JP6687526B2 - NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質 - Google Patents

NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質 Download PDF

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JP6687526B2
JP6687526B2 JP2016549449A JP2016549449A JP6687526B2 JP 6687526 B2 JP6687526 B2 JP 6687526B2 JP 2016549449 A JP2016549449 A JP 2016549449A JP 2016549449 A JP2016549449 A JP 2016549449A JP 6687526 B2 JP6687526 B2 JP 6687526B2
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amino acid
seq
acid sequence
ngf
antibody
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JP2017509323A (ja
JP2017509323A5 (enExample
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ダレン・スコフィールド
マシュー・アレクサンダー・スリーマン
イアン・パトリック・チェッセル
ジョナサン・ハッチャー
デイヴィッド・ロウ
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MedImmune Ltd
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/48Nerve growth factor [NGF]
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/32Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2016549449A 2014-02-02 2015-02-02 NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質 Active JP6687526B2 (ja)

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US201461934828P 2014-02-02 2014-02-02
US61/934,828 2014-02-02
PCT/EP2015/052098 WO2015114150A1 (en) 2014-02-02 2015-02-02 Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain

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JP2017509323A JP2017509323A (ja) 2017-04-06
JP2017509323A5 JP2017509323A5 (enExample) 2018-03-08
JP6687526B2 true JP6687526B2 (ja) 2020-04-22

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JP2016549449A Active JP6687526B2 (ja) 2014-02-02 2015-02-02 NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質
JP2020065513A Active JP7074792B2 (ja) 2014-02-02 2020-04-01 NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質
JP2022077858A Active JP7520070B2 (ja) 2014-02-02 2022-05-11 NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質
JP2024109298A Pending JP2024133644A (ja) 2014-02-02 2024-07-08 NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質

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JP2022077858A Active JP7520070B2 (ja) 2014-02-02 2022-05-11 NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質
JP2024109298A Pending JP2024133644A (ja) 2014-02-02 2024-07-08 NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質

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EP (2) EP3696193A1 (enExample)
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CN (2) CN106459190A (enExample)
AU (3) AU2015212787B2 (enExample)
CA (1) CA2938066C (enExample)
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DK (1) DK3099713T3 (enExample)
ES (1) ES2784238T3 (enExample)
HR (1) HRP20200477T1 (enExample)
HU (1) HUE048478T2 (enExample)
LT (1) LT3099713T (enExample)
MX (1) MX382763B (enExample)
PL (1) PL3099713T3 (enExample)
PT (1) PT3099713T (enExample)
RS (1) RS60156B1 (enExample)
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SI (1) SI3099713T1 (enExample)
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JP2022106951A (ja) * 2014-02-02 2022-07-20 メドイミューン・リミテッド NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質

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WO2021142573A1 (zh) * 2020-01-13 2021-07-22 丁邦 一种融合蛋白及其制法和用途
KR20230084199A (ko) * 2020-09-28 2023-06-12 메디뮨 리미티드 통증 치료를 위한 화합물 및 방법
CN114574444B (zh) * 2020-12-01 2024-05-03 达达生物技术(北京)有限公司 自体纤维母细胞在制备抗类风湿关节炎药物中的应用
TWI821881B (zh) * 2021-01-29 2023-11-11 醫研生物科技有限公司 腫瘤壞死因子α重組抗體及其用途
CN116179667A (zh) * 2022-09-21 2023-05-30 福建中妆技术研究有限公司 基于斑马鱼模型中trpv1信号通路筛选皮肤疼痛舒缓原料的试剂盒及应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022106951A (ja) * 2014-02-02 2022-07-20 メドイミューン・リミテッド NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質
JP7520070B2 (ja) 2014-02-02 2024-07-22 メドイミューン・リミテッド NGFアンタゴニストドメインおよびTNFαアンタゴニストドメインから構成されるキメラタンパク質

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DK3099713T3 (da) 2020-04-14
ES2784238T3 (es) 2020-09-23
JP2017509323A (ja) 2017-04-06
AU2015212787B2 (en) 2020-06-18
EP3099713A1 (en) 2016-12-07
HUE048478T2 (hu) 2020-08-28
KR20160113711A (ko) 2016-09-30
KR102489452B1 (ko) 2023-01-16
AU2020230316B2 (en) 2023-10-05
JP2020120666A (ja) 2020-08-13
RU2019102141A (ru) 2019-03-22
AU2015212787A1 (en) 2016-09-08
WO2015114150A1 (en) 2015-08-06
PT3099713T (pt) 2020-04-16
SMT202000182T1 (it) 2020-05-08
US11053307B2 (en) 2021-07-06
US11897949B2 (en) 2024-02-13
BR112016017698A2 (pt) 2017-10-10
US20210347871A1 (en) 2021-11-11
JP2024133644A (ja) 2024-10-02
AU2023285832A1 (en) 2024-03-14
MX382763B (es) 2025-03-13
EP3099713B1 (en) 2020-01-15
US20180222971A1 (en) 2018-08-09
US10457728B2 (en) 2019-10-29
US20240262902A1 (en) 2024-08-08
JP2022106951A (ja) 2022-07-20
MX2016010030A (es) 2017-04-27
CA2938066C (en) 2025-05-06
JP7520070B2 (ja) 2024-07-22
EP3696193A1 (en) 2020-08-19
RS60156B1 (sr) 2020-05-29
AU2020230316A1 (en) 2020-10-01
RU2016132370A (ru) 2018-03-07
CA2938066A1 (en) 2015-08-06
SI3099713T1 (sl) 2020-06-30
JP7074792B2 (ja) 2022-05-24
HRP20200477T1 (hr) 2020-06-26
CN118085103A (zh) 2024-05-28
US20150274818A1 (en) 2015-10-01
US9884911B2 (en) 2018-02-06
CY1123248T1 (el) 2021-10-29
US20200123241A1 (en) 2020-04-23
CN106459190A (zh) 2017-02-22
PL3099713T3 (pl) 2020-06-29
LT3099713T (lt) 2020-07-10
RU2016132370A3 (enExample) 2018-03-21
RU2678810C2 (ru) 2019-02-01

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