融合蛋白及其制法和用途 |
| AU2021350424A1 (en) | 2020-09-28 | 2023-06-01 | Medimmune Limited | Compounds and methods for treating pain |
| CN114574444B (zh) * | 2020-12-01 | 2024-05-03 | 达达生物技术(北京)有限公司 | 自体纤维母细胞在制备抗类风湿关节炎药物中的应用 |
| TWI821881B (zh) * | 2021-01-29 | 2023-11-11 | 醫研生物科技有限公司 | 腫瘤壞死因子α重組抗體及其用途 |
| CN116179667A (zh) * | 2022-09-21 | 2023-05-30 | 福建中妆技术研究有限公司 | 基于斑马鱼模型中trpv1信号通路筛选皮肤疼痛舒缓原料的试剂盒及应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| DK0939121T4 (da) | 1989-09-12 | 2008-02-04 | Ahp Mfg B V | TNF-bindende proteiner |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EP1042459A4 (en) * | 1997-12-24 | 2003-07-23 | Diatech Pty Ltd | BIFUNCTIONAL MOLECULES |
| US20040220103A1 (en) | 1999-04-19 | 2004-11-04 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
| DE19926068C1 (de) * | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| AU2002308722B2 (en) | 2001-05-30 | 2007-05-17 | Genentech, Inc. | Anti-NGF antibodies for the treatment of various disorders |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| WO2004032870A2 (en) | 2002-10-08 | 2004-04-22 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| WO2005075514A2 (en) | 2004-03-10 | 2005-08-18 | Lonza Ltd. | Method for producing antibodies |
| WO2006024497A1 (en) | 2004-08-30 | 2006-03-09 | Lonza Biologics Plc. | Affinity- plus ion exchange- chromatography for purifying antibodies |
| CN101107268B (zh) | 2005-01-24 | 2012-06-27 | 剑桥抗体技术有限公司 | 针对ngf的特异性结合成员 |
| NZ596865A (en) * | 2006-06-12 | 2013-07-26 | Emergent Product Dev Seattle | Single-chain multivalent binding proteins with effector function |
| GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| KR20100021601A (ko) * | 2007-05-14 | 2010-02-25 | 바이오겐 아이덱 엠에이 인코포레이티드 | 단일-쇄 Ｆｃ(ＳｃＦｃ) 부분, 이를 포함하는 결합 폴리펩타이드, 및 이에 관련된 방법 |
| EP2275431A3 (en) | 2008-01-18 | 2011-05-25 | Bio-Rad Laboratories, Inc. | Enhanced fractionation of phosphorylated and nonphosphorylated biomolecules by apatite chromotography |
| AU2009256250B2 (en) | 2008-06-03 | 2013-05-30 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| SG192489A1 (en) * | 2008-07-08 | 2013-08-30 | Abbott Lab | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
| JP2011016676A (ja) * | 2009-07-07 | 2011-01-27 | Sumitomo Electric Ind Ltd | 窒化物半導体基板の製造方法 |
| PH12012500691A1 (en) * | 2009-10-15 | 2012-11-12 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| JP2013512674A (ja) * | 2009-12-02 | 2013-04-18 | アクセルロン ファーマ， インコーポレイテッド | Ｆｃ融合タンパク質の血清半減期を増加させるための組成物および方法 |
| EP2555797A4 (en) * | 2010-04-07 | 2014-02-12 | Abbvie Inc | TNF-ALPHA-BINDING PROTEINS |
| WO2012162561A2 (en) * | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| CN103906533A (zh) | 2011-11-07 | 2014-07-02 | 米迪缪尼有限公司 | 多特异性和多价结合蛋白及其用途 |
| AR090047A1 (es) | 2011-12-30 | 2014-10-15 | Abbvie Inc | Dominio variable dual de inmunoglobulinas y sus usos |
| WO2014106001A2 (en) * | 2012-12-28 | 2014-07-03 | Abbvie, Inc. | Dual specific binding proteins having a receptor sequence |
| BR112015023557A2 (pt) | 2013-03-15 | 2017-10-24 | Abbvie Inc | proteínas de ligações dual específicas direcionadas contra tnfa |
| EP3099713B1 (en) | 2014-02-02 | 2020-01-15 | MedImmune Limited | Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain |
| CA2874083C (en) * | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
| US20210009671A1 (en) | 2019-05-10 | 2021-01-14 | Medimmune Limited | Compounds and methods for treating pain |
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2015
- 2015-02-02 EP EP15701985.2A patent/EP3099713B1/en active Active
- 2015-02-02 AU AU2015212787A patent/AU2015212787B2/en active Active
- 2015-02-02 HU HUE15701985A patent/HUE048478T2/hu unknown
- 2015-02-02 JP JP2016549449A patent/JP6687526B2/ja active Active
- 2015-02-02 US US14/612,137 patent/US9884911B2/en active Active
- 2015-02-02 HR HRP20200477TT patent/HRP20200477T1/hr unknown
- 2015-02-02 RU RU2016132370A patent/RU2678810C2/ru active
- 2015-02-02 MX MX2016010030A patent/MX382763B/es unknown
- 2015-02-02 ES ES15701985T patent/ES2784238T3/es active Active
- 2015-02-02 PL PL15701985T patent/PL3099713T3/pl unknown
- 2015-02-02 PT PT157019852T patent/PT3099713T/pt unknown
- 2015-02-02 WO PCT/EP2015/052098 patent/WO2015114150A1/en not_active Ceased
- 2015-02-02 KR KR1020167023831A patent/KR102489452B1/ko active Active
- 2015-02-02 CN CN201580017113.5A patent/CN106459190A/zh active Pending
- 2015-02-02 DK DK15701985.2T patent/DK3099713T3/da active
- 2015-02-02 EP EP19214210.7A patent/EP3696193A1/en active Pending
- 2015-02-02 RS RS20200396A patent/RS60156B1/sr unknown
- 2015-02-02 CA CA2938066A patent/CA2938066C/en active Active
- 2015-02-02 CN CN202311359790.8A patent/CN118085103A/zh active Pending
- 2015-02-02 SI SI201531149T patent/SI3099713T1/sl unknown
- 2015-02-02 SM SM20200182T patent/SMT202000182T1/it unknown
- 2015-02-02 LT LTEP15701985.2T patent/LT3099713T/lt unknown
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2017
- 2017-12-21 US US15/849,771 patent/US10457728B2/en active Active
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2019
- 2019-09-17 US US16/573,192 patent/US11053307B2/en active Active
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2020
- 2020-04-01 JP JP2020065513A patent/JP7074792B2/ja active Active
- 2020-04-10 CY CY20201100338T patent/CY1123248T1/el unknown
- 2020-09-11 AU AU2020230316A patent/AU2020230316B2/en active Active
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2021
- 2021-05-28 US US17/333,291 patent/US11897949B2/en active Active
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2022
- 2022-05-11 JP JP2022077858A patent/JP7520070B2/ja active Active
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2023
- 2023-12-21 AU AU2023285832A patent/AU2023285832A1/en active Pending
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2024
- 2024-01-03 US US18/403,043 patent/US20240262902A1/en not_active Abandoned
- 2024-07-08 JP JP2024109298A patent/JP2024133644A/ja active Pending