|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
MA24512A1
(fr)
*
|
1996-01-17 |
1998-12-31 |
Univ Vermont And State Agrienl |
Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
|
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
WO1999003496A1
(en)
*
|
1997-07-21 |
1999-01-28 |
The University Of North Carolina At Chapel Hill |
Factor ix antihemophilic factor with increased clotting activity
|
|
AT411997B
(de)
*
|
1999-09-14 |
2004-08-26 |
Baxter Ag |
Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
|
|
EP1355919B1
(en)
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
|
US7297336B2
(en)
|
2003-09-12 |
2007-11-20 |
Baxter International Inc. |
Factor IXa specific antibodies displaying factor VIIIa like activity
|
|
AU2003271174A1
(en)
*
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
|
AU2003271186A1
(en)
|
2003-10-14 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
|
KR101374454B1
(ko)
|
2005-03-31 |
2014-03-17 |
추가이 세이야쿠 가부시키가이샤 |
회합제어에 의한 폴리펩티드 제조방법
|
|
EP2824183B1
(en)
*
|
2005-04-08 |
2020-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing bispecific antibodies
|
|
CA2614076A1
(en)
|
2005-07-05 |
2007-01-11 |
Glaxo Group Limited |
Humanised antibodies specific for nogo-a and pharmaceutical uses thereof
|
|
DK1999154T3
(da)
|
2006-03-24 |
2012-12-03 |
Merck Patent Gmbh |
Fremstillede heterodimere proteindomæner
|
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
|
JOP20080381B1
(ar)
|
2007-08-23 |
2023-03-28 |
Amgen Inc |
بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
|
|
TWI507525B
(zh)
|
2009-06-26 |
2015-11-11 |
Regeneron Pharma |
具天然免疫球蛋白形式之易分離的雙專一性抗體
|
|
DK3241435T3
(da)
|
2009-07-08 |
2021-08-23 |
Kymab Ltd |
Dyremodeller og terapeutiske molekyler
|
|
WO2011143545A1
(en)
|
2010-05-14 |
2011-11-17 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
|
CN103228130B
(zh)
|
2010-06-17 |
2016-03-16 |
科马布有限公司 |
动物模型及治疗分子
|
|
CN105859889B
(zh)
*
|
2010-11-17 |
2020-01-07 |
中外制药株式会社 |
具有代替凝血因子viii的功能的功能的多特异性抗原结合分子
|
|
US20140356377A1
(en)
|
2011-08-25 |
2014-12-04 |
Umc Utrecht Holding B.V. |
Compounds for use in boosting coagulation
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
WO2013157953A1
(en)
|
2012-04-20 |
2013-10-24 |
Merus B.V. |
Methods and means for the production of ig-like molecules
|
|
CN104854133B
(zh)
|
2012-10-12 |
2018-10-30 |
新加坡科技研究局 |
用于制备重组抗体治疗剂的最佳重链和轻链信号肽
|
|
EP3065768B1
(en)
|
2013-11-04 |
2020-09-23 |
The Regents of the University of California |
Composition for use in treatment or prevention of conditions associated with bleeding or hypocoagulationcompostion
|
|
AU2014374055B2
(en)
|
2013-12-30 |
2018-11-08 |
Epimab Biotherapeutics Inc. |
Fabs-in-tandem immunoglobulin and uses thereof
|
|
TW201625299A
(zh)
|
2014-06-20 |
2016-07-16 |
Chugai Pharmaceutical Co Ltd |
用於因第ｖｉｉｉ凝血因子及／或活化的第ｖｉｉｉ凝血因子的活性降低或欠缺而發病及／或進展的疾病之預防及／或治療之醫藥組成物
|
|
TWI700300B
(zh)
|
2014-09-26 |
2020-08-01 |
日商中外製藥股份有限公司 |
中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體
|
|
CA2978038A1
(en)
|
2015-04-17 |
2016-10-20 |
F. Hoffmann-La Roche Ag |
Combination therapy with coagulation factors and multispecific antibodies
|
|
JP2018123055A
(ja)
|
2015-04-24 |
2018-08-09 |
公立大学法人奈良県立医科大学 |
血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第ｘｉ因子（ｆｘｉ）異常症の予防および／または治療に用いられる医薬組成物
|
|
JP6920293B2
(ja)
|
2015-10-30 |
2021-08-18 |
メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ |
ＩｇＧ軽鎖におけるＮ末端切断の防止
|
|
US20200270363A1
(en)
|
2015-12-25 |
2020-08-27 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody having enhanced activity, and method for modifying same
|
|
JP7014724B2
(ja)
|
2016-02-06 |
2022-02-01 |
エピムアブ バイオセラピューティクス インコーポレイテッド |
タンデム型Ｆａｂ免疫グロブリンおよびその使用
|
|
SG11201809642TA
(en)
|
2016-05-16 |
2018-11-29 |
Baxalta Inc |
Anti-factor ix padua antibodies
|
|
CA3027018A1
(en)
|
2016-07-29 |
2018-02-01 |
Chugai Seiyaku Kabushiki Kaisha |
Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity
|
|
US11352438B2
(en)
|
2016-09-06 |
2022-06-07 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X
|
|
AU2017363309A1
(en)
|
2016-11-23 |
2019-07-11 |
Bioverativ Therapeutics Inc. |
Mono- and bispecific antibodies binding to coagulation factor IX and coagulation factor X
|
|
AU2018216008A1
(en)
|
2017-02-01 |
2019-08-01 |
Novo Nordisk A/S |
Procoagulant antibodies
|
|
WO2018145125A1
(en)
|
2017-02-06 |
2018-08-09 |
Applied Stemcell, Inc. |
Coagulation factor viii mimetic protein and uses thereof
|
|
WO2018209265A1
(en)
|
2017-05-11 |
2018-11-15 |
Atreca, Inc. |
Anti-malarial antibodies that bind circumsporozoite protein
|
|
GB201709970D0
(en)
|
2017-06-22 |
2017-08-09 |
Kymab Ltd |
Bispecific antigen-binding molecules
|
|
CA3071236A1
(en)
|
2017-09-29 |
2019-04-04 |
Chugai Seiyaku Kabushiki Kaisha |
Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said moleculeas active ingredient
|
|
CN111386285B
(zh)
|
2017-11-15 |
2024-08-27 |
诺和诺德股份有限公司 |
增强fx活化的因子x结合物
|
|
TWI772724B
(zh)
|
2018-12-21 |
2022-08-01 |
英商克馬伯有限公司 |
具有共同輕鏈的FIXaxFX雙專一性抗體
|